KEGG   ORTHOLOGY: K22225
Entry
K22225                      KO                                     
Symbol
ahbAB
Name
siroheme decarboxylase [EC:4.1.1.111]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01240  Biosynthesis of cofactors
Module
M00847  Heme biosynthesis, archaea, siroheme => heme
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K22225  ahbAB; siroheme decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.111  siroheme decarboxylase
     K22225  ahbAB; siroheme decarboxylase
Other DBs
RN: R12000
COG: COG1522
Genes
PAE: PA0512 PA0513 PA0514(nirL) PA0515
PAEV: N297_524 N297_525 N297_526 N297_527
PAEI: N296_524 N296_525 N296_526 N296_527
PAU: PA14_06680(nirH) PA14_06690(nirG) PA14_06700(nirL) PA14_06710(nirD)
PAP: PSPA7_0613 PSPA7_0614 PSPA7_0615(nirL) PSPA7_0616
PAG: PLES_05091(nirH) PLES_05101 PLES_05111(nirL) PLES_05121
PAF: PAM18_0511(nirH) PAM18_0512 PAM18_0513(nirL) PAM18_0514
PNC: NCGM2_5681(nirD) NCGM2_5682(nirL) NCGM2_5683(nirG) NCGM2_5684(nirH)
PAEB: NCGM1900_0524(nirH) NCGM1900_0525(nirG) NCGM1900_0526(nirL) NCGM1900_0527(nirD)
PDK: PADK2_02575 PADK2_02580 PADK2_02585 PADK2_02590
PFE: PSF113_3747(nirH) PSF113_3748(nirG) PSF113_3749(nirL) PSF113_3750(nirD)
PMAN: OU5_0461(nirD) OU5_0462(nirL) OU5_0463(nirG) OU5_0464(nirH) OU5_P0211 OU5_P0212(nirL) OU5_P0214
PSA: PST_3523(nirH) PST_3524(nirG) PST_3525(nirL) PST_3526(nirD)
PSZ: PSTAB_3497(nirH) PSTAB_3498(nirG) PSTAB_3499(nirL) PSTAB_3500(nirD)
PSR: PSTAA_3620(nirH) PSTAA_3621(nirG) PSTAA_3622(nirL) PSTAA_3623(nirD)
MHC: MARHY3065(nirD) MARHY3066(nirL) MARHY3067(nirG) MARHY3068(nirH)
TNI: TVNIR_1644(nirD_[H]) TVNIR_1645(nirL_[H]) TVNIR_1646(nirG_[H]) TVNIR_1647(nirH_[H])
OAI: OLEAN_C22280(nirH) OLEAN_C22290(nirG) OLEAN_C22300(nirL) OLEAN_C22310(nirD)
GPB: HDN1F_37020(nirH)
ENM: EBS_1576(nirGH) EBS_1577(nirL) EBS_1578(nirD)
PSE: NH8B_1426(nirG) NH8B_1427(nirH)
REH: H16_B2280(nirD) H16_B2281(nirG) H16_B2282(nirH)
CNC: CNE_2c22480(nirD2) CNE_2c22490(nirG) CNE_2c22500(nirH)
RME: Rmet_2081(nirG) Rmet_4937 Rmet_6507(nirH)
CTI: RALTA_B2052(nirD) RALTA_B2053(nirG) RALTA_B2054(nirH)
BPT: Bpet4059(nirD) Bpet4060(nirL) Bpet4061(nirG) Bpet4062(nirH)
RGE: RGE_06620(nirDL) RGE_06630(nirG) RGE_06640(nirH)
DOE: DENOEST_2948(nirH) DENOEST_2949(nirG) DENOEST_2950(nirD)
SLAC: SKTS_25500(nirH) SKTS_25510(nirG) SKTS_25520
EBA: ebA878(nirH) ebA880(nirG) ebA881(nirD)
APET: ToN1_15110(nirH) ToN1_15120(nirG) ToN1_15130(nirD2)
AZA: AZKH_3542(nirH) AZKH_3543(nirG) AZKH_3544
SUA: Saut_0825
SULC: CVO_00335
ATP: ATR_0633
ACRE: ACRYA_1448
ALK: ALEK_0523
AMYT: AMYT_0450
PACO: AACT_0546
HYO: NNO_0554
SUN: SUN_0294
NIS: NIS_1776
DTR: RSDT_0964(ahbA) RSDT_1048(ahbB)
LIP: LI0207(nirD) LI0907(nirH)
SAT: SYN_02265
SFU: Sfum_4037
PSF: PSE_2204 PSE_2205(nirG)
SIL: SPOA0224 SPOA0225(nirG) SPOA0226(nirH)
