KEGG   ORTHOLOGY: K22813
Entry
K22813                      KO                                     
Symbol
E4.1.1.110
Name
bisphosphomevalonate decarboxylase [EC:4.1.1.110]
Pathway
map00900  Terpenoid backbone biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Reaction
R10781  (R)-3,5-bisphosphomevalonate carboxy-lyase (isopentenyl-phosphate-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K22813  E4.1.1.110; bisphosphomevalonate decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.110  bisphosphomevalonate decarboxylase
     K22813  E4.1.1.110; bisphosphomevalonate decarboxylase
Other DBs
COG: COG3407
Genes
TAC: Ta0893
TVO: TVG0411662(TVG0411662)
PTO: PTO0478
FAC: FACI_IFERC01G1792
FAI: FAD_0762
CDIV: CPM_0958
MARH: Mia14_0535
MIY: Micr_00574
Reference
PMID:28004831
  Authors
Vinokur JM, Cummins MC, Korman TP, Bowie JU
  Title
An Adaptation To Life In Acid Through A Novel Mevalonate Pathway.
  Journal
Sci Rep 6:39737 (2016)
DOI:10.1038/srep39737
  Sequence
[tac:Ta0893]
LinkDB

KEGG   ENZYME: 4.1.1.110
Entry
EC 4.1.1.110                Enzyme                                 
Name
bisphosphomevalonate decarboxylase;
mevalonate 3,5-bisphosphate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
(R)-3,5-bisphosphomevalonate carboxy-lyase (isopentenyl-phosphate-forming)
Reaction(IUBMB)
(R)-3,5-bisphosphomevalonate = isopentenyl phosphate + CO2 + phosphate [RN:R10781]
Reaction(KEGG)
R10781
Substrate
(R)-3,5-bisphosphomevalonate [CPD:C20848]
Product
isopentenyl phosphate [CPD:C20345];
CO2 [CPD:C00011];
phosphate [CPD:C00009]
Comment
The enzyme participates in an alternative mevalonate pathway that takes place in extreme acidophiles of the Thermoplasmatales order. cf. EC 4.1.1.99, phosphomevalonate decarboxylase.
History
EC 4.1.1.110 created 2018
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22813  bisphosphomevalonate decarboxylase
Genes
TAC: Ta0893
TVO: TVG0411662(TVG0411662)
PTO: PTO0478
FAC: FACI_IFERC01G1792
FAI: FAD_0762
CDIV: CPM_0958
MARH: Mia14_0535
MIY: Micr_00574
Reference
1  [PMID:28004831]
  Authors
Vinokur JM, Cummins MC, Korman TP, Bowie JU
  Title
An Adaptation To Life In Acid Through A Novel Mevalonate Pathway.
  Journal
Sci Rep 6:39737 (2016)
DOI:10.1038/srep39737
  Sequence
[tac:Ta0893]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.110
IUBMB Enzyme Nomenclature: 4.1.1.110
ExPASy - ENZYME nomenclature database: 4.1.1.110
BRENDA, the Enzyme Database: 4.1.1.110
LinkDB

KEGG   REACTION: R10781
Entry
R10781                      Reaction                               
Name
(R)-3,5-bisphosphomevalonate carboxy-lyase (isopentenyl-phosphate-forming)
Definition
(R)-Mevalonate 3,5-bisphosphate <=> Isopentenyl phosphate + CO2 + Orthophosphate
Equation
C20848 <=> C20345 + C00011 + C00009
Reaction class
RC03276  C20345_C20848
Enzyme
4.1.1.110
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.110
     R10781  (R)-Mevalonate 3,5-bisphosphate <=> Isopentenyl phosphate + CO2 + Orthophosphate
Orthology
K22813  bisphosphomevalonate decarboxylase [EC:4.1.1.110]
Other DBs
RHEA: 56503
LinkDB

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