KEGG   ORTHOLOGY: K23447
Entry
K23447                      KO                                     
Symbol
sfnaB
Name
staphyloferrin A synthase [EC:6.3.2.57]
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00876  Staphyloferrin A biosynthesis, L-ornithine => staphyloferrin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various other secondary metabolites
    K23447  sfnaB; staphyloferrin A synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.57  staphyloferrin A synthase
     K23447  sfnaB; staphyloferrin A synthase
Other DBs
RN: R12354
Genes
LPN: lpg1325(frgA)
LPH: LPV_1432(FrgA)
LPO: LPO_1303(FrgA)
LPU: LPE509_01881
LPM: LP6_1307(frgA)
LPF: lpl1279
LPP: lpp1280
LPC: LPC_0740(frgA)
LPA: lpa_01955
LPE: lp12_1263
LLO: LLO_3129(FrgA)
LHA: LHA_3006(FrgA)
LCD: clem_01380(iucC)
LLG: 44548918_02520(iucC)
RPI: Rpic_0174
HHD: HBHAL_4881(figA)
HLI: HLI_03745
SAU: SA1981
SAV: SAV2179
SAW: SAHV_2163
SAM: MW2105
SAS: SAS2080
SAR: SAR2270
SAC: SACOL2169
SAE: NWMN_2080
SAD: SAAV_2240
SUU: M013TW_2145(sfaB)
SUZ: MS7_2202
SUG: SAPIG2239
SAUA: SAAG_00014
SAUS: SA40_1934
SAUU: SA957_2018
SAUG: SA268_2089
SAUF: X998_2164
SAB: SAB2060c
SAUB: C248_2217
SAUC: CA347_2264
SAUR: SABB_01483
SAUI: AZ30_11520
SAUD: CH52_08050
SAMS: NI36_10760
SER: SERP1779
SEP: SE_1770
SEPP: SEB_01779
SEPS: DP17_723
SHA: SH0861
SSP: SSP0707
SCA: SCA_1682
SDT: SPSE_0634
SDP: NCTC12225_00707(iucC_2)
SPAS: STP1_0608
SXO: SXYL_00749(sfaB)
SCAP: AYP1020_1372(iucA)
SSCH: LH95_03230
SSCZ: RN70_03505
SAGQ: EP23_06670
SARL: SAP2_07760
SPIC: SAMEA4384060_0849(iucA)
SSH: NCTC13712_02124(iucA_2)
SSIM: SAMEA4384339_2024(iucC_1)
ASE: ACPL_4368
ACTN: L083_3994
ACTS: ACWT_4239
SNA: Snas_3733
 » show all
Reference
  Authors
Cotton JL, Tao J, Balibar CJ
  Title
Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.
  Journal
Biochemistry 48:1025-35 (2009)
DOI:10.1021/bi801844c
  Sequence
[sau:SA1981]
LinkDB