RDE: RD1_1569(nirD) RD1_1570(nirG) RD1_1571(nirH)
DSH: Dshi_3174(nirH) Dshi_3175(nirG) Dshi_3176(nirD)
PAMN: pAMV3p0217(nirH) pAMV3p0218(nirG) pAMV3p0219(nirD)
MAGX: XM1_2033(nirD) XM1_2034(nirL) XM1_2035(nirG) XM1_2036(nirH)
PPOY: RE92_24465
PSAB: PSAB_13040
BTS: Btus_0655
CAE: SMB_G2829(nirH) SMB_G2830
TEB: T8CH_0279(ahbA) T8CH_0280
SWO: Swol_0692
SLP: Slip_1422
SALQ: SYNTR_0463
DSY: DSY2220
DHD: Dhaf_3349
SGY: Sgly_1409
PTH: PTH_0977(Lrp) PTH_0978(Lrp)
AACX: DEACI_2422
TACI: TDSAC_1392
MHG: MHY_22630
RXY: Rxyl_0505
CWO: Cwoe_5931
ELE: Elen_2066
DGE: Dgeo_2287
KST: KSMBR1_2939(nirD_nirG) KSMBR1_2940(nirH_nirL)
HTH: HTH_0209(nirD)
MOX: DAMO_2409
MAC: MA_0574(nirD) MA_0575(nirH)
MMA: MM_1727(nirD) MM_1728(nirH) MM_1738(nirD) MM_1739(nirH)
MHI: Mhar_0167
HAL: VNG_1776G(nirH) VNG_1911G(nirD)
HSL: OE_3500R(ahbB) OE_3689R(ahbA)
HHB: Hhub_3077(ahbB) Hhub_3245(ahbA)
HMA: rrnAC1711(nirH) rrnAC3307(nirD)
HHI: HAH_0544(nirH1) HAH_2245(nirH3)
NPH: NP_3064A(ahbA) NP_4498A(ahbB)
NMO: Nmlp_2396(ahbA) Nmlp_3268(ahbB)
HWA: HQ_3121A(ahbA) HQ_3334A(ahbB)
HWC: Hqrw_3659(ahbA) Hqrw_3863(ahbB)
HVO: HVO_2227(ahbA) HVO_2313(ahbB)
HME: HFX_2279(nirD) HFX_2323(nirH)
NMG: Nmag_1221(ahbB) Nmag_2894(ahbA)
NMR: Nmar_0512
NCT: NMSP_1162
NEV: NTE_01248
NCV: NCAV_0216
NBV: T478_0462
NDV: NDEV_0469
LOKI: Lokiarch_30580(lrpA_2)
 » show all
Reference
  Authors
Kuhner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G
  Title
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri.
  Journal
Archaea 2014:327637 (2014)
DOI:10.1155/2014/327637
  Sequence
Reference
PMID:8982003
  Authors
Kawasaki S, Arai H, Kodama T, Igarashi Y
  Title
Gene cluster for dissimilatory nitrite reductase (nir) from Pseudomonas aeruginosa: sequencing and identification of a locus for heme d1 biosynthesis.
  Journal
J Bacteriol 179:235-42 (1997)
DOI:10.1128/jb.179.1.235-242.1997
  Sequence
Reference
  Authors
Bali S, Lawrence AD, Lobo SA, Saraiva LM, Golding BT, Palmer DJ, Howard MJ, Ferguson SJ, Warren MJ
  Title
Molecular hijacking of siroheme for the synthesis of heme and d1 heme.
  Journal
Proc Natl Acad Sci U S A 108:18260-5 (2011)
DOI:10.1073/pnas.1108228108
LinkDB

KEGG   ENZYME: 4.1.1.111
Entry
EC 4.1.1.111                Enzyme                                 
Name
siroheme decarboxylase;
sirohaem decarboxylase;
nirDLHG (gene name);
ahbAB (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
siroheme carboxy-lyase
Reaction(IUBMB)
siroheme = 12,18-didecarboxysiroheme + 2 CO2 [RN:R12000]
Reaction(KEGG)
R12000
Substrate
siroheme [CPD:C00748]
Product
12,18-didecarboxysiroheme [CPD:C21835];
CO2 [CPD:C00011]
Comment
The enzyme from archaea is involved in an alternative heme biosynthesis pathway. The enzyme from denitrifying bacteria is involved in the heme d1 biosynthesis pathway.
