KEGG   ORTHOLOGY: K23385
Entry
K23385                      KO                                     
Symbol
dokD
Name
D-ornithine/D-lysine decarboxylase [EC:4.1.1.116]
Pathway
map00310  Lysine degradation
map00470  D-Amino acid metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K23385  dokD; D-ornithine/D-lysine decarboxylase
  09106 Metabolism of other amino acids
   00470 D-Amino acid metabolism
    K23385  dokD; D-ornithine/D-lysine decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.116  D-ornithine/D-lysine decarboxylase
     K23385  dokD; D-ornithine/D-lysine decarboxylase
Other DBs
RN: R12304 R12305
COG: COG0019
Genes
STY: STY2590
STT: t0504
SEX: STBHUCCB_5420
SENT: TY21A_02565
STM: STM2360
SEO: STM14_2907
SEV: STMMW_23821
SEY: SL1344_2329
SEM: STMDT12_C23820
SEJ: STMUK_2390
SENI: CY43_12630
SPT: SPA0504
SEK: SSPA0468
SEI: SPC_1346
SEC: SCH_2362(dcdA)
SHB: SU5_02955
SENS: Q786_11650
SED: SeD_A2711
SEG: SG2389
SEL: SPUL_0525
SET: SEN2342
SENA: AU38_11845
SENO: AU37_11860
SENV: AU39_11855
SENQ: AU40_13270
SENL: IY59_12180
SEEP: I137_02420
SENE: IA1_11770
BIZ: HC231_15555(lysA)
MINT: C7M51_04183(lysA_2)
MTHI: C7M52_02873(lysA_2)
ETR: ETAE_3108
ETD: ETAF_2803
ETE: ETEE_1297(lysA)
HPAR: AL518_07035(lysA)
AMAH: DLM_1427
AQS: DKK66_15610(lysA)
SWS: I6J16_08305(lysA)
BTS: Btus_0317
CNO: NT01CX_2116(lysA)
 » show all
Reference
  Authors
Phillips RS, Poteh P, Miller KA, Hoover TR
  Title
STM2360 encodes a d-ornithine/d-lysine decarboxylase in Salmonella enterica serovar typhimurium.
  Journal
Arch Biochem Biophys 634:83-87 (2017)
DOI:10.1016/j.abb.2017.09.010
  Sequence
[stm:STM2360]
LinkDB

KEGG   ENZYME: 4.1.1.116
Entry
EC 4.1.1.116                Enzyme                                 
Name
D-ornithine/D-lysine decarboxylase;
dokD (gene name);
DOKDC
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
D-ornithine/D-lysine carboxy-lyase
Reaction(IUBMB)
(1) D-ornithine = putrescine + CO2 [RN:R12304];
(2) D-lysine = cadaverine + CO2 [RN:R12305]
Reaction(KEGG)
R12304 R12305
Substrate
D-ornithine [CPD:C00515];
D-lysine [CPD:C00739]
Product
putrescine [CPD:C00134];
CO2 [CPD:C00011];
cadaverine [CPD:C01672]
Comment
The enzyme, characterized from the bacterium Salmonella typhimurium LT2, is specific for D-ornithine and D-lysine. Requires pyridoxal 5'-phosphate.
History
EC 4.1.1.116 created 2019
Pathway
ec00310  Lysine degradation
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K23385  D-ornithine/D-lysine decarboxylase
Genes
STYSTY2590
STTt0504
SEXSTBHUCCB_5420
SENTTY21A_02565
STMSTM2360
SEOSTM14_2907
SEVSTMMW_23821
SEYSL1344_2329
SEMSTMDT12_C23820
SEJSTMUK_2390
SEBSTM474_2458
SEFUMN798_2547
SETUSTU288_08185
SETCCFSAN001921_04990
SENRSTMDT2_23291
SENDDT104_24161
SENICY43_12630
SEENSE451236_18000
SPTSPA0504
SEKSSPA0468
SPQSPAB_00611
SEISPC_1346
SECSCH_2362(dcdA)
SEHSeHA_C2602
SHBSU5_02955
SENHCFSAN002069_20050
SEEHSEEH1578_21075
SEESNSL254_A2548
SENNSN31241_34670
SEWSeSA_A2590
SEASeAg_B2502
SENSQ786_11650
SEDSeD_A2711
SEGSG2389
SELSPUL_0525
SEGASPUCDC_0525
SETSEN2342
SENAAU38_11845
SENOAU37_11860
SENVAU39_11855
SENQAU40_13270
SENLIY59_12180
SENJCFSAN001992_21780
SEECCFSAN002050_18730
SEEBSEEB0189_007775
SEEPI137_02420
SENBBN855_24460
SENEIA1_11770
SENCSEET0819_18895
SESSARI_00539
SALZEOS98_07210
KPYKPNIH31_17990
KQVB8P98_08245
KARLGL98_07250
CARSE1B03_18525
YREHEC60_10965
BIZHC231_15555(lysA)
MINTC7M51_04183(lysA_2)
MTHIC7M52_02873(lysA_2)
ETRETAE_3108
ETDETAF_2803
ETEETEE_1297(lysA)
ETCETAC_14815
EDWQY76_05080
EDLAAZ33_16125
HAVAT03_19525
HPARAL518_07035(lysA)
PMAOPMYSY11_3569
GAPGAPWK_0408
AMAHDLM_1427
AQSDKK66_15610(lysA)
SWSI6J16_08305(lysA)
HTQFRZ44_28070 FRZ44_40730
HADHFRZ61_19510(lysA) FRZ61_38830
BTSBtus_0317
KYRCVV65_03090
CNONT01CX_2116(lysA)
AMIJEQM06_04195
AMICAmi3637_02380
ABUTAmi103574_10075
 » show all
Reference
1  [PMID:29024617]
  Authors
Phillips RS, Poteh P, Miller KA, Hoover TR
  Title
STM2360 encodes a d-ornithine/d-lysine decarboxylase in Salmonella enterica serovar typhimurium.
  Journal
Arch Biochem Biophys 634:83-87 (2017)
DOI:10.1016/j.abb.2017.09.010
  Sequence
[stm:STM2360]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.116
IUBMB Enzyme Nomenclature: 4.1.1.116
ExPASy - ENZYME nomenclature database: 4.1.1.116
BRENDA, the Enzyme Database: 4.1.1.116
LinkDB

KEGG   REACTION: R12305
Entry
R12305                      Reaction                               
Name
D-lysine carboxy-lyase
Definition
D-Lysine <=> Cadaverine + CO2
Equation
Enzyme
Pathway
rn00310  Lysine degradation
rn00470  D-Amino acid metabolism
rn01100  Metabolic pathways
Orthology
K23385  D-ornithine/D-lysine decarboxylase [EC:4.1.1.116]
LinkDB

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