KEGG ORTHOLOGY: K23992

ORTHOLOGY: K23992

Entry

K23992                      KO

Symbol

K23992

Name

1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase [EC:2.7.7.74 2.7.8.34]

Pathway

map00562

Inositol phosphate metabolism

map01100

Metabolic pathways

Reaction

R09669

CTP:1L-myo-inositol 1-phosphate cytidylyltransferase

R09670

CDP-1L-myo-inositol:1L-myo-inositol 1-phosphate myo-inositolphosphotransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K23992  K23992; 1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.74  1L-myo-inositol 1-phosphate cytidylyltransferase
     K23992  K23992; 1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase
   2.7.8  Transferases for other substituted phosphate groups
    2.7.8.34  CDP-L-myo-inositol myo-inositolphosphotransferase
     K23992  K23992; 1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase

Other DBs

COG:	COG1213 COG0558

Genes

MTHD:

A3224_07290

ENM:

EBS_0412

NAR:

Saro_0100

NOR:	FA702_11455

SPAP:

H3Z74_16915

ERY:	CP97_03755

PORL:

BG023_11496

PHZ:	CHX26_13940

DBK:	DGMP_08060

DAO:	Desac_2272

SFU:

Sfum_2920

TID:	Thein_0126

TAV:	G4V39_06760

TMAI:

CCRO:

PAUU:

BSED:

PCAY:

CTHU:

NTR:	B0W44_00905

TMR:

Tmar_0126

THEF:

E1B22_04180

THEP:

DYI95_000435

TCP:	Q5761_00445

TPZ:	Tph_c20790

KME:	H0A61_00158(spsI)

ATL:	Athai_19700

RXY:

Rxyl_1212

TTR:

Tter_0472

SSM:	Spirs_4227

ADIN:

H7849_05720

NOB:	CW736_12840

AAE:	aq_1367(spsI)

PMX:	PERMA_1921

TTK:

TST_0884

NDE:

NIDE0736

NMV:	NITMOv2_0605

NIO:	NITINOP_0313

NJA:

NSJP_1717

NTI:	DNFV4_01008

NALL:

PP769_08355

NNEO:

PQG83_19595

NLI:	G3M70_02610 G3M70_02615

MOX:

DAMO_2608

MIF:	Metin_0454

MIG:	Metig_1787

METF:

CFE53_00410

AFU:

AF_0263

AFG:	AFULGI_00002550

APO:	Arcpr_0766

AVE:	Arcve_1159 Arcve_2013

AST:	Asulf_00859

FPL:	Ferp_0148 Ferp_0859

GAC:

GAH:

PFU:

PFI:

PHO:	PH1219(PH1219)

PAB:

PAB2433

PYN:

PNA2_1704

PYA:	PYCH_00120

PYS:

Py04_1010

PYC:	TQ32_04290

TKO:

TON:

TGA:

TSI:

TBA:	TERMP_01130

THE:

THA:

THM:

TLT:

THS:

TNU:

TEU:

TCH:	CHITON_0904

TPEP:

A0127_03970

TGG:	A3K92_01915

TCE:	A3L02_05685

TBS:	A3L01_06850

THH:	CDI07_06820

TSL:	A3L11_01110

TTD:	A3L14_09240

TPRF:

A3L09_03245

TRL:	A3L10_06295

TPAF:

A3L08_00135

THY:	A3L12_02080

TCQ:	TIRI35C_1679

THEI:

PPAC:

IAG:

KCR:

Reference

PMID:17526717

Authors

Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H

Title

Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.

Journal

J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07

Sequence

[rxy:Rxyl_1212]

LinkDB

ORTHOLOGY: K07281

Entry

K07281                      KO

Symbol

ipct

Name

1L-myo-inositol 1-phosphate cytidylyltransferase [EC:2.7.7.74]

Pathway

map00562

Inositol phosphate metabolism

map01100

Metabolic pathways

Reaction

R09669

CTP:1L-myo-inositol 1-phosphate cytidylyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K07281  ipct; 1L-myo-inositol 1-phosphate cytidylyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.74  1L-myo-inositol 1-phosphate cytidylyltransferase
     K07281  ipct; 1L-myo-inositol 1-phosphate cytidylyltransferase

Other DBs

COG:

COG1213

Genes

NAR:

Saro_0102

NOT:	C7W88_05615

NOR:	FA702_11445

NGF:	FRF71_04960

NOG:	GKE62_14325

STAX:

MC45_06680

SNJ:	A7E77_02155

SMY:	BJP26_11175

SKR:	BRX40_00985

SPLM:

