KEGG ORTHOLOGY: K25004

ORTHOLOGY: K25004

Entry

K25004                      KO

Symbol

MTHFR

Name

methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.53]

Pathway

map00670

One carbon pool by folate

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01523

Antifolate resistance

map04981

Folate transport and metabolism

Reaction

R01224

5-methyltetrahydrofolate:NADP+ oxidoreductase

Disease

H00183

Homocystinuria

H00262

Neural tube defects, folate-sensitive

H01649

Schizophrenia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K25004  MTHFR; methylenetetrahydrofolate reductase (NADPH)
09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    K25004  MTHFR; methylenetetrahydrofolate reductase (NADPH)
09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K25004  MTHFR; methylenetetrahydrofolate reductase (NADPH)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.53  methylenetetrahydrofolate reductase (NADPH)
     K25004  MTHFR; methylenetetrahydrofolate reductase (NADPH)

Other DBs

COG:

COG0685

GO:

0106313

Genes

HSA:	4524(MTHFR)

PTR:	469800(MTHFR)

PPS:	100975693(MTHFR)

GGO:	101134157(MTHFR)

PON:	100454623(MTHFR)

PPYG:

129007712(MTHFR)

NLE:	105738058(MTHFR)

HMH:	116812932(MTHFR)

SSYN:

129471863(MTHFR)

MCC:	714840(MTHFR)

MCF:	102117536(MTHFR)

MTHB:

126953028

MNI:	105473166(MTHFR)

CSAB:

103225598(MTHFR)

CATY:

105580856(MTHFR)

PANU:

101019898(MTHFR)

TGE:	112616737(MTHFR)

MLEU:

105551372(MTHFR)

RRO:	104657549(MTHFR)

RBB:	108539360(MTHFR)

TFN:	117093311(MTHFR)

PTEH:

111526316(MTHFR)

CANG:

105507372(MTHFR)

CJC:	100391000(MTHFR)

SBQ:	101043467(MTHFR)

CIMI:

108286453(MTHFR)

ANAN:

105731778(MTHFR)

CSYR:

103266205(MTHFR)

MMUR:

105882714(MTHFR)

LCAT:

123634470(MTHFR)

ERUF:

138390453(MTHFR)

PCOQ:

105824906(MTHFR)

OGA:	100960485(MTHFR)

MMU:	17769(Mthfr)

MCAL:

110293543(Mthfr)

MPAH:

110323320(Mthfr)

RNO:	362657(Mthfr)

MCOC:

116097006(Mthfr)

ANU:	117708999(Mthfr)

ASYL:

127681655(Mthfr)

MUN:	110555748(Mthfr)

CGE:	100774930(Mthfr)

MAUA:

101832815(Mthfr)

PROB:

127213260(Mthfr)

PLEU:

114709673(Mthfr)

PMAV:

102904692(Mthfr)

MORG:

121441775(Mthfr) 121447985

MFOT:

126508160

AAMP:

119817717(Mthfr)

CNL:	130883314(Mthfr)

NGI:	103747470(Mthfr)

HGL:	101719335(Mthfr)

CPOC:

100715703(Mthfr)

CCAN:

109697792(Mthfr)

DORD:

105997431(Mthfr)

DSP:	122121484(Mthfr)

DMER:

138838182(Mthfr)

PLOP:

125354578(Mthfr)

NCAR:

124983882

MMMA:

107155492(Mthfr)

ITI:	101956899(Mthfr)

OCU:

100352874

OPI:	101527929(MTHFR)

OCZ:	121161501(MTHFR)

TUP:	102476978(MTHFR)

GVR:	103605195(MTHFR)

CFA:	478230(MTHFR)

CLUD:

112678116(MTHFR)

VVP:	112929750(MTHFR)

VLG:	121496764(MTHFR)

NPO:	129513898(MTHFR)

AML:	100469351(MTHFR)

UMR:	103666650(MTHFR)

UAH:	113270501(MTHFR)

UAR:	123779081(MTHFR)

ELK:

111154700

LLV:

125096774

MPUF:

101694159(MTHFR)

MNP:	132001220(MTHFR)

MLK:	131810442(MTHFR)

NVS:	122899460(MTHFR)

ORO:	101367692(MTHFR)

EJU:	114213206(MTHFR)

ZCA:	113933704(MTHFR)

MLX:	118020001(MTHFR)

NSU:	110574669(MTHFR)

LWW:	102742884(MTHFR)

FCA:	101100576(MTHFR)

PYU:	121021216(MTHFR)

PCOO:

112871980(MTHFR)

PBG:	122479932(MTHFR)

PVIV:

125171998(MTHFR)

LRUF:

124514789

LGF:	123597189(MTHFR)

AJU:

106971872

PTG:	102969340(MTHFR)

PPAD:

109274118(MTHFR)

PUC:

125913110

PLEZ:

122228801(MTHFR)

HHV:	120233615(MTHFR)

BTA:	497032(MTHFR)

BOM:	102286710(MTHFR)

BIU:	109570335(MTHFR)

BBUB:

102395627(MTHFR)

BKE:	129653043(MTHFR)

BBIS:

104995835(MTHFR)

CHX:	102182523(MTHFR)

OAS:	101111645(MTHFR)

BTAX:

128061407(MTHFR)

CSUM:

138090547(MTHFR)

