KEGG   ORTHOLOGY: K22210
Entry
K22210                      KO                                     
Symbol
DGLUCY
Name
D-glutamate cyclase [EC:4.2.1.48]
Pathway
map00470  D-Amino acid metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00470 D-Amino acid metabolism
    K22210  DGLUCY; D-glutamate cyclase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.48  D-glutamate cyclase
     K22210  DGLUCY; D-glutamate cyclase
Other DBs
RN: R01583
GO: 0047820
Genes
HSA: 80017(DGLUCY)
PTR: 453104(DGLUCY)
PPS: 100971567(DGLUCY)
GGO: 101153207(DGLUCY)
PON: 100172319(DGLUCY)
NLE: 100586901(DGLUCY)
MCC: 700168(DGLUCY)
MCF: 102135732(DGLUCY)
CSAB: 103229551(C24H14orf159)
CATY: 105596569
PANU: 101012503(DGLUCY)
TGE: 112628451(DGLUCY)
RRO: 104656701(DGLUCY)
RBB: 108523309(CUNH14orf159)
TFN: 117071547(DGLUCY)
PTEH: 111538216(DGLUCY)
SBQ: 101047007
CSYR: 103275586(CUNH14orf159)
MMUR: 105876286(C3H14orf159)
OGA: 100949551(DGLUCY)
MMU: 217830(Dglucy)
MCAL: 110306840(C12H14orf159)
MPAH: 110324645(C7H14orf159)
RNO: 362769(Dglucy)
MCOC: 116080006(Dglucy)
MUN: 110558364(CUNH14orf159)
CGE: 100753550(Dglucy)
PLEU: 114705025(Dglucy)
NGI: 103724611(CUNH14orf159)
HGL: 101711224
CPOC: 100735106(Dglucy)
CCAN: 109699498(CUNH14orf159)
TUP: 102469364
CFA: 100688910(DGLUCY)
VVP: 112907347(DGLUCY)
VLG: 121492493(DGLUCY)
AML: 100482436(DGLUCY)
UMR: 103670181
UAH: 113267360(DGLUCY)
UAR: 123798891(DGLUCY)
ELK: 111148542
LLV: 125104759
MPUF: 101689641
ORO: 101371157
EJU: 114204443(DGLUCY)
ZCA: 113909354(DGLUCY)
MLX: 118002490(DGLUCY)
PYU: 121032192(DGLUCY)
PBG: 122468118(DGLUCY)
PTG: 102949759
PPAD: 109274456(CUNH14orf159)
AJU: 106987920(DGLUCY)
HHV: 120232099(DGLUCY)
SSC: 100626547(C7H14orf159)
CFR: 102521322(DGLUCY)
CBAI: 105079860
CDK: 105095965(DGLUCY)
VPC: 102529318(DGLUCY)
BACU: 102999377
LVE: 103084864
OOR: 101287758
DLE: 111175940(DGLUCY)
PSIU: 116746127(DGLUCY)
ECB: 100063012(DGLUCY)
EPZ: 103558013
EAI: 106825335(DGLUCY)
MYB: 102252495
MYD: 102753826
MMYO: 118659289(DGLUCY)
MLF: 102432492(DGLUCY)
MNA: 107531588
PKL: 118712976(DGLUCY)
HAI: 109382680(CUNH14orf159)
DRO: 112311934(DGLUCY)
SHON: 118976806(DGLUCY)
AJM: 119037910(DGLUCY)
PDIC: 114492950(DGLUCY)
PHAS: 123808597(DGLUCY)
MMF: 118636098(DGLUCY)
RFQ: 117023309(DGLUCY)
PALE: 102898067(DGLUCY)
PGIG: 120619609(DGLUCY)
PVP: 105300806(DGLUCY)
RAY: 107515436
MJV: 108399442(CUNH14orf159)
TOD: 119239281(DGLUCY)
SARA: 101546022
LAV: 100659904(DGLUCY)
DNM: 101419340(DGLUCY)
MDO: 100017774(C1H14orf159)
GAS: 123234039(DGLUCY)
SHR: 100931620(DGLUCY)
PCW: 110217799(CUNH14orf159)
OAA: 100083826(DGLUCY)
GGA: 423409(C5H14orf159)
PCOC: 116228912(DGLUCY)
MGP: 100539918(DGLUCY)
CJO: 107315200(DGLUCY)
NMEL: 110402184(C6H14orf159)
APLA: 101791243(DGLUCY)
ACYG: 106036649
AFUL: 116489751(DGLUCY)
TGU: 100229540(DGLUCY)
LSR: 110471379(DGLUCY)
SCAN: 103826477(DGLUCY)
PMOA: 120503771(DGLUCY)
OTC: 121332518(DGLUCY)
PRUF: 121355992(DGLUCY)
GFR: 102037421
FAB: 101806679(C5H14orf159)
PHI: 102108442
PMAJ: 107205561(C5H14orf159)
CCAE: 111929884(DGLUCY)
CCW: 104685987(DGLUCY)
ETL: 114058212(DGLUCY)
ZAB: 102073109(DGLUCY)
FPG: 101913280
