KEGG   ORTHOLOGY: K24442
Entry
K24442                      KO                                     
Symbol
xacA
Name
D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming) [EC:1.1.1.424]
Pathway
map00040  Pentose and glucuronate interconversions
map01100  Metabolic pathways
Reaction
R12643  D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,4-lactone-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00040 Pentose and glucuronate interconversions
    K24442  xacA; D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.424  D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
     K24442  xacA; D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
Other DBs
COG: COG0673
Genes
HHB: Hhub_4012 Hhub_4091
HNO: LT974_07990
HALR: EFA46_009975 EFA46_010985 EFA46_011180
HJE: HacjB3_02295 HacjB3_03200 HacjB3_05780
HDO: MUK72_10720
HALX: M0R89_09680 M0R89_16690
HAXZ: M0R88_09955 M0R88_16895
HAYC: NGM10_05935
HAXY: NGM07_02755 NGM07_15595 NGM07_22850 NGM07_22960
SALI: L593_08020
HMA: pNG7191(gfo2) rrnAC3034(gfo6)
HHI: HAH_0291 HAH_5355(gfo4)
HHN: HISP_01540 HISP_19955
HAB: SG26_09370 SG26_18100
HTA: BVU17_01425 BVU17_16040
HALJ: G9465_01150 G9465_11050
HSIN: KDQ40_12210 KDQ40_20300
HUT: Huta_2274
HTI: HTIA_1971
HALA: Hrd1104_00795
HASV: SVXHr_2301(xacA)
HABN: HBNXHr_2292(xacA)
HMU: Hmuk_2533
HALZ: E5139_15810
HALL: LC1Hm_1813(xdh)
HAZP: GBQ70_15830
HALI: BV210_12335
HDS: HSR122_1642(mviM3)
HRR: HZS55_09950 HZS55_16380 HZS55_21940
HPEL: HZS54_15205 HZS54_19155 HZS54_25430
HLT: I7X12_14445 I7X12_19035 I7X12_19515
SSAI: N0B31_02385
HAAD: MW046_12180 MW046_12920 MW046_14155 MW046_14340
HWA: HQ_3202A
HWC: Hqrw_3764
HVO: HVO_A0330 HVO_B0028(xacA)
HALE: G3A49_05315 G3A49_07045
HLN: SVXHx_3444(xacA) SVXHx_4189(xacA)
HGI: ABY42_15585
HALM: FCF25_13805
HLA: Hlac_1560 Hlac_2241
HALP: DOS48_12410
HALB: EKH57_12905
HEZZ: EO776_13375
HALQ: Hrr1229_008625
HSS: J7656_02875
HSAI: HPS36_08250
HAZZ: KI388_12275
SRUB: C2R22_01265 C2R22_14900
HALN: B4589_002340 B4589_002525
HALG: HUG10_06145 HUG10_08065 HUG10_16045
HALU: HUG12_08080
HMP: K6T50_05830 K6T50_17825
HRE: K6T36_05565 K6T36_16885
HRM: K6T25_10215 K6T25_13160
HACB: Hbl1158_12160 Hbl1158_15055
HDF: AArcSl_0519
HAH: Halar_3506
HTU: Htur_0531 Htur_4116 Htur_4497
HSAL: JMJ58_06465 JMJ58_22330 JMJ58_23275
HAKZ: J0X25_10045
HXA: Halxa_0582 Halxa_1863 Halxa_3767 Halxa_3993
NAT: NJ7G_0683
NPE: Natpe_3458
NVR: FEJ81_08200 FEJ81_16840
NPL: FGF80_15705
NAY: HYG81_01595 HYG81_01625
HALY: HYG82_17880
HJT: DVR14_07440
HLO: J0X27_10455
SAWL: NGM29_12785
HALV: NGM15_11720
NOU: Natoc_1104 Natoc_3157
HLR: HALLA_04515 HALLA_06500
NAS: GCU68_19960
HDA: BB347_11275
 » show all
Reference
PMID:15342590
  Authors
Johnsen U, Schonheit P
  Title
Novel xylose dehydrogenase in the halophilic archaeon Haloarcula marismortui.
  Journal
J Bacteriol 186:6198-207 (2004)
DOI:10.1128/JB.186.18.6198-6207.2004
  Sequence
[hma:rrnAC3034]
Reference
PMID:28854683
  Authors
Sutter JM, Johnsen U, Schonheit P
  Title
Characterization of a pentonolactonase involved in D-xylose and L-arabinose catabolism in the haloarchaeon Haloferax volcanii.
  Journal
FEMS Microbiol Lett 364:3898818 (2017)
DOI:10.1093/femsle/fnx140
  Sequence
[hvo:HVO_B0028]
LinkDB

