KEGG   ORTHOLOGY: K21331
Entry
K21331                      KO                                     
Symbol
calS8, atmS8
Name
dTDP-alpha-D-glucose dehydrogenase [EC:1.1.1.-]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R11471  dTDP-glucose:NAD+ 6-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K21331  calS8, atmS8; dTDP-alpha-D-glucose dehydrogenase
Other DBs
COG: COG0677
Genes
ODH: DHf2319_04530
MYE: AB431_22430
MCOO: MCOO_29710
MBRD: MBRA_32460
MPAA: MKK62_05225
MLL: B1R94_07630
MAUU: NCTC10437_02891(tuaD_2)
MAIC: MAIC_39790
MTY: MTOK_49870
MHEV: MHEL_06940
MSAR: MSAR_29460
MANY: MANY_23230
NDA: Ndas_4714
NAL: B005_1437
ACTI: UA75_17995
ACAD: UA74_17470
AG: AAM70332(calS8) ABC02801(atmS8) ABY66024(mdpA2)
 » show all
Reference
  Authors
Singh S, Michalska K, Bigelow L, Endres M, Kharel MK, Babnigg G, Yennamalli RM, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr
  Title
Structural Characterization of CalS8, a TDP-alpha-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis.
  Journal
J Biol Chem 290:26249-58 (2015)
DOI:10.1074/jbc.M115.673459
Reference
PMID:26289554 (atmS8)
  Authors
Peltier-Pain P, Singh S, Thorson JS
  Title
Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433.
  Journal
Chembiochem 16:2141-6 (2015)
DOI:10.1002/cbic.201500365
  Sequence
Reference
PMID:12183629 (calS8)
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
LinkDB

KEGG   REACTION: R11471
Entry
R11471                      Reaction                               
Name
dTDP-glucose:NAD+ 6-oxidoreductase
Definition
dTDP-glucose + 2 NAD+ + H2O <=> dTDP-D-glucuronate + 2 NADH + 2 H+
Equation
C00842 + 2 C00003 + C00001 <=> C06017 + 2 C00004 + 2 C00080
Reaction class
RC00291  C00842_C06017
Enzyme
1.1.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R11471  dTDP-glucose + 2 NAD+ + H2O <=> dTDP-D-glucuronate + 2 NADH + 2 H+
Orthology
K21331  dTDP-alpha-D-glucose dehydrogenase [EC:1.1.1.-]
LinkDB

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