FCH: 102058374(DGLUCY)
CLV: 102096431(CUNH14orf159)
EGZ: 104135348
NNI: 104022218
ACUN: 113480812(DGLUCY)
TALA: 104364674(DGLUCY)
PADL: 103912999
ACHC: 115333825(DGLUCY)
AAM: 106482923
AROW: 112972654(DGLUCY)
NPD: 112953467(DGLUCY)
DNE: 112990234(DGLUCY)
ASN: 102380281(DGLUCY)
AMJ: 102576478(CUNH14orf159)
CPOO: 109321685(CUNH14orf159)
GGN: 109298523(CUNH14orf159)
PSS: 102453950(DGLUCY)
CMY: 102931212(DGLUCY)
CPIC: 101937326(DGLUCY)
TST: 117876192(DGLUCY)
CABI: 116816894(DGLUCY)
MRV: 120403369(DGLUCY)
ACS: 100562196(c1h14orf159)
PVT: 110086580(CUNH14orf159)
SUND: 121914907(DGLUCY)
PBI: 103063698(DGLUCY)
PMUR: 107297288(DGLUCY)
TSR: 106546543
PGUT: 117665912(DGLUCY)
VKO: 123026939(DGLUCY)
PMUA: 114591021(DGLUCY)
ZVI: 118078179(DGLUCY)
GJA: 107113340
XLA: 108698713(dglucy.L)
XTR: 549215(dglucy)
NPR: 108788696(CUNH14orf159)
RTEM: 120921213(DGLUCY)
BBUF: 120982146(DGLUCY)
BGAR: 122922084(DGLUCY)
DRE: 560387(c17h14orf159)
SRX: 107730207
SANH: 107679776
SGH: 107582942
CCAR: 109107902(c34h14orf159)
CAUA: 113117328(dglucy)
AMEX: 103041880(dglucy)
EEE: 113574126(dglucy)
TRU: 101064729(dglucy)
PLEP: 121953640(dglucy)
SLUC: 116065766(dglucy)
ECRA: 117935476(dglucy)
PFLV: 114546972(dglucy)
GAT: 120833002(dglucy)
PPUG: 119227288(dglucy)
MSAM: 119910853(dglucy)
MZE: 101472904(dglucy)
ONL: 100699337(dglucy)
OAU: 116327984(dglucy)
OLA: 101156702(dglucy)
OML: 112145000(dglucy)
XMA: 102226444(dglucy)
XCO: 114134371(dglucy)
XHE: 116709043(dglucy)
PRET: 103460669
PFOR: 103154203
PLAI: 106940573
PMEI: 106909503
GAF: 122845725(dglucy)
CVG: 107101552
CTUL: 119785374(dglucy)
GMU: 124855425(dglucy)
NFU: 107391670(csgr16h14orf159)
KMR: 108247027(dglucy)
ALIM: 106521235
NWH: 119427802(dglucy)
POV: 109628237(cunh14orf159)
SSEN: 122782986(dglucy)
HHIP: 117756188(dglucy)
XGL: 120795425(dglucy)
BPEC: 110163870 110166339(cunh14orf159)
MALB: 109965009(cunh14orf159)
SASA: 106611165(cssa09h14orf159)
OTW: 112256792(dglucy)
OMY: 110505723(dglucy)
OGO: 124046597(dglucy)
ONE: 115138649(dglucy)
SALP: 111963420(dglucy)
SNH: 120023204(dglucy)
ELS: 105015466(dglucy)
SFM: 108933257(dglucy)
PKI: 111852007(dglucy)
AANG: 118225631(dglucy)
LOC: 102682775(clg7h14orf159) 102692206
PSPA: 121323817 121329475(dglucy)
LCM: 102346195
CMK: 103189663(dglucy)
RTP: 109913902(cunh14orf159)
SCLV: 120326613
SPU: 577417
SKO: 100368287
ADF: 107345094
DGT: 114520257
XEN: 124441941
HMG: 100204445
AQU: 100637788
SMIN: v1.2.019446.t1(symbB.v1.2.019446.t1) v1.2.019446.t2(symbB.v1.2.019446.t2)
SPAR: SPRG_00060
SMER: DU99_19640
CID: P73_2835
RSU: NHU_04230
LPIL: LIP_2227
BLA: BLA_0133
BBB: BIF_01419
BBC: BLC1_0133
BLV: BalV_0138
BLW: W7Y_0140
BLS: W91_0141
BANI: Bl12_0130
BANL: BLAC_00730
BANM: EN10_00730
BDE: BDP_0108
BDN: BBDE_0098
BTP: D805_1222
FTJ: FTUN_6987
BARC: AOA65_1114
 » show all
Reference
  Authors
Ariyoshi M, Katane M, Hamase K, Miyoshi Y, Nakane M, Hoshino A, Okawa Y, Mita Y, Kaimoto S, Uchihashi M, Fukai K, Ono K, Tateishi S, Hato D, Yamanaka R, Honda S, Fushimura Y, Iwai-Kanai E, Ishihara N, Mita M, Homma H, Matoba S
  Title
D-Glutamate is metabolized in the heart mitochondria.
