KEGG   ORTHOLOGY: K22925
Entry
K22925                      KO                                     
Symbol
tviC, vipB
Name
UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase [EC:5.1.3.45]
Pathway
map00520  Amino sugar and nucleotide sugar metabolism
map00541  O-Antigen nucleotide sugar biosynthesis
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Module
M00857  Salmonella enterica pathogenicity signature, Vi antigen
Reaction
R08706  UDP-N-acetyl-D-glucosaminuronate 4-epimerase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00520 Amino sugar and nucleotide sugar metabolism
    K22925  tviC, vipB; UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K22925  tviC, vipB; UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.3  Acting on carbohydrates and derivatives
    5.1.3.45  UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase
     K22925  tviC, vipB; UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase
Other DBs
COG: COG0451
Genes
STY: STY4660(tviC)
STT: t4351(tviC)
SEX: STBHUCCB_46070
SENT: TY21A_22160
SEI: SPC_4465(tviC)
CBRA: A6J81_21665
CFQ: C2U38_20580
CIB: HF677_004215(tviC)
MENY: LSQ66_21050
Reference
PMID:8331073
  Authors
Hashimoto Y, Li N, Yokoyama H, Ezaki T
  Title
Complete nucleotide sequence and molecular characterization of ViaB region encoding Vi antigen in Salmonella typhi.
  Journal
J Bacteriol 175:4456-65 (1993)
DOI:10.1128/jb.175.14.4456-4465.1993
  Sequence
[sty:STY4660]
Reference
  Authors
Zhang H, Zhou Y, Bao H, Liu HW
  Title
Vi antigen biosynthesis in Salmonella typhi: characterization of UDP-N-acetylglucosamine C-6 dehydrogenase (TviB) and UDP-N-acetylglucosaminuronic acid C-4 epimerase (TviC).
  Journal
Biochemistry 45:8163-73 (2006)
DOI:10.1021/bi060446d
LinkDB

KEGG   ORTHOLOGY: K02473
Entry
K02473                      KO                                     
Symbol
wbpP
Name
UDP-N-acetylglucosamine/UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase [EC:5.1.3.7 5.1.3.45]
Pathway
map00520  Amino sugar and nucleotide sugar metabolism
map00541  O-Antigen nucleotide sugar biosynthesis
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Reaction
R00418  UDP-N-acetyl-D-glucosamine 4-epimerase
R08706  UDP-N-acetyl-D-glucosaminuronate 4-epimerase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00520 Amino sugar and nucleotide sugar metabolism
    K02473  wbpP; UDP-N-acetylglucosamine/UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K02473  wbpP; UDP-N-acetylglucosamine/UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.3  Acting on carbohydrates and derivatives
    5.1.3.7  UDP-N-acetylglucosamine 4-epimerase
     K02473  wbpP; UDP-N-acetylglucosamine/UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase
    5.1.3.45  UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase
     K02473  wbpP; UDP-N-acetylglucosamine/UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase
Other DBs
COG: COG0451
GO: 0003974
Genes
ECW: EcE24377A_2324(vipB)
SSN: SSON_P225(wbgU)
CAMA: F384_10980
PSHI: SAMEA2665130_0111(strE)
TOE: QMG90_13835
PPEU: DUT67_15010
PAY: PAU_04338(wbpP)
PSKY: A6B44_03050
LLZ: LYB30171_01680(wbgU)
LUM: CNR27_00755
VSC: VSVS12_00379(wbpP)
SCOT: HBA18_09120(tviC)
PAEP: PA1S_09595
PAEL: T223_09605
