KEGG   ORTHOLOGY: K21612
Entry
K21612                      KO                                     
Symbol
cfbE
Name
coenzyme F430 synthetase [EC:6.4.1.9]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K21612  cfbE; coenzyme F430 synthetase
Enzymes [BR:ko01000]
 6. Ligases
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.9  coenzyme F430 synthetase
     K21612  cfbE; coenzyme F430 synthetase
Other DBs
RN: R11629
COG: COG0770
Genes
MJA: MJ_0258
MFE: Mefer_0369
MVU: Metvu_0835
MFS: MFS40622_0485
MIF: Metin_0369
MJH: JH146_0166
MESG: MLAUSG7_0002(cfbE)
MESA: MLASG1_1035
MIG: Metig_0368
MMP: MMP0173
MMQ: MmarC5_1502
MMX: MmarC6_0778
MMZ: MmarC7_1173
MMD: GYY_00885
MMAK: MMKA1_01780
MMAO: MMOS7_02040
MMAD: MMJJ_09110
MAE: Maeo_1414
MVN: Mevan_1177
MVO: Mvol_1454
MOK: Metok_0796
METF: CFE53_01605
MTH: MTH_873
MMG: MTBMA_c12680(murF)
MWO: MWSIV6_1247
MTEE: MTTB_05080
METC: MTCT_0791
METE: tca_00838(murF)
METZ: METMT2_0941
METK: FVF72_07190(cfbE)
MTHM: FZP57_05930(cfbE)
METJ: FZP68_00275(cfbE)
MST: Msp_1331
METB: AW729_08865
MRU: mru_1745
MSI: Msm_0880
MEB: Abm4_0460
MMIL: sm9_1831
MEYE: TL18_08530
MOL: YLM1_1199
MARO: MarbSA_18380
METV: K4897_07095(cfbE)
MEL: Metbo_2343
MEW: MSWAN_0316
METH: MBMB1_0355
MFC: BRM9_1909
MFI: DSM1535_0095
MCUB: MCBB_0331
MSUB: BK009_11970
METN: BK008_07610
METT: CIT01_02205
METO: CIT02_05050
MEME: HYG87_03660(cfbE)
MFEG: GCM10025860_12510
MFV: Mfer_1205
MKA: MK1590(murF)
MBA: Mbar_A0345
MBY: MSBRM_0574
MBW: MSBRW_0652
MBAR: MSBR2_1805
MBAK: MSBR3_2860
MAC: MA_3630(murD)
MMA: MM_0516
MMJ: MSMAS_0790
MMAC: MSMAC_0769
MVC: MSVAZ_3048
MEK: MSKOL_2990
MLS: MSLAZ_2303
METM: MSMTP_0888
MEF: MSWH1_2456
MEQ: MSWHS_2587
MSJ: MSSAC_1226
MSZ: MSSIH_2812
MSW: MSSIT_2846
MTHR: MSTHT_2449
MTHE: MSTHC_0833
MHOR: MSHOH_0893
MFZ: AOB57_003180(cfbE)
MBU: Mbur_1036
MMET: MCMEM_1518
MELO: J7W08_06400(cfbE)
MMH: Mmah_1411
MHAZ: BHR79_06620
MEV: Metev_0557
MZH: Mzhil_0470
MPY: Mpsy_0961
MZI: HWN40_03730(cfbE)
MHZ: Metho_0544
MTP: Mthe_0105
MCJ: MCON_1929
MHI: Mhar_2390
MHU: Mhun_0669
MRTJ: KHC33_10025(cfbE)
MLA: Mlab_0519
MEM: Memar_1732
MBG: BN140_0719
MCHK: MchiMG62_19340
MSUM: OH143_02890(cfbE)
MPI: Mpet_1001
MANQ: L1994_05915
MBN: Mboo_1418
MFO: Metfor_1749
MPL: Mpal_0680
MPD: MCP_0362
MEZ: Mtc_0062(murD)
RCI: RCIX2005(murD)
MELU: MTLP_03860
MEAM: MU439_05085
MEAE: QEN48_05070
TAR: TALC_01252
MAX: MMALV_13220
MER: MMINT_17240
MEAR: Mpt1_c08030
MEUZ: KRP56_02455(cfbE)
MARC: AR505_0361
 » show all
Reference
PMID:27846569
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3630]
LinkDB

