KEGG   ORTHOLOGY: K23975
Entry
K23975                      KO                                     
Symbol
E2.8.1.16
Name
L-aspartate semialdehyde sulfurtransferase [EC:2.8.1.16]
Pathway
map00270  Cysteine and methionine metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K23975  E2.8.1.16; L-aspartate semialdehyde sulfurtransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.1  Sulfurtransferases
    2.8.1.16  L-aspartate semialdehyde sulfurtransferase
     K23975  E2.8.1.16; L-aspartate semialdehyde sulfurtransferase
Other DBs
RN: R12505
COG: COG1900
Genes
DVU: DVU_2938
DVL: Dvul_0430
DVM: DvMF_1464
DVG: Deval_2713
DFL: DFE_2712
DSD: GD606_13500
DMA: DMR_46290
DCB: C3Y92_19940
DGG: DGI_1165
DDE: Dde_3007
DAS: Daes_3322
DPI: BN4_12199
PPRF: DPRO_1935
DBA: Dbac_3098
DRT: Dret_2469
DSF: UWK_02633
DAL: Dalk_1368
DALK: DSCA_04730
DLI: dnl_08380
SAT: SYN_01778
SFU: Sfum_1059
DBR: Deba_3156
SWO: Swol_1441
SLP: Slip_0735
PTH: PTH_1472
DRM: Dred_0101
DAE: Dtox_3584
DAU: Daud_0911
ELM: ELI_3644
ADG: Adeg_1432
TACI: TDSAC_0221
SYN: slr0689
SYZ: MYO_14070
SYY: SYNGTS_0403(slr0689)
SYT: SYNGTI_0403(slr0689)
SYS: SYNPCCN_0403(slr0689)
SYQ: SYNPCCP_0403(slr0689)
SYC: syc1103_c
CYA: CYA_1941
CYB: CYB_0133
AMR: AM1_4338
TEL: tll2362
MAR: MAE_17670
MPK: VL20_3116
CYT: cce_2273
TER: Tery_2393
GVI: glr3673
GLJ: GKIL_0338
ANA: all1701
NSH: GXM_04842
AVA: Ava_0664
NAZ: Aazo_2809
CALH: IJ00_20895
CTHE: Chro_2043
CEO: ETSB_1648
DET: DET0921
DEH: cbdbA872
DEV: DhcVS_792
DMC: btf_817
DMD: dcmb_855
DMG: GY50_0800
DORI: FH5T_06660
TLE: Tlet_1363
TME: Tmel_0733
TAF: THA_1098
FNO: Fnod_1281
DTU: Dtur_0732
CTHI: THC_0177
MJA: MJ_0100
MMP: MMP1359
MMD: GYY_07625
MMAD: MMJJ_14800(guaB_5)
MAE: Maeo_0793
MVO: Mvol_1031
MTH: MTH_855
METC: MTCT_0768
METE: tca_00822
MSI: Msm_0085
MEB: Abm4_0692
MMIL: sm9_0981
MEYE: TL18_05465
MOL: YLM1_0877
METH: MBMB1_0672
MFC: BRM9_1523
MCUB: MCBB_0683
MFV: Mfer_1260
MKA: MK0907
AFU: AF_1186
FPL: Ferp_1951
GAC: GACE_0621
GAH: GAH_01959
MBAR: MSBR2_2388
MBAK: MSBR3_2445
MAC: MA_1821
MMA: MM_0241
MMAC: MSMAC_2424
METM: MSMTP_1092
MTHR: MSTHT_0029
MTHE: MSTHC_0699
MHOR: MSHOH_1266
MBU: Mbur_0311
MMET: MCMEM_0825
MMH: Mmah_1251
MPY: Mpsy_0868
MTP: Mthe_0019
MCJ: MCON_1340
MHI: Mhar_2345
MHU: Mhun_0138
MLA: Mlab_0451
MEMA: MMAB1_2385
MPI: Mpet_1603
MBN: Mboo_1272
MPL: Mpal_1290
MPD: MCP_0132
MEZ: Mtc_0355
RCI: RCIX1241
MELU: MTLP_06200
MARC: AR505_0724
BARB: AOA66_0665(guaB_3)
 » show all
Reference
  Authors
Allen KD, Miller DV, Rauch BJ, Perona JJ, White RH
  Title
Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea.
