KEGG   ORTHOLOGY: K23120
Entry
K23120                      KO                                     
Symbol
cntL
Name
histidine 2-aminobutanoyltransferase [EC:2.5.1.152 2.5.1.-]
Pathway
map00470  D-Amino acid metabolism
map01100  Metabolic pathways
Module
M00949  Staphylopine biosynthesis, L-histidine => staphylopine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00470 D-Amino acid metabolism
    K23120  cntL; histidine 2-aminobutanoyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.152  D-histidine 2-aminobutanoyltransferase
     K23120  cntL; histidine 2-aminobutanoyltransferase
    2.5.1.-
     K23120  cntL; histidine 2-aminobutanoyltransferase
Other DBs
RN: R12341
Genes
YPE: YPO1346
YPK: y2836
YPH: YPC_2841
YPA: YPA_0632
YPN: YPN_2638
YPM: YP_1250(smtA3)
YPP: YPDSF_2353
YPG: YpAngola_A1576
YPZ: YPZ3_1228
YPT: A1122_18845
YPD: YPD4_1191
YPX: YPD8_0954
YPW: CH59_496
YPJ: CH55_1202
YPV: BZ15_2208
YPL: CH46_3783
YPS: YPTB1372
YPO: BZ17_1147
YPY: YPK_2717
YPB: YPTS_1471
YPQ: DJ40_856
YPU: BZ21_648
YPR: BZ20_607
YPC: BZ23_982
YPF: BZ19_780
SERF: L085_18085
PAE: PA4836
PAEV: N297_5005
PAEI: N296_5005
PAEP: PA1S_26285
PAEM: U769_26540
PAEL: T223_26735
PAEG: AI22_07715
PAEC: M802_5003
PAEO: M801_4870
SECH: B18_11685
BHA: BH2072
LSP: Bsph_1830
SAU: SA2257
SAV: SAV2469
SAW: SAHV_2453
SAM: MW2393
SAS: SAS2360
SAR: SAR2556
SAC: SACOL2478
SAE: NWMN_2366
SAD: SAAV_2535
SUU: M013TW_2429(cntL)
SUJ: SAA6159_02366(fmrO)
SUK: SAA6008_02510(fmrO)
SUZ: MS7_2482
SUG: SAPIG2519
SAUA: SAAG_00295
SAUS: SA40_2217
SAUU: SA957_2301
SAUG: SA268_2374
SAUF: X998_2453
SAB: SAB2352c
SAUB: C248_2519
SAUC: CA347_2548
SAUR: SABB_01208
SAUI: AZ30_12965
SAUD: CH52_06640
SAMS: NI36_12275
SER: SERP2374
SEP: SE_0202
SEPP: SEB_00130
SEPS: DP17_1262
SDT: SPSE_2400
SPAS: STP1_1305
SSCH: LH95_11155
SSCZ: RN70_11905
SCAR: DWB96_00445(cntL)
SCHR: DWB92_11725(cntL)
SLLO: ISP08_00445(cntL)
SFF: FOB90_08235(cntL)
PMW: B2K_11200
PALO: E6C60_2223
AMT: Amet_2051
AMI: Amir_3919
 » show all
Reference
  Authors
Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P
  Title
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
  Journal
Science 352:1105-9 (2016)
DOI:10.1126/science.aaf1018
  Sequence
[sav:SAV2469]
Reference
  Authors
McFarlane JS, Lamb AL
  Title
Biosynthesis of an Opine Metallophore by Pseudomonas aeruginosa.
  Journal
Biochemistry 56:5967-5971 (2017)
DOI:10.1021/acs.biochem.7b00804
  Sequence
[pae:PA4836]
Reference
  Authors
McFarlane JS, Davis CL, Lamb AL
  Title
Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural and kinetic analysis of a new functional class of opine dehydrogenase.
  Journal
J Biol Chem 293:8009-8019 (2018)
DOI:10.1074/jbc.RA118.002007
  Sequence
[ypk:y2836]
LinkDB

