KEGG   ORTHOLOGY: K22012
Entry
K22012                      KO                                     
Symbol
cfbB
Name
Ni-sirohydrochlorin a,c-diamide synthase [EC:6.3.5.12]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K22012  cfbB; Ni-sirohydrochlorin a,c-diamide synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.12  Ni-sirohydrochlorin a,c-diamide synthase
     K22012  cfbB; Ni-sirohydrochlorin a,c-diamide synthase
Other DBs
RN: R11627
COG: COG1797
Genes
MBA: Mbar_A0348
MBY: MSBRM_0571
MBW: MSBRW_0649
MBAR: MSBR2_1808
MBAK: MSBR3_2863
MAC: MA_3626(cbiA2)
MMA: MM_0513
MMJ: MSMAS_0793
MMAC: MSMAC_0772
MVC: MSVAZ_3045
METM: MSMTP_0885
MTHR: MSTHT_2452
MTHE: MSTHC_0830
MHOR: MSHOH_0896
MFZ: AOB57_003160(cfbB)
MBU: Mbur_1039(cbiA_cobB)
MMET: MCMEM_1521
MELO: J7W08_06415(cfbB)
MMH: Mmah_1414
MPY: Mpsy_0957
MZI: HWN40_03745(cfbB)
MTP: Mthe_1179
MCJ: MCON_0502(cobB1)
MHI: Mhar_0046
MHU: Mhun_0671
MRTJ: KHC33_10015(cfbB)
MLA: Mlab_0521
MBG: BN140_0717(cobB)
MPI: Mpet_1003
MBN: Mboo_1420
MPL: Mpal_0678
MPD: MCP_0365(cobB)
MEZ: Mtc_0065(cbiA-1)
RCI: RCIX2001(cbiA-1)
MELU: MTLP_01910
MEAM: MU439_05070(cfbB)
 » show all
Reference
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3626]
LinkDB

KEGG   ENZYME: 6.3.5.12
Entry
EC 6.3.5.12                 Enzyme                                 
Name
Ni-sirohydrochlorin a,c-diamide synthase;
cfbB (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Carbon-nitrogen ligases with glutamine as amido-N-donor
Sysname
Ni-sirohydrochlorin:L-glutamine amido-ligase (ADP-forming)
Reaction(IUBMB)
2 ATP + Ni-sirohydrochlorin + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + Ni-sirohydrochlorin a,c-diamide + 2 L-glutamate [RN:R11627]
Reaction(KEGG)
R11627
Substrate
ATP [CPD:C00002];
Ni-sirohydrochlorin [CPD:C21510];
L-glutamine [CPD:C00064];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Ni-sirohydrochlorin a,c-diamide [CPD:C21511];
L-glutamate [CPD:C00025]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.3.5.12 created 2017
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K22012  Ni-sirohydrochlorin a,c-diamide synthase
Genes
MBAMbar_A0348
MBYMSBRM_0571
MBWMSBRW_0649
MBARMSBR2_1808
MBAKMSBR3_2863
MACMA_3626(cbiA2)
MMAMM_0513
MMJMSMAS_0793
MMACMSMAC_0772
MVCMSVAZ_3045
MEKMSKOL_2993
MLSMSLAZ_2306
METMMSMTP_0885
MEFMSWH1_2459
MEQMSWHS_2584
MSJMSSAC_1229
MSZMSSIH_2815
MSWMSSIT_2849
MTHRMSTHT_2452
MTHEMSTHC_0830
MHORMSHOH_0896
MFZAOB57_003160(cfbB)
MBUMbur_1039(cbiA_cobB)
MMETMCMEM_1521
MELOJ7W08_06415(cfbB)
MMHMmah_1414
MHAZBHR79_06605
MEVMetev_0554
MZHMzhil_0467
MPYMpsy_0957
MZIHWN40_03745(cfbB)
MHZMetho_0541
MTPMthe_1179
MCJMCON_0502(cobB1)
MHIMhar_0046
MHUMhun_0671
MRTJKHC33_10015(cfbB)
MLAMlab_0521
MEMMemar_1734
MBGBN140_0717(cobB)
MCHKMchiMG62_19360
MPIMpet_1003
MBNMboo_1420
MFOMetfor_1747
MPLMpal_0678
MPDMCP_0365(cobB)
MEZMtc_0065(cbiA-1)
RCIRCIX2001(cbiA-1)
MELUMTLP_01910
MEAMMU439_05070(cfbB)
 » show all
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3626]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.5.12
IUBMB Enzyme Nomenclature: 6.3.5.12
ExPASy - ENZYME nomenclature database: 6.3.5.12
BRENDA, the Enzyme Database: 6.3.5.12
LinkDB

KEGG   REACTION: R11627
Entry
R11627                      Reaction                               
Name
Ni-sirohydrochlorin:L-glutamine amido-ligase (ADP-forming)
Definition
Nickel-sirohydrochlorin + 2 ATP + 2 L-Glutamine + 2 H2O <=> Nickel-sirohydrochlorin a,c-diamide + 2 ADP + 2 L-Glutamate + 2 Orthophosphate
Equation
C21510 + 2 C00002 + 2 C00064 + 2 C00001 <=> C21511 + 2 C00008 + 2 C00025 + 2 C00009
Comment
Ni-sirohydrochlorin a,c-diamide synthetase
Reaction class
RC01301  C21510_C21511
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Orthology
K22012  Ni-sirohydrochlorin a,c-diamide synthase [EC:6.3.5.12]
Other DBs
RHEA: 52899
LinkDB

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