KEGG   ORTHOLOGY: K21895
Entry
K21895            Tight     KO                                     
Symbol
16OMT
Name
tabersonine 16-O-methyltransferase [EC:2.1.1.94]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Reaction
R05885  S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K21895  16OMT; tabersonine 16-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.94  tabersonine 16-O-methyltransferase
     K21895  16OMT; tabersonine 16-O-methyltransferase
Other DBs
GO: 0030766
Genes
AG: ABR20103(16OMT)
Reference
PMID:18053006
  Authors
Levac D, Murata J, Kim WS, De Luca V
  Title
Application of carborundum abrasion for investigating the leaf epidermis: molecular cloning of Catharanthus roseus 16-hydroxytabersonine-16-O-methyltransferase.
  Journal
Plant J 53:225-36 (2008)
DOI:10.1111/j.1365-313X.2007.03337.x
  Sequence
[ag:ABR20103]
LinkDB

KEGG   ENZYME: 2.1.1.94
Entry
EC 2.1.1.94                 Enzyme                                 
Name
tabersonine 16-O-methyltransferase;
11-demethyl-17-deacetylvindoline 11-methyltransferase;
11-O-demethyl-17-O-deacetylvindoline O-methyltransferase;
S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 16-hydroxytabersonine = S-adenosyl-L-homocysteine + 16-methoxytabersonine [RN:R05885]
Reaction(KEGG)
R05885;
(other) R03229
Substrate
S-adenosyl-L-methionine [CPD:C00019];
16-hydroxytabersonine [CPD:C11643]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
16-methoxytabersonine [CPD:C11675]
Comment
Involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle, Catharanthus roseus.
History
EC 2.1.1.94 created 1989, modified 2005
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21895  tabersonine 16-O-methyltransferase
Reference
1
  Authors
De Luca V, Balsevich J, Tyler RT, Eilert U, Panchuk BD, Kurz WGW.
  Title
Biosynthesis of indole alkaloids - developmental regulation of the biosynthetic-pathway from tabersonine to vindoline in Catharanthus roseus.
  Journal
J Plant Physiol 125:147-156 (1986)
Reference
2  [PMID:24254077]
  Authors
Fahn W, Laussermair E, Deus-Neumann B, Stockigt J
  Title
Late enzymes of vindoline biosynthesis : S-Adenosyl-L-methionine: 11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase and unspecific acetylesterase.
  Journal
Plant Cell Rep 4:337-40 (1985)
DOI:10.1007/BF00269893
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.94
IUBMB Enzyme Nomenclature: 2.1.1.94
ExPASy - ENZYME nomenclature database: 2.1.1.94
BRENDA, the Enzyme Database: 2.1.1.94
CAS: 100984-95-0
LinkDB

KEGG   REACTION: R05885
Entry
R05885                      Reaction                               
Name
S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase
Definition
16-Hydroxytabersonine + S-Adenosyl-L-methionine <=> 16-Methoxytabersonine + S-Adenosyl-L-homocysteine + H+
Equation
C11643 + C00019 <=> C11675 + C00021 + C00080
Comment
Ref:1. J Plant Physiol 1986; 125: 147-156
Reaction class
RC00003  C00019_C00021
RC00392  C11643_C11675
Enzyme
2.1.1.94
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.94
     R05885  16-Hydroxytabersonine + S-Adenosyl-L-methionine <=> 16-Methoxytabersonine + S-Adenosyl-L-homocysteine + H+
Orthology
K21895  tabersonine 16-O-methyltransferase [EC:2.1.1.94]
Other DBs
RHEA: 20995
LinkDB

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