KEGG   ORTHOLOGY: K21540
Entry
K21540            Tight     KO                                     
Symbol
mycE
Name
mycinamicin VI 2''-O-methyltransferase [EC:2.1.1.238]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Reaction
R09822  S-adenosyl-L-methionine:mycinamicin VI 2''-O-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K21540  mycE; mycinamicin VI 2''-O-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21540  mycE; mycinamicin VI 2''-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.238  mycinamicin VI 2''-O-methyltransferase
     K21540  mycE; mycinamicin VI 2''-O-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K21540  mycE; mycinamicin VI 2''-O-methyltransferase
Other DBs
GO: 0102302
Genes
AG: BAC57026(mycE)
Reference
PMID:19415708
  Authors
Li S, Anzai Y, Kinoshita K, Kato F, Sherman DH
  Title
Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics.
  Journal
Chembiochem 10:1297-301 (2009)
DOI:10.1002/cbic.200900088
  Sequence
[ag:BAC57026]
LinkDB

KEGG   ENZYME: 2.1.1.238
Entry
EC 2.1.1.238                Enzyme                                 
Name
mycinamicin VI 2''-O-methyltransferase;
MycE
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:mycinamicin VI 2''-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + mycinamicin VI = S-adenosyl-L-homocysteine + mycinamicin III [RN:R09822]
Reaction(KEGG)
R09822
Substrate
S-adenosyl-L-methionine [CPD:C00019];
mycinamicin VI [CPD:C15682]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
mycinamicin III [CPD:C15681]
Comment
The enzyme is involved in the biosynthesis of mycinamicin macrolide antibiotics. Requires Mg2+ for optimal activity.
History
EC 2.1.1.238 created 2011
Pathway
ec00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21540  mycinamicin VI 2''-O-methyltransferase
Reference
1  [PMID:19415708]
  Authors
Li S, Anzai Y, Kinoshita K, Kato F, Sherman DH
  Title
Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics.
  Journal
Chembiochem 10:1297-301 (2009)
DOI:10.1002/cbic.200900088
  Sequence
[ag:BAC57026]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.238
IUBMB Enzyme Nomenclature: 2.1.1.238
ExPASy - ENZYME nomenclature database: 2.1.1.238
BRENDA, the Enzyme Database: 2.1.1.238
LinkDB

KEGG   REACTION: R09822
Entry
R09822                      Reaction                               
Name
S-adenosyl-L-methionine:mycinamicin VI 2''-O-methyltransferase
Definition
Mycinamicin VI + S-Adenosyl-L-methionine <=> Mycinamicin III + S-Adenosyl-L-homocysteine
Equation
C15682 + C00019 <=> C15681 + C00021
Reaction class
RC00003  C00019_C00021
RC00466  C15681_C15682
Enzyme
2.1.1.238
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.238
     R09822  Mycinamicin VI + S-Adenosyl-L-methionine <=> Mycinamicin III + S-Adenosyl-L-homocysteine
Orthology
K21540  mycinamicin VI 2''-O-methyltransferase [EC:2.1.1.238]
Other DBs
RHEA: 31646
LinkDB

DBGET integrated database retrieval system