KEGG   ORTHOLOGY: K22604
Entry
K22604                      KO                                     
Symbol
E1.1.1.52
Name
3alpha-hydroxycholanate dehydrogenase (NAD+) [EC:1.1.1.52]
Pathway
map00121  Secondary bile acid biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00121 Secondary bile acid biosynthesis
    K22604  E1.1.1.52; 3alpha-hydroxycholanate dehydrogenase (NAD+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.52  3alpha-hydroxycholanate dehydrogenase (NAD+)
     K22604  E1.1.1.52; 3alpha-hydroxycholanate dehydrogenase (NAD+)
Other DBs
COG: COG1028
GO: 0047043
Genes
ELE: Elen_0690
EYY: EGYY_08520(FabG)
EGD: GS424_013575
GPA: GPA_01510
RTS: CE91St31_25700
Reference
  Authors
Devlin AS, Fischbach MA
  Title
A biosynthetic pathway for a prominent class of microbiota-derived bile acids.
  Journal
Nat Chem Biol 11:685-90 (2015)
DOI:10.1038/nchembio.1864
  Sequence
[ele:Elen_0690]
LinkDB

KEGG   ENZYME: 1.1.1.52
Entry
EC 1.1.1.52                 Enzyme                                 
Name
3alpha-hydroxycholanate dehydrogenase (NAD+);
alpha-hydroxy-cholanate dehydrogenase;
lithocholate:NAD+ oxidoreductase;
3alpha-hydroxycholanate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
lithocholate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
lithocholate + NAD+ = 3-oxo-5beta-cholan-24-oate + NADH + H+ [RN:R04139]
Reaction(KEGG)
R04139
Substrate
lithocholate [CPD:C03990];
NAD+ [CPD:C00003]
Product
3-oxo-5beta-cholan-24-oate [CPD:C03070];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on other 3alpha-hydroxysteroids with an acidic side-chain. cf. EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+).
History
EC 1.1.1.52 created 1961, modified 1976, modified 2016
Pathway
ec00121  Secondary bile acid biosynthesis
Orthology
K22604  3alpha-hydroxycholanate dehydrogenase (NAD+)
Genes
ELEElen_0690
EYYEGYY_08520(FabG)
EGDGS424_013575
GPAGPA_01510
RTSCE91St31_25700
Reference
1  [PMID:14377608]
  Authors
HAYAISHI O, SATO Y, JAKOBY WB, STOHLMAN EF.
  Title
Reversible enzymatic oxidation of bile acids.
  Journal
Arch Biochem 56:554-5 (1955)
DOI:10.1016/0003-9861(55)90278-2
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.52
IUBMB Enzyme Nomenclature: 1.1.1.52
ExPASy - ENZYME nomenclature database: 1.1.1.52
BRENDA, the Enzyme Database: 1.1.1.52
CAS: 9028-57-3
LinkDB

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