KEGG   ENZYME: 6.3.2.57
Entry
EC 6.3.2.57                 Enzyme                                 
Name
staphyloferrin A synthase;
sfnaB (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
N5-[(S)-citryl]-D-ornithine:citrate ligase (staphyloferrin A-forming)
Reaction(IUBMB)
ATP + N5-[(S)-citryl]-D-ornithine + citrate = AMP + diphosphate + staphyloferrin A [RN:R12354]
Reaction(KEGG)
R12354
Substrate
ATP [CPD:C00002];
N5-[(S)-citryl]-D-ornithine [CPD:C22101];
citrate [CPD:C00158]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
staphyloferrin A [CPD:C22102]
Comment
Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation.
History
EC 6.3.2.57 created 2019
Pathway
ec00997  Biosynthesis of various other secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23447  staphyloferrin A synthase
Genes
LPNlpg1325(frgA)
LPHLPV_1432(FrgA)
LPOLPO_1303(FrgA)
LPULPE509_01881
LPMLP6_1307(frgA)
LPFlpl1279
LPPlpp1280
LPCLPC_0740(frgA)
LPAlpa_01955
LPElp12_1263
LLOLLO_3129(FrgA)
LHALHA_3006(FrgA)
LCDclem_01380(iucC)
LSHCAB17_02135
LLG44548918_02520(iucC)
LGTE4T54_08065
RPIRpic_0174
RPFRpic12D_0181
SDOSD1155_00625
BWHA9C19_09105
GCTGC56T3_0421
GJFM493_02170
GSRGS3922_13790
HHDHBHAL_4881(figA)
HLIHLI_03745
SJEAAV35_000860
SAUSA1981
SAVSAV2179
SAWSAHV_2163
SAHSaurJH1_2249
SAJSaurJH9_2210
SAMMW2105
SASSAS2080
SARSAR2270
SACSACOL2169
SAXUSA300HOU_2171
SAASAUSA300_2138
SAOSAOUHSC_02434
SAENWMN_2080
SADSAAV_2240
SUUM013TW_2145(sfaB)
SUVSAVC_09765
SUESAOV_2226c
SUJSAA6159_02090
SUKSAA6008_02217
SUCECTR2_2040
SUTSAT0131_02348
SUQHMPREF0772_11012
SUZMS7_2202
SUDST398NM01_2239
SUXSAEMRSA15_20840
SUWSATW20_23140
SUGSAPIG2239
SUFSARLGA251_19740
SAUASAAG_00014
SAUERSAU_002023
SAUNSAKOR_02147
SAUSSA40_1934
SAUUSA957_2018
SAUGSA268_2089
SAUZSAZ172_2280
SAUTSAI1T1_2016210
SAUJSAI2T2_1016220
SAUKSAI3T3_1016210
SAUQSAI4T8_1016220
SAUVSAI7S6_1016210
SAUWSAI5S5_1016150
SAUXSAI6T6_1016160
SAUYSAI8T7_1016190
SAUFX998_2164
SABSAB2060c
SUYSA2981_2117
SAUBC248_2217
SAUMBN843_22190
SAUCCA347_2264
SAURSABB_01483
SAUIAZ30_11520
SAUDCH52_08050
SAMSNI36_10760
SUHSAMSHR1132_20110
SERSERP1779
SEPSE_1770
SEPPSEB_01779
SEPSDP17_723
SHASH0861
SHHShL2_00754
SSPSSP0707
SCASCA_1682
SLGSLGD_00838
SLNSLUG_08960
SSDSPSINT_1841
SDTSPSE_0634
SDPNCTC12225_00707(iucC_2)
SWAA284_03590
SPASSTP1_0608
SXYBE24_08450
SXLSXYLSMQ121_0739
SXOSXYL_00749(sfaB)
SHUSHYC_03405
SCAPAYP1020_1372(iucA)
SSCHLH95_03230
SSCZRN70_03505
SAGQEP23_06670
SEQOSE1039_18700
SSIFAL483_01430
SCVA4G25_11715
SPETCEP67_04915 CEP67_08225
SLZB5P37_02890
SCOHBZ166_07960
SNLBJD96_03860
SKLC7J89_05040
SFQC7J90_00580
SHOMEGX58_07745
SMUSC7J88_05160
SCARDWB96_03755
SCHRDWB92_03205
SARLSAP2_07760
SPICSAMEA4384060_0849(iucA)
SSHNCTC13712_02124(iucA_2)
SSIMSAMEA4384339_2024(iucC_1)
SDBCNQ82_10375
SLLOISP08_03705
SAULI6G39_03105
SSACI6I31_00925
SSCUCEP64_13505
SFFFOB90_04535
SSTESAMEA4384403_0110(iucC) SAMEA4384403_0111(iucA)
MVTI6J10_10595
PANABBH88_03995
PANCE2636_16090
ASEACPL_4368
AMSAMIS_41860
ACTNL083_3994
ACTSACWT_4239
PFLAPflav_024190
PSUUPsuf_079590
PRYPrubr_61740
CATICS0771_66370
SNASnas_3733
NAVJQS30_07795 JQS30_07800
GLYK3N28_09090
FPCFPSM_02589
FPYFPG101_12935
FPQIB65_12400
FPVIA03_12175
FPWIA04_12060
FPKIA06_12135
 » show all
Reference
1  [PMID:19138128]
  Authors
Cotton JL, Tao J, Balibar CJ
  Title
Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.
  Journal
Biochemistry 48:1025-35 (2009)
DOI:10.1021/bi801844c
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.57
IUBMB Enzyme Nomenclature: 6.3.2.57
ExPASy - ENZYME nomenclature database: 6.3.2.57
BRENDA, the Enzyme Database: 6.3.2.57
LinkDB

KEGG   REACTION: R12354
Entry
R12354                      Reaction                               
Definition
N5-Citryl-D-ornithine + Citrate + ATP <=> Staphyloferrin A + AMP + Diphosphate
Equation
Enzyme
Pathway
rn00997  Biosynthesis of various other secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00876  Staphyloferrin A biosynthesis, L-ornithine => staphyloferrin A
Orthology
K23447  staphyloferrin A synthase [EC:6.3.2.57]
Reference
1  [PMID:19138128]
  Authors
Cotton JL, Tao J, Balibar CJ
  Title
Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.
  Journal
Biochemistry 48:1025-35 (2009)
DOI:10.1021/bi801844c
Other DBs
RHEA: 59143
LinkDB

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