KEGG   ORTHOLOGY: K21672
Entry
K21672                      KO                                     
Symbol
ord
Name
2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
Pathway
map00310  Lysine degradation
map00330  Arginine and proline metabolism
map00470  D-Amino acid metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
   00330 Arginine and proline metabolism
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
  09106 Metabolism of other amino acids
   00470 D-Amino acid metabolism
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.12  2,4-diaminopentanoate dehydrogenase
     K21672  ord; 2,4-diaminopentanoate dehydrogenase
    1.4.1.26  2,4-diaminopentanoate dehydrogenase (NAD+)
     K21672  ord; 2,4-diaminopentanoate dehydrogenase
Other DBs
RN: R02825 R04200 R04201 R04687 R04688
GO: 0047530
Genes
CEH: CEW89_15600
EAV: EH197_05050
VCP: H9L18_06400
VHY: G7082_14535
CSQ: CSCA_0127
CACE: CACET_c17480(dapB2)
CEU: A7L45_16560
CFM: BJL90_14515
CARG: RSJ17_08675
CDRK: B9W14_17905
AMT: Amet_2367
AOE: Clos_1699
CDF: CD630_04420(ord)
PDC: CDIF630_00570(ord)
PDF: CD630DERM_04420(ord)
CST: CLOST_1294(ord)
TEB: T8CH_0873(ord)
AACX: DEACI_0846
ETM: CE91St48_39740(ord)
TTE: TTE1234
THX: Thet_1426
TOC: Toce_1489
NCD: ACONDI_00602(ord)
KME: H0A61_00511(ord)
PFT: JBW_01651
MANR: MPAN_008560(ord)
MPHU: MPHO_01310
PAC: PPA2276
PAW: PAZ_c23740(dapB2)
PACC: PAC1_11610
PACH: PAGK_2185
CACN: RN83_00010
SBR: SY1_03600
TME: Tmel_0905
TAF: THA_1160
THER: Y592_05345
FNO: Fnod_1646
FIA: NA23_09975(ord)
OCY: OSSY52_03900(ord)
PMO: Pmob_1166
MARN: LN42_08170
DTN: DTL3_0759
KOL: Kole_0356
ASAC: ATHSA_0997
AG: CAQ42978(ord)
 » show all
Reference
PMID:4684685
  Authors
Somack R, Costilow RN
  Title
2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein.
  Journal
J Biol Chem 248:385-8 (1973)
  Sequence
Reference
  Authors
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M
  Title
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
  Journal
J Bacteriol 191:3162-7 (2009)
DOI:10.1128/JB.01777-08
  Sequence
LinkDB

