KEGG   ORTHOLOGY: K24530
Entry
K24530                      KO                                     
Symbol
mycCII
Name
ferredoxin
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Reaction
R10875  mycinamicin-VIII,NADPH:oxygen oxidoreductase (21-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24530  mycCII; ferredoxin
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24530  mycCII; ferredoxin
Polyketide biosynthesis proteins [BR:ko01008]
 Nonribosomal peptide tailoring proteins
  Others
   K24530  mycCII; ferredoxin
Other DBs
COG: COG1141
Genes
MPHU: MPHO_50900
MHOL: K3U96_00550
KBU: Q4V64_44880
KCH: O1G21_10140
AG: BAC57024(mycCII)
Reference
PMID:12583909
  Authors
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F
  Title
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
  Journal
FEMS Microbiol Lett 218:135-41 (2003)
DOI:10.1111/j.1574-6968.2003.tb11509.x
  Sequence
[ag:BAC57024]
LinkDB

KEGG   REACTION: R10875
Entry
R10875                      Reaction                               
Name
mycinamicin-VIII,NADPH:oxygen oxidoreductase (21-hydroxylating)
Definition
Mycinamicin VIII + NADPH + Oxygen + H+ <=> Mycinamicin VII + NADP+ + H2O
Equation
C15684 + C00005 + C00007 + C00080 <=> C15683 + C00006 + C00001
Reaction class
RC00001  C00005_C00006
RC03228  C15683_C15684
Enzyme
1.14.13.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R10875  Mycinamicin VIII + NADPH + Oxygen + H+ <=> Mycinamicin VII + NADP+ + H2O
Orthology
K24292  mycinamicin VIII C21 methyl hydroxylase [EC:1.14.-.-]
K24530  ferredoxin
LinkDB

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