KEGG   ORTHOLOGY: K24390
Entry
K24390            Tight     KO                                     
Symbol
mycG, CYP107E1
Name
mycinamicin IV hydroxylase/epoxidase [EC:1.14.-.-]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Reaction
R10877  mycinamicin-IV,NADPH:oxygen oxidoreductase (14-hydroxylating)
R10878  mycinamicin-V,NADPH:oxygen oxidoreductase (12,13-epoxidizing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24390  mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24390  mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase
   00199 Cytochrome P450
    K24390  mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K24390  mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP107 family
   K24390  mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase
Other DBs
COG: COG2124
Genes
AG: BAA03672(mycG)
Reference
PMID:12583909
  Authors
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F
  Title
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
  Journal
FEMS Microbiol Lett 218:135-41 (2003)
DOI:10.1111/j.1574-6968.2003.tb11509.x
  Sequence
[ag:BAA03672]
LinkDB

KEGG   REACTION: R10878
Entry
R10878                      Reaction                               
Name
mycinamicin-V,NADPH:oxygen oxidoreductase (12,13-epoxidizing)
Definition
Mycinamicin V + NADPH + Oxygen + H+ <=> Mycinamicin II + NADP+ + H2O
Equation
C18847 + C00005 + C00007 + C00080 <=> C15680 + C00006 + C00001
Reaction class
RC00001  C00005_C00006
RC03294  C15680_C18847
Enzyme
1.14.13.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R10878  Mycinamicin V + NADPH + Oxygen + H+ <=> Mycinamicin II + NADP+ + H2O
Orthology
K24390  mycinamicin IV hydroxylase/epoxidase [EC:1.14.-.-]
LinkDB

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