KEGG   ENZYME: 6.4.1.9
Entry
EC 6.4.1.9                  Enzyme                                 
Name
coenzyme F430 synthetase;
cfbE (gene name)
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
Sysname
15,173-seco-F430-173-acid cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + 15,173-seco-F430-173-acid = ADP + phosphate + coenzyme F430 [RN:R11629]
Reaction(KEGG)
R11629
Substrate
ATP [CPD:C00002];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
coenzyme F430 [CPD:C05777]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, catalyses the last step in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.4.1.9 created 2017
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K21612  coenzyme F430 synthetase
Genes
MJA: MJ_0258
MFE: Mefer_0369
MVU: Metvu_0835
MFS: MFS40622_0485
MIF: Metin_0369
MJH: JH146_0166
MESG: MLAUSG7_0002(cfbE)
MESA: MLASG1_1035
MIG: Metig_0368
MMP: MMP0173
MMQ: MmarC5_1502
MMX: MmarC6_0778
MMZ: MmarC7_1173
MMD: GYY_00885
MMAK: MMKA1_01780
MMAO: MMOS7_02040
MMAD: MMJJ_09110
MAE: Maeo_1414
MVN: Mevan_1177
MVO: Mvol_1454
MOK: Metok_0796
METF: CFE53_01605
MTH: MTH_873
MMG: MTBMA_c12680(murF)
MWO: MWSIV6_1247
MTEE: MTTB_05080
METC: MTCT_0791
METE: tca_00838(murF)
METZ: METMT2_0941
METK: FVF72_07190(cfbE)
MTHM: FZP57_05930(cfbE)
METJ: FZP68_00275(cfbE)
MST: Msp_1331
METB: AW729_08865
MRU: mru_1745
MSI: Msm_0880
MEB: Abm4_0460
MMIL: sm9_1831
MEYE: TL18_08530
MOL: YLM1_1199
MARO: MarbSA_18380
METV: K4897_07095(cfbE)
MEL: Metbo_2343
MEW: MSWAN_0316
METH: MBMB1_0355
MFC: BRM9_1909
MFI: DSM1535_0095
MCUB: MCBB_0331
MSUB: BK009_11970
METN: BK008_07610
METT: CIT01_02205
METO: CIT02_05050
MEME: HYG87_03660(cfbE)
MFEG: GCM10025860_12510
MFV: Mfer_1205
MKA: MK1590(murF)
MBA: Mbar_A0345
MBY: MSBRM_0574
MBW: MSBRW_0652
MBAR: MSBR2_1805
MBAK: MSBR3_2860
MAC: MA_3630(murD)
MMA: MM_0516
MMJ: MSMAS_0790
MMAC: MSMAC_0769
MVC: MSVAZ_3048
MEK: MSKOL_2990
MLS: MSLAZ_2303
METM: MSMTP_0888
MEF: MSWH1_2456
MEQ: MSWHS_2587
MSJ: MSSAC_1226
MSZ: MSSIH_2812
MSW: MSSIT_2846
MTHR: MSTHT_2449
MTHE: MSTHC_0833
MHOR: MSHOH_0893
MFZ: AOB57_003180(cfbE)
MBU: Mbur_1036
MMET: MCMEM_1518
MELO: J7W08_06400(cfbE)
MMH: Mmah_1411
MHAZ: BHR79_06620
MEV: Metev_0557
MZH: Mzhil_0470
MPY: Mpsy_0961
MZI: HWN40_03730(cfbE)
MHZ: Metho_0544
MTP: Mthe_0105
MCJ: MCON_1929
MHI: Mhar_2390
MHU: Mhun_0669
MRTJ: KHC33_10025(cfbE)
MLA: Mlab_0519
MEM: Memar_1732
MBG: BN140_0719
MCHK: MchiMG62_19340
MSUM: OH143_02890(cfbE)
MPI: Mpet_1001
MANQ: L1994_05915
MBN: Mboo_1418
MFO: Metfor_1749
MPL: Mpal_0680
MPD: MCP_0362
MEZ: Mtc_0062(murD)
RCI: RCIX2005(murD)
MELU: MTLP_03860
MEAM: MU439_05085
MEAE: QEN48_05070
TAR: TALC_01252
MAX: MMALV_13220
MER: MMINT_17240
MEAR: Mpt1_c08030
MEUZ: KRP56_02455(cfbE)
MARC: AR505_0361
 » show all
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3630]
Other DBs
ExplorEnz - The Enzyme Database: 6.4.1.9
IUBMB Enzyme Nomenclature: 6.4.1.9
ExPASy - ENZYME nomenclature database: 6.4.1.9
BRENDA, the Enzyme Database: 6.4.1.9
LinkDB

KEGG   REACTION: R11629
Entry
R11629                      Reaction                               
Name
15,17(3)-seco-F430-17(3)-acid cyclo-ligase (ADP-forming)
Definition
15,17(3)-Seco-F430-17(3)-acid + ATP <=> Coenzyme F430 + ADP + Orthophosphate
Equation
C21512 + C00002 <=> C05777 + C00008 + C00009
Enzyme
6.4.1.9
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Orthology
K21612  coenzyme F430 synthetase [EC:6.4.1.9]
Other DBs
RHEA: 52907
LinkDB

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