KEGG   ORTHOLOGY: K24972
Entry
K24972                      KO                                     
Symbol
purZ
Name
2-amino-2'-deoxyadenylo-succinate synthase [EC:6.3.4.25]
Pathway
map00230  Purine metabolism
Reaction
R12786  dGMP:L-aspartate ligase (ADP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K24972  purZ; 2-amino-2'-deoxyadenylo-succinate synthase
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K24972  purZ; 2-amino-2'-deoxyadenylo-succinate synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.25  2-amino-2'-deoxyadenylo-succinate synthase
     K24972  purZ; 2-amino-2'-deoxyadenylo-succinate synthase
Viral proteins [BR:ko03200]
 dsDNA viruses (phages)
  Other phage
   K24972  purZ; 2-amino-2'-deoxyadenylo-succinate synthase
Genes
VG: 24366411(phiVC8_p27) 24725180(ACQ42_gp27) 24725405(ACQ41_gp26) 2845928(purA) 2948094(VP2p26)
AG: QQG31319(purZ)
Reference
PMID:33926955
  Authors
Sleiman D, Garcia PS, Lagune M, Loc'h J, Haouz A, Taib N, Rothlisberger P, Gribaldo S, Marliere P, Kaminski PA.
  Title
A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes.
  Journal
Science 372:516-520 (2021)
DOI:10.1126/science.abe6494
  Sequence
[vg:24366411]
LinkDB

KEGG   ENZYME: 6.3.4.25
Entry
EC 6.3.4.25                 Enzyme                                 
Name
2-amino-2'-deoxyadenylo-succinate synthase;
purZ (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
Sysname
dGMP:L-aspartate ligase (ADP-forming)
Reaction(IUBMB)
ATP + dGMP + L-aspartate = ADP + phosphate + 2-amino-2'-deoxy-N6-[(2S)-succino]adenylate [RN:R12786]
Reaction(KEGG)
R12786
Substrate
ATP [CPD:C00002];
dGMP [CPD:C00362];
L-aspartate [CPD:C00049]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
2-amino-2'-deoxy-N6-[(2S)-succino]adenylate [CPD:C22395]
Comment
The enzyme, characterized from a number of bacteriophages, participates in the biosynthesis of dZTP, which replaces dATP in the genome of these phages.
History
EC 6.3.4.25 created 2021
Pathway
ec00230  Purine metabolism
Orthology
K24972  2-amino-2'-deoxyadenylo-succinate synthase
Reference
1  [PMID:33926954]
  Authors
Zhou Y, Xu X, Wei Y, Cheng Y, Guo Y, Khudyakov I, Liu F, He P, Song Z, Li Z, Gao Y, Ang EL, Zhao H, Zhang Y, Zhao S
  Title
A widespread pathway for substitution of adenine by diaminopurine in phage genomes.
  Journal
Science 372:512-516 (2021)
DOI:10.1126/science.abe4882
Reference
2  [PMID:33926955]
  Authors
Sleiman D, Garcia PS, Lagune M, Loc'h J, Haouz A, Taib N, Rothlisberger P, Gribaldo S, Marliere P, Kaminski PA.
  Title
A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes.
  Journal
Science 372:516-520 (2021)
DOI:10.1126/science.abe6494
  Sequence
[vg:24366411]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.25
IUBMB Enzyme Nomenclature: 6.3.4.25
ExPASy - ENZYME nomenclature database: 6.3.4.25
BRENDA, the Enzyme Database: 6.3.4.25
LinkDB

KEGG   REACTION: R12786
Entry
R12786                      Reaction                               
Name
dGMP:L-aspartate ligase (ADP-forming)
Definition
ATP + dGMP + L-Aspartate <=> ADP + Orthophosphate + N6-Succino-2-amino-2'-deoxyadenylate
Equation
C00002 + C00362 + C00049 <=> C00008 + C00009 + C22395
Enzyme
6.3.4.25
Pathway
rn00230  Purine metabolism
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.25
     R12786  ATP + dGMP + L-Aspartate <=> ADP + Orthophosphate + N6-Succino-2-amino-2'-deoxyadenylate
Orthology
K24972  2-amino-2'-deoxyadenylo-succinate synthase [EC:6.3.4.25]
LinkDB

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