KEGG   ORTHOLOGY: K24292
Entry
K24292                      KO                                     
Symbol
mycCI, CYP105L2
Name
mycinamicin VIII C21 methyl hydroxylase [EC:1.14.-.-]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Reaction
R10875  mycinamicin-VIII,NADPH:oxygen oxidoreductase (21-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase
   00199 Cytochrome P450
    K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP105 family
   K24292  mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase
Other DBs
COG: COG2124
Genes
SROI: IAG44_15950
SGK: PET44_28330
SYUN: MOV08_16370
AG: BAC57023(mycCI)
Reference
PMID:12583909
  Authors
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F
  Title
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
  Journal
FEMS Microbiol Lett 218:135-41 (2003)
DOI:10.1111/j.1574-6968.2003.tb11509.x
  Sequence
[ag:BAC57023]
Reference
PMID:27420774
  Authors
DeMars MD 2nd, Sheng F, Park SR, Lowell AN, Podust LM, Sherman DH
  Title
Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.
  Journal
ACS Chem Biol 11:2642-54 (2016)
DOI:10.1021/acschembio.6b00479
LinkDB

KEGG   REACTION: R10875
Entry
R10875                      Reaction                               
Name
mycinamicin-VIII,NADPH:oxygen oxidoreductase (21-hydroxylating)
Definition
Mycinamicin VIII + NADPH + Oxygen + H+ <=> Mycinamicin VII + NADP+ + H2O
Equation
C15684 + C00005 + C00007 + C00080 <=> C15683 + C00006 + C00001
Reaction class
RC00001  C00005_C00006
RC03228  C15683_C15684
Enzyme
1.14.13.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R10875  Mycinamicin VIII + NADPH + Oxygen + H+ <=> Mycinamicin VII + NADP+ + H2O
Orthology
K24292  mycinamicin VIII C21 methyl hydroxylase [EC:1.14.-.-]
K24530  ferredoxin
LinkDB

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