KEGG   ORTHOLOGY: K23169
Entry
K23169                      KO                                     
Symbol
murD2
Name
UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase [EC:6.3.2.53]
Pathway
map00550  Peptidoglycan biosynthesis
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00550 Peptidoglycan biosynthesis
    K23169  murD2; UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.53  UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase
     K23169  murD2; UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase
Other DBs
RN: R12272
COG: COG0771
Genes
XFA: XF_1118
XFT: PD_0410(murD)
XFM: Xfasm12_0463
XFN: XfasM23_0404
XFF: XFLM_07445(murD)
XFL: P303_01520(murD)
XFS: D934_03165(murD)
XFH: XFHB_09980(murD)
XCC: XCC2738(murD)
XCB: XC_1375
XCA: xcc-b100_1423(murD)
XCP: XCR_3103(murD)
XCV: XCV3053(murD)
XAX: XACM_2840(murD)
XAC: XAC2908(murD)
XCI: XCAW_03185(murD)
XFU: XFF4834R_chr17310(murD)
XAO: XAC29_14785(murD)
XOM: XOO1320(XOO1320)
XOO: XOO1436(murD)
XOP: PXO_02013(murD)
XOY: AZ54_17285(murD)
XOR: XOC_1508(murD)
XOZ: BE73_15870(murD)
XAL: XALC_1040(murD)
XSA: SB85_19215(murD)
XTN: FD63_12880(murD)
XPH: XppCFBP6546_21370(XppCFBP6546P_21370)
XAN: AC801_14450(murD)
XAR: XB05_09285(murD)
XHD: LMG31886_14450(murD2)
SML: Smlt1170(murD)
SMT: Smal_1013
SMZ: SMD_1091(murD)
SACZ: AOT14_11460(murD)
STEK: AXG53_12015(murD)
SINC: DAIF1_10570(murD)
PSUW: WQ53_12435(murD)
PSD: DSC_05875(murD)
PJP: LAG73_03195(murD)
PDD: MNQ95_10950(murD)
LAB: LA76x_1652(murD)
LAQ: GLA29479_622(murD)
LCP: LC55x_1440(murD)
LGU: LG3211_3705(murD)
LEZ: GLE_3730(murD)
LEM: LEN_1404(murD)
LHX: LYSHEL_19050(murD)
LCAS: LYSCAS_19050(murD)
LLZ: LYB30171_00860(murD2)
RTH: LRK53_15935(murD)
DKO: I596_815
LANH: KR767_11545(murD)
RBD: ALSL_0763
SUA: Saut_0607
SPAL: FM071_02350(murD)
PHL: KKY_2208
DEI: C4375_13235(murD)
DEA: FPZ08_10315(murD)
DSAL: K1X15_14525(murD)
YTI: FNA67_16185(murD)
FSA: C5Q98_01705(murD)
ESR: ES1_22010
ESU: EUS_07940
BFI: CIY_04060
RIX: RO1_21100
RIM: ROI_08450
PXV: FXF36_08210(murD)
CBOL: CGC65_00545(murD)
CBAR: PATL70BA_0973(murD)
BULL: JOS54_04620(murD)
MMAG: MMAD_25840(murD)
MARZ: MARA_13720(murD)
MAUB: MAUB_03040(murD)
MPHU: MPHO_09770(murD)
MMUC: C1S78_013345(murD)
LTR: EVS81_15155(murD)
NOI: FCL41_11765(murD)
NDP: E2C04_12315(murD)
NAK: EH165_15010(murD)
GOB: Gobs_4629
SAQ: Sare_3229
MIL: ML5_4080
MSAG: GCM10017556_04310(murD)
VMA: VAB18032_25490(murD)
ASE: ACPL_1938(murD)
ACTN: L083_2284(murD)
AFS: AFR_11175(murD)
ACTS: ACWT_1816
AIH: Aiant_62820(murD)
PFLA: Pflav_048860(murD)
PSUU: Psuf_006650(murD)
CCAZ: COUCH_28460(murD)
SBAE: DSM104329_01985(murD2)
MIN: Minf_2246(murD)
MKC: kam1_2041
MEAP: MTHMO_2232(murD)
 » show all
Reference
  Authors
Feng R, Satoh Y, Ogasawara Y, Yoshimura T, Dairi T
  Title
A Glycopeptidyl-Glutamate Epimerase for Bacterial Peptidoglycan Biosynthesis.