KEGG   ENZYME: 2.5.1.152
Entry
EC 2.5.1.152                Enzyme                                 
Name
D-histidine 2-aminobutanoyltransferase;
cntL (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
S-adenosyl-L-methionine:D-histidine N-[(3S)-3-amino-3-carboxypropyl]-transferase
Reaction(IUBMB)
S-adenosyl-L-methionine + D-histidine = N-[(3S)-3-amino-3-carboxypropyl]-D-histidine + S-methyl-5'-thioadenosine [RN:R12341]
Reaction(KEGG)
R12341
Substrate
S-adenosyl-L-methionine [CPD:C00019];
D-histidine [CPD:C06419]
Product
N-[(3S)-3-amino-3-carboxypropyl]-D-histidine [CPD:C22025];
S-methyl-5'-thioadenosine [CPD:C00170]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.
History
EC 2.5.1.152 created 2019
Pathway
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K23120  histidine 2-aminobutanoyltransferase
Genes
YPEYPO1346
YPKy2836
YPHYPC_2841
YPAYPA_0632
YPNYPN_2638
YPMYP_1250(smtA3)
YPPYPDSF_2353
YPGYpAngola_A1576
YPZYPZ3_1228
YPTA1122_18845
YPDYPD4_1191
YPXYPD8_0954
YPWCH59_496
YPJCH55_1202
YPVBZ15_2208
YPLCH46_3783
YPSYPTB1372
YPOBZ17_1147
YPIYpsIP31758_2632
YPYYPK_2717
YPBYPTS_1471
YPQDJ40_856
YPUBZ21_648
YPRBZ20_607
YPCBZ23_982
YPFBZ19_780
YSIBF17_15910
SMWSMWW4_v1c21340
SERFL085_18085
SERSSERRSCBI_09995
SSURATE40_007155
SURIJ0X03_13345
ANSArsFIN_50690
VNIVIBNI_B0488
VAQFIV01_17880
PAEPA4836
PAEVN297_5005
PAEIN296_5005
PAUPA14_63940
PAPPSPA7_5555
PAGPLES_52211
PAFPAM18_4947
PNCNCGM2_0693
PAEBNCGM1900_5574
PDKPADK2_25665
PSGG655_25510
PRPM062_25525
PAEPPA1S_26285
PAERPA1R_gp2757
PAEMU769_26540
PAELT223_26735
PAESSCV20265_5494
PAEUBN889_05385
PAEGAI22_07715
PAECM802_5003
PAEOM801_4870
THISHZT40_09135
SDOSD1155_03780
SECHB18_11685
BSONS101395_03012
BHABH2072
ANDGRQ40_16005
LSPBsph_1830
LFUHR49_17250
LYBC3943_14840
LMACI6G82_11165
FPNABE65_005805
FARABE41_005930
MEKUHUW50_21735
MDGK8L98_19850
SAUSA2257
SAVSAV2469
SAWSAHV_2453
SAHSaurJH1_2545
SAJSaurJH9_2496
SAMMW2393
SASSAS2360
SARSAR2556
SACSACOL2478
SAXUSA300HOU_2460
SAASAUSA300_2413
SAOSAOUHSC_02769
SAENWMN_2366
SADSAAV_2535
SUUM013TW_2429(cntL)
SUVSAVC_11215
SUESAOV_2519c
SUJSAA6159_02366(fmrO)
SUKSAA6008_02510(fmrO)
SUCECTR2_2326
SUTSAT0131_02668
SUQHMPREF0772_10720
SUZMS7_2482
SUDST398NM01_2519
SUXSAEMRSA15_23670
SUWSATW20_25970
SUGSAPIG2519
SUFSARLGA251_22490
SAUASAAG_00295
SAUERSAU_002307
SAUNSAKOR_02453
SAUSSA40_2217
SAUUSA957_2301
SAUGSA268_2374
SAUZSAZ172_2572
SAUTSAI1T1_2018390
SAUJSAI2T2_1018400
SAUKSAI3T3_1018390
SAUQSAI4T8_1018400
SAUVSAI7S6_1018390
SAUWSAI5S5_1018330
SAUXSAI6T6_1018330
SAUYSAI8T7_1018370
SAUFX998_2453
SABSAB2352c
SUYSA2981_2406
SAUBC248_2519
SAUMBN843_25090
SAUCCA347_2548
SAURSABB_01208
SAUIAZ30_12965
SAUDCH52_06640
SAMSNI36_12275
SUHSAMSHR1132_22940
SERSERP2374
SEPSE_0202
SEPPSEB_00130
SEPSDP17_1262
SSDSPSINT_0077
SDTSPSE_2400
SDPNCTC12225_02595
SWAA284_00415
SPASSTP1_1305
SXYBE24_11760
SXLSXYLSMQ121_0068
SXOSXYL_00069
SHUSHYC_11650
SSCHLH95_11155
SSCZRN70_11905
SLZB5P37_06430
SFQC7J90_03770
SCARDWB96_00445(cntL)
SCHRDWB92_11725(cntL)
SSHNCTC13712_02421
SLLOISP08_00445(cntL)
SFFFOB90_08235(cntL)
SSTESAMEA4384403_1089
BBEBBR47_28210
BFMBP422_09280
BAGRBA6348_01050
GYMGYMC10_2836
PMSKNP414_01894
PMQPM3016_2179
PMWB2K_11200
PAEAR70723_16825
PNPIJ22_25000
PVOPVOR_17334
PLWD5F53_15605
PCHIPC41400_19305 PC41400_19395
PPRTET464_05575
PBACHUB98_11425
PLYCGXP70_07675
PTRIKDC22_17090
PALOE6C60_2223
COHNKCTCHS21_30100
PANABBH88_13390
CFMBJL90_00605
CARGRSJ17_16760
AMTAmet_2051
HHWNCTC503_01797
VPYHZI73_24755
GPDGII33_20955
AAIAARI_10890
GARAOZ07_05770
GLUF0M17_05430
PAEYKUF55_05515
APRECNX65_19685
AMIAmir_3919
PLKCIK06_26260
FNTHMPREF0405_01275
FNEFSDG_01138
FVAFV113G1_15610
FULC4N20_14595
FMOC4N19_08460
 » show all
Reference
1  [PMID:27230378]
  Authors
Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P
  Title
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
  Journal
Science 352:1105-9 (2016)
DOI:10.1126/science.aaf1018
  Sequence
[sav:SAV2469]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.152
IUBMB Enzyme Nomenclature: 2.5.1.152
ExPASy - ENZYME nomenclature database: 2.5.1.152
BRENDA, the Enzyme Database: 2.5.1.152
LinkDB

KEGG   REACTION: R12341
Entry
R12341                      Reaction                               
Name
S-adenosyl-L-methionine:D-histidine N-[(3S)-3-amino-3-carboxypropyl]-transferase
Definition
S-Adenosyl-L-methionine + D-Histidine <=> (2S)-2-Amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 5'-Methylthioadenosine
Equation
Reaction class
RC00215  C06419_C22025
Enzyme
Pathway
rn00470  D-Amino acid metabolism
rn01100  Metabolic pathways
Module
M00949  Staphylopine biosynthesis, L-histidine => staphylopine
Orthology
K23120  histidine 2-aminobutanoyltransferase [EC:2.5.1.152 2.5.1.-]
LinkDB

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