  Journal
Biochemistry 54:3129-32 (2015)
DOI:10.1021/acs.biochem.5b00118
  Sequence
[mja:MJ_0100]
LinkDB

KEGG   ORTHOLOGY: K23976
Entry
K23976                      KO                                     
Symbol
K23976
Name
L-aspartate semialdehyde sulfurtransferase ferredoxin
Pathway
map00270  Cysteine and methionine metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K23976  K23976; L-aspartate semialdehyde sulfurtransferase ferredoxin
Other DBs
RN: R12505
COG: COG1145
Genes
HAXI: HAALTHF_34940n
DVU: DVU_1931
DVL: Dvul_1236
DVM: DvMF_0262
DVG: Deval_1379
DFL: DFE_1027
DSD: GD606_05530
DMA: DMR_22210
DCB: C3Y92_10680
DGG: DGI_2778
DDE: Dde_2146
DAS: Daes_1713
DPI: BN4_10390
PPRF: DPRO_0805
DBA: Dbac_0483
DRT: Dret_1113
DSF: UWK_01650
DAL: Dalk_1885
DALK: DSCA_12640
DLI: dnl_38910
SAT: SYN_00800
SFU: Sfum_0168
DBR: Deba_3155
RUM: CK1_37340
SWO: Swol_1440
SLP: Slip_0736
PTH: PTH_1473(NapF)
DRM: Dred_0102
DAE: Dtox_3585
DAU: Daud_0910
ELM: ELI_3643
CHY: CHY_0181
MTHO: MOTHE_c19200(rsxB4)
MTHZ: MOTHA_c19990(rsxB4)
ADG: Adeg_1431
TACI: TDSAC_0222
KME: H0A61_00692(metN)
AFO: Afer_1840
SYN: slr2059
SYY: SYNGTS_1289(slr2059)
SYT: SYNGTI_1289(slr2059)
SYS: SYNPCCN_1288(slr2059)
SYQ: SYNPCCP_1288(slr2059)
SYC: syc1963_c
CYA: CYA_2579
CYB: CYB_2374
AMR: AM1_0839
TEL: tll1800
LET: O77CONTIG1_01623(nuoI)
HHG: XM38_032430(boxA)
MAR: MAE_01950
MPK: VL20_6272
CYT: cce_0971
TER: Tery_1505
GVI: glr0935
GLJ: GKIL_3980
ANA: all0569
AVA: Ava_0339
NAZ: Aazo_3612
DOU: BMF77_04310(ndhI_3)
CTHE: Chro_4107
CEO: ETSB_1346
DET: DET0920
DEH: cbdbA871
DEV: DhcVS_791
DMC: btf_816
DMD: dcmb_854
DMG: GY50_0799
HAU: Haur_1296
MIN: Minf_1250(napF)
MKC: kam1_1242(napF2)
MEAP: MTHMO_1431
FSC: FSU_2658
DORI: FH5T_06665
TAL: Thal_0866
CEX: CSE_02850
DTU: Dtur_0733
LFC: LFE_1737
CTHI: THC_0798
ALAM: RT761_01520(ndhI)
MJA: MJ_0099
MMP: MMP1358
MMD: GYY_07620
MMAD: MMJJ_14810(fer)
MAE: Maeo_0794
MVO: Mvol_1032
MTH: MTH_854
METC: MTCT_0767
MWO: MWSIV6_1230(vorD)
METE: tca_00821
MCUB: MCBB_0682
MFV: Mfer_1259
MKA: MK0903
AFU: AF_1185
FPL: Ferp_1952
GAC: GACE_0622
GAH: GAH_01960
TON: TON_0317
TGA: TGAM_1304
TSI: TSIB_0989
THE: GQS_03685
THA: TAM4_2167
THM: CL1_0387
TLT: OCC_08465
THS: TES1_0612
TNU: BD01_0183
TEU: TEU_06545
PPAC: PAP_07215
MBAR: MSBR2_2387
MBAK: MSBR3_2444
MAC: MA_1822
MMA: MM_0240
MMAC: MSMAC_2425
METM: MSMTP_1093
MTHR: MSTHT_0030
MTHE: MSTHC_0698
MHOR: MSHOH_1267
MBU: Mbur_0310
MMET: MCMEM_0826
MMH: Mmah_1252
MPY: Mpsy_0867
MTP: Mthe_0020
MCJ: MCON_1339
MHI: Mhar_2344
MHU: Mhun_0137
MLA: Mlab_0452
MEMA: MMAB1_2386
MPI: Mpet_1604
MBN: Mboo_1273
MPD: MCP_0133
MEZ: Mtc_0354
RCI: RCIX1242
MELU: MTLP_06190
TVO: TVG1047273(TVG1047273)
PTO: PTO0897
FAI: FAD_1078
MARC: AR505_0725
BARB: AOA66_0666(vorD)
 » show all
Reference
  Authors
Allen KD, Miller DV, Rauch BJ, Perona JJ, White RH
  Title
Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea.