History
EC 4.1.1.111 created 2018
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22225  siroheme decarboxylase
Genes
PAEPA0512 PA0513 PA0514(nirL) PA0515
PAEVN297_524 N297_525 N297_526 N297_527
PAEIN296_524 N296_525 N296_526 N296_527
PAUPA14_06680(nirH) PA14_06690(nirG) PA14_06700(nirL) PA14_06710(nirD)
PAPPSPA7_0613 PSPA7_0614 PSPA7_0615(nirL) PSPA7_0616
PAGPLES_05091(nirH) PLES_05101 PLES_05111(nirL) PLES_05121
PAFPAM18_0511(nirH) PAM18_0512 PAM18_0513(nirL) PAM18_0514
PNCNCGM2_5681(nirD) NCGM2_5682(nirL) NCGM2_5683(nirG) NCGM2_5684(nirH)
PAEBNCGM1900_0524(nirH) NCGM1900_0525(nirG) NCGM1900_0526(nirL) NCGM1900_0527(nirD)
PDKPADK2_02575 PADK2_02580 PADK2_02585 PADK2_02590
PSGG655_02585 G655_02590 G655_02595 G655_02600
PRPM062_02560 M062_02565 M062_02570 M062_02575
PAEPPA1S_02585 PA1S_02590 PA1S_02595 PA1S_02600
PAERPA1R_gp4022 PA1R_gp4023 PA1R_gp4024 PA1R_gp4025
PAEMU769_02610 U769_02615 U769_02620 U769_02625
PAELT223_02585 T223_02590 T223_02595 T223_02600
PAESSCV20265_0539 SCV20265_0540 SCV20265_0541 SCV20265_0542
PAEUBN889_00593(nirH) BN889_00594 BN889_00595(nirL) BN889_00596
PAEGAI22_01305 AI22_01310 AI22_01315 AI22_01320
PAECM802_523 M802_524 M802_525 M802_526
PAEOM801_524 M801_525 M801_526 M801_527
PFEPSF113_3747(nirH) PSF113_3748(nirG) PSF113_3749(nirL) PSF113_3750(nirD)
PMANOU5_0461(nirD) OU5_0462(nirL) OU5_0463(nirG) OU5_0464(nirH) OU5_P0211 OU5_P0212(nirL) OU5_P0214
PCGAXG94_03530 AXG94_03535 AXG94_03540 AXG94_03545
PVRPverR02_18630 PverR02_18635 PverR02_18640 PverR02_18645
PRXHRH33_16065 HRH33_16070 HRH33_16075 HRH33_16080
PSAPST_3523(nirH) PST_3524(nirG) PST_3525(nirL) PST_3526(nirD)
PSZPSTAB_3497(nirH) PSTAB_3498(nirG) PSTAB_3499(nirL) PSTAB_3500(nirD)
PSRPSTAA_3620(nirH) PSTAA_3621(nirG) PSTAA_3622(nirL) PSTAA_3623(nirD)
PSCA458_03815 A458_03820 A458_03825 A458_03830
PSJPSJM300_03195 PSJM300_03200 PSJM300_03205 PSJM300_03210
PSHPsest_0822 Psest_0823 Psest_0824 Psest_0825
PSTUUIB01_03625 UIB01_03630 UIB01_03635 UIB01_03640
PCHLLLJ08_03700 LLJ08_03705 LLJ08_03710 LLJ08_03715
PBMCL52_16850 CL52_16855 CL52_16860 CL52_16865
PBAPSEBR_a3176 PSEBR_a3177 PSEBR_a3178 PSEBR_c2g64
PBCCD58_13000 CD58_13005 CD58_13010 CD58_13015
PDRH681_19215 H681_19225
PSKU771_13710 U771_13715 U771_13720 U771_13725
PFKPFAS1_27735 PFAS1_27740 PFAS1_27745 PFAS1_27750
PSILPMA3_16325 PMA3_16330 PMA3_16335 PMA3_16340
PSEDDM292_01545 DM292_01550 DM292_01555 DM292_01560
PVKEPZ47_12925 EPZ47_12930 EPZ47_12935 EPZ47_12940
PBZGN234_04975 GN234_04980 GN234_04985 GN234_04990
PDWBV82_3254 BV82_3255 BV82_3256 BV82_3257
PSEPC4K39_2865 C4K39_2866 C4K39_2867 C4K39_2868
PVWHU752_019055 HU752_019060 HU752_019065 HU752_019070
PSHHHU773_015125 HU773_015130 HU773_015135 HU773_015140
PASGKSS96_17040 KSS96_17045 KSS96_17050 KSS96_17055
PALVKSS97_14380 KSS97_14385 KSS97_14390 KSS97_14395
PTKEXN22_12495 EXN22_12500 EXN22_12505 EXN22_12510
PZAHU749_017115 HU749_017120 HU749_017125 HU749_017130
MAQMaqu_3126 Maqu_3127 Maqu_3128 Maqu_3129
MHCMARHY3065(nirD) MARHY3066(nirL) MARHY3067(nirG) MARHY3068(nirH)
MARAD0851_08700 D0851_08705 D0851_08710 D0851_08715
MARJMARI_00430 MARI_00440 MARI_00450 MARI_00460
CPSCPS_4224 CPS_4225
COVEKO29_12265 EKO29_12270