  Journal
Sci Rep 7:43911 (2017)
DOI:10.1038/srep43911
  Sequence
[mmu:217830]
LinkDB

KEGG   ENZYME: 4.2.1.48
Entry
EC 4.2.1.48                 Enzyme                                 
Name
D-glutamate cyclase;
D-glutamate hydro-lyase (cyclizing)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)
Reaction(IUBMB)
D-glutamate = 5-oxo-D-proline + H2O [RN:R01583]
Reaction(KEGG)
R01583
Substrate
D-glutamate [CPD:C00217]
Product
5-oxo-D-proline [CPD:C02237];
H2O [CPD:C00001]
Comment
Also acts on various derivatives of D-glutamate.
History
EC 4.2.1.48 created 1972
Pathway
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K22210  D-glutamate cyclase
Genes
HSA80017(DGLUCY)
PTR453104(DGLUCY)
PPS100971567(DGLUCY)
GGO101153207(DGLUCY)
PON100172319(DGLUCY)
NLE100586901(DGLUCY)
MCC700168(DGLUCY)
MCF102135732(DGLUCY)
CSAB103229551(C24H14orf159)
CATY105596569
PANU101012503(DGLUCY)
TGE112628451(DGLUCY)
RRO104656701(DGLUCY)
RBB108523309(CUNH14orf159)
TFN117071547(DGLUCY)
PTEH111538216(DGLUCY)
SBQ101047007
CSYR103275586(CUNH14orf159)
MMUR105876286(C3H14orf159)
OGA100949551(DGLUCY)
MMU217830(Dglucy)
MCAL110306840(C12H14orf159)
MPAH110324645(C7H14orf159)
RNO362769(Dglucy)
MCOC116080006(Dglucy)
MUN110558364(CUNH14orf159)
CGE100753550(Dglucy)
PLEU114705025(Dglucy)
NGI103724611(CUNH14orf159)
HGL101711224
CPOC100735106(Dglucy)
CCAN109699498(CUNH14orf159)
TUP102469364
CFA100688910(DGLUCY)
VVP112907347(DGLUCY)
VLG121492493(DGLUCY)
AML100482436(DGLUCY)
UMR103670181
UAH113267360(DGLUCY)
UAR123798891(DGLUCY)
ELK111148542
LLV125104759
MPUF101689641
ORO101371157
EJU114204443(DGLUCY)
ZCA113909354(DGLUCY)
MLX118002490(DGLUCY)
PYU121032192(DGLUCY)
PBG122468118(DGLUCY)
PTG102949759
PPAD109274456(CUNH14orf159)
AJU106987920(DGLUCY)
HHV120232099(DGLUCY)
SSC100626547(C7H14orf159)
CFR102521322(DGLUCY)
CBAI105079860
CDK105095965(DGLUCY)
VPC102529318(DGLUCY)
BACU102999377
LVE103084864
OOR101287758
DLE111175940(DGLUCY)
PSIU116746127(DGLUCY)
ECB100063012(DGLUCY)
EPZ103558013
EAI106825335(DGLUCY)
MYB102252495
MYD102753826
MMYO118659289(DGLUCY)
MLF102432492(DGLUCY)
MNA107531588
PKL118712976(DGLUCY)
HAI109382680(CUNH14orf159)
DRO112311934(DGLUCY)
SHON118976806(DGLUCY)
AJM119037910(DGLUCY)
PDIC114492950(DGLUCY)
PHAS123808597(DGLUCY)
MMF118636098(DGLUCY)
RFQ117023309(DGLUCY)
PALE102898067(DGLUCY)
PGIG120619609(DGLUCY)
PVP105300806(DGLUCY)
RAY107515436
MJV108399442(CUNH14orf159)
TOD119239281(DGLUCY)
SARA101546022
LAV100659904(DGLUCY)
DNM101419340(DGLUCY)
MDO100017774(C1H14orf159)
GAS123234039(DGLUCY)
SHR100931620(DGLUCY)
PCW110217799(CUNH14orf159)
OAA100083826(DGLUCY)
GGA423409(C5H14orf159)