  Journal
J Am Chem Soc 139:4243-4245 (2017)
DOI:10.1021/jacs.7b01221
  Sequence
[xom:XOO1320]
LinkDB

KEGG   ENZYME: 6.3.2.53
Entry
EC 6.3.2.53                 Enzyme                                 
Name
UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase;
murD2 (gene name);
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate synthetase;
UDP-MurNAc-L-Ala-L-Glu synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + L-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate [RN:R12272]
Reaction(KEGG)
R12272
Substrate
ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-muramoyl-L-alanine [CPD:C01212];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate [CPD:C22053]
Comment
The enzyme, characterized from the bacterium Xanthomonas oryzae, catalyses the ligation of a terminal L-glutamate to UDP-N-acetyl-alpha-D-muramoyl-L-alanine. The combined activity of this enzyme and EC 5.1.1.23, UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase, provides an alternative route for incorporating D-glutamate into peptidoglycan, replacing the more common combination of EC 5.1.1.3, glutamate racemase, and EC 6.3.2.9, UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase.
History
EC 6.3.2.53 created 2018
Pathway
ec00550  Peptidoglycan biosynthesis
ec01100  Metabolic pathways
Orthology
K23169  UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase
Genes
XFAXF_1118
XFTPD_0410(murD)
XFMXfasm12_0463
XFNXfasM23_0404
XFFXFLM_07445(murD)
XFLP303_01520(murD)
XFSD934_03165(murD)
XFHXFHB_09980(murD)
XCCXCC2738(murD)
XCBXC_1375
XCAxcc-b100_1423(murD)
XCPXCR_3103(murD)
XCVXCV3053(murD)
XAXXACM_2840(murD)
XACXAC2908(murD)
XCIXCAW_03185(murD)
XCTJ151_03093
XCJJ158_03072
XCUJ159_03068
XCNJ169_03091
XCWJ162_03071
XCRJ163_03068
XCMJ164_03068
XCFJ172_03084
XFUXFF4834R_chr17310(murD)
XAOXAC29_14785(murD)
XOMXOO1320(XOO1320)
XOOXOO1436(murD)
XOPPXO_02013(murD)
XOYAZ54_17285(murD)
XORXOC_1508(murD)
XOZBE73_15870(murD)
XALXALC_1040(murD)
XSASB85_19215(murD)
XTNFD63_12880(murD)
XFRBER92_13375
XVEBJD12_05415
XPEBJD13_02105
XHRXJ27_01680
XGABI317_14830
XPHXppCFBP6546_21370(XppCFBP6546P_21370)
XVAC7V42_14840
XANAC801_14450(murD)
XARXB05_09285(murD)
XHYFZ025_02780
XCZEBN15_12515
XTHG4Q83_06635
XEUXSP_002828
XHDLMG31886_14450(murD2)
SMLSmlt1170(murD)
SMTSmal_1013
BUJBurJV3_1007
SMZSMD_1091(murD)
SACZAOT14_11460(murD)
STEKAXG53_12015(murD)
SRHBAY15_1165
SLMBIZ42_14380
STENCCR98_05430
STEMCLM74_05420
STESMG068_05045
SINCDAIF1_10570(murD)
SPAQSTNY_R11340
PSUPsesu_0813
PSUWWQ53_12435(murD)
PSDDSC_05875(murD)
PMEXH4W19_08625
PJPLAG73_03195(murD)
PDDMNQ95_10950(murD)
LABLA76x_1652(murD)
LAQGLA29479_622(murD)
LCPLC55x_1440(murD)
LGULG3211_3705(murD)
LEZGLE_3730(murD)
LEMLEN_1404(murD)
LMBC9I47_0893
LYTDWG18_03455
LUEDCD74_07525
LYJFKV23_04210
LSOLGOY17_14340
LSXH8B22_02545
LAREHIV01_000510
LHXLYSHEL_19050(murD)
LCASLYSCAS_19050(murD)
LCICINQ41_04415