LSDEMK97_08060 EMK97_08065
MMTMetme_4004 Metme_4005 Metme_4006 Metme_4007
MDNJT25_014100 JT25_014105 JT25_014110 JT25_014115
MDHAYM39_03570 AYM39_03580 AYM39_03585
MKOMKLM6_0753 MKLM6_0754 MKLM6_0755 MKLM6_0756
METLU737_19775 U737_19780 U737_19785 U737_19790
MPADKEF85_04280 KEF85_04285 KEF85_04290 KEF85_04295
MELLIVG45_15005 IVG45_15010 IVG45_15015 IVG45_15020
MPSYCEK71_13010 CEK71_13015 CEK71_13020
MEINmethR_P1343 methR_P1344 methR_P1345 methR_P1346
MISZMishRS11D_12260(nirD_2) MishRS11D_12270(nirL) MishRS11D_12280(nirG) MishRS11D_12290(nirH)
MESLKKZ03_10945 KKZ03_10950 KKZ03_10955 KKZ03_10960
TIGTHII_2878 THII_2879 THII_2880 THII_2881
TNITVNIR_1644(nirD_[H]) TVNIR_1645(nirL_[H]) TVNIR_1646(nirG_[H]) TVNIR_1647(nirH_[H])
TTCFOKN1_0463 FOKN1_0464 FOKN1_0465
HCHHCH_04419 HCH_04420 HCH_04421 HCH_04422
HAHEENC22_19625 ENC22_19630 ENC22_19635 ENC22_19640
HCOLOKO_01706 LOKO_01707 LOKO_01708 LOKO_01709
HSIBOX17_07115 BOX17_07120 BOX17_07125 BOX17_07130
HCAMI4484_01210 I4484_01215 I4484_01220 I4484_01225
HSXHNO51_01075 HNO51_01080 HNO51_01085 HNO51_01090
HSVHNO53_00930 HNO53_00935 HNO53_00940 HNO53_00945
HTXEKK97_01245
PAURFGL86_16665 FGL86_16670 FGL86_16675 FGL86_16680
KAKKalk_09690 Kalk_09695 Kalk_09700 Kalk_09705
OAIOLEAN_C22280(nirH) OLEAN_C22290(nirG) OLEAN_C22300(nirL) OLEAN_C22310(nirD)
SDFACG33_09130 ACG33_09135 ACG33_09140
SLIMSCL_0267 SCL_0268 SCL_0269 SCL_0270
SVASVA_0353 SVA_0354 SVA_0355 SVA_0356
TBNTBH_C2678 TBH_C2679 TBH_C2680 TBH_C2681
SEDSAAY24_08970 AAY24_08975 AAY24_08980 AAY24_08985
GPBHDN1F_37020(nirH)
ENMEBS_1576(nirGH) EBS_1577(nirL) EBS_1578(nirD)
PSENH8B_1426(nirG) NH8B_1427(nirH)
AQLBXU06_11155 BXU06_11160
AMAHDLM_2752 DLM_2753
AQSDKK66_13270 DKK66_13275
VOGLCH97_16215 LCH97_16220
RPJN234_32850 N234_32855 N234_32860
REHH16_B2280(nirD) H16_B2281(nirG) H16_B2282(nirH)
CNCCNE_2c22480(nirD2) CNE_2c22490(nirG) CNE_2c22500(nirH)
REUReut_B5014 Reut_B5015 Reut_B5016
RMERmet_2081(nirG) Rmet_4937 Rmet_6507(nirH)
CTIRALTA_B2052(nirD) RALTA_B2053(nirG) RALTA_B2054(nirH)
CPAUEHF44_07505 EHF44_07510 EHF44_07515 EHF44_24455
COXE0W60_04855 E0W60_04860 E0W60_04865
BPTBpet4059(nirD) Bpet4060(nirL) Bpet4061(nirG) Bpet4062(nirH)
AFAUZ73_01540 UZ73_01545 UZ73_01550
AFQAFA_11250 AFA_11255 AFA_11260
AAQUD3M96_12070 D3M96_12075 D3M96_12080
AAMMFE795_10485 FE795_10490 FE795_10495
AJSAjs_1907 Ajs_1908 Ajs_1909
ACIDCBP33_02340 CBP33_02345 CBP33_02350
ACIPCBP36_02745 CBP36_02750 CBP36_02755
ACINCBP34_02305 CBP34_02310
ACISCBP35_16190 CBP35_16195
ACIOEAG14_01140 EAG14_01145
ARADKI609_13885 KI609_13890 KI609_13895
ADNAlide_2158 Alide_2159
ADKAlide2_2347 Alide2_2348
HYLLPB072_17220 LPB072_17225 LPB072_17230
HYCE5678_09445 E5678_09450 E5678_09455
HPSEHPF_07375 HPF_07380 HPF_07385
HTNKI616_18925 KI616_18930 KI616_18935
DPYBA022_05525 BA022_05530 BA022_05535
DIHG7047_07840 G7047_07845 G7047_07850
DAERH9K75_00875 H9K75_00880 H9K75_00885
DIADtpsy_1712 Dtpsy_1713 Dtpsy_1714
MELMC7H73_08590 C7H73_08595 C7H73_08600
UPVEJN92_06340 EJN92_06345
UPIEJG51_009740 EJG51_009745 EJG51_009750
NOKFAY22_14005
LCHLcho_1445 Lcho_1446 Lcho_1447
RGERGE_06620(nirDL) RGE_06630(nirG) RGE_06640(nirH)
RBNRBXJA2T_16157 RBXJA2T_16162 RBXJA2T_16167
PKTAT984_08210