  Journal
Biochemistry 54:3129-32 (2015)
DOI:10.1021/acs.biochem.5b00118
  Sequence
[mja:MJ_0099]
LinkDB

KEGG   ENZYME: 2.8.1.16
Entry
EC 2.8.1.16                 Enzyme                                 
Name
L-aspartate semialdehyde sulfurtransferase;
MA1821 (locus name);
MJ0100 (locus name)
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
Sysname
hydrogen sulfide:L-aspartate-4-semialdehyde sulfurtransferase
Reaction(IUBMB)
hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster [RN:R12505]
Reaction(KEGG)
R12505
Substrate
hydrogen sulfide [CPD:C00283];
L-aspartate 4-semialdehyde [CPD:C00441];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]
Product
L-homocysteine [CPD:C00155];
H2O [CPD:C00001];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Comment
The enzyme, characterized from the archaeon Methanosarcina acetivorans, participates in an L-methionine biosysnthetic pathway found in most of the methanogenic archaea.
History
EC 2.8.1.16 created 2019
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K23975  L-aspartate semialdehyde sulfurtransferase
Genes
DVUDVU_2938
DVLDvul_0430
DVMDvMF_1464
DVGDeval_2713
DFLDFE_2712
DSDGD606_13500
DMADMR_46290
DCBC3Y92_19940
DGGDGI_1165
DDEDde_3007
DMSE8L03_15160
DSADesal_3782
DHYDESAM_20787
DAFDesaf_1190
DASDaes_3322
DPIBN4_12199
DEJAWY79_02770
PPRFDPRO_1935
PSELGM415_05005
DDNDND132_2281
DSXGD604_18225
PBIZLWC08_11720
DBADbac_3098
DRTDret_2469
DSFUWK_02633
DPRDespr_3243
DOGHP555_05040
DBKDGMP_14500
DMLDmul_10250
DALDalk_1368
DATHRM2_27800
DTOTOL2_C21940
DOVDSCO28_01030
DWDDSCW_12590
DALKDSCA_04730
DLIdnl_08380
DMMdnm_024620
DEKDSLASN_02770
SATSYN_01778
DAODesac_0386
DTIDesti_2525
SFUSfum_1059
DAXFDQ92_09500
DBRDeba_3156
HMRHipma_0164
DAVDESACE_02220
DHRLGS26_07215
CRSFQB35_11345
SWOSwol_1441
SLPSlip_0735
CALKHUE98_00810
DORDesor_0315
DAIDesaci_0590
DMIDesmer_0317
DCADesca_0089
PTHPTH_1472
DRMDred_0101
DRUDesru_0171
DFGB0537_01265
DAEDtox_3584
DKUDesku_1645
DAUDaud_0911
TFRBR63_10460
FWADCMF_03305
TJRTherJR_1173
DGIDesgi_2433
ELMELI_3644
EMTCPZ25_018535
ELIMB2M23_08225
AWOAwo_c28040
ALKAJ0B03_00425
ADGAdeg_1432
TPZTph_c18160
TNRThena_0230
TACITDSAC_0221
TEPTepRe1_2592
TAETepiRe1_2794
HALSD7D81_00205
IFNGM661_16200
KMEH0A61_00691
SYNslr0689
SYZMYO_14070
SYYSYNGTS_0403(slr0689)
SYTSYNGTI_0403(slr0689)
SYSSYNPCCN_0403(slr0689)
SYQSYNPCCP_0403(slr0689)
SYJD082_06630
SYOC7I86_02090
SYCsyc1103_c
SYUM744_00900
SYFSynpcc7942_0414
SYRSynRCC307_0741
SYPSYNPCC7002_A0581
CYACYA_1941
CYBCYB_0133
SYNESyn6312_3160
SYNPSyn7502_00796
SYVAWQ23_03070
SYLAWQ21_03040
