KEGG   ORTHOLOGY: K23891
Entry
K23891            Tight     KO                                     
Symbol
ROQN
Name
glandicoline B O-methyltransferase [EC:2.1.1.-]
Pathway
map00404  Staurosporine biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R12443  
R12447  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K23891  ROQN; glandicoline B O-methyltransferase
Genes
PCS: N7525_008083
Reference
PMID:23776469
  Authors
Ali H, Ries MI, Nijland JG, Lankhorst PP, Hankemeier T, Bovenberg RA, Vreeken RJ, Driessen AJ
  Title
A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum.
  Journal
PLoS One 8:e65328 (2013)
DOI:10.1371/journal.pone.0065328
  Sequence
[pcs:N7525_008083]
Reference
PMID:24225953
  Authors
Ries MI, Ali H, Lankhorst PP, Hankemeier T, Bovenberg RA, Driessen AJ, Vreeken RJ
  Title
Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway.
  Journal
J Biol Chem 288:37289-95 (2013)
DOI:10.1074/jbc.M113.512665
  Sequence
[pcs:N7525_008083]
LinkDB

KEGG   REACTION: R12447
Entry
R12447                      Reaction                               
Definition
N1-Hydroxy-roquefortine C + S-Adenosyl-L-methionine <=> Roquefortine F + S-Adenosyl-L-homocysteine
Equation
C22169 + C00019 <=> C22171 + C00021
Comment
N1-Hydroxy-roquefortine C O-methyltransferase
Reaction class
RC03543  C22169_C22171
Enzyme
2.1.1.-
Pathway
rn00404  Staurosporine biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-
     R12447  N1-Hydroxy-roquefortine C + S-Adenosyl-L-methionine <=> Roquefortine F + S-Adenosyl-L-homocysteine
Orthology
K23891  glandicoline B O-methyltransferase [EC:2.1.1.-]
LinkDB

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