AONDEH84_05450 DEH84_05455 DEH84_05460
SHDSUTH_02578 SUTH_02579 SUTH_02580
DOEDENOEST_2948(nirH) DENOEST_2949(nirG) DENOEST_2950(nirD)
TBDTbd_0072 Tbd_0073 Tbd_0074
SDRSCD_n00373 SCD_n00374 SCD_n00375
SLACSKTS_25500(nirH) SKTS_25510(nirG) SKTS_25520
DSUDsui_1930 Dsui_1931 Dsui_1932
ARESIWH25_08365 IWH25_08370 IWH25_08375
AIQAzoinq_02145 Azoinq_02150 Azoinq_02155
OTROTERR_20900(nirH) OTERR_20910(nirG) OTERR_20920
NIVJY500_02635 JY500_02640 JY500_02645
EBAebA878(nirH) ebA880(nirG) ebA881(nirD)
ABREpbN1_29650 pbN1_29660(nirG) pbN1_29670
APETToN1_15110(nirH) ToN1_15120(nirG) ToN1_15130(nirD2)
RBHB4966_09400 B4966_09405 B4966_09410
DARDaro_3267 Daro_3268 Daro_3269
DEYHYN24_11635 HYN24_11640 HYN24_11645
FLEKI610_06685 KI610_06690 KI610_06695
AZAAZKH_3542(nirH) AZKH_3543(nirG) AZKH_3544
AZIAzCIB_3602 AzCIB_3603 AzCIB_3604
ACOMCEW83_06720 CEW83_06725 CEW83_06730
AZDCDA09_17490 CDA09_17495 CDA09_17500
TMZTmz1t_2610 Tmz1t_2611 Tmz1t_2612
THUAC731_006315 AC731_006320 AC731_006325
TCLTchl_2597 Tchl_2598 Tchl_2599
THKCCZ27_06730 CCZ27_06735 CCZ27_06740
TAKTharo_1749 Tharo_1750 Tharo_1751
AZQG3580_16660 G3580_16665 G3580_16670
ZPAC3497_08950 C3497_08955 C3497_08960
APPCAP2UW1_3405 CAP2UW1_3406 CAP2UW1_3407
DDZDSYM_09020 DSYM_09030 DSYM_09040
TDNSuden_1976
SUASaut_0825
SULNFJR47_09120
SULGFJR48_01635
SULCCVO_00335
SPALFM071_03445
SSEIFJR45_08400
ATPATR_0633
ACREACRYA_1448
AFCAFAEC_1655
ALKALEK_0523
ALPLPB137_02455
AMYTAMYT_0450
HBVABIV_0419 ABIV_1675
PACOAACT_0546
HYONNO_0554
NSANitsa_1609
SUNSUN_0294
SLHYH65_09595
SINUIMZ28_09440
NISNIS_1776
DVUDVU_0854 DVU_3167
DVLDvul_0219 Dvul_2129
DVMDvMF_2503 DvMF_2900
DVGDeval_0784 Deval_2924
DDSDdes_0286 Ddes_2018
DFIAXF13_00530 AXF13_12305
DPGDESPIGER_1530 DESPIGER_1626
DEFCNY67_02025 CNY67_13560
DTRRSDT_0964(ahbA) RSDT_1048(ahbB)
DFLDFE_1925 DFE_2970
DSDGD606_09940 GD606_13860
DMADMR_11820 DMR_44420
DCBC3Y92_00955 C3Y92_15140
DGGDGI_1391 DGI_2627
DDEDde_2578 Dde_3179
DMSE8L03_09625 E8L03_10320
DSADesal_0752 Desal_1239
DHYDESAM_20148 DESAM_22935
DAFDesaf_1777 Desaf_2641
DASDaes_0752 Daes_2207
DPIBN4_11716 BN4_20514
DEJAWY79_04940 AWY79_14420
PPRFDPRO_1658 DPRO_4011
PSELGM415_02955 GM415_11935
DDNDND132_2674 DND132_3454
LIPLI0207(nirD) LI0907(nirH)
LIRLAW_00210 LAW_00936
DSXGD604_15315 GD604_17955
PBIZLWC08_08460 LWC08_10840
DBADbac_2394 Dbac_3002
DOAAXF15_03645 AXF15_04765
DRTDret_1956 Dret_2422
DOLDole_0464 Dole_2996
DMLDmul_30620 Dmul_30780
DALDalk_4142 Dalk_4278
DATHRM2_05170 HRM2_22040(nirD)
DTOTOL2_C24240 TOL2_C42380
DOVDSCO28_36170 DSCO28_69090
DWDDSCW_23860 DSCW_47620
DALKDSCA_21820 DSCA_28010
DLIdnl_04740 dnl_52340
DMMdnm_081690 dnm_084890
DEKDSLASN_39250 DSLASN_48480
SATSYN_02265
DAODesac_0396 Desac_2594
DTIDesti_3601 Desti_3748
SFUSfum_4037
DAXFDQ92_05085
AOLS58_68150 S58_68160 S58_68170
PSFPSE_2204 PSE_2205(nirG)
LABPFJ695_27655 FJ695_27660 FJ695_27665
LABTFIU93_29295 FIU93_29300 FIU93_29305
LAGGB0E33_29370 B0E33_29375 B0E33_29380
SILSPOA0224 SPOA0225(nirG) SPOA0226(nirH)
RUAD1823_20265 D1823_20270 D1823_20275
RUTFIU92_19635 FIU92_19640 FIU92_19645
RDERD1_1569(nirD) RD1_1570(nirG) RD1_1571(nirH)
RLIRLO149_c031320(nirH) RLO149_c031330(nirG) RLO149_c031340(nirD)
DSHDshi_3174(nirH) Dshi_3175(nirG) Dshi_3176(nirD)
