KEGG   ORTHOLOGY: K21332
Entry
K21332                      KO                                     
Symbol
calS9, atmS9
Name
dTDP-alpha-D-glucuronic acid decarboxylase [EC:1.1.1.-]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R11472  dTDP-D-glucuronate:NAD+ oxidoreductase (decarboxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K21332  calS9, atmS9; dTDP-alpha-D-glucuronic acid decarboxylase
Other DBs
COG: COG0451
Genes
TMK: QGN29_03000
DMP: FAK_34380
MYE: AB431_22425
MCOO: MCOO_29720(galE)
MBRD: MBRA_32470
MLL: B1R94_07635
MAUU: NCTC10437_02890(strE_2)
MAIC: MAIC_39780(galE_2)
MTY: MTOK_49860(galE)
MHEV: MHEL_06930(galE_1)
MSAR: MSAR_29470
MANY: MANY_23220(galE_1)
NDA: Ndas_4713
NAL: B005_1438
ACTI: UA75_18075
ACAD: UA74_17550
PSUU: Psuf_058450(galE_2)
BALA: DSM104299_04577(rffG)
AG: AAM70333(calS9) ABC02802(atmS9) ABY66025(mdpA3)
 » show all
Reference
PMID:26289554 (atmS9)
  Authors
Peltier-Pain P, Singh S, Thorson JS
  Title
Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433.
  Journal
Chembiochem 16:2141-6 (2015)
DOI:10.1002/cbic.201500365
  Sequence
Reference
PMID:12183629 (calS9)
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
LinkDB

KEGG   REACTION: R11472
Entry
R11472                      Reaction                               
Name
dTDP-D-glucuronate:NAD+ oxidoreductase (decarboxylating)
Definition
dTDP-D-glucuronate + NAD+ <=> dTDP-4-oxo-alpha-D-xylose + CO2 + NADH + H+
Equation
Reaction class
RC01812  C06017_C21351
Enzyme
1.1.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R11472  dTDP-D-glucuronate + NAD+ <=> dTDP-4-oxo-alpha-D-xylose + CO2 + NADH + H+
Orthology
K21332  dTDP-alpha-D-glucuronic acid decarboxylase [EC:1.1.1.-]
LinkDB

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