KEGG   ORTHOLOGY: K22574
Entry
K22574            Tight     KO                                     
Symbol
AF380
Name
fumagillin biosynthesis transferase
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00969  Fumagillin biosynthesis, farnesyl-PP => fumagillin
Reaction
R13146  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K22574  AF380; fumagillin biosynthesis transferase
Other DBs
COG: COG1073
Genes
AFM: AFUA_8G00380
NFI: NFIA_093920
Reference
PMID:24568283
  Authors
Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y
  Title
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
  Journal
J Am Chem Soc 136:4426-36 (2014)
DOI:10.1021/ja500881e
  Sequence
[afm:AFUA_8G00380]
LinkDB

KEGG   REACTION: R13146
Entry
R13146                      Reaction                               
Definition
Fumagillol + Dodecapentaenoyl-[acyl-carrier protein] <=> Prefumagillin + Acyl-carrier protein
Equation
C22618 + C22651 <=> C22650 + C00229
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00969  Fumagillin biosynthesis, farnesyl-PP => fumagillin
Orthology
K22574  fumagillin biosynthesis transferase
Reference
1  [PMID:31861936]
  Authors
Guruceaga X, Perez-Cuesta U, Abad-Diaz de Cerio A, Gonzalez O, Alonso RM, Hernando FL, Ramirez-Garcia A, Rementeria A.
  Title
Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications.
  Journal
Toxins (Basel) 12:7 (2019)
DOI:10.3390/toxins12010007
LinkDB

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