SULIC1J05_18625 C1J05_18630 C1J05_18635
ROMEI983_08765 EI983_08770 EI983_08775
RHPLPB142_12495 LPB142_12500 LPB142_12505
PDEPden_2491 Pden_2492 Pden_2493
PARUCYR75_07945 CYR75_07950 CYR75_07955
PAMNpAMV3p0217(nirH) pAMV3p0218(nirG) pAMV3p0219(nirD)
PKDF8A10_01585 F8A10_01590 F8A10_01595
PPANESD82_11790 ESD82_11795 ESD82_11800
PSANHGN31_08475 HGN31_08480 HGN31_08485
PSEBEOK75_11590 EOK75_11595 EOK75_11600
PAMOBAR1_16535 BAR1_16540 BAR1_16545
PGVSL003B_0570(nirH) SL003B_0571 SL003B_0572
THASC6Y53_13600 C6Y53_13605 C6Y53_13610
SECHB18_05295 B18_05300 B18_05305 B18_05310
ABFAMK58_28560 AMK58_28565 AMK58_28570 AMK58_28575
AZZDEW08_19045 DEW08_19050 DEW08_19055 DEW08_19060
SMUCJL100_027805 JL100_027810 JL100_027815
SROEJL101_013175 JL101_013180 JL101_013185 JL101_013190 JL101_026205 JL101_026210 JL101_026215
MAGamb1403 amb1404 amb1405 amb1407
MGYMGMSRv2__1393(nirH) MGMSRv2__1394(nirG) MGMSRv2__1395(nirL) MGMSRv2__1396(nirD)
MGRYMSR1_08450 MSR1_08460 MSR1_08470 MSR1_08480
MAGXXM1_2033(nirD) XM1_2034(nirL) XM1_2035(nirG) XM1_2036(nirH)
MAGNWV31_17855 WV31_17860 WV31_17865 WV31_17870
TXITH3_16180 TH3_16190
HTLHPTL_0923 HPTL_0924
BLRBRLA_c012270
BRWGOP56_22005
PPOYRE92_24465
PSABPSAB_13040
PDUPDUR_14785
PSTEPSTEL_13810
PSOPKP014_18130
BTSBtus_0655
KYRCVV65_04730
PABSJIR001_10130
CACCA_C2793 CA_C2794
CAESMB_G2829(nirH) SMB_G2830
CAYCEA_G2801 CEA_G2802
CBECbei_2009 Cbei_2010
CBZCbs_2009 Cbs_2010
CBEILF65_02178 LF65_02179
CKLCKL_0377 CKL_0378
CKRCKR_0327 CKR_0328
CSRCspa_c47260 Cspa_c47270
CPASClopa_0540 Clopa_0541
CPATCLPA_c04450(nirD) CLPA_c04460
CPAECPAST_c04450(nirD) CPAST_c04460
CSQCSCA_2625 CSCA_2639
CACECACET_c33610 CACET_c33620
CCKCcar_01390 Ccar_01460
CTYKCTK_C24940 CTK_C24950
CEUA7L45_05720 A7L45_05725
CFMBJL90_02220 BJL90_02225
CDRKB9W14_06485 B9W14_06555
CDYF3K33_10015 F3K33_10020
AMTAmet_0049 Amet_0050
GFEGferi_06070
ANRAna3638_21900 Ana3638_21905
TEBT8CH_0279(ahbA) T8CH_0280
SWOSwol_0692
SLPSlip_1422
SALQSYNTR_0463
CALKHUE98_13065 HUE98_13070
DSYDSY2220
DHDDhaf_3349
DDHDesde_2795
DDLDesdi_2313
DMTDESME_09250
SGYSgly_1409
DORDesor_1314
DAIDesaci_1936
DMIDesmer_1213
DEDDHBDCA_p1024
DECDCF50_p1080
DRSDEHRE_09590
DCADesca_1538 Desca_1539
PTHPTH_0977(Lrp) PTH_0978(Lrp)
DRMDred_2157 Dred_2158
DRUDesru_1626 Desru_1627
DFGB0537_10730 B0537_10735
DAEDtox_1256 Dtox_1257
DKUDesku_1515 Desku_1516
DAUDaud_1341 Daud_1342
TFRBR63_18650 BR63_18655
AACXDEACI_2422
TJRTherJR_1140 TherJR_1141
DGIDesgi_2069 Desgi_2070 Desgi_2974 Desgi_2975
HMOHM1_1970 HM1_1971
HCVFTV88_1674 FTV88_1675
MTAMoth_2197 Moth_2198
MTHOMOTHE_c22570 MOTHE_c22580
MTHZMOTHA_c23300 MOTHA_c23310
ADGAdeg_1254 Adeg_1255
TNRThena_1417
TACITDSAC_1392
NTHNther_1129 Nther_1130
NCDACONDI_00762 ACONDI_00763
AARAcear_0546 Acear_0547
SSGSelsp_1300 Selsp_1301
SRISELR_15400 SELR_15410
SELEADJ74_08260 ADJ74_08265
SELOAXE86_01325 AXE86_01330
SELTBCS37_04530 BCS37_04535
MHGMHY_22630
MFUNGXM21_09475 GXM21_09480
PUFUFO1_3026 UFO1_3027 UFO1_3410 UFO1_3411
PFTJBW_01636 JBW_01637
MANAMAMMFC1_00491 MAMMFC1_00492
STEDSPTER_13480 SPTER_13490
ABAIIMCC26256_111978
RXYRxyl_0505
RRDRradSPS_2515
RUBGBA63_01415
RMARGBA65_01270
BSOLFSW04_03705
CWOCwoe_5931
CCUCcur_12320
