KEGG   ORTHOLOGY: K21718
Entry
K21718                      KO                                     
Symbol
CYP76M6
Name
oryzalexin E synthase [EC:1.14.14.122]
Pathway
map00904  Diterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R11657  ent-sandaracopimaradien-3beta-ol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (oryzalexin E forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K21718  CYP76M6; oryzalexin E synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K21718  CYP76M6; oryzalexin E synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.122  oryzalexin E synthase
     K21718  CYP76M6; oryzalexin E synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP76 family
   K21718  CYP76M6; oryzalexin E synthase
Other DBs
GO: 0102597
Genes
OSA: 4329730(CYP76M6)
DOSA: Os02g0571900
OBR: 102708034
OGL: 127761381
Reference
PMID:23795884
  Authors
Wu Y, Wang Q, Hillwig ML, Peters RJ
  Title
Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis.
  Journal
Biochem J 454:209-16 (2013)
DOI:10.1042/BJ20130574
  Sequence
[osa:4329730]
LinkDB

KEGG   ENZYME: 1.14.14.122
Entry
EC 1.14.14.122              Enzyme                                 
Name
oryzalexin E synthase;
CYP76M6
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
ent-sandaracopimaradien-3beta-ol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (oryzalexin-E-forming)
Reaction(IUBMB)
ent-sandaracopimaradien-3beta-ol + [reduced NADPH---hemoprotein reductase] + O2 = oryzalexin E + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11657]
Reaction(KEGG)
R11657
Substrate
ent-sandaracopimaradien-3beta-ol [CPD:C21560];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
oryzalexin E [CPD:C21561];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. Isolated from Oryza sativa (rice). Oryzalexin E is a phytoalexin.
History
EC 1.14.14.122 created 2014 as EC 1.14.13.192, transferred 2018 to EC 1.14.14.122
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K21718  oryzalexin E synthase
Genes
OSA: 4329730(CYP76M6)
DOSA: Os02g0571900
OBR: 102708034
OGL: 127761381
Reference
1  [PMID:23795884]
  Authors
Wu Y, Wang Q, Hillwig ML, Peters RJ
  Title
Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis.
  Journal
Biochem J 454:209-16 (2013)
DOI:10.1042/BJ20130574
  Sequence
[osa:4329730]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.122
IUBMB Enzyme Nomenclature: 1.14.14.122
ExPASy - ENZYME nomenclature database: 1.14.14.122
BRENDA, the Enzyme Database: 1.14.14.122
LinkDB

KEGG   REACTION: R11657
Entry
R11657                      Reaction                               
Name
ent-sandaracopimaradien-3beta-ol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (oryzalexin E forming)
Definition
ent-Sandaracopimaradien-3beta-ol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Oryzalexin E + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C21560 + C03024 + C00007 <=> C21561 + C03161 + C00001
Reaction class
RC03138  C21560_C21561
Enzyme
1.14.14.122
Pathway
rn00904  Diterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.122
     R11657  ent-Sandaracopimaradien-3beta-ol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Oryzalexin E + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K21718  oryzalexin E synthase [EC:1.14.14.122]
Other DBs
RHEA: 41471
LinkDB

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