KEGG   ORTHOLOGY: K23373
Entry
K23373                      KO                                     
Symbol
sbnH
Name
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase [EC:4.1.1.117]
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00875  Staphyloferrin B biosynthesis, L-serine => staphyloferrin B
Reaction
R12309  2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate carboxy-lyase (2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various other secondary metabolites
    K23373  sbnH; 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.117  2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
     K23373  sbnH; 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
Other DBs
COG: COG0019
Genes
SDN: Sden_0584
TACT: SG35_002330 SG35_003620
PSAL: PSLF89_1986
HSV: HNO53_08405
RSO: RSp0424(ssd)
RSE: F504_3900
RPU: CDC45_19750
RNC: GO999_24090
RSL: RPSI07_mp0385
RSN: RSPO_m01404
RSM: CMR15_mp10437
RSY: RSUY_34920(btrK)
RSG: JK151_14150
CNC: CNE_2c14900(lysA)
CUH: BJN34_08290
RME: Rmet_1110(lysA)
CUK: KB879_12600
BPLA: bpln_2g05080
NET: Neut_1742
NLC: EBAPG3_006485
NIZ: NNRS527_01543
ALEG: CFBP4996_27415
MNO: Mnod_6954
MAQU: Maq22A_c25460(lysA)
MHAR: L1P08_12095
MIWA: SS37A_35480(sbnH_1) SS37A_39120(sbnH_2)
PPHR: APZ00_12890
SBD: ATN00_04605
MAES: Ga0123461_0244
MFN: Ga0123462_2021
CPEL: CPEL_0305
BWH: A9C19_09115
BBAD: K7T73_21430
GCT: GC56T3_0418
GJF: M493_02155
GSR: GS3922_13805
PCAL: BV455_03917(btrK)
LGY: T479_22375
HHD: HBHAL_4879
HLI: HLI_03735
SJE: AAV35_000870
RUE: DT065_14635
SALE: EPH95_16140
MSEM: GMB29_11065
ALKG: MOJ78_16620
SAU: SA0119(sbnH)
SAV: SAV0123
SAW: SAHV_0122
SAH: SaurJH1_0114
SAJ: SaurJH9_0110
SAM: MW0096(sbnH)
SAS: SAS0097
SAR: SAR0126
SAC: SACOL0107
SAX: USA300HOU_0134(lysA1)
SAA: SAUSA300_0125
SAO: SAOUHSC_00082
SAE: NWMN_0067(sbnH)
SAD: SAAV_0091
SUU: M013TW_0113(sbnH)
SUV: SAVC_00355
SUE: SAOV_0070
SUJ: SAA6159_00106(sbnH)
SUK: SAA6008_00101(sbnH)
SUC: ECTR2_79
SUT: SAT0131_00109
SUQ: HMPREF0772_10374
SUZ: MS7_0115
SUD: ST398NM01_0135
SUX: SAEMRSA15_00890
SUW: SATW20_01350(sbnH)
SUG: SAPIG0135
SUF: SARLGA251_00980(sbnH)
SAUA: SAAG_00607
SAUE: RSAU_000077
SAUN: SAKOR_00097
SAUS: SA40_0090(sbnH)
SAUU: SA957_0105(sbnH)
SAUG: SA268_0102(sbnH)
SAUZ: SAZ172_0134(sbnH)
SAUT: SAI1T1_2000790
SAUJ: SAI2T2_1000790
SAUK: SAI3T3_1000790
SAUQ: SAI4T8_1000790
SAUV: SAI7S6_1000790
SAUW: SAI5S5_1000790
SAUX: SAI6T6_1000790
SAUY: SAI8T7_1000790
SAUF: X998_0102
SAB: SAB0062
SUY: SA2981_0124(sbnH)
SAUB: C248_0111
SAUM: BN843_1250
SAUC: CA347_134
SAUR: SABB_01717(sbnH)
SAUI: AZ30_00640
SAUD: CH52_05105
SAMS: NI36_00535
SUH: SAMSHR1132_00990
SSD: SPSINT_0341
SDT: SPSE_2117
SDP: NCTC12225_02334(lysA_2)
SHU: SHYC_00390(sbnH)
SSCH: LH95_00390
SSCZ: RN70_00610
SAGQ: EP23_09735
SEQO: SE1039_25040
SPET: CEP67_08210
SLZ: B5P37_07625
SARL: SAP2_02100
SSH: NCTC13712_00076(lysA_1)
SRAI: LN051_00265
SSCU: CEP64_13490
SFF: FOB90_07400
SSTE: SAMEA4384403_0108(lysA_1)