ELEElen_2066
DLYDehly_0451
DFODform_01789
DGEDgeo_2287
DMRDeima_3285
DGODGo_CA2941
DPDDeipe_1366
DSWQR90_06060
DPUSU48_02350
DEZDKM44_14750
DEINDAAJ005_09180
DPHEHF33_10890
KSTKSMBR1_2939(nirD_nirG) KSMBR1_2940(nirH_nirL)
BROCIPI25_06335 IPI25_06340
BPITBPIT_22720 BPIT_22730
JETL3J17_06485 L3J17_06490
ALUSSTSP2_00884
TAERGT409_03770
SCORJ3U87_32750 J3U87_32755 J3U87_32760 J3U87_32765
HYAHY04AAS1_0344
HTHHTH_0209(nirD)
HTEHydth_0208
SULSYO3AOP1_0453
PMXPERMA_0311
TIDThein_0059 Thein_0172 Thein_0848
TOPTOPB45_0032 TOPB45_0789 TOPB45_0798
TCMHL41_00210 HL41_04215 HL41_04985
THETF1847_01855 F1847_03270 F1847_06510
CTHITHC_1164 THC_1535 THC_1636
TAVG4V39_04665 G4V39_06005 G4V39_10530
TMAIFVE67_03270 FVE67_03825 FVE67_03905
MOXDAMO_2409
MBAMbar_A1459 Mbar_A1460
MBYMSBRM_0433 MSBRM_0434
MBWMSBRW_3267 MSBRW_3268
MBARMSBR2_1948 MSBR2_1949
MBAKMSBR3_1993 MSBR3_1994
MACMA_0574(nirD) MA_0575(nirH)
MMAMM_1727(nirD) MM_1728(nirH) MM_1738(nirD) MM_1739(nirH)
MMAZMmTuc01_1817 MmTuc01_1818
MMJMSMAS_2940 MSMAS_2941 MSMAS_2947 MSMAS_2948
MMACMSMAC_1493 MSMAC_1494
MVCMSVAZ_0558 MSVAZ_0559
MEKMSKOL_0536 MSKOL_0537
MLSMSLAZ_0313 MSLAZ_0314
METMMSMTP_2888 MSMTP_2889
MEFMSWH1_2710 MSWH1_2711
MEQMSWHS_2326 MSWHS_2327
MSJMSSAC_0508 MSSAC_0509
MSZMSSIH_0469 MSSIH_0470
MSWMSSIT_0492 MSSIT_0493
MTHRMSTHT_2088 MSTHT_2089
MTHEMSTHC_1195 MSTHC_1196
MHORMSHOH_3652 MSHOH_3653
MFZAOB57_005510 AOB57_005515
MBUMbur_1231 Mbur_1232
MMETMCMEM_1683 MCMEM_1684
MELOJ7W08_07265 J7W08_07270
MMHMmah_1455 Mmah_1456
MHAZBHR79_06400 BHR79_06405
MEVMetev_0226 Metev_0227
MZHMzhil_1491 Mzhil_1492
MPYMpsy_2493 Mpsy_2494
MZIHWN40_09425 HWN40_09430
MHZMetho_0826 Metho_0827
MTPMthe_0047 Mthe_1134
MCJMCON_1213 MCON_1504
MHIMhar_0167
MRTJKHC33_07220 KHC33_07225
MEMMemar_0877 Memar_0878
MEMAMMAB1_3017 MMAB1_3018
MCHKMchiMG62_13790 MchiMG62_13800
MBNMboo_0956 Mboo_0957
MPLMpal_2627 Mpal_2628
HALVNG_1776G(nirH) VNG_1911G(nirD)
HSLOE_3500R(ahbB) OE_3689R(ahbA)
HDLHALDL1_13875 HALDL1_14550
HHBHhub_3077(ahbB) Hhub_3245(ahbA)
HAGSJT689_08505 JT689_09025
HABOJRZ79_06915 JRZ79_07435
HNOLT974_12295 LT974_13005
HLULT972_01850 LT972_02620
HANRLJ422_07160 LJ422_07695
HJEHacjB3_03595 HacjB3_06120
SALRFQU85_06540 FQU85_06940
HALREFA46_001200 EFA46_002040
HARAAArcS_1969 AArcS_2707 AArcS_2837
HAADMW046_01895 MW046_09800
HMArrnAC1711(nirH) rrnAC3307(nirD)
HHIHAH_0544(nirH1) HAH_2245(nirH3)
HHNHISP_02815 HISP_11435
HABSG26_03805 SG26_10605
HTABVU17_02700 BVU17_10960
HALJG9465_16160 G9465_17410
HSINKDQ40_02155 KDQ40_10785
NPHNP_3064A(ahbA) NP_4498A(ahbB)
NMONmlp_2396(ahbA) Nmlp_3268(ahbB)
NHOHWV23_03140 HWV23_14060
NSALHWV07_17050 HWV07_18080
HMUHmuk_1585 Hmuk_1614
HALZE5139_11050 E5139_11200
HALLLC1Hm_0661 LC1Hm_0740
HAZPGBQ70_11045 GBQ70_11195
HALIBV210_12195 BV210_13490
HRRHZS55_18335 HZS55_19675
HPELHZS54_21880 HZS54_22615
HLTI7X12_15710 I7X12_17370
HARCHARCEL1_06040 HARCEL1_06200
HDOMUK72_01580 MUK72_12560
HWAHQ_3121A(ahbA) HQ_3334A(ahbB)
HWCHqrw_3659(ahbA) Hqrw_3863(ahbB)
HVOHVO_2227(ahbA) HVO_2313(ahbB)
HMEHFX_2279(nirD) HFX_2323(nirH)
HGIABY42_11145 ABY42_11510
HALEG3A49_14565 G3A49_14780
HBOHbor_06620 Hbor_07280
HLMDV707_03450 DV707_06605
HALMFCF25_02595 FCF25_03635
HLAHlac_0086 Hlac_2130
