KEGG   ORTHOLOGY: K21612
Entry
K21612                      KO                                     
Symbol
cfbE
Name
coenzyme F430 synthetase [EC:6.4.1.9]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K21612  cfbE; coenzyme F430 synthetase
Enzymes [BR:ko01000]
 6. Ligases
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.9  coenzyme F430 synthetase
     K21612  cfbE; coenzyme F430 synthetase
Other DBs
RN: R11629
COG: COG0770
Genes
MJA: MJ_0258
MFE: Mefer_0369
MVU: Metvu_0835
MFS: MFS40622_0485
MIF: Metin_0369
MJH: JH146_0166
MESG: MLAUSG7_0002(cfbE)
MESA: MLASG1_1035
MIG: Metig_0368
MMP: MMP0173
MMD: GYY_00885
MMAD: MMJJ_09110
MAE: Maeo_1414
MVO: Mvol_1454
MTH: MTH_873
MMG: MTBMA_c12680(murF)
METC: MTCT_0791
METE: tca_00838(murF)
METK: FVF72_07190(cfbE)
MTHM: FZP57_05930(cfbE)
METJ: FZP68_00275(cfbE)
MST: Msp_1331
MRU: mru_1745
MSI: Msm_0880
MEB: Abm4_0460
MMIL: sm9_1831
MEYE: TL18_08530
MOL: YLM1_1199
METH: MBMB1_0355
MFC: BRM9_1909
MCUB: MCBB_0331
MEME: HYG87_03660(cfbE)
MFV: Mfer_1205
MKA: MK1590(murF)
MBAR: MSBR2_1805
MBAK: MSBR3_2860
MAC: MA_3630(murD)
MMA: MM_0516
MMAC: MSMAC_0769
METM: MSMTP_0888
MTHR: MSTHT_2449
MTHE: MSTHC_0833
MHOR: MSHOH_0893
MFZ: AOB57_003180(cfbE)
MBU: Mbur_1036
MMET: MCMEM_1518
MELO: J7W08_06400(cfbE)
MMH: Mmah_1411
MPY: Mpsy_0961
MZI: HWN40_03730(cfbE)
MTP: Mthe_0105
MCJ: MCON_1929
MHI: Mhar_2390
MHU: Mhun_0669
MRTJ: KHC33_10025(cfbE)
MLA: Mlab_0519
MPI: Mpet_1001
MBN: Mboo_1418
MPL: Mpal_0680
MPD: MCP_0362
MEZ: Mtc_0062(murD)
RCI: RCIX2005(murD)
MELU: MTLP_03860
MARC: AR505_0361
 » show all
Reference
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3630]
LinkDB

KEGG   ENZYME: 6.4.1.9
Entry
EC 6.4.1.9                  Enzyme                                 
Name
coenzyme F430 synthetase;
cfbE (gene name)
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
Sysname
15,173-seco-F430-173-acid cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + 15,173-seco-F430-173-acid = ADP + phosphate + coenzyme F430 [RN:R11629]
Reaction(KEGG)
R11629
Substrate
ATP [CPD:C00002];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
coenzyme F430 [CPD:C05777]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, catalyses the last step in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.4.1.9 created 2017
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K21612  coenzyme F430 synthetase
Genes
MJAMJ_0258
MFEMefer_0369
MVUMetvu_0835
MFSMFS40622_0485
MIFMetin_0369
MJHJH146_0166
MESGMLAUSG7_0002(cfbE)
MESAMLASG1_1035
MIGMetig_0368
MMPMMP0173
MMQMmarC5_1502
MMXMmarC6_0778
MMZMmarC7_1173
MMDGYY_00885
MMAKMMKA1_01780
MMAOMMOS7_02040
MMADMMJJ_09110
MAEMaeo_1414
MVNMevan_1177
MVOMvol_1454
MOKMetok_0796
METFCFE53_01605
MTHMTH_873
MMGMTBMA_c12680(murF)
METCMTCT_0791
MWOMWSIV6_1247
METEtca_00838(murF)
METZMETMT2_0941
METKFVF72_07190(cfbE)
MTHMFZP57_05930(cfbE)
METJFZP68_00275(cfbE)
MSTMsp_1331
METBAW729_08865
MRUmru_1745
MSIMsm_0880
MEBAbm4_0460
MMILsm9_1831
MEYETL18_08530
MOLYLM1_1199
MAROMarbSA_18380
MELMetbo_2343
MEWMSWAN_0316
METHMBMB1_0355
MFCBRM9_1909
MFIDSM1535_0095
MCUBMCBB_0331
MSUBBK009_11970
METNBK008_07610
METTCIT01_02205
METOCIT02_05050
MEMEHYG87_03660(cfbE)
MFVMfer_1205
MKAMK1590(murF)
MBAMbar_A0345
MBYMSBRM_0574
MBWMSBRW_0652
MBARMSBR2_1805
MBAKMSBR3_2860
MACMA_3630(murD)
MMAMM_0516
MMJMSMAS_0790
MMACMSMAC_0769
MVCMSVAZ_3048
MEKMSKOL_2990
MLSMSLAZ_2303
METMMSMTP_0888
MEFMSWH1_2456
MEQMSWHS_2587
MSJMSSAC_1226
MSZMSSIH_2812
MSWMSSIT_2846
MTHRMSTHT_2449
MTHEMSTHC_0833
MHORMSHOH_0893
MFZAOB57_003180(cfbE)
MBUMbur_1036
MMETMCMEM_1518
MELOJ7W08_06400(cfbE)
MMHMmah_1411
MHAZBHR79_06620
MEVMetev_0557
MZHMzhil_0470
MPYMpsy_0961
MZIHWN40_03730(cfbE)
MHZMetho_0544
MTPMthe_0105
MCJMCON_1929
MHIMhar_2390
MHUMhun_0669
MRTJKHC33_10025(cfbE)
MLAMlab_0519
MEMMemar_1732
MBGBN140_0719
MCHKMchiMG62_19340
MPIMpet_1001
MBNMboo_1418
MFOMetfor_1749
MPLMpal_0680
MPDMCP_0362
MEZMtc_0062(murD)
RCIRCIX2005(murD)
MELUMTLP_03860
MEAMMU439_05085
TARTALC_01252
MAXMMALV_13220
MERMMINT_17240
MEARMpt1_c08030
MARCAR505_0361
 » show all
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3630]
Other DBs
ExplorEnz - The Enzyme Database: 6.4.1.9
IUBMB Enzyme Nomenclature: 6.4.1.9
ExPASy - ENZYME nomenclature database: 6.4.1.9
BRENDA, the Enzyme Database: 6.4.1.9
LinkDB

KEGG   REACTION: R11629
Entry
R11629                      Reaction                               
Name
15,17(3)-seco-F430-17(3)-acid cyclo-ligase (ADP-forming)
Definition
15,17(3)-Seco-F430-17(3)-acid + ATP <=> Coenzyme F430 + ADP + Orthophosphate
Equation
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Orthology
K21612  coenzyme F430 synthetase [EC:6.4.1.9]
Other DBs
RHEA: 52907
LinkDB

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