KEGG   ORTHOLOGY: K21618
Entry
K21618                      KO                                     
Symbol
DLD3
Name
(R)-2-hydroxyglutarate---pyruvate transhydrogenase [EC:1.1.99.40]
Pathway
map00620  Pyruvate metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K21618  DLD3; (R)-2-hydroxyglutarate---pyruvate transhydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.99  With unknown physiological acceptors
    1.1.99.40  (R)-2-hydroxyglutarate---pyruvate transhydrogenase
     K21618  DLD3; (R)-2-hydroxyglutarate---pyruvate transhydrogenase
Other DBs
RN: R11593
COG: COG0277
Genes
QSU: 111983797 112000937
SCE: YDL178W(DLD2) YEL071W(DLD3)
AGO: AGOS_ACL021C
ERC: Ecym_8034
KLA: KLLA0_F05753g
KMX: KLMA_60482(DLD2)
LTH: KLTH0A05280g
ZRO: ZYRO0C09218g
CGR: CAGL0J06314g
NCS: NCAS_0E03520(NCAS0E03520) NCAS_0H00160(NCAS0H00160)
NDI: NDAI_0A03060(NDAI0A03060) NDAI_0H04030(NDAI0H04030)
TPF: TPHA_0A03280(TPHA0A03280)
TBL: TBLA_0F01970(TBLA0F01970)
TDL: TDEL_0A08020(TDEL0A08020) TDEL_0E05730(TDEL0E05730) TDEL_0H01580(TDEL0H01580)
KAF: KAFR_0L01170(KAFR0L01170)
PIC: PICST_89565(DLD2)
CAL: CAALFM_C303040WA(AIP2)
SLB: AWJ20_5329(DLD2)
BNN: FOA43_004635(DLD2)
NCR: NCU06441
NTE: NEUTE1DRAFT146088(NEUTE1DRAFT_146088)
MGR: MGG_12830
SSCK: SPSK_03231
MAW: MAC_00625
MAJ: MAA_05955
CMT: CCM_01480
MBE: MBM_06930
ANI: AN8033.2
ANG: ANI_1_1492024(An02g10670)
ABE: ARB_00809
TVE: TRV_00678
PTE: PTT_18111
TASA: A1Q1_08226
MRR: Moror_99
ABP: AGABI1DRAFT110375(AGABI1DRAFT_110375)
ABV: AGABI2DRAFT60921(AGABI2DRAFT_60921)
MGL: MGL_2442
MRT: MRET_3321
 » show all
Reference
  Authors
Becker-Kettern J, Paczia N, Conrotte JF, Kay DP, Guignard C, Jung PP, Linster CL
  Title
Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.
  Journal
J Biol Chem 291:6036-58 (2016)
DOI:10.1074/jbc.M115.704494
  Sequence
LinkDB