KEGG   ENZYME: 1.1.1.424
Entry
EC 1.1.1.424                Enzyme                                 
Name
D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming);
xacA (gene name);
xdh (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,4-lactone-forming)
Reaction(IUBMB)
D-xylose + NADP+ = D-xylono-1,4-lactone + NADPH + H+ [RN:R12643]
Reaction(KEGG)
R12643
Substrate
D-xylose [CPD:C00181];
NADP+ [CPD:C00006]
Product
D-xylono-1,4-lactone [CPD:C02753];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which participates in the degradation of D-xylose, has been characterized from several halophilic archaeal species. cf. EC 1.1.1.179, D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming).
History
EC 1.1.1.424 created 2020
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K24442  D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
Genes
HHB: Hhub_4012 Hhub_4091
HNO: LT974_07990
HALR: EFA46_009975 EFA46_010985 EFA46_011180
HJE: HacjB3_02295 HacjB3_03200 HacjB3_05780
HDO: MUK72_10720
HALX: M0R89_09680 M0R89_16690
HAXZ: M0R88_09955 M0R88_16895
HAYC: NGM10_05935
HAXY: NGM07_02755 NGM07_15595 NGM07_22850 NGM07_22960
SALI: L593_08020
HMA: pNG7191(gfo2) rrnAC3034(gfo6)
HHI: HAH_0291 HAH_5355(gfo4)
HHN: HISP_01540 HISP_19955
HAB: SG26_09370 SG26_18100
HTA: BVU17_01425 BVU17_16040
HALJ: G9465_01150 G9465_11050
HSIN: KDQ40_12210 KDQ40_20300
HUT: Huta_2274
HTI: HTIA_1971
HALA: Hrd1104_00795
HASV: SVXHr_2301(xacA)
HABN: HBNXHr_2292(xacA)
HMU: Hmuk_2533
HALZ: E5139_15810
HALL: LC1Hm_1813(xdh)
HAZP: GBQ70_15830
HALI: BV210_12335
HDS: HSR122_1642(mviM3)
HRR: HZS55_09950 HZS55_16380 HZS55_21940
HPEL: HZS54_15205 HZS54_19155 HZS54_25430
HLT: I7X12_14445 I7X12_19035 I7X12_19515
SSAI: N0B31_02385
HAAD: MW046_12180 MW046_12920 MW046_14155 MW046_14340
HWA: HQ_3202A
HWC: Hqrw_3764
HVO: HVO_A0330 HVO_B0028(xacA)
HALE: G3A49_05315 G3A49_07045
HLN: SVXHx_3444(xacA) SVXHx_4189(xacA)
HGI: ABY42_15585
HALM: FCF25_13805
HLA: Hlac_1560 Hlac_2241
HALP: DOS48_12410
HALB: EKH57_12905
HEZZ: EO776_13375
HALQ: Hrr1229_008625
HSS: J7656_02875
HSAI: HPS36_08250
HAZZ: KI388_12275
SRUB: C2R22_01265 C2R22_14900
HALN: B4589_002340 B4589_002525
HALG: HUG10_06145 HUG10_08065 HUG10_16045
HALU: HUG12_08080
HMP: K6T50_05830 K6T50_17825
HRE: K6T36_05565 K6T36_16885
HRM: K6T25_10215 K6T25_13160
HACB: Hbl1158_12160 Hbl1158_15055
HDF: AArcSl_0519
HAH: Halar_3506
HTU: Htur_0531 Htur_4116 Htur_4497
HSAL: JMJ58_06465 JMJ58_22330 JMJ58_23275
HAKZ: J0X25_10045
HXA: Halxa_0582 Halxa_1863 Halxa_3767 Halxa_3993
NAT: NJ7G_0683
NPE: Natpe_3458
NVR: FEJ81_08200 FEJ81_16840
NPL: FGF80_15705
NAY: HYG81_01595 HYG81_01625
HALY: HYG82_17880
HJT: DVR14_07440
HLO: J0X27_10455
SAWL: NGM29_12785
HALV: NGM15_11720
NOU: Natoc_1104 Natoc_3157
HLR: HALLA_04515 HALLA_06500
NAS: GCU68_19960
HDA: BB347_11275
 » show all
Reference
1  [PMID:15342590]
  Authors
Johnsen U, Schonheit P
  Title
Novel xylose dehydrogenase in the halophilic archaeon Haloarcula marismortui.
  Journal
J Bacteriol 186:6198-207 (2004)
DOI:10.1128/JB.186.18.6198-6207.2004
  Sequence
[hma:rrnAC3034]
Reference
2  [PMID:19584053]
  Authors
Johnsen U, Dambeck M, Zaiss H, Fuhrer T, Soppa J, Sauer U, Schonheit P
  Title
D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii.
  Journal
J Biol Chem 284:27290-303 (2009)
DOI:10.1074/jbc.M109.003814
  Sequence
[hvo:HVO_B0028]
Reference
3  [PMID:28854683]
  Authors
Sutter JM, Johnsen U, Schonheit P
  Title
Characterization of a pentonolactonase involved in D-xylose and L-arabinose catabolism in the haloarchaeon Haloferax volcanii.
  Journal
FEMS Microbiol Lett 364:3898818 (2017)
DOI:10.1093/femsle/fnx140
  Sequence
[hvo:HVO_B0028]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.424
IUBMB Enzyme Nomenclature: 1.1.1.424
ExPASy - ENZYME nomenclature database: 1.1.1.424
BRENDA, the Enzyme Database: 1.1.1.424
LinkDB

KEGG   REACTION: R12643
Entry
R12643                      Reaction                               
Name
D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,4-lactone-forming)
Definition
D-Xylose + NADP+ <=> D-Xylono-1,4-lactone + NADPH + H+
Equation
C00181 + C00006 <=> C02753 + C00005 + C00080
Enzyme
1.1.1.424
Pathway
rn00040  Pentose and glucuronate interconversions
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.424
     R12643  D-Xylose + NADP+ <=> D-Xylono-1,4-lactone + NADPH + H+
Orthology
K24442  D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming) [EC:1.1.1.424]
LinkDB

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