| Entry |
|
|---|
| Name |
(-)-kolavenyl diphosphate synthase;
SdKPS;
TwTPS14;
TwTPS10/KPS;
SdCPS2;
clerodienyl diphosphate synthase;
CLPP
|
|---|
| Class |
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
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| Sysname |
(-)-kolavenyl diphosphate lyase (ring-opening)
|
|---|
| Reaction(IUBMB) |
geranylgeranyl diphosphate = (-)-kolavenyl diphosphate [RN: R11869]
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| Reaction(KEGG) |
|
|---|
| Substrate |
geranylgeranyl diphosphate [CPD: C00353]
|
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| Product |
(-)-kolavenyl diphosphate [CPD: C21735]
|
|---|
| Comment |
Isolated from the hallucinogenic plant Salvia divinorum (seer's sage) and the medicinal plant Tripterygium wilfordii (thunder god vine).
|
|---|
| History |
EC 5.5.1.28 created 2017
|
|---|
| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
| K22948 | (-)-kolavenyl diphosphate synthase |
|
|---|
| Genes |
| SHIS: | 125188980 125217217 |
|
|---|
| Reference |
|
|---|
| Authors |
Hansen NL, Heskes AM, Hamberger B, Olsen CE, Hallstrom BM, Andersen-Ranberg J, Hamberger B |
|---|
| Title |
The terpene synthase gene family in Tripterygium wilfordii harbors a labdane-type diterpene synthase among the monoterpene synthase TPS-b subfamily. |
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| Journal |
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| Sequence |
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|---|
| Reference |
|
|---|
| Authors |
Chen X, Berim A, Dayan FE, Gang DR |
|---|
| Title |
A (-)-kolavenyl diphosphate synthase catalyzes the first step of salvinorin A biosynthesis in Salvia divinorum. |
|---|
| Journal |
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| Sequence |
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|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.5.1.28 |
| ExPASy - ENZYME nomenclature database: | 5.5.1.28 |
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| LinkDB |
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