PCOC116228912(DGLUCY)
MGP100539918(DGLUCY)
CJO107315200(DGLUCY)
NMEL110402184(C6H14orf159)
APLA101791243(DGLUCY)
ACYG106036649
AFUL116489751(DGLUCY)
TGU100229540(DGLUCY)
LSR110471379(DGLUCY)
SCAN103826477(DGLUCY)
PMOA120503771(DGLUCY)
OTC121332518(DGLUCY)
PRUF121355992(DGLUCY)
GFR102037421
FAB101806679(C5H14orf159)
PHI102108442
PMAJ107205561(C5H14orf159)
CCAE111929884(DGLUCY)
CCW104685987(DGLUCY)
ETL114058212(DGLUCY)
ZAB102073109(DGLUCY)
FPG101913280
FCH102058374(DGLUCY)
CLV102096431(CUNH14orf159)
EGZ104135348
NNI104022218
ACUN113480812(DGLUCY)
TALA104364674(DGLUCY)
PADL103912999
ACHC115333825(DGLUCY)
AAM106482923
AROW112972654(DGLUCY)
NPD112953467(DGLUCY)
DNE112990234(DGLUCY)
ASN102380281(DGLUCY)
AMJ102576478(CUNH14orf159)
CPOO109321685(CUNH14orf159)
GGN109298523(CUNH14orf159)
PSS102453950(DGLUCY)
CMY102931212(DGLUCY)
CPIC101937326(DGLUCY)
TST117876192(DGLUCY)
CABI116816894(DGLUCY)
MRV120403369(DGLUCY)
ACS100562196(c1h14orf159)
PVT110086580(CUNH14orf159)
SUND121914907(DGLUCY)
PBI103063698(DGLUCY)
PMUR107297288(DGLUCY)
TSR106546543
PGUT117665912(DGLUCY)
VKO123026939(DGLUCY)
PMUA114591021(DGLUCY)
ZVI118078179(DGLUCY)
GJA107113340
XLA108698713(dglucy.L)
XTR549215(dglucy)
NPR108788696(CUNH14orf159)
RTEM120921213(DGLUCY)
BBUF120982146(DGLUCY)
BGAR122922084(DGLUCY)
DRE560387(c17h14orf159)
SRX107730207
SANH107679776
SGH107582942
CCAR109107902(c34h14orf159)
CAUA113117328(dglucy)
AMEX103041880(dglucy)
EEE113574126(dglucy)
TRU101064729(dglucy)
PLEP121953640(dglucy)
SLUC116065766(dglucy)
ECRA117935476(dglucy)
PFLV114546972(dglucy)
GAT120833002(dglucy)
PPUG119227288(dglucy)
MSAM119910853(dglucy)
CUD121526235 121526683
MZE101472904(dglucy)
ONL100699337(dglucy)
OAU116327984(dglucy)
OLA101156702(dglucy)
OML112145000(dglucy)
XMA102226444(dglucy)
XCO114134371(dglucy)
XHE116709043(dglucy)
PRET103460669
PFOR103154203
PLAI106940573
PMEI106909503
GAF122845725(dglucy)
CVG107101552
CTUL119785374(dglucy)
GMU124855425(dglucy)
NFU107391670(csgr16h14orf159)
KMR108247027(dglucy)
ALIM106521235
NWH119427802(dglucy)
AOCE111576395 111576396
CSEM103383443 103383463
POV109628237(cunh14orf159)
SSEN122782986(dglucy)
HHIP117756188(dglucy)
LCF108886860 108896079 108897871
XGL120795425(dglucy)
HCQ109519777 109519787
BPEC110163870 110166339(cunh14orf159)
MALB109965009(cunh14orf159)
SASA106611165(cssa09h14orf159)
OTW112256792(dglucy)
OMY110505723(dglucy)
OGO124046597(dglucy)
ONE115138649(dglucy)
SALP111963420(dglucy)
SNH120023204(dglucy)
ELS105015466(dglucy)
SFM108933257(dglucy)
PKI111852007(dglucy)
AANG118225631(dglucy)
LOC102682775(clg7h14orf159) 102692206
PSPA121323817 121329475(dglucy)
