KEGG   ORTHOLOGY: K21610
Entry
K21610                      KO                                     
Symbol
cfbC
Name
Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC [EC:6.3.3.7]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K21610  cfbC; Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.7  Ni-sirohydrochlorin a,c-diamide reductive cyclase
     K21610  cfbC; Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC
Other DBs
RN: R11628
COG: COG1348
Genes
MTH: MTH_643
MMG: MTBMA_c10230(nifH2)
METC: MTCT_0570
MWO: MWSIV6_1015(nifH2)
METE: tca_00613(nifH1_1)
METZ: METMT2_0422
METK: FVF72_08355(cfbC)
MTHM: FZP57_04835(cfbC)
METJ: FZP68_05275(cfbC)
MST: Msp_1120(nifH)
MRU: mru_1466
MSI: Msm_1707
MEB: Abm4_0733
MMIL: sm9_1376
MEYE: TL18_04160
MOL: YLM1_0966
METH: MBMB1_0311(nifH2)
MFC: BRM9_1962
MFI: DSM1535_0151(nifH2-1)
MCUB: MCBB_0533(nifH2)
METT: CIT01_00825(nifH)
MEME: HYG87_02415(cfbC)
MFV: Mfer_0380
MBAR: MSBR2_1807
MBAK: MSBR3_2862
MAC: MA_3627(nifH)
MMA: MM_0514(nifH2)
MMAC: MSMAC_0771
METM: MSMTP_0886
MTHR: MSTHT_2451
MTHE: MSTHC_0831
MHOR: MSHOH_0895
MFZ: AOB57_003165(cfbC)
MBU: Mbur_1038
MMET: MCMEM_1520
MELO: J7W08_06410(cfbC)
MMH: Mmah_1413
MPY: Mpsy_0958
MZI: HWN40_03740(cfbC)
MTP: Mthe_1178
MCJ: MCON_0503(nifH)
MHI: Mhar_0047
MPD: MCP_0364(nifH-1)
MEZ: Mtc_0064(nifH-1)
RCI: RCIX2002(nifH-2)
 » show all
Reference
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3627]
LinkDB

KEGG   ORTHOLOGY: K21611
Entry
K21611                      KO                                     
Symbol
cfbD
Name
Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD [EC:6.3.3.7]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K21611  cfbD; Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.7  Ni-sirohydrochlorin a,c-diamide reductive cyclase
     K21611  cfbD; Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD
Other DBs
RN: R11628
COG: COG2710
Genes
MJA: MJ_1423
MFE: Mefer_1398
MVU: Metvu_0736
MFS: MFS40622_0630
MIF: Metin_0570
MJH: JH146_0545
MESG: MLAUSG7_0646(cfbD)
MESA: MLASG1_0179(cfbD)
MIG: Metig_1723
MMP: MMP0428
MMD: GYY_02215
MMAD: MMJJ_06040
MAE: Maeo_1313
MVO: Mvol_1630
MTH: MTH_1522
METC: MTCT_1386
METE: tca_01470(nifD_1)
MST: Msp_1461
MRU: mru_0181
MSI: Msm_1160
MEB: Abm4_0121
MMIL: sm9_0152
MEYE: TL18_10060
MOL: YLM1_1498
METH: MBMB1_0045
MFC: BRM9_0099
MCUB: MCBB_0063
MEME: HYG87_06895(cfbD)
MFV: Mfer_0362
MKA: MK1385(nifD)
MBAR: MSBR2_1806
MBAK: MSBR3_2861
MAC: MA_3628
MMA: MM_0515
MMAC: MSMAC_0770
METM: MSMTP_0887
MTHR: MSTHT_2450
MTHE: MSTHC_0832
MHOR: MSHOH_0894
MBU: Mbur_1037
MMET: MCMEM_1519
MELO: J7W08_06405(cfbD)
MMH: Mmah_1412
MPY: Mpsy_0959
MZI: HWN40_03735(cfbD)
MTP: Mthe_0106
MCJ: MCON_1930
MHI: Mhar_2391
MHU: Mhun_0670
MRTJ: KHC33_10020(cfbD)
MLA: Mlab_0520
MPI: Mpet_1002
MBN: Mboo_1419
MPL: Mpal_0679
MPD: MCP_0363
MEZ: Mtc_0063
RCI: RCIX2003
MELU: MTLP_03850
MEAM: MU439_05080(cfbD)
MEAR: Mpt1_c08020(bchB2)
MARC: AR505_0362
 » show all
Reference
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3628]
LinkDB

