KEGG   ORTHOLOGY: K23529
Entry
K23529                      KO                                     
Symbol
E1.6.5.7
Name
2-hydroxy-1,4-benzoquinone reductase [EC:1.6.5.7]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00627  Aminobenzoate degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K23529  E1.6.5.7; 2-hydroxy-1,4-benzoquinone reductase
   00361 Chlorocyclohexane and chlorobenzene degradation
    K23529  E1.6.5.7; 2-hydroxy-1,4-benzoquinone reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.5  With a quinone or similar compound as acceptor
    1.6.5.7  2-hydroxy-1,4-benzoquinone reductase
     K23529  E1.6.5.7; 2-hydroxy-1,4-benzoquinone reductase
Other DBs
RN: R05399
COG: COG0431
GO: 0050625
Genes
IGN: MMG00_06180
BYI: BYI23_B013640
BUE: BRPE67_BCDS00600
BUM: AXG89_19320
BUI: AX768_29085
BUO: BRPE64_BCDS00690
RTS: CE91St31_14040
FEI: K9M53_03830
FLP: LK994_08340
Reference
PMID:20480210
  Authors
Takenaka S, Koshiya J, Okugawa S, Takata A, Murakami S, Aoki K
  Title
Fe-superoxide dismutase and 2-hydroxy-1,4-benzoquinone reductase preclude the auto-oxidation step in 4-aminophenol metabolism by Burkholderia sp. strain AK-5.
  Journal
Biodegradation 22:1-11 (2011)
DOI:10.1007/s10532-010-9369-5
  Sequence
[byi:BYI23_B013640]
LinkDB

KEGG   ENZYME: 1.6.5.7
Entry
EC 1.6.5.7                  Enzyme                                 
Name
2-hydroxy-1,4-benzoquinone reductase;
hydroxybenzoquinone reductase;
1,2,4-trihydroxybenzene:NAD oxidoreductase
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
Sysname
NADH:2-hydroxy-1,4-benzoquinone oxidoreductase
Reaction(IUBMB)
2-hydroxy-1,4-benzoquinone + NADH + H+ = hydroxyquinol + NAD+ [RN:R05399]
Reaction(KEGG)
R05399
Substrate
2-hydroxy-1,4-benzoquinone [CPD:C07103];
NADH [CPD:C00004];
H+ [CPD:C00080]
Product
hydroxyquinol [CPD:C02814];
NAD+ [CPD:C00003]
Comment
A flavoprotein (FMN) that differs in substrate specificity from other quinone reductases. The enzyme in Burkholderia cepacia is inducible by 2,4,5-trichlorophenoxyacetate.
History
EC 1.6.5.7 created 2000, modified 2004
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K23529  2-hydroxy-1,4-benzoquinone reductase
Genes
IGN: MMG00_06180
BYI: BYI23_B013640
BUE: BRPE67_BCDS00600
BUM: AXG89_19320
BUI: AX768_29085
BUO: BRPE64_BCDS00690
RTS: CE91St31_14040
FEI: K9M53_03830
FLP: LK994_08340
Reference
1  [PMID:9721310]
  Authors
Zaborina O, Daubaras DL, Zago A, Xun L, Saido K, Klem T, Nikolic D, Chakrabarty AM.
  Title
Novel pathway for conversion of chlorohydroxyquinol to maleylacetate in Burkholderia cepacia AC1100.
  Journal
J Bacteriol 180:4667-75 (1998)
DOI:10.1128/JB.180.17.4667-4675.1998
Other DBs
ExplorEnz - The Enzyme Database: 1.6.5.7
IUBMB Enzyme Nomenclature: 1.6.5.7
ExPASy - ENZYME nomenclature database: 1.6.5.7
UM-BBD (Biocatalysis/Biodegradation Database): 1.6.5.7
BRENDA, the Enzyme Database: 1.6.5.7
CAS: 214466-94-1
LinkDB

KEGG   REACTION: R05399
Entry
R05399                      Reaction                               
Name
NADH:2-hydroxy-1,4-benzoquinone oxidoreductase
Definition
2-Hydroxy-1,4-benzoquinone + NADH + H+ <=> Benzene-1,2,4-triol + NAD+
Equation
C07103 + C00004 + C00080 <=> C02814 + C00003
Comment
hydroxybenzoquinone reductase
Reaction class
RC00001  C00003_C00004
RC01360  C02814_C07103
Enzyme
1.6.5.7
Pathway
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn00627  Aminobenzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K23529  2-hydroxy-1,4-benzoquinone reductase [EC:1.6.5.7]
Other DBs
RHEA: 12431
LinkDB

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