KEGG   ORTHOLOGY: K21338
Entry
K21338            Tight     KO                                     
Symbol
ppzP
Name
5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase [EC:2.5.1.121]
Pathway
map00405  Phenazine biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R10966  dimethylallyl-diphosphate:5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00405 Phenazine biosynthesis
    K21338  ppzP; 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.121  5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
     K21338  ppzP; 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
Genes
AG: CAX48655(ppzP)
Reference
  Authors
Saleh O, Gust B, Boll B, Fiedler HP, Heide L
  Title
Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus.
  Journal
J Biol Chem 284:14439-47 (2009)
DOI:10.1074/jbc.M901312200
  Sequence
LinkDB

KEGG   ENZYME: 2.5.1.121
Entry
EC 2.5.1.121                Enzyme                                 
Name
5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase;
PpzP;
dihydrophenazine-1-carboxylate dimethylallyltransferase;
5,10-dihydrophenazine 1-carboxylate dimethylallyltransferase;
dimethylallyl diphosphate:5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
prenyl-diphosphate:5,10-dihydrophenazine-1-carboxylate 9-prenyltransferase
Reaction(IUBMB)
prenyl diphosphate + 5,10-dihydrophenazine-1-carboxylate = diphosphate + 9-prenyl-5,10-dihydrophenazine-1-carboxylate [RN:R10966]
Reaction(KEGG)
R10966
Substrate
prenyl diphosphate [CPD:C00235];
5,10-dihydrophenazine-1-carboxylate [CPD:C20981]
Product
diphosphate [CPD:C00013];
9-prenyl-5,10-dihydrophenazine-1-carboxylate [CPD:C20982]
Comment
The enzyme is involved in the biosynthesis of prenylated phenazines by the bacterium Streptomyces anulatus. It is specific for both prenyl diphosphate and 5,10-dihydrophenazine-1-carboxylate.
History
EC 2.5.1.121 created 2014
Pathway
ec00405  Phenazine biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K21338  5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
Reference
1  [PMID:19339241]
  Authors
Saleh O, Gust B, Boll B, Fiedler HP, Heide L
  Title
Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus.
  Journal
J Biol Chem 284:14439-47 (2009)
DOI:10.1074/jbc.M901312200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.121
IUBMB Enzyme Nomenclature: 2.5.1.121
ExPASy - ENZYME nomenclature database: 2.5.1.121
BRENDA, the Enzyme Database: 2.5.1.121
LinkDB

KEGG   REACTION: R10966
Entry
R10966                      Reaction                               
Name
dimethylallyl-diphosphate:5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
Definition
Dimethylallyl diphosphate + 5,10-Dihydrophenazine-1-carboxylate <=> Diphosphate + 9-(Dimethylallyl)-5,10-dihydrophenazine-1-carboxylate
Equation
Reaction class
RC00209  C20981_C20982
Enzyme
Pathway
rn00405  Phenazine biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.121
     R10966  Dimethylallyl diphosphate + 5,10-Dihydrophenazine-1-carboxylate <=> Diphosphate + 9-(Dimethylallyl)-5,10-dihydrophenazine-1-carboxylate
Orthology
K21338  5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase [EC:2.5.1.121]
LinkDB

DBGET integrated database retrieval system