HALPDOS48_00465 DOS48_10275
HALBEKH57_05950 EKH57_10735
HEZZEO776_00615 EO776_06575
HALQHrr1229_006495 Hrr1229_011380
HSSJ7656_10035
HSAIHPS36_00385 HPS36_06100
HAZZKI388_04160 KI388_14255
SRUBC2R22_16745 C2R22_17055
HAEhalTADL_3065 halTADL_3318
HALGHUG10_09260 HUG10_09625
HALUHUG12_06265 HUG12_06890
HMPK6T50_06850 K6T50_07115
HREK6T36_06635 K6T36_06890
HRMK6T25_08925 K6T25_09190
HACBHbl1158_12745 Hbl1158_13450
HTUHtur_0511 Htur_3248
HDABB347_00360 BB347_11010
HJTDVR14_07800 DVR14_12110
HALYHYG82_10375 HYG82_15615
HSALJMJ58_06580 JMJ58_12215
HLOJ0X27_07100 J0X27_08090
HAKZJ0X25_04475 J0X25_09940
NMGNmag_1221(ahbB) Nmag_2894(ahbA)
NATNJ7G_0120 NJ7G_2497
NPENatpe_0577 Natpe_3535
NVRFEJ81_03220 FEJ81_17080
NPLFGF80_07740 FGF80_15905
NAYHYG81_07630 HYG81_11960
SALIL593_08205 L593_09710
HLRHALLA_06430 HALLA_17040
HLCCHINAEXTREME02215 CHINAEXTREME08135
NASGCU68_03480 GCU68_09085
MEAMMU439_05275 MU439_05280
NMRNmar_0512
NIRNSED_02570
NKRNKOR_02630
NIDNPIRD3C_1766
NINNADRNF5_1674
NIWNisw_02330
NCLC5F47_02610
NOXC5F49_02780
NUEC5F50_03740
NIPNsoK4_05820
NCTNMSP_1162
NICDSQ20_02825
CSYCENSYa_1301
NGANgar_c28830
NVNNVIE_029650
NEVNTE_01248
TAANMY3_00561
NFNNFRAN_1567
NCVNCAV_0216
NBVT478_0462
TAHSU86_003560
NIUDSQ19_02575
NDVNDEV_0469
LOKILokiarch_30580(lrpA_2)
 » show all
Reference
1  [PMID:21969545]
  Authors
Bali S, Lawrence AD, Lobo SA, Saraiva LM, Golding BT, Palmer DJ, Howard MJ, Ferguson SJ, Warren MJ
  Title
Molecular hijacking of siroheme for the synthesis of heme and d1 heme.
  Journal
Proc Natl Acad Sci U S A 108:18260-5 (2011)
DOI:10.1073/pnas.1108228108
Reference
2  [PMID:24669201]
  Authors
Kuhner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G
  Title
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri.
  Journal
Archaea 2014:327637 (2014)
DOI:10.1155/2014/327637
  Sequence
Reference
3  [PMID:24865947]
  Authors
Palmer DJ, Schroeder S, Lawrence AD, Deery E, Lobo SA, Saraiva LM, McLean KJ, Munro AW, Ferguson SJ, Pickersgill RW, Brown DG, Warren MJ
  Title
The structure, function and properties of sirohaem decarboxylase--an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.
  Journal
Mol Microbiol 93:247-61 (2014)
DOI:10.1111/mmi.12656
  Sequence
Reference
4  [PMID:25083922]
  Authors
Haufschildt K, Schmelz S, Kriegler TM, Neumann A, Streif J, Arai H, Heinz DW, Layer G
  Title
The crystal structure of siroheme decarboxylase in complex with iron-uroporphyrin III reveals two essential histidine residues.
  Journal
J Mol Biol 426:3272-3286 (2014)
DOI:10.1016/j.jmb.2014.07.021
  Sequence
[hth:HTH_0209]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.111
IUBMB Enzyme Nomenclature: 4.1.1.111
ExPASy - ENZYME nomenclature database: 4.1.1.111
BRENDA, the Enzyme Database: 4.1.1.111
LinkDB

KEGG   REACTION: R12000
Entry
R12000                      Reaction                               
Name
siroheme carboxy-lyase
Definition
Siroheme <=> 12,18-Didecarboxysiroheme + 2 CO2
Equation
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00847  Heme biosynthesis, archaea, siroheme => heme
Orthology
K22225  siroheme decarboxylase [EC:4.1.1.111]
Other DBs
RHEA: 19096
LinkDB

DBGET integrated database retrieval system