ODA:	120880227(MTHFR)

CCAD:

122451796(MTHFR)

MREE:

136168371(MTHFR)

OVR:	110137929(MTHFR)

MBEZ:

129551542(MTHFR)

SSC:	397180(MTHFR)

CFR:	102505417(MTHFR)

CBAI:

105070965(MTHFR)

CDK:	105107034(MTHFR)

VPC:	102532634(MTHFR)

BACU:

102998853(MTHFR)

BMUS:

118905488(MTHFR)

LVE:	103079236(MTHFR)

OOR:	101287316(MTHFR)

LALB:

132515228(MTHFR)

GMF:	115864539(MTHFR)

DDP:	132427212(MTHFR)

DLE:	111187289(MTHFR)

PCAD:

102986652(MTHFR)

PSIU:

116748237(MTHFR)

PPHC:

136121646(MTHFR)

NASI:

112402713(MTHFR)

ECB:	100050979(MTHFR)

EPZ:	103552183(MTHFR)

EAI:	106836668(MTHFR)

MYB:	102245334(MTHFR)

MYD:	102764267(MTHFR)

MMYO:

118675486(MTHFR)

MLF:	102437960(MTHFR)

MDT:	132231678(MTHFR)

MYUM:

139002875(MTHFR)

PKL:	118732048(MTHFR)

EFUS:

103295330(MTHFR)

MNA:	107531557(MTHFR)

DRO:	112299114(MTHFR)

SHON:

118986343(MTHFR)

AJM:	119064129(MTHFR)

PDIC:

114496601(MTHFR)

PHAS:

123831738(MTHFR)

MMF:	118626195(MTHFR)

PPAM:

129075652(MTHFR)

HAI:	109381260(MTHFR)

RFQ:	117027712(MTHFR)

PALE:

102882062(MTHFR)

PGIG:

120585812(MTHFR)

PVP:	105294362(MTHFR)

RAY:	107513124(MTHFR)

MJV:	108385719(MTHFR)

TOD:	119236603(MTHFR)

SFUM:

130020331(MTHFR)

SETR:

126011521(MTHFR)

LAV:	100661160(MTHFR)

TMU:

101359718

ETF:	101638069(MTHFR)

DNM:	101428504(MTHFR)

MDO:	100018128(MTHFR)

GAS:	123240311(MTHFR)

AFZ:

127555865

PCW:	110199057(MTHFR)

TVP:	118838870(MTHFR)

PBRV:

138154551(MTHFR)

MLAO:

141509141(MTHFR)

OAA:	100086119(MTHFR)

TACU:

119928296(MTHFR)

GGA:	419489(MTHFR)

PCOC:

116242702(MTHFR)

MGP:	100543073(MTHFR)

CJO:	107323372(MTHFR)

TPAI:

128084952(MTHFR)

LMUT:

125703509(MTHFR)

NMEL:

110408579(MTHFR)

APLA:

101805333(MTHFR)

AACU:

137843222(MTHFR)

ACYG:

106040241(MTHFR)

CATA:

118253386(MTHFR)

AFUL:

116497721(MTHFR)

TGU:	100220660(MTHFR)

LSR:	110479731(MTHFR)

SCAN:

103820847(MTHFR)

PMOA:

120496725(MTHFR)

OTC:	121343904(MTHFR)

PRUF:

121358379(MTHFR)

ATRC:

139600792(MTHFR)

GFR:	102033068(MTHFR)

FAB:	101817361(MTHFR)

OMA:	130261721(MTHFR)

PHI:	102109675(MTHFR)

PMAJ:

107213633(MTHFR)

CCAE:

111938714(MTHFR)

CCW:	104693242(MTHFR)

CBRC:

103616120(MTHFR)

ACOE:

138121462(MTHFR)

ETL:	114056920(MTHFR)

ZAB:	102071430(MTHFR)

ZLE:	135456507(MTHFR)

ACHL:

103807228(MTHFR)

SVG:	106856415(MTHFR)

MMEA:

130583060(MTHFR)

HRT:	120762427(MTHFR)

SATI:

136370757(MTHFR)

CFAI:

136300708(MTHFR)

CCIC:

134053014(MTHFR)

FPG:	101920680(MTHFR)

FCH:	102053108(MTHFR)

CCRI:

104162212(MTHFR)

NNT:	104403185(MTHFR)

SHAB:

115617312(MTHFR)

ACUN:

113487781(MTHFR)

SURA:

141953970(MTHFR)

TALA:

104368439(MTHFR)

ACHC:

115343387(MTHFR)

HALD:

104317869(MTHFR)

HLE:	104837887(MTHFR)

AGEN:

126036762

HHAR:

128144633(MTHFR)

BBUT:

142030914(MTHFR)

GCL:

127024779

CSTI:

104554865(MTHFR)

LDI:	104347526(MTHFR)

MNB:	103776798(MTHFR)

DPUB:

104305839(MTHFR)

PPUS:

135190648(MTHFR)

AVIT:

104269937(MTHFR)

EGZ:	104133086(MTHFR)

NNI:	104009002(MTHFR)

PCRI:

104028163(MTHFR)

PCAO:

104042256(MTHFR)

PADL:

103918045(MTHFR)

AFOR:

103907443(MTHFR)

FGA:	104079210(MTHFR)

CBOR:

142092447(MTHFR)

GSTE:