LAVIINQ42_04185
LLZLYB30171_00860(murD2)
LUMCNR27_12535
LUSE5843_04845
LUGFPZ22_04125
THESFHQ07_12080
THEHG7079_04620
TCNH9L16_01115
TBVH9L17_12625
XBCELE36_04540
FAUFraau_2758
RHDR2APBS1_3189
RGLCS053_04850
RTHLRK53_15935(murD)
DJICH75_02000
DJAHY57_07400
DTXATSB10_38180
DYEEO087_15600
DCSISN74_03625
DTLH8F01_14060
DTADYST_04094
DKOI596_815
LRZBJI69_02825
LPYFIV34_16565
LANHKR767_11545(murD)
XBAC7S18_07690
RBDALSL_0763
WMAWM2015_2023
SUASaut_0607
SPALFM071_02350(murD)
PHLKKY_2208
DEQXM25_12460
DEIC4375_13235(murD)
DEAFPZ08_10315(murD)
DSALK1X15_14525(murD)
MMYRMXMO3_01240
YTIFNA67_16185(murD)
MBRYB1812_02585
PBRPB2503_10389
ECOGFIV45_12580
FSAC5Q98_01705(murD)
ESRES1_22010
ESUEUS_07940
BFICIY_04060
RIXRO1_21100
RIMROI_08450
LACYA4V08_15955
PXVFXF36_08210(murD)
CBOLCGC65_00545(murD)
LBWC3V36_02640
CBARPATL70BA_0973(murD)
BULLJOS54_04620(murD)
MGROFZ046_18265
MNED174_13165
MYNMyAD_12925
MMAGMMAD_25840(murD)
MARZMARA_13720(murD)
MAUBMAUB_03040(murD)
MPHUMPHO_09770(murD)
MMUCC1S78_013345(murD)
PSAIC3B54_111517
SALCC2138_03505
SALDFVA74_09830
LTREVS81_15155(murD)
NOIFCL41_11765(murD)
NDPE2C04_12315(murD)
FSYFsymDg_3110
NAKEH165_15010(murD)
GOBGobs_4629
STPStrop_3005
SAQSare_3229
MAUMicau_4222
MILML5_4080
MICBMicB006_3213
MTUACSH63_03520
MICHFJK98_22630
MTEMGCE86_15450
MCABHXZ27_21490
MSAGGCM10017556_04310(murD)
VMAVAB18032_25490(murD)
MCRAID554_25220
ASEACPL_1938(murD)
AMSAMIS_16910
ACTNL083_2284(murD)
AFSAFR_11175(murD)
ACTSACWT_1816
AIHAiant_62820(murD)
ACTRAsp14428_22960
PLKCIK06_19240
PLABC6361_35835
PLATC6W10_06560
PFLAPflav_048860(murD)
PSUUPsuf_006650(murD)
VERHUT12_22125
PRYPrubr_01400
DVCDvina_14080
CCAZCOUCH_28460(murD)
SBAEDSM104329_01985(murD2)
AQZKSP35_00795
MINMinf_2246(murD)
MKCkam1_2041
MEAPMTHMO_2232(murD)
UAMUABAM_00997
PRFPeribacterA2_0609
MIBUY43_C0001G0610
 » show all
Reference
1  [PMID:28294606]
  Authors
Feng R, Satoh Y, Ogasawara Y, Yoshimura T, Dairi T
  Title
A Glycopeptidyl-Glutamate Epimerase for Bacterial Peptidoglycan Biosynthesis.
  Journal
J Am Chem Soc 139:4243-4245 (2017)
DOI:10.1021/jacs.7b01221
  Sequence
[xom:XOO1320]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.53
IUBMB Enzyme Nomenclature: 6.3.2.53
ExPASy - ENZYME nomenclature database: 6.3.2.53
BRENDA, the Enzyme Database: 6.3.2.53
LinkDB

KEGG   REACTION: R12272
Entry
R12272                      Reaction                               
Name
UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase (ADP-forming)
Definition
ATP + UDP-N-acetylmuramoyl-L-alanine + L-Glutamate <=> ADP + Orthophosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
Equation
Reaction class
RC00064  C00025_C22053
RC00141  C01212_C22053
Enzyme
Pathway
rn00550  Peptidoglycan biosynthesis
rn01100  Metabolic pathways
Orthology
K23169  UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase [EC:6.3.2.53]
LinkDB

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