Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].
Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide.
Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
1.4 Acting on the CH-NH2 group of donors
1.4.1 With NAD+ or NADP+ as acceptor
1.4.1.12
R02825 5-Aminopentanoate <=> D-Proline
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.4 With a disulfide as acceptor
1.21.4.1
R02825 5-Aminopentanoate <=> D-Proline