KEGG   ENZYME: 1.1.99.40
Entry
EC 1.1.99.40                Enzyme                                 
Name
(R)-2-hydroxyglutarate---pyruvate transhydrogenase;
DLD3 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
(R)-2-hydroxyglutarate:pyruvate oxidoreductase [(R)-lactate-forming]
Reaction(IUBMB)
(R)-2-hydroxyglutarate + pyruvate = 2-oxoglutarate + (R)-lactate [RN:R11593]
Reaction(KEGG)
R11593
Substrate
(R)-2-hydroxyglutarate [CPD:C01087];
pyruvate [CPD:C00022]
Product
2-oxoglutarate [CPD:C00026];
(R)-lactate [CPD:C00256]
Comment
The enzyme, characterized in the yeast Saccharomyces cerevisiae, also functions as EC 1.1.2.4, D-lactate dehydrogenase (cytochrome), and is active with oxaloacetate as electron acceptor forming (R)-malate.
History
EC 1.1.99.40 created 2017
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Orthology
K21618  (R)-2-hydroxyglutarate---pyruvate transhydrogenase
Genes
QSU111983797 112000937
SCEYDL178W(DLD2) YEL071W(DLD3)
AGOAGOS_ACL021C
ERCEcym_8034
KLAKLLA0_F05753g
KMXKLMA_60482(DLD2)
LTHKLTH0A05280g
ZROZYRO0C09218g
CGRCAGL0J06314g
NCSNCAS_0E03520(NCAS0E03520) NCAS_0H00160(NCAS0H00160)
NDINDAI_0A03060(NDAI0A03060) NDAI_0H04030(NDAI0H04030)
TPFTPHA_0A03280(TPHA0A03280)
TBLTBLA_0F01970(TBLA0F01970)
TDLTDEL_0A08020(TDEL0A08020) TDEL_0E05730(TDEL0E05730) TDEL_0H01580(TDEL0H01580)
TGBHG536_0C05350 HG536_0G04870
KAFKAFR_0L01170(KAFR0L01170)
ZMKHG535_0C06490 HG535_0G01630
PPAPAS_chr3_0674
DHADEHA2B10142g
PICPICST_89565(DLD2)
PGUPGUG_01680
SPAASPAPADRAFT_51529
LELLELG_02107
CALCAALFM_C303040WA(AIP2)
CTPCTRG_02583
COTCORT_0B03720
CDUCD36_83020
CTENCANTEDRAFT_103656
YLIYALI0C06446g
CLUCLUG_05807
CLUSA9F13_05g01430
CAURCJI97_002835
SLBAWJ20_5329(DLD2)
PKZC5L36_0A01180
BNNFOA43_004635(DLD2)
BBRXBRETT_001775
NCRNCU06441
NTENEUTE1DRAFT146088(NEUTE1DRAFT_146088)
SMPSMAC_02202
PANPODANSg5397
TTTTHITE_2119881
MTMMYCTH_2303826
CTHRCTHT_0069840
MGRMGG_12830
TMNUCRPA7_2227
SSCKSPSK_03231
FGRFGSG_13110
FPUFPSE_01095
FVRFVEG_05295
FOXFOXG_02132
NHENECHADRAFT_68595
TRETRIREDRAFT_76013
TRRM419DRAFT_23753
MAWMAC_00625
MAJMAA_05955
CMTCCM_01480
PLJVFPFJ_05626
VALVDBG_02828
VDAVDAG_03746
CFJCFIO01_10052
SAPOSAPIO_CDS5745
ELAUCREL1_1651
PFYPFICI_11909
SSLSS1G_07702
BFUBCIN_15g02730
MBEMBM_06930
PSCOLY89DRAFT_60738
GLZGLAREA_06857
ANIAN8033.2
AFMAFUA_5G02230
ACTACLA_003010
NFINFIA_039880
AORAO090102000291
ANGANI_1_1492024(An02g10670)
AFVAFLA_011734
ALUCAKAW2_10900S
ACHEACHE_51025S
APUUAPUU_41540A
PCSPc21g14970
PDPPDIP_48140
TMFPMAA_081390
TRGTRUGW13939_08504
CIMCIMG_06424
CPWCPC735_029240
UREUREG_03983
PBLPAAG_07804
PBNPADG_02733
ABEARB_00809
TVETRV_00678
AJEHCAG_00349
BGHBDBG_01546
PNOSNOG_11128
PTEPTT_18111
BZECOCCADRAFT_5082
BSCCOCSADRAFT_82172
BORCOCMIDRAFT_93512
AALTCC77DRAFT_741863
ZTRMYCGRDRAFT_74344
PFJMYCFIDRAFT_215437
BCOMBAUCODRAFT_150031
NPAUCRNP2_192
TMLGSTUM_00011704001
SPOSPBC713.03
CNECNB01750 CNK01540
CNBCNBB3980 CNBK2000
CGICGB_B5760W CGB_K2470C
TMSTREMEDRAFT_44101
TASAA1Q1_08226
TVSTRAVEDRAFT_159410 TRAVEDRAFT_16748
DSQDICSQDRAFT_75448
PCOPHACADRAFT_180107
SHSSTEHIDRAFT_117557
HIRHETIRDRAFT_307493
PSQPUNSTDRAFT_58716
ADLAURDEDRAFT_111902
FMEFOMMEDRAFT_121754
GTRGLOTRDRAFT_31335
LBCLACBIDRAFT_175753
MRRMoror_99
CCICC1G_03657
SCMSCHCODRAFT_255698
ABPAGABI1DRAFT110375(AGABI1DRAFT_110375)
ABVAGABI2DRAFT60921(AGABI2DRAFT_60921)
CPUTCONPUDRAFT_115042
SLASERLADRAFT_358276 SERLADRAFT_456132
WSEWALSEDRAFT_58973
WICJ056_004400
UMAUMAG_01314
PFPPFL1_04079
MGLMGL_2442
MRTMRET_3321
MSYMMSY001_1771
PGRPGTG_05096
MLRMELLADRAFT_49675
 » show all
Reference
1  [PMID:26774271]
  Authors
Becker-Kettern J, Paczia N, Conrotte JF, Kay DP, Guignard C, Jung PP, Linster CL
  Title
Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.
  Journal
J Biol Chem 291:6036-58 (2016)
DOI:10.1074/jbc.M115.704494
  Sequence
[sce:YEL071W]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.40
IUBMB Enzyme Nomenclature: 1.1.99.40
ExPASy - ENZYME nomenclature database: 1.1.99.40
BRENDA, the Enzyme Database: 1.1.99.40
LinkDB

KEGG   REACTION: R11593
Entry
R11593                      Reaction                               
Name
(R)-2-hydroxyglutarate:pyruvate oxidoreductase [(R)-lactate-forming]
Definition
Pyruvate + (R)-2-Hydroxyglutarate <=> (R)-Lactate + 2-Oxoglutarate
Equation
Reaction class
RC00044  C00022_C00256
Enzyme
Pathway
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
Orthology
K21618  (R)-2-hydroxyglutarate---pyruvate transhydrogenase [EC:1.1.99.40]
LinkDB

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