KEGG   ENZYME: 6.3.3.7
Entry
EC 6.3.3.7                  Enzyme                                 
Name
Ni-sirohydrochlorin a,c-diamide reductive cyclase;
cfbC (gene name);
cfbD (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Cyclo-ligases
Sysname
Ni-sirohydrochlorin a,c-diamide reductive cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + Ni-sirohydrochlorin a,c-diamide + 3 reduced electron acceptor + H2O = ADP + phosphate + 15,173-seco-F430-173-acid + 3 electron acceptor [RN:R11628]
Reaction(KEGG)
R11628
Substrate
ATP [CPD:C00002];
Ni-sirohydrochlorin a,c-diamide [CPD:C21511];
reduced electron acceptor;
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512];
electron acceptor
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.3.3.7 created 2017
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K21610  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC
K21611  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD
Genes
MJAMJ_1423
MFEMefer_1398
MVUMetvu_0736
MFSMFS40622_0630
MIFMetin_0570
MJHJH146_0545
MESGMLAUSG7_0646(cfbD)
MESAMLASG1_0179(cfbD)
MIGMetig_1723
MMPMMP0428
MMQMmarC5_1209
MMXMmarC6_0483
MMZMmarC7_1425
MMDGYY_02215
MMAKMMKA1_04480
MMAOMMOS7_04440
MMADMMJJ_06040
MAEMaeo_1313
MVNMevan_1413
MVOMvol_1630
MOKMetok_0580
METFCFE53_05865
MTHMTH_1522 MTH_643
MMGMTBMA_c01050 MTBMA_c10230(nifH2)
METCMTCT_0570 MTCT_1386
MWOMWSIV6_0061 MWSIV6_1015(nifH2)
METEtca_00613(nifH1_1) tca_01470(nifD_1)
METZMETMT2_0422 METMT2_1600
METKFVF72_04015 FVF72_08355(cfbC)
MTHMFZP57_00245 FZP57_04835(cfbC)
METJFZP68_01455 FZP68_05275(cfbC)
MSTMsp_1120(nifH) Msp_1461
METBAW729_08130 AW729_10175
MRUmru_0181 mru_1466
MSIMsm_1160 Msm_1707
MEBAbm4_0121 Abm4_0733
MMILsm9_0152 sm9_1376
MEYETL18_04160 TL18_10060
MOLYLM1_0966 YLM1_1498
MAROMarbSA_02330 MarbSA_10930
MELMetbo_0037 Metbo_2093
MEWMSWAN_0064 MSWAN_0543
METHMBMB1_0045 MBMB1_0311(nifH2)
MFCBRM9_0099 BRM9_1962
MFIDSM1535_0151(nifH2-1) DSM1535_1422
MCUBMCBB_0063 MCBB_0533(nifH2)
MSUBBK009_10140 BK009_11725
METNBK008_05605 BK008_07360
METTCIT01_00825(nifH) CIT01_06000
METOCIT02_05310 CIT02_06840
MEMEHYG87_02415(cfbC) HYG87_06895(cfbD)
MFVMfer_0362 Mfer_0380
MKAMK1385(nifD)
MBAMbar_A0346 Mbar_A0347
MBYMSBRM_0572 MSBRM_0573
MBWMSBRW_0650 MSBRW_0651
MBARMSBR2_1806 MSBR2_1807
MBAKMSBR3_2861 MSBR3_2862
MACMA_3627(nifH) MA_3628
MMAMM_0514(nifH2) MM_0515
MMAZMmTuc01_0532 MmTuc01_0533
MMJMSMAS_0791 MSMAS_0792
MMACMSMAC_0770 MSMAC_0771
MVCMSVAZ_3046 MSVAZ_3047
MEKMSKOL_2991 MSKOL_2992
MLSMSLAZ_2304 MSLAZ_2305
METMMSMTP_0886 MSMTP_0887
MEFMSWH1_2457 MSWH1_2458
MEQMSWHS_2585 MSWHS_2586
MSJMSSAC_1227 MSSAC_1228
MSZMSSIH_2813 MSSIH_2814
MSWMSSIT_2847 MSSIT_2848
MTHRMSTHT_2450 MSTHT_2451
MTHEMSTHC_0831 MSTHC_0832
MHORMSHOH_0894 MSHOH_0895
MFZAOB57_003165(cfbC) AOB57_003170
MBUMbur_1037 Mbur_1038
MMETMCMEM_1519 MCMEM_1520
MELOJ7W08_06405(cfbD) J7W08_06410(cfbC)
MMHMmah_1412 Mmah_1413
MHAZBHR79_06610 BHR79_06615
MEVMetev_0555 Metev_0556
MZHMzhil_0468 Mzhil_0469
MPYMpsy_0958 Mpsy_0959
MZIHWN40_03735(cfbD) HWN40_03740(cfbC)
MHZMetho_0542 Metho_0543
MTPMthe_0106 Mthe_1178
MCJMCON_0503(nifH) MCON_1930
MHIMhar_0047 Mhar_2391
MHUMhun_0670
MRTJKHC33_10020(cfbD)
MLAMlab_0520
MEMMemar_1733
MBGBN140_0718
MCHKMchiMG62_19350
MPIMpet_1002
MBNMboo_1419
MFOMetfor_1748
MPLMpal_0679
MPDMCP_0363 MCP_0364(nifH-1)
MEZMtc_0063 Mtc_0064(nifH-1)
RCIRCIX2002(nifH-2) RCIX2003
MELUMTLP_03850
MEAMMU439_05075 MU439_05080(cfbD)
TARTALC_01251
MAXMMALV_13210
MERMMINT_17220 MMINT_17230
MEARMpt1_c08020(bchB2)
MARCAR505_0362
 » show all
Reference
1  [PMID:3691535]
  Authors
Pfaltz A, Kobelt A, Huster R, Thauer RK
  Title
Biosynthesis of coenzyme F430 in methanogenic bacteria. Identification of 15,17(3)-seco-F430-17(3)-acid as an intermediate.
  Journal
Eur J Biochem 170:459-67 (1987)
DOI:10.1111/j.1432-1033.1987.tb13722.x
Reference
2  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.3.7
IUBMB Enzyme Nomenclature: 6.3.3.7
ExPASy - ENZYME nomenclature database: 6.3.3.7
BRENDA, the Enzyme Database: 6.3.3.7
LinkDB

KEGG   REACTION: R11628
Entry
R11628                      Reaction                               
Name
Ni-sirohydrochlorin a,c-diamide reductive cyclo-ligase (ADP-forming)
Definition
ATP + Nickel-sirohydrochlorin a,c-diamide + 3 Reduced acceptor + H2O <=> ADP + Orthophosphate + 15,17(3)-Seco-F430-17(3)-acid + 3 Acceptor
Equation
Comment
nickel-sirohydrochlorin a,c-diamide reductase
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Orthology
K21610  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC [EC:6.3.3.7]
K21611  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD [EC:6.3.3.7]
Other DBs
RHEA: 52903
LinkDB

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