MVT: I6J10_10610
MBRU: MGG13_01660
BAGR: BA6348_15320
BBOR: RFB14_00515
PTA: HPL003_19625
PPEO: ABE82_04655
POW: IJ21_46070
PXL: BS614_08695
PKB: B4V02_14030
PAIH: ASL14_00105
PPSC: EHS13_31645
PBAC: HUB98_21850
PKA: PQ456_10730
PMAH: PTQ21_17795
PAMY: P9222_32695
PMAE: LMZ02_21530
ANX: ACH33_02525
ATHE: K3F53_16425
CCHL: FPL14_15130
SACA: FFV09_03650
TUM: CBW65_11365 CBW65_11415
TAB: CIG75_16800
PANA: BBH88_04010
PANC: E2636_16075
LFB: C1X05_04265
KPUL: GXN76_14210
PABS: JIR001_05150
STU: STH8232_0696
CSEP: CP523_06275
CCT: CC1_17280
ROB: CK5_31170
BYL: A4V09_07165
BLUI: Blut17040_33070(sbnH)
MHW: ACT01_03350
ERH: ERH_0207(lysA)
ERS: K210_08220
EIO: H9L01_08060
EBM: SG0102_00780(lysA_1)
NAH: F5544_31195
SHY: SHJG_0926
SHO: SHJGH_0759
SGS: AVL59_29350
SNW: BBN63_16025
SALJ: SMD11_0162(lysA)
SRJ: SRO_0366 SRO_7379
SRK: FGW37_30385
SVR: CP971_06275
SFY: GFH48_07845
SGF: HEP81_00355 HEP81_07705
SBY: H7H31_05365
SGOB: test1122_12320
SYUN: MOV08_35445
KAU: B6264_01465
KIT: CFP65_6208
RSA: RSal33209_1689
NCG: KGD84_12355
FRA: Francci3_4053
FRE: Franean1_0663
FAL: FRAAL6420
FSY: FsymDg_0715
SACG: FDZ84_26465
PSEQ: AD006_29035
PECQ: AD017_29425
PMAD: BAY61_28595
CROS: N8J89_30765
ASE: ACPL_4370(lysA)
AMS: AMIS_41880
ACTN: L083_3996(lysA)
AFS: AFR_21240
ACTS: ACWT_4241
AIH: Aiant_88100(lysA_3)
ACTR: Asp14428_06990(sbnH)
ACTL: L3i22_055200(lysA)
ASIC: Q0Z83_030800
PFLA: Pflav_024170(sbnH)
PSUU: Psuf_079620(sbnH)
PRY: Prubr_61760(lysA_4)
CATI: CS0771_66390(lysA_2)
DVC: Dvina_27455
DFU: Dfulv_25325
DROS: Drose_20240
DAUR: Daura_26770
DMAT: Dmats_22890
CCAZ: COUCH_21220
SNA: Snas_3735
NAV: JQS30_07790
GLY: K3N28_09085
LET: O77CONTIG1_03927(btrK)
TSU: Tresu_1002
 » show all
Reference
PMID:14688077
  Authors
Dale SE, Doherty-Kirby A, Lajoie G, Heinrichs DE
  Title
Role of siderophore biosynthesis in virulence of Staphylococcus aureus: identification and characterization of genes involved in production of a siderophore.
  Journal
Infect Immun 72:29-37 (2004)
DOI:10.1128/IAI.72.1.29-37.2004
  Sequence
[sam:MW0096]
Reference
PMID:19775248
  Authors
Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE
  Title
Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.
  Journal
Mol Microbiol 74:594-608 (2009)
DOI:10.1111/j.1365-2958.2009.06880.x
LinkDB

KEGG   ENZYME: 4.1.1.117
Entry
EC 4.1.1.117                Enzyme                                 
Name
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase;
sbnH (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate carboxy-lyase (2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate-forming)
Reaction(IUBMB)
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 [RN:R12309]
Reaction(KEGG)
R12309
Substrate
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate [CPD:C22072]
Product
2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate [CPD:C22073];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the siderophore staphyloferrin B.