SYNCCB0101_13020
DSLDacsa_1741
CGCCyagr_3295
CYICBM981_1238
CMPCha6605_4919
AMRAM1_4338
TVNNIES2134_103410
SLWBRW62_11990
TELtll2362
THNNK55_08785
THECFFX45_06715
LEPLepto7376_4246
LENLEP3755_12480
LETO77CONTIG1_03371
LBOLBWT_38250
KOVK9N68_18600
LSCKIK02_03005
LSKJ5X98_24355
HHGXM38_043210
PSEUPse7367_2607
PSERABRG53_1141
THEUHPC62_06500
GLPGlo7428_2384
GENGM3709_1191
GEEGM3708_3030
CHONNIES4102_17580
MARMAE_17670
MPKVL20_3116
MIQB5D77_16555
MVZmyaer102_50970
CANCyan10605_3460
CSNCyast_0235
CYLAA637_05905
HAOPCC7418_0404
ENNFRE64_14180
CYTcce_2273
CWACwatDRAFT_3992
CYPPCC8801_2541
CYHCyan8802_3565
CYCPCC7424_5211
CYJCyan7822_1085
CYNCyan7425_0812
TERTery_2393
ARPNIES39_C02980
PAGHNIES204_23590
OXYHCG48_20610
MVAGD0A34_06710
LFSHFV01_11580
MICMic7113_6125
GEIGEI7407_3368
OACOscil6304_3994
ONIOsc7112_0745
MPROBJP34_25695
PHORJWS08_20780
CEPCri9333_1242
GVIglr3673
GLJGKIL_0338
GMLISF26_18310
ANAall1701
NPUNpun_F2759
NOSNos7107_1988
NOPNos7524_2333
NONNOS3756_00480
NFLCOO91_04664
NOECLI64_09945
NSHGXM_04842
NEDHUN01_20545
AVAAva_0664
NAZAazo_2809
ANBANA_C20754
ACYAnacy_2710
AWAAA650_18190
ANNEH233_29085
CSGCylst_3583
RSINB6N60_03724
CALOCal7507_3004
CALTCal6303_4507
CALHIJ00_20895
RIVRiv7116_1289
FISFIS3754_48300
DOUBMF77_03441
DFSHGD76_03375
CCURIAR63_07475
AFLOHEQ12_02920
TOQHCG51_08075
NCNBZZ01_28855
CTHEChro_2043
PLPPle7327_0717
SCSSta7437_2930
STANSTA3757_20740
CEOETSB_1648
CERRGRSB_1363
DETDET0921
DEHcbdbA872
DEBDehaBAV1_0805
DEVDhcVS_792
DEGDehalGT_0766
DMCbtf_817
DMDdcmb_855
DMGGY50_0800
DMXX792_04160
DMYX793_04330
DMZX794_03960
DUCUCH007_07530
DEWDGWBC_0778
DFODform_00758
SCDSpica_1547
SSMSpirs_1309
OCKEXM22_00480
SBUSpiBuddy_0032
SGPSpiGrapes_1889
BHCJFL75_11025
OSPOdosp_3419
BUYD8S85_03050
BVIRI6J59_10590
ACOUA5CBH24_17170
DORIFH5T_06660
DRCG0Q07_00095
MCOSGM418_14080
TTKTST_1097 TST_1600
TAMTheam_1635
DTEDester_1534
TLETlet_1363
TTATheth_0529
PHYAJ81_01635
TMETmel_0733
TAFTHA_1098
TFEJYK00_07385
FNOFnod_1281
FPEFerpe_1660
FIANA23_08215
OCYOSSY52_04190
CPOCOPRO5265_0016
DTHDICTH_0569
DTUDtur_0732
TIDThein_1355
TOPTOPB45_0044
TCMHL41_05065
THETF1847_01765
CTHITHC_0177
TAVG4V39_02840
TMAIFVE67_05875
ALAMRT761_01519
MJAMJ_0100
MFEMefer_0355
MVUMetvu_0926
MFSMFS40622_1018
MIFMetin_0262
MJHJH146_0779
MESGMLAUSG7_0883
MESAMLASG1_0976
MIGMetig_0741 Metig_1786
MMPMMP1359
MMQMmarC5_0219
MMXMmarC6_1314
MMZMmarC7_0604
MMDGYY_07625
MMAKMMKA1_15830
MMAOMMOS7_14640
MMADMMJJ_14800(guaB_5)
MAEMaeo_0793
MVNMevan_0669
MVOMvol_1031
MOKMetok_0495
METFCFE53_04920
MTHMTH_855
MMGMTBMA_c12520
METCMTCT_0768
MWOMWSIV6_1231
METEtca_00822