SPLK:

SPHC:

SPHF:

SPAP:

SARI:

SPHJ:

SMIC:

SPHS:

SAND:

ERY:	CP97_03775

PORL:

BG023_11492

PHZ:	CHX26_13960

GBE:	GbCGDNIH1_0237

GBH:	GbCGDNIH2_0237

GBC:	GbCGDNIH3_0237

GBS:	GbCGDNIH4_0237

GDI:	GDI0629(hasC)

GDJ:

Gdia_1377

LCK:	HN018_00880

NAO:	Y958_26660

ECOG:

CCRO:

BSED:

PCAY:

TBH:	Tbon_07190

RMR:

Rmar_1196

RMG:	Rhom172_1617

CACI:

CLOAM0421

TMM:	Tmari_1425

TMI:	THEMA_07220

TMW:

TMQ:

TMX:

TPT:

TNP:

TRQ:

TNA:

THQ:	T2812B_07090

THZ:	CELL2_07150

THR:	TRQ7_06825

CABY:

Cabys_1832

APE:	APE_1514.1

ACJ:

ACAM_0951

HBU:

Hbut_0150

PFM:	Pyrfu_0046

PDL:	Pyrde_0746

PARE:

PYJP_15560

TPE:

Tpen_1250

THB:	N186_00105

THEL:

IG193_09070

BARC:

AOA65_0707

» show all

Reference

PMID:17360515

Authors

Rodionov DA, Kurnasov OV, Stec B, Wang Y, Roberts MF, Osterman AL

Title

Genomic identification and in vitro reconstitution of a complete biosynthetic pathway for the osmolyte di-myo-inositol-phosphate.

Journal

Proc Natl Acad Sci U S A 104:4279-84 (2007)
DOI:10.1073/pnas.0609279104

LinkDB

ENZYME: 2.7.7.74

Entry

EC 2.7.7.74                 Enzyme

Name

1L-myo-inositol 1-phosphate cytidylyltransferase;
CTP:inositol-1-phosphate cytidylyltransferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
IPCT (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
L-myo-inositol-1-phosphate cytidylyltransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Sysname

CTP:1L-myo-inositol 1-phosphate cytidylyltransferase

Reaction(IUBMB)

CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol [RN:R09669]

Reaction(KEGG)

R09669

Substrate

CTP [CPD:C00063];
1L-myo-inositol 1-phosphate [CPD:C04006]

Product

diphosphate [CPD:C00013];
CDP-1L-myo-inositol [CPD:C19794]

Comment

In many organisms this activity is catalysed by a bifunctional enzyme. The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.

History

EC 2.7.7.74 created 2011

Pathway

ec00562

Inositol phosphate metabolism

ec01100

Metabolic pathways

Orthology

K07281

1L-myo-inositol 1-phosphate cytidylyltransferase

K23992

1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase

Genes

MTHD:

A3224_07290

ENM:

EBS_0412

NAR:	Saro_0100 Saro_0102

NOT:	C7W88_05615

NOR:	FA702_11445 FA702_11455

NGF:	FRF71_04960

NOG:	GKE62_14325

STAX:

MC45_06680

SNJ:	A7E77_02155

SMY:	BJP26_11175

SKR:	BRX40_00985

SPLM:

BXU08_09805

SPLK:

AV944_05835

SPHC:

CVN68_10510

SPHF:

DM480_12980

SPAP:

H3Z74_16915 H3Z74_19210

SARI:

H5J25_13030

SPHJ:

BSL82_01690

SMIC:

SmB9_25610

SPHS:

ETR14_18250

SAND:

H3309_10530

ERY:	CP97_03755 CP97_03775

PORL:

BG023_11492 BG023_11496

PHZ:	CHX26_13940 CHX26_13960

GBE:	GbCGDNIH1_0237

GBH:	GbCGDNIH2_0237

GBC:	GbCGDNIH3_0237

GBS:	GbCGDNIH4_0237

GDI:	GDI0629(hasC)

GDJ:

Gdia_1377

LCK:	HN018_00880

NAO:	Y958_26660

ECOG:

FIV45_13855

DBK:	DGMP_08060

DAO:	Desac_2272

SFU:

Sfum_2920

TID:	Thein_0126

TAV:	G4V39_06760

TMAI:

FVE67_04000

CCRO:

CMC5_034520 CMC5_075830

PAUU:

E8A73_025990

BSED:

DN745_05540 DN745_10835

PCAY:

FRD00_02815 FRD00_21750

CTHU:

HUR95_02260

NTR:	B0W44_00905

TMR:

