| Entry |
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| Name |
psilocybin synthase;
PsiM
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:4-hydroxytryptamine-4-phosphate N,N-dimethyltransferase
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| Reaction(IUBMB) |
2 S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate = 2 S-adenosyl-L-homocysteine + psilocybin (overall reaction) [RN: R11934];
(1a) S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate = S-adenosyl-L-homocysteine + 4-hydroxy-N-methyltryptamine 4-phosphate [RN: R11935];
(1b) S-adenosyl-L-methionine + 4-hydroxy-N-methyltryptamine 4-phosphate = S-adenosyl-L-homocysteine + psilocybin [RN: R11936]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
4-hydroxytryptamine 4-phosphate [CPD: C21778];
4-hydroxy-N-methyltryptamine 4-phosphate [CPD: C21779]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
psilocybin [CPD: C07576];
4-hydroxy-N-methyltryptamine 4-phosphate [CPD: C21779]
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| Comment |
Isolated from the fungus Psilocybe cubensis. The product, psilocybin, is a psychoactive compound.
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| History |
EC 2.1.1.345 created 2017
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| Pathway |
| ec00901 | Indole alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
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| Reference |
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| Authors |
Fricke J, Blei F, Hoffmeister D |
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| Title |
Enzymatic Synthesis of Psilocybin. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.345 |
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| LinkDB |
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