KEGG   ORTHOLOGY: K23231
Entry
K23231                      KO                                     
Symbol
E1.1.1.201
Name
7beta-hydroxysteroid dehydrogenase (NADP+) [EC:1.1.1.201]
Pathway
map00121  Secondary bile acid biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00121 Secondary bile acid biosynthesis
    K23231  E1.1.1.201; 7beta-hydroxysteroid dehydrogenase (NADP+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.201  7beta-hydroxysteroid dehydrogenase (NADP+)
     K23231  E1.1.1.201; 7beta-hydroxysteroid dehydrogenase (NADP+)
Other DBs
COG: COG0300
GO: 0047022
Genes
ESS: ATZ33_15000
RTO: RTO_16120
PCAT: Pcatena_10380(fabG_2)
AG: AGN52919
Reference
  Authors
Lee JY, Arai H, Nakamura Y, Fukiya S, Wada M, Yokota A
  Title
Contribution of the 7beta-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon.
  Journal
J Lipid Res 54:3062-9 (2013)
DOI:10.1194/jlr.M039834
  Sequence
LinkDB

KEGG   ENZYME: 1.1.1.201
Entry
EC 1.1.1.201                Enzyme                                 
Name
7beta-hydroxysteroid dehydrogenase (NADP+);
NADP+-dependent 7beta-hydroxysteroid dehydrogenase;
7beta-hydroxysteroid dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
7beta-hydroxysteroid:NADP+ 7-oxidoreductase
Reaction(IUBMB)
a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+ [RN:R03753]
Reaction(KEGG)
R03753
Substrate
7beta-hydroxysteroid [CPD:C02956];
NADP+ [CPD:C00006]
Product
7-oxosteroid [CPD:C01881];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the oxidation of the 7beta-hydroxy group of bile acids such as ursodeoxycholate.
History
EC 1.1.1.201 created 1984
Pathway
ec00121  Secondary bile acid biosynthesis
Orthology
K23231  7beta-hydroxysteroid dehydrogenase (NADP+)
Genes
ESSATZ33_15000
RTORTO_16120
PCATPcatena_10380(fabG_2)
Reference
1  [PMID:6954878]
  Authors
Hirano S, Masuda N.
  Title
Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens.
  Journal
Appl Environ Microbiol 43:1057-63 (1982)
DOI:10.1128/AEM.43.5.1057-1063.1982
Reference
2  [PMID:6945134]
  Authors
MacDonald IA, Roach PD.
  Title
Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum.
  Journal
Biochim Biophys Acta 665:262-9 (1981)
DOI:10.1016/0005-2760(81)90011-4
Reference
3  [PMID:6758698]
  Authors
MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV.
  Title
Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms.
  Journal
Appl Environ Microbiol 44:1187-95 (1982)
DOI:10.1128/AEM.44.5.1187-1195.1982
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.201
IUBMB Enzyme Nomenclature: 1.1.1.201
ExPASy - ENZYME nomenclature database: 1.1.1.201
BRENDA, the Enzyme Database: 1.1.1.201
CAS: 79393-83-2
LinkDB

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