History
EC 4.1.1.117 created 2019
Pathway
ec00997  Biosynthesis of various other secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23373  2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
Genes
SDN: Sden_0584
TACT: SG35_002330 SG35_003620
PSAL: PSLF89_1986
HSV: HNO53_08405
RSO: RSp0424(ssd)
RSE: F504_3900
RPU: CDC45_19750
RNC: GO999_24090
RSL: RPSI07_mp0385
RSN: RSPO_m01404
RSM: CMR15_mp10437
RSY: RSUY_34920(btrK)
RSG: JK151_14150
CNC: CNE_2c14900(lysA)
CUH: BJN34_08290
RME: Rmet_1110(lysA)
CUK: KB879_12600
BPLA: bpln_2g05080
NET: Neut_1742
NLC: EBAPG3_006485
NIZ: NNRS527_01543
ALEG: CFBP4996_27415
MNO: Mnod_6954
MAQU: Maq22A_c25460(lysA)
MHAR: L1P08_12095
MIWA: SS37A_35480(sbnH_1) SS37A_39120(sbnH_2)
PPHR: APZ00_12890
SBD: ATN00_04605
MAES: Ga0123461_0244
MFN: Ga0123462_2021
CPEL: CPEL_0305
BWH: A9C19_09115
BBAD: K7T73_21430
GCT: GC56T3_0418
GJF: M493_02155
GSR: GS3922_13805
PCAL: BV455_03917(btrK)
LGY: T479_22375
HHD: HBHAL_4879
HLI: HLI_03735
SJE: AAV35_000870
RUE: DT065_14635
SALE: EPH95_16140
MSEM: GMB29_11065
ALKG: MOJ78_16620
SAU: SA0119(sbnH)
SAV: SAV0123
SAW: SAHV_0122
SAH: SaurJH1_0114
SAJ: SaurJH9_0110
SAM: MW0096(sbnH)
SAS: SAS0097
SAR: SAR0126
SAC: SACOL0107
SAX: USA300HOU_0134(lysA1)
SAA: SAUSA300_0125
SAO: SAOUHSC_00082
SAE: NWMN_0067(sbnH)
SAD: SAAV_0091
SUU: M013TW_0113(sbnH)
SUV: SAVC_00355
SUE: SAOV_0070
SUJ: SAA6159_00106(sbnH)
SUK: SAA6008_00101(sbnH)
SUC: ECTR2_79
SUT: SAT0131_00109
SUQ: HMPREF0772_10374
SUZ: MS7_0115
SUD: ST398NM01_0135
SUX: SAEMRSA15_00890
SUW: SATW20_01350(sbnH)
SUG: SAPIG0135
SUF: SARLGA251_00980(sbnH)
SAUA: SAAG_00607
SAUE: RSAU_000077
SAUN: SAKOR_00097
SAUS: SA40_0090(sbnH)
SAUU: SA957_0105(sbnH)
SAUG: SA268_0102(sbnH)
SAUZ: SAZ172_0134(sbnH)
SAUT: SAI1T1_2000790
SAUJ: SAI2T2_1000790
SAUK: SAI3T3_1000790
SAUQ: SAI4T8_1000790
SAUV: SAI7S6_1000790
SAUW: SAI5S5_1000790
SAUX: SAI6T6_1000790
SAUY: SAI8T7_1000790
SAUF: X998_0102
SAB: SAB0062
SUY: SA2981_0124(sbnH)
SAUB: C248_0111
SAUM: BN843_1250
SAUC: CA347_134
SAUR: SABB_01717(sbnH)
SAUI: AZ30_00640
SAUD: CH52_05105
SAMS: NI36_00535
SUH: SAMSHR1132_00990
SSD: SPSINT_0341
SDT: SPSE_2117
SDP: NCTC12225_02334(lysA_2)
SHU: SHYC_00390(sbnH)
SSCH: LH95_00390
SSCZ: RN70_00610
SAGQ: EP23_09735
SEQO: SE1039_25040
SPET: CEP67_08210
SLZ: B5P37_07625
SARL: SAP2_02100
SSH: NCTC13712_00076(lysA_1)
SRAI: LN051_00265
SSCU: CEP64_13490
SFF: FOB90_07400
SSTE: SAMEA4384403_0108(lysA_1)
MVT: I6J10_10610
MBRU: MGG13_01660
BAGR: BA6348_15320
BBOR: RFB14_00515
PTA: HPL003_19625
PPEO: ABE82_04655
POW: IJ21_46070
PXL: BS614_08695
PKB: B4V02_14030
PAIH: ASL14_00105
PPSC: EHS13_31645
PBAC: HUB98_21850
PKA: PQ456_10730
PMAH: PTQ21_17795
PAMY: P9222_32695
PMAE: LMZ02_21530
ANX: ACH33_02525
ATHE: K3F53_16425
CCHL: FPL14_15130