PAEG: AI22_24275
PMAM: KSS90_19115(tviC)
PAZE: KSS91_07755(tviC)
PWY: HU734_007705(tviC)
PPAO: K3169_22105(tviC)
AVN: Avin_29920(wbpP)
AVL: AvCA_29920(wbpP)
AVD: AvCA6_29920(wbpP)
ACX: Achr_17940(wbpP)
HAES: LO767_04855(tviC)
MARJ: MARI_04550(wbgU_1)
MANP: EHN06_13760(tviC)
PAR: Psyc_0651
PSYA: AOT82_2605
PKY: PKHYL_30530(wbpP)
ABY: ABAYE3814
ABN: AB57_06085(gne2)
ABB: ABBFA_03427(gne2)
ABAD: ABD1_00530(galE)
ABAU: IX87_14855
ACI: ACIAD0088
ASJ: AsACE_CH02815(vipB)
ACUM: C9E88_003910(tviC)
ALW: FOB21_09575(tviC)
ALJ: G8D99_15105(tviC)
AWG: GFH30_12910(tviC)
AVB: RYU24_00690(wbpP)
ABOU: ACBO_00640(wbpP_1) ACBO_00730(wbpP_2)
SON: SO_3189(wbpP)
SWD: Swoo_1655
SWP: swp_1576
CPS: CPS_3643
COV: EKO29_16640(tviC)
LSD: EMK97_05210(tviC)
THT: E2K93_01385(tviC)
THAB: LP316_08465(tviC)
PEA: PESP_a0479(wbpP)
PART: PARC_a0576(wbpP)
PAGA: PAGA_a0506(wbpP)
SALH: HMF8227_01167(wbpP)
AGAR: OAG1_05610
LHA: LHA_1181(vipB)
LADL: NCTC12735_01343(galE_4)
FTU: FTT_1459c(wbtF)
FTQ: RO31_1714
FTF: FTF1459c(wbtF)
FTW: FTW_0416(wbtF)
FTT: FTV_1393(wbtF)
FTG: FTU_1477(wbtF)
FTL: FTL_0597
FTH: FTH_0597
FTA: FTA_0631(wbtF)
FTS: F92_03255
FTI: FTS_0596(wbtF)
FTC: DA46_86
FTV: CH67_910
FTZ: CH68_644
FTM: FTM_1493(wbtF)
FTN: FTN_1425(wbtF)
FTX: AW25_576
RHH: E0Z06_09970(tviC)
THIM: KFB96_07025(tviC) KFB96_07155(tviC)
TBOG: LT988_19590(tviC)
TBN: TBH_C2545
PAUR: FGL86_13835(tviC)
ABO: ABO_0909(galE)
NJP: NEJAP_0753(wbpP)
NCI: NCTC10296_01422(galE)
NWD: H3L96_07090(tviC)
CFON: HZU75_06105(tviC)
CNC: CNE_2c00240(vipB)
BUB: BW23_5922
PIU: AOC20_01675(tviC)
PPUL: RO07_07450
LMIR: NCTC12852_00420(galE_1)
CABA: SBC2_28700(wbgU)
CABK: NK8_81540
BPE: BP1630(wbpP) BP3149
BPC: BPTD_1610(wbpP) BPTD_3111
BPER: BN118_1793(wbpP) BN118_2814
BPET: B1917_0673 B1917_1552(wbpP)
BPEU: Q425_18060(wbpP) Q425_31270
BPA: BPP0792 BPP2956(wbpP)
BBR: BB0877 BB2924(wbpP)
BPT: Bpet4029(wbpP)
BAV: BAV0512(wbpP)
BHO: D560_0480(wbgU)
BHM: D558_0475(wbgU)
BTRM: SAMEA390648701802(wbpP)
AXX: ERS451415_05398(strE_2)
ACHB: DVB37_24115(tviC)
APES: FOC84_17715(tviC)
PUT: PT7_2138
AMIM: MIM_c32570
AFQ: AFA_02720
ODI: ODI_R3769
OUE: I6G29_04565(tviC)
KGY: EHF36_14550(tviC)
POL: Bpro_3996
PVAC: HC248_01051(wbgU)
LCH: Lcho_3068
JAG: GJA_2626(wbgU)
HSE: Hsero_2737(galE) Hsero_4194(galE)
MVAR: MasN3_03620(wbpP)
TIN: Tint_1301
THI: THI_1625(vipB)
BBAG: E1O_08510
TBD: Tbd_0099
NIM: W01_08050(wbpP)
NARC: NTG6680_2254(vipB)
SLAC: SKTS_14410
EBA: ebA5873(wbpP)
ABRE: pbN1_35320
SWI: Swit_1202
SPHD: HY78_20565
PAQI: KW060_14915(tviC)
ACIB: ACBT_2151
ALK: ALEK_0976
GEB: GM18_1432
TAMM: GEAMG1_1584(vipB)
PPD: Ppro_2440
DEU: DBW_2321
DEP: AOP6_1872
DDS: Ddes_0109
DTR: RSDT_1073(wbpP)
DGG: DGI_1709
DDE: Dde_0358
DVU: DVU_0319
DVL: Dvul_2662
DVM: DvMF_2280
CLIH: KPS_002648
DBA: Dbac_1464
DPS: DP0046
DSF: UWK_01812
DOG: HP555_07025(tviC)
DDU: GF1_05330
DAT: HRM2_23110(ispL)
SFU: Sfum_3358
DMP: FAK_22590
APAU: AMPC_16340
HOH: Hoch_5210
BMX: BMS_0345(wbpP)
BALM: BsLM_2681
BCL: ABC0508
OIH: OB2082
PTH: PTH_1095(WcaG)
DAE: Dtox_2855
BPB: bpr_I2537
BHU: bhn_I2403
CBAR: PATL70BA_0369(vipB)
CHY: CHY_1057
ABRA: BN85301170
STPB: QR97_33810
AIR: NCTC12972_00422(galE_2)
RCA: Rcas_3084
HAU: Haur_4278
TRA: Trad_0292
LLH: I41_34020
BGOK: Pr1d_33310
TPLA: ElP_76230
PCOR: KS4_29670
