KEGG ORTHOLOGY: K23233

ORTHOLOGY: K23233

Entry

K23233                      KO

Symbol

ODH1

Name

D-octopine dehydrogenase [EC:1.5.1.11]

Pathway

map00330

Arginine and proline metabolism

map01100

Metabolic pathways

Reaction

R00562

N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K23233  ODH1; D-octopine dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.11  D-octopine dehydrogenase
     K23233  ODH1; D-octopine dehydrogenase

Other DBs

GO:

0047830

Genes

LGI:	LOTGIDRAFT_202998

PVUL:

126817613 126817614

LSAX:

138954702 138979639

BARL:

143276945 143276946 143279971

GAE:	121375148 121375171 121375569

HRF:	124130929 124130932 124135646 124141222 124141236 124143581

HRJ:	124269418 124275434 124275436 124275497 124279633 124285795 124285908

HASI:

137281013 137290908 137290961 137291576 137291937 137292024

HCRA:

139447505 139448735 139479363 139480015 139480152 139480207

CRG:	105331524 105331526 105331583 105342796

CANU:

128165198 128166457 128167379 128167958

CVN:	111118735 111118741 111118934 111119819 111119820 111120370 111122144 111122441

OED:	125670414 125670567 125671462

MYI:	110451252 110457910

PMAX:

117318100 117325339 117332653

AIRR:

138324799 138325198 138328231 138331180

YBA:	132552709 132556766 132558674 132565358

MCAF:

127699589 127704786 127704952 127726270 127726287

MMER:

123524662 123525369 123525370

RPHI:

132733507 132758115 132758118 132760106

DPOL:

127862474 127862524

MAEA:

128213050 128213110 128213168 128215533

OBI:	106869612 106880801

OSN:	115219799 115219972

LJP:

135470748

LLON:

135484369 135484371 135499408

MCAZ:

138024866

HSY:

130612781

AG:	CAC36305(ODH1)

» show all

Reference

PMID:18028427

Authors

Muller A, Janssen F, Grieshaber MK

Title

Putative reaction mechanism of heterologously expressed octopine dehydrogenase from the great scallop, Pecten maximus (L).

Journal

FEBS J 274:6329-39 (2007)
DOI:10.1111/j.1742-4658.2007.06151.x

Sequence

[ag:CAC36305]

LinkDB

ENZYME: 1.5.1.11

Entry

EC 1.5.1.11                 Enzyme

Name

D-octopine dehydrogenase;
D-octopine synthase;
octopine dehydrogenase;
octopine:NAD+ oxidoreductase;
ODH;
2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)

Reaction(IUBMB)

N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH + H+ [RN:R00562]

Reaction(KEGG)

R00562

Substrate

N2-(D-1-carboxyethyl)-L-arginine [CPD:C04137];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Product

L-arginine [CPD:C00062];
pyruvate [CPD:C00022];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

In the reverse direction, acts also on L-ornithine, L-lysine and L-histidine.

History

EC 1.5.1.11 created 1972

Pathway

ec00330

Arginine and proline metabolism

ec01100

Metabolic pathways

Orthology

K23233

D-octopine dehydrogenase

Genes

LGI:	LOTGIDRAFT_202998

PVUL:

126817613 126817614

LSAX:

138954702 138979639

BARL:

143276945 143276946 143279971

GAE:	121375148 121375171 121375569

HRF:	124130929 124130932 124135646 124141222 124141236 124143581

HRJ:	124269418 124275434 124275436 124275497 124279633 124285795 124285908

HASI:

137281013 137290908 137290961 137291576 137291937 137292024

HCRA:

139447505 139448735 139479363 139480015 139480152 139480207

CRG:	105331524 105331526 105331583 105342796

CANU:

128165198 128166457 128167379 128167958

CVN:	111118735 111118741 111118934 111119819 111119820 111120370 111122144 111122441

OED:	125670414 125670567 125671462

MYI:	110451252 110457910

PMAX:

117318100 117325339 117332653

AIRR:

138324799 138325198 138328231 138331180

YBA:	132552709 132556766 132558674 132565358

MCAF:

127699589 127704786 127704952 127726270 127726287

MMER:

123524662 123525369 123525370

RPHI:

132733507 132758115 132758118 132760106

DPOL:

127862474 127862524

MAEA:

128213050 128213110 128213168 128215533

OBI:	106869612 106880801

OSN:	115219799 115219972

LJP:

135470748

LLON:

135484369 135484371 135499408

MCAZ:

138024866

HSY:

130612781

» show all

Reference

Authors

Kemp JD, Hack E, Sutton DW, El-Wakil M.

Title

Unusual amino acids and their relationship to tumorigenesis.

Journal

Proc Int Conf Plant Pathol Bact 4th:183-188 (1979)

Reference

2 [PMID:4310628]

Authors

van Thoai N, Huc C, Pho DB, Olomucki A.

Title

[Octopine dehydrogenase. Purification and catalytic properties]

Journal

Biochim Biophys Acta 191:46-57 (1969)
DOI:10.1016/0005-2744(69)90313-1

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.11

IUBMB Enzyme Nomenclature:

1.5.1.11

ExPASy - ENZYME nomenclature database:

1.5.1.11

BRENDA, the Enzyme Database:

1.5.1.11

CAS:	37256-27-2

LinkDB

REACTION: R00562

Entry

R00562                      Reaction

Name

N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)

Definition

Octopine + NAD+ + H2O <=> L-Arginine + Pyruvate + NADH + H+

Equation

C04137 + C00003 + C00001 <=> C00062 + C00022 + C00004 + C00080

Reaction class

RC00001

C00003_C00004

RC00283

C00062_C04137

RC00581

C00022_C04137

Enzyme

1.5.1.11

Pathway

rn00330

Arginine and proline metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.11
     R00562  Octopine + NAD+ + H2O <=> L-Arginine + Pyruvate + NADH + H+

Orthology

K23233

D-octopine dehydrogenase [EC:1.5.1.11]

Other DBs

RHEA:

16288

LinkDB

DBGET integrated database retrieval system