KEGG   ORTHOLOGY: K21333
Entry
K21333                      KO                                     
Symbol
calS14, atmS14
Name
dTDP-4-oxo-alpha-D-xylose 2,3-dehydratase [EC:4.2.1.-]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R11473  dTDP-4-oxo-alpha-D-xylose hydro-lyase (dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K21333  calS14, atmS14; dTDP-4-oxo-alpha-D-xylose 2,3-dehydratase
Genes
GER: KP004_03985
GSUB: KP001_11420
GPL: M1B72_16740
SAOV: G3H79_01875
SARM: DVA86_12540
STRH: GXP74_22430
SAIU: J4H86_24145
ACIR: OG979_40535
AMOG: QRX60_49385
SAQ: Sare_2025
MCAY: PVK37_23845
MICF: QQG74_13770
UAM: UABAM_05897
AG: AAM70359(calS14) ABC02799(atmS14)
 » show all
Reference
PMID:26289554 (atmS14)
  Authors
Peltier-Pain P, Singh S, Thorson JS
  Title
Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433.
  Journal
Chembiochem 16:2141-6 (2015)
DOI:10.1002/cbic.201500365
  Sequence
[ag:ABC02799]
Reference
PMID:12183629 (calS14)
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
[ag:AAM70359]
LinkDB

KEGG   REACTION: R11473
Entry
R11473                      Reaction                               
Name
dTDP-4-oxo-alpha-D-xylose hydro-lyase (dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene-forming)
Definition
dTDP-4-oxo-alpha-D-xylose <=> dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene + H2O
Equation
C21351 <=> C21352 + C00001
Reaction class
RC01448  C21351_C21352
Enzyme
4.2.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-
     R11473  dTDP-4-oxo-alpha-D-xylose <=> dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene + H2O
Orthology
K21333  dTDP-4-oxo-alpha-D-xylose 2,3-dehydratase [EC:4.2.1.-]
LinkDB

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