KEGG   ORTHOLOGY: K22102
Entry
K22102                      KO                                     
Symbol
E4.1.2.59
Name
dihydroneopterin phosphate aldolase [EC:4.1.2.59]
Pathway
map00790  Folate biosynthesis
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K22102  E4.1.2.59; dihydroneopterin phosphate aldolase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.59  dihydroneopterin phosphate aldolase
     K22102  E4.1.2.59; dihydroneopterin phosphate aldolase
Other DBs
RN: R11718
COG: COG0720
Genes
PFU: PF1278
PFI: PFC_05605
PHO: PH0634(PH0634)
PAB: PAB1445
PYN: PNA2_1253
PYS: Py04_1120
PYC: TQ32_04640
TCH: CHITON_0626
Reference
  Authors
de Crecy-Lagard V, Phillips G, Grochowski LL, El Yacoubi B, Jenney F, Adams MW, Murzin AG, White RH
  Title
Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate.
  Journal
ACS Chem Biol 7:1807-16 (2012)
DOI:10.1021/cb300342u
  Sequence
[pfu:PF1278]
LinkDB

KEGG   ENZYME: 4.1.2.59
Entry
EC 4.1.2.59                 Enzyme                                 
Name
dihydroneopterin phosphate aldolase;
H2NMP aldolase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
7,8-dihydroneopterin 3'-phosphate glycolaldehyde phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
Reaction(IUBMB)
7,8-dihydroneopterin 3'-phosphate = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde phosphate [RN:R11718]
Reaction(KEGG)
R11718
Substrate
7,8-dihydroneopterin 3'-phosphate [CPD:C05925]
Product
6-(hydroxymethyl)-7,8-dihydropterin [CPD:C01300];
glycolaldehyde phosphate [CPD:C21614]
Comment
The enzyme participates in methanopterin biosynthesis the archaeon Pyrococcus furiosus. The enzyme is specific for 7,8-dihydroneopterin 3'-phosphate. cf. EC 4.1.2.25, dihydroneopterin aldolase and EC 4.1.2.60, dihydroneopterin triphosphate aldolase.
History
EC 4.1.2.59 created 2017
Pathway
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K22102  dihydroneopterin phosphate aldolase
Genes
PFUPF1278
PFIPFC_05605
PHOPH0634(PH0634)
PABPAB1445
PYNPNA2_1253
PYSPy04_1120
PYCTQ32_04640
TCHCHITON_0626
Reference
1  [PMID:22931285]
  Authors
de Crecy-Lagard V, Phillips G, Grochowski LL, El Yacoubi B, Jenney F, Adams MW, Murzin AG, White RH
  Title
Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate.
  Journal
ACS Chem Biol 7:1807-16 (2012)
DOI:10.1021/cb300342u
  Sequence
[pfu:PF1278]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.59
IUBMB Enzyme Nomenclature: 4.1.2.59
ExPASy - ENZYME nomenclature database: 4.1.2.59
BRENDA, the Enzyme Database: 4.1.2.59
LinkDB

KEGG   REACTION: R11718
Entry
R11718                      Reaction                               
Name
7,8-dihydroneopterin-3'-phosphate glycolaldehyde-phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
Definition
Dihydroneopterin phosphate <=> 6-(Hydroxymethyl)-7,8-dihydropterin + Glycolaldehyde phosphate
Equation
Reaction class
RC00721  C05925_C21614
RC00943  C01300_C05925
Enzyme
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Orthology
K22102  dihydroneopterin phosphate aldolase [EC:4.1.2.59]
Other DBs
RHEA: 51019
LinkDB

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