METZMETMT2_0925
METKFVF72_07270
MTHMFZP57_05850
METJFZP68_00355
MSIMsm_0085
MEBAbm4_0692
MMILsm9_0981
MEYETL18_05465
MOLYLM1_0877
MELMetbo_1965
MEWMSWAN_0653
METHMBMB1_0672
MFCBRM9_1523
MFIDSM1535_2225
MCUBMCBB_0683
MSUBBK009_01590
METNBK008_09335
METTCIT01_02115
METOCIT02_03405
MEMEHYG87_03580
MFVMfer_1260
MKAMK0907
AFUAF_1186
AFGAFULGI_00012860
APOArcpr_1399
AVEArcve_1085
ASTAsulf_01823
FPLFerp_1951
GACGACE_0621
GAHGAH_01959
MBAMbar_A2085
MBYMSBRM_2423
MBWMSBRW_2654
MBARMSBR2_2388
MBAKMSBR3_2445
MACMA_1821
MMAMM_0241
MMAZMmTuc01_0248
MMJMSMAS_1060
MMACMSMAC_2424
MVCMSVAZ_1104
MEKMSKOL_1059
MLSMSLAZ_2048
METMMSMTP_1092
MEFMSWH1_1180
MEQMSWHS_1256
MSJMSSAC_2171
MSZMSSIH_1745
MSWMSSIT_1805
MTHRMSTHT_0029
MTHEMSTHC_0699
MHORMSHOH_1266
MFZAOB57_002390
MBUMbur_0311
MMETMCMEM_0825
MELOJ7W08_02345
MMHMmah_1251
MHAZBHR79_07280
MEVMetev_1059
MZHMzhil_0894
MPYMpsy_0868
MZIHWN40_04325
MHZMetho_0925
MTPMthe_0019
MCJMCON_1340
MHIMhar_2345
MHUMhun_0138
MRTJKHC33_13525
MLAMlab_0451
MEMMemar_1517
MBGBN140_1854
MEMAMMAB1_2385
MCHKMchiMG62_16830
MPIMpet_1603
MBNMboo_1272
MFOMetfor_2035
MPLMpal_1290
MPDMCP_0132
MEZMtc_0355
RCIRCIX1241
MELUMTLP_06200
MERMMINT_14480
MARCAR505_0724
BARBAOA66_0665(guaB_3)
FLTSv326_0760
LOKILokiarch_29370
 » show all
Reference
1  [PMID:25315403]
  Authors
Rauch BJ, Gustafson A, Perona JJ
  Title
Novel proteins for homocysteine biosynthesis in anaerobic microorganisms.
  Journal
Mol Microbiol 94:1330-42 (2014)
DOI:10.1111/mmi.12832
  Sequence
Reference
2  [PMID:25938369]
  Authors
Allen KD, Miller DV, Rauch BJ, Perona JJ, White RH
  Title
Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea.
  Journal
Biochemistry 54:3129-32 (2015)
DOI:10.1021/acs.biochem.5b00118
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.1.16
IUBMB Enzyme Nomenclature: 2.8.1.16
ExPASy - ENZYME nomenclature database: 2.8.1.16
BRENDA, the Enzyme Database: 2.8.1.16
LinkDB

KEGG   REACTION: R12505
Entry
R12505                      Reaction                               
Name
hydrogen sulfide:L-aspartate-4-semialdehyde sulfurtransferase
Definition
Hydrogen sulfide + L-Aspartate 4-semialdehyde + 2 Reduced ferredoxin + 2 H+ <=> L-Homocysteine + H2O + 2 Oxidized ferredoxin
Equation
Reaction class
RC02444  C00155_C00441
RC02814  C00155_C00283
Enzyme
Pathway
rn00270  Cysteine and methionine metabolism
rn01100  Metabolic pathways
Orthology
K23975  L-aspartate semialdehyde sulfurtransferase [EC:2.8.1.16]
K23976  L-aspartate semialdehyde sulfurtransferase ferredoxin
LinkDB

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