LUB: TBR22_A25320(wbtF)
GEX: GETHOR_25560(wbtF)
MSIL: METEAL_09450(wbpP)
TLI: Tlie_1573
BEG: INE88_04312(wbgU_3) INE88_04346(wbgU_4)
PBT: ING2E5B_0527(vipB)
PMUC: ING2E5A_2821(vipB)
PDI: BDI_0026
PMER: INE87_03953(wbgU)
ASH: AL1_18440
DORI: FH5T_21455
MBAS: ALGA_4350
SGN: SGRA_1906(galE)
SMIZ: 4412673_03833(galE_4)
CHU: CHU_0833(galE)
HSW: Hsw_0081
FLM: MY04_2879
GFO: GFO_2041
GFL: GRFL_0107
FPS: FP1297
FJO: Fjoh_0359
FJG: BB050_02158(galE_2)
FIN: KQS_03270
FSN: GS03_01354(wbgU_1)
FCS: TRV642_0348(vipB) TRV642_0356(vipB)
ZPR: ZPR_2256
DDO: I597_2197
ZGA: ZOBELLIA_3772(wbpP)
NDO: DDD_3560(wbpP)
NMF: NMS_2748
PHG: KCTC32516_01445(wbgU)
MPW: MPR_2139
WIN: WPG_0185
TJE: TJEJU_1136(vipB)
KOS: KORDIASMS9_01180(wbgU)
KAN: IMCC3317_28530(wbgU)
MARF: CJ739_3409
MESQ: C7H62_1074
SPON: HME9304_02840(wbpP)
FBA: FIC_00329
RAI: RA0C_0995
RAR: RIA_1491
RAG: B739_1126
RAE: G148_0865
RAT: M949_1595
ELB: VO54_03331(galE_4)
CGLE: NCTC11432_04885(galE_3)
CSAL: NBC122_02869(wbgU_2)
CHRJ: CHRYMOREF3P_4043(vipB)
CANT: NCTC13489_01590(galE_3)
BPOR: BPO_1799(wbpP)
PTAN: CRYO30217_02713(wbgU_2)
CACI: CLOAM0691
CABY: Cabys_766
SCHV: BRCON_0491
MTH: MTH_380
MMG: MTBMA_c07800(galE1)
MWO: MWSIV6_0771(wbgU)
MTEE: MTTB_07340
METC: MTCT_0325
METE: tca_00348(wbgU)
MRU: mru_1413
MSI: Msm_0327
MEB: Abm4_0955
MMIL: sm9_0708
MEYE: TL18_03420
MOL: YLM1_0911
METH: MBMB1_1104
MFC: BRM9_1313
MCUB: MCBB_0994
MFV: Mfer_0810
MBAR: MSBR2_1609
MBAK: MSBR3_1625
MHOR: MSHOH_0179
MPY: Mpsy_0543
MTP: Mthe_0136
MLA: Mlab_0910
MBG: BN140_1115(wcaG)
MEMA: MMAB1_1426
MAQE: RJ40_10365
MPL: Mpal_2132
MEZ: Mtc_1450(galE-4)
HAL: VNG_0065G(gmd)
HSL: OE_1115F
HSU: HLASF_0926(galE2)
HSF: HLASA_0916(galE2)
 » show all
Reference
  Authors
Belanger M, Burrows LL, Lam JS
  Title
Functional analysis of genes responsible for the synthesis of the B-band O antigen of Pseudomonas aeruginosa serotype O6 lipopolysaccharide.
  Journal
Microbiology 145 ( Pt 12):3505-21 (1999)
DOI:10.1099/00221287-145-12-3505
  Sequence
Reference
  Authors
Miller WL, Matewish MJ, McNally DJ, Ishiyama N, Anderson EM, Brewer D, Brisson JR, Berghuis AM, Lam JS
  Title
Flagellin glycosylation in Pseudomonas aeruginosa PAK requires the O-antigen biosynthesis enzyme WbpO.
  Journal
J Biol Chem 283:3507-18 (2008)
DOI:10.1074/jbc.M708894200
LinkDB

KEGG   REACTION: R08706
Entry
R08706                      Reaction                               
Name
UDP-N-acetyl-D-glucosaminuronate 4-epimerase
Definition
UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate <=> UDP-N-acetyl-D-galactosaminuronic acid
Equation
Reaction class
RC00289  C04573_C13952
Enzyme
Pathway
rn00520  Amino sugar and nucleotide sugar metabolism
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:br08201]
 5. Isomerase reactions
  5.1  Racemases and epimerases
   5.1.3  Acting on carbohydrates and derivatives
    5.1.3.45
     R08706  UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate <=> UDP-N-acetyl-D-galactosaminuronic acid
Orthology
K02473  UDP-N-acetylglucosamine/UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase [EC:5.1.3.7 5.1.3.45]
K22925  UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase [EC:5.1.3.45]
LinkDB

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