SACA: FFV09_03650
TUM: CBW65_11365 CBW65_11415
TAB: CIG75_16800
PANA: BBH88_04010
PANC: E2636_16075
LFB: C1X05_04265
KPUL: GXN76_14210
PABS: JIR001_05150
STU: STH8232_0696
CSEP: CP523_06275
CCT: CC1_17280
ROB: CK5_31170
BYL: A4V09_07165
BLUI: Blut17040_33070(sbnH)
MHW: ACT01_03350
ERH: ERH_0207(lysA)
ERS: K210_08220
EIO: H9L01_08060
EBM: SG0102_00780(lysA_1)
NAH: F5544_31195
SHY: SHJG_0926
SHO: SHJGH_0759
SGS: AVL59_29350
SNW: BBN63_16025
SALJ: SMD11_0162(lysA)
SRJ: SRO_0366 SRO_7379
SRK: FGW37_30385
SVR: CP971_06275
SFY: GFH48_07845
SGF: HEP81_00355 HEP81_07705
SBY: H7H31_05365
SGOB: test1122_12320
SYUN: MOV08_35445
KAU: B6264_01465
KIT: CFP65_6208
RSA: RSal33209_1689
NCG: KGD84_12355
FRA: Francci3_4053
FRE: Franean1_0663
FAL: FRAAL6420
FSY: FsymDg_0715
SACG: FDZ84_26465
PSEQ: AD006_29035
PECQ: AD017_29425
PMAD: BAY61_28595
CROS: N8J89_30765
ASE: ACPL_4370(lysA)
AMS: AMIS_41880
ACTN: L083_3996(lysA)
AFS: AFR_21240
ACTS: ACWT_4241
AIH: Aiant_88100(lysA_3)
ACTR: Asp14428_06990(sbnH)
ACTL: L3i22_055200(lysA)
ASIC: Q0Z83_030800
PFLA: Pflav_024170(sbnH)
PSUU: Psuf_079620(sbnH)
PRY: Prubr_61760(lysA_4)
CATI: CS0771_66390(lysA_2)
DVC: Dvina_27455
DFU: Dfulv_25325
DROS: Drose_20240
DAUR: Daura_26770
DMAT: Dmats_22890
CCAZ: COUCH_21220
SNA: Snas_3735
NAV: JQS30_07790
GLY: K3N28_09085
LET: O77CONTIG1_03927(btrK)
TSU: Tresu_1002
 » show all
Reference
1  [PMID:19775248]
  Authors
Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE
  Title
Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.
  Journal
Mol Microbiol 74:594-608 (2009)
DOI:10.1111/j.1365-2958.2009.06880.x
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.117
IUBMB Enzyme Nomenclature: 4.1.1.117
ExPASy - ENZYME nomenclature database: 4.1.1.117
BRENDA, the Enzyme Database: 4.1.1.117
LinkDB

KEGG   REACTION: R12309
Entry
R12309                      Reaction                               
Name
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate carboxy-lyase (2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate-forming)
Definition
2-[(L-Alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate <=> 2-[(2-Aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2
Equation
C22072 <=> C22073 + C00011
Enzyme
4.1.1.117
Pathway
rn00997  Biosynthesis of various other secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00875  Staphyloferrin B biosynthesis, L-serine => staphyloferrin B
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.117
     R12309  2-[(L-Alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate <=> 2-[(2-Aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2
Orthology
K23373  2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase [EC:4.1.1.117]
LinkDB

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