KEGG   ORTHOLOGY: K24390
Entry
K24390            Tight     KO                                     

Symbol
mycG, CYP107E1
Name
mycinamicin IV hydroxylase/epoxidase [EC:1.14.-.-]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24390  mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24390  mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase
   00199 Cytochrome P450
    K24390  mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.-  Acting on paired donors, with incorporation or reduction of molecular oxygen
    1.14.-.-  
     K24390  mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K24390  mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP107 family
   K24390  mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase
Other DBs
RN: R10877 R10878
COG: COG2124
Genes
AG: BAA03672(mycG)
Reference
  Authors
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F
  Title
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
  Journal
FEMS Microbiol Lett 218:135-41 (2003)
DOI:10.1111/j.1574-6968.2003.tb11509.x
  Sequence
LinkDB

KEGG   REACTION: R10878
Entry
R10878                      Reaction                               

Name
mycinamicin-V,NADPH:oxygen oxidoreductase (12,13-epoxidizing)
Definition
Mycinamicin V + NADPH + Oxygen + H+ <=> Mycinamicin II + NADP+ + H2O
Equation
Reaction class
RC00001  C00005_C00006
RC03294  C15680_C18847
Enzyme
1.14.13.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Orthology
K24390  mycinamicin IV hydroxylase/epoxidase [EC:1.14.-.-]
LinkDB

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