KEGG   ORTHOLOGY: K24000
Entry
K24000            Tight     KO                                     
Symbol
fomD
Name
HPP-CMP hydrolase [EC:3.6.1.-]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00903  Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K24000  fomD; HPP-CMP hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.1  In phosphorus-containing anhydrides
    3.6.1.-
     K24000  fomD; HPP-CMP hydrolase
Other DBs
RN: R12499
Genes
AG: BAA32492(fomD)
Reference
  Authors
Sato S, Miyanaga A, Kim SY, Kuzuyama T, Kudo F, Eguchi T
  Title
Biochemical and Structural Analysis of FomD That Catalyzes the Hydrolysis of Cytidylyl ( S)-2-Hydroxypropylphosphonate in Fosfomycin Biosynthesis.
  Journal
Biochemistry 57:4858-4866 (2018)
DOI:10.1021/acs.biochem.8b00690
  Sequence
LinkDB

KEGG   REACTION: R12499
Entry
R12499                      Reaction                               
Definition
Cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + H2O <=> (S)-2-Hydroxypropylphosphonate + CMP
Equation
Comment
HPP-CMP hydrolase
Reaction class
RC00002  C06452_C22217
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00903  Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin
Orthology
K24000  HPP-CMP hydrolase [EC:3.6.1.-]
Reference
1  [PMID:29969250]
  Authors
McLaughlin MI, van der Donk WA.
  Title
Stereospecific Radical-Mediated B12-Dependent Methyl Transfer by the Fosfomycin Biosynthesis Enzyme Fom3.
  Journal
Biochemistry 57:4967-4971 (2018)
DOI:10.1021/acs.biochem.8b00616
LinkDB

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