Tmar_0126

THEF:

E1B22_04180

THEP:

DYI95_000435

TCP:	Q5761_00445

TPZ:	Tph_c20790

KME:	H0A61_00158(spsI)

ATL:	Athai_19700

RXY:

Rxyl_1212

TBH:	Tbon_07190

TTR:

Tter_0472

SSM:	Spirs_4227

ADIN:

H7849_05720

NOB:	CW736_12840

RMR:

Rmar_1196

RMG:	Rhom172_1617

CACI:

CLOAM0421

AAE:	aq_1367(spsI)

PMX:	PERMA_1921

TTK:

TST_0884

TMM:	Tmari_1425

TMI:	THEMA_07220

TMW:

THMA_1449

TMQ:

THMB_1449

TMX:

THMC_1449

TPT:

Tpet_1374

TNP:

Tnap_1392

TRQ:

TRQ2_1312

TNA:

CTN_1074

THQ:	T2812B_07090

THZ:	CELL2_07150

THR:	TRQ7_06825

CABY:

Cabys_1832

NDE:

NIDE0736

NMV:	NITMOv2_0605

NIO:	NITINOP_0313

NJA:

NSJP_1717

NTI:	DNFV4_01008

NALL:

PP769_08355

NNEO:

PQG83_19595

NLI:	G3M70_02610 G3M70_02615

MOX:

DAMO_2608

MIF:	Metin_0454

MIG:	Metig_1787

METF:

CFE53_00410

AFU:

AF_0263

AFG:	AFULGI_00002550

APO:	Arcpr_0766

AVE:	Arcve_1159 Arcve_2013

AST:	Asulf_00859

FPL:	Ferp_0148 Ferp_0859

GAC:

GACE_2065

GAH:

GAH_01161

PFU:

PF1058

PFI:

PFC_04525

PHO:	PH1219(PH1219)

PAB:

PAB2433

PYN:

PNA2_1704

PYA:	PYCH_00120

PYS:

Py04_1010

PYC:	TQ32_04290

TKO:

TK2279

TON:

TON_1248

TGA:

TGAM_1853

TSI:

TSIB_1010

TBA:	TERMP_01130

THE:

GQS_09430

THA:

TAM4_5

THM:

CL1_1475

TLT:

OCC_08385

THS:

TES1_1181

TNU:

BD01_1626

TEU:

TEU_00190

TCH:	CHITON_0904

TPEP:

A0127_03970

TGG:	A3K92_01915

TCE:	A3L02_05685

TBS:	A3L01_06850

THH:	CDI07_06820

TSL:	A3L11_01110

TTD:	A3L14_09240

TPRF:

A3L09_03245

TRL:	A3L10_06295

TPAF:

A3L08_00135

THY:	A3L12_02080

TCQ:	TIRI35C_1679

THEI:

K1720_08170

PPAC:

PAP_05835

APE:	APE_1514.1

ACJ:

ACAM_0951

IAG:

Igag_0487

HBU:

Hbut_0150

PFM:	Pyrfu_0046

PDL:	Pyrde_0746

PARE:

PYJP_15560

TPE:

Tpen_1250

THB:	N186_00105

THEL:

IG193_09070

KCR:

Kcr_0184

BARC:

AOA65_0707

» show all

Reference

1 [PMID:17526717]

Authors

Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H

Title

Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.

Journal

J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07

Sequence

[aae:aq_1367] [afu:AF_0263] [pfu:PF1058][rxy:Rxyl_1212] [tko:TK2279]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.7.74

IUBMB Enzyme Nomenclature:

2.7.7.74

ExPASy - ENZYME nomenclature database:

2.7.7.74

BRENDA, the Enzyme Database:

2.7.7.74

LinkDB

REACTION: R09669

Entry

R09669                      Reaction

Name

CTP:1L-myo-inositol 1-phosphate cytidylyltransferase

Definition

CTP + 1D-myo-Inositol 3-phosphate <=> Diphosphate + CDP-1L-myo-inositol

Equation

C00063 + C04006 <=> C00013 + C19794

Reaction class

RC00002

C04006_C19794

Enzyme

2.7.7.74

Pathway

rn00562

Inositol phosphate metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.74
     R09669  CTP + 1D-myo-Inositol 3-phosphate <=> Diphosphate + CDP-1L-myo-inositol

Orthology

K07281

1L-myo-inositol 1-phosphate cytidylyltransferase [EC:2.7.7.74]

K23992

1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase [EC:2.7.7.74 2.7.8.34]

Other DBs

RHEA:

30650

LinkDB

DBGET integrated database retrieval system