ARUT117402760 117424686 117974027
LCM102346195
CMK103189663(dglucy)
RTP109913902(cunh14orf159)
BFO118417907 118420680 118421745
BBEL109473801 109482494
CIN100180171 100182513
SCLV120326613
SPU577417
APLC110976733 110976775
SKO100368287
NVE5517941 5520806
EPA110237437 110242750
ATEN116306890 116306892
ADF107345094
AMIL114947960 114963825
PDAM113669485 113670518 113670519 113671845 113671883
SPIS111323950 111333603 111339366
DGT114520257
XEN124441941
HMG100204445
AQU100637788
SREPTSG_03849
TGOTGME49_254760
SMINv1.2.019446.t1(symbB.v1.2.019446.t1) v1.2.019446.t2(symbB.v1.2.019446.t2)
FCYFRACYDRAFT_234119
SPARSPRG_00060
GTTGUITHDRAFT_115230
NGRNAEGRDRAFT_67691
TVATVAG_477110
PCAFDSC91_003834 DSC91_007304
PACSFAZ98_16120 FAZ98_16130 FAZ98_30245
PANDDRB87_00220 DRB87_00230
BBHBN112_2783
BBMBN115_0626
BBXBBS798_0630
PIGEGT29_25985
DIHG7047_04775
SIMPC6571_14745 C6571_14755
DMSE8L03_06740
MESOBSQ44_13830
SMQSinmeB_6592
SMIBN406_06782
SMERDU99_19640
SFHSFHH103_04193
SAMESAMCFNEI73_pC1585
SINOSS05631_a42580 SS05631_a42600
ESJSJ05684_a37780
BOFFQV39_07995
PSTGE8M01_06755
CIDP73_2835
PABYGa0080574_TMP528
SAGUCDO87_23055
RSUNHU_04230
RHMB5V46_17770
PAEDG5B38_21360
KNAB0W47_14230
HADHFRZ61_46790
FWADCMF_00955
LPILLIP_2227
MGOAFA91_03835
BLBBBMN68_890
BLZBLGT_03245
BLABLA_0133
BLCBalac_0142
BLTBalat_0142
BBBBIF_01419
BBCBLC1_0133
BNMBALAC2494_00981
BLVBalV_0138
BLWW7Y_0140
BLSW91_0141
BANIBl12_0130
BANLBLAC_00730
BANMEN10_00730
BDEBDP_0108
BDNBBDE_0098
BTPD805_1222
RIVRiv7116_1919
FISFIS3754_24270
GMRGmarT_08600
GIMF1728_09980
GPNPan110_09310
MRIMal4_49100
SDYNMal52_21760
PLONPla110_04020
GOGC1280_24635
TIMGMBLW1_22520
LRSPX52LOC_06605
FTJFTUN_6987
TSPHKIH39_25660
FFOFFONT_0039
CSUCSUB_C1123
BARCAOA65_1114
 » show all
Reference
1  [PMID:14087295]
  Authors
MEISTER A, BUKENBERGER MW, STRASSBURGER M.
  Title
THE OPTICALLY-SPECIFIC  ENZYMATIC CYCLIZATION OF D-GLUTAMATE.
  Journal
Biochem Z 338:217-29 (1963)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.48
IUBMB Enzyme Nomenclature: 4.2.1.48
ExPASy - ENZYME nomenclature database: 4.2.1.48
BRENDA, the Enzyme Database: 4.2.1.48
CAS: 37290-80-5
LinkDB

KEGG   REACTION: R01583
Entry
R01583                      Reaction                               
Name
D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)
Definition
D-Glutamate <=> 5-Oxo-D-proline + H2O
Equation
Reaction class
RC00553  C00217_C02237
Enzyme
Pathway
rn00470  D-Amino acid metabolism
rn01100  Metabolic pathways
Orthology
K22210  D-glutamate cyclase [EC:4.2.1.48]
Other DBs
RHEA: 22363
LinkDB

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