KEGG   ENZYME: 1.4.1.12
Entry
EC 1.4.1.12                 Enzyme                                 
Name
2,4-diaminopentanoate dehydrogenase;
2,4-diaminopentanoic acid C4 dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R,4S)-2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)
Reaction(IUBMB)
(2R,4S)-2,4-diaminopentanoate + H2O + NAD(P)+ = (2R)-2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+ [RN:R04200 R04201]
Reaction(KEGG)
Substrate
(2R,4S)-2,4-diaminopentanoate [CPD:C03943];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
(2R)-2-amino-4-oxopentanoate [CPD:C03341];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].
History
EC 1.4.1.12 created 1976, modified 2017
Pathway
ec00310  Lysine degradation
ec00330  Arginine and proline metabolism
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K21672  2,4-diaminopentanoate dehydrogenase
Genes
CEHCEW89_15600
EAVEH197_05050
VCPH9L18_06400
VHYG7082_14535
CSQCSCA_0127
CACECACET_c17480(dapB2)
CEUA7L45_16560
CFMBJL90_14515
CARGRSJ17_08675
CDRKB9W14_17905
AMTAmet_2367
AOEClos_1699
GFEGferi_26730
CALEFDN13_03020
CRSFQB35_06685
CPRFK7H06_09005
FPLAA4U99_15095
CDFCD630_04420(ord)
PDCCDIF630_00570(ord)
CDCCD196_0399
CDLCDR20291_0385
PDFCD630DERM_04420(ord)
CSTCLOST_1294(ord)
TEMJW646_03950
TEBT8CH_0873(ord)
DAIDesaci_1873
AACXDEACI_0846
VGUHYG85_19050
VPYHZI73_17680
ACAEHYG86_08075
AMIJEQM06_12600
AMICAmi3637_07690
ABUTAmi103574_00595
ETMCE91St48_39740(ord)
EUUADJ67_00765
TTETTE1234
TEXTeth514_1477
THXThet_1426
TPDTeth39_1040
TBOThebr_1067
TWIThewi_1184
TOCToce_1489
NTHNther_1166
NCDACONDI_00602(ord)
HORHore_21120
AFTBBF96_13560
KMEH0A61_00511(ord)
SPOAEQM13_10965
KPARJL105_07140
CAZOG3A45_03845
SEDZJYG23_00910
PFTJBW_01651
MANRMPAN_008560(ord)
MBJKQ51_00248
TBMBK010_05560
TBZBK011_05600
TBKHF295_00050
MPHUMPHO_01310
ARSADJ73_08360
PACPPA2276
PAKHMPREF0675_5353
PAVTIA2EST22_11160
PAXTIA2EST36_11135
PAZTIA2EST2_11080
PAWPAZ_c23740(dapB2)
PADTIIST44_04200
PCNTIB1ST10_11600
PACCPAC1_11610
PACHPAGK_2185
PACNTIA1EST1_11230
CACNRN83_00010
PRLBCB70_06960
CGRN4412665_00379
PAUSNCTC13651_02412
PPCHMPREF9154_0892
ARUBJ5A65_10535
ABATCFX1CAM_0745
TPITREPR_1364
SLRL21SP2_1023
FHWRN87_08680
FPDCTM68_09160
FCII6I83_05765
SBRSY1_03600
TMETmel_0905
TAFTHA_1160
THPBG95_05265
THERY592_05345
TFEJYK00_04200
FNOFnod_1646
FPEFerpe_1990
FIANA23_09975(ord)
OCYOSSY52_03900(ord)
PMOPmob_1166
MPZMarpi_1533
MARNLN42_08170
DTNDTL3_0759
KOLKole_0356
KPFIX53_10190
MPGTheba_1251
MINFMESINF_2284
ASACATHSA_0997
 » show all
Reference
1  [PMID:4684685]
  Authors
Somack R, Costilow RN
  Title
2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein.
  Journal
J Biol Chem 248:385-8 (1973)
  Sequence
Reference
2
  Authors
Stadtman, T.C.
  Title
Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase).
  Journal
Adv Enzymol Relat Areas Mol Biol 38:441-445 (1973)
Reference
3  [PMID:4394942]
  Authors
Tsuda Y, Friedmann HC.
  Title
Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide.
  Journal
J Biol Chem 245:5914-26 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.12
IUBMB Enzyme Nomenclature: 1.4.1.12
ExPASy - ENZYME nomenclature database: 1.4.1.12
BRENDA, the Enzyme Database: 1.4.1.12
CAS: 39346-26-4
LinkDB

KEGG   REACTION: R02825
Entry
R02825                      Reaction                               
Definition
5-Aminopentanoate <=> D-Proline
Equation
Comment
incomplete reaction (donor is unidentified in vivo, dl-dihydrolipoate [CPD:C02147] or other dithiols in vitro)
Reaction class
RC00790  C00431_C00763
Enzyme
1.4.1.12        1.21.4.1
Pathway
rn00330  Arginine and proline metabolism
rn00470  D-Amino acid metabolism
rn01100  Metabolic pathways
Orthology
K10793  D-proline reductase (dithiol) PrdA [EC:1.21.4.1]
K10794  D-proline reductase (dithiol) PrdB [EC:1.21.4.1]
K21672  2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
Other DBs
RHEA: 12740
LinkDB

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