Entry Name staphylopine dehydrogenase;
Class Oxidoreductases;BRITE hierarchy
Sysname staphylopine:NADP+ oxidoreductase [(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate]-forming
Reaction(IUBMB) staphylopine + NADP+ + H2O = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + pyruvate + NADPH + H+ [RN:
R12237 ]
Reaction(KEGG) Substrate Product (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate [CPD:
C22025 ];
pyruvate [CPD:
C00022 ];
NADPH [CPD:
C00005 ];
H+ [CPD:
C00080 ]
Comment The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.
History EC 1.5.1.52 created 2018
Pathway Orthology K23122 staphylopine/pseudopaline/yersinopine synthase
Genes PCHI : PC41400_19300 PC41400_19390
PPRT : ET464_05565 ET464_05570
» show all Taxonomy Reference Authors Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P
Title Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
Journal Sequence Reference Authors McFarlane JS, Davis CL, Lamb AL
Title Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural and kinetic analysis of a new functional class of opine dehydrogenase.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 1.5.1.52
ExPASy - ENZYME nomenclature database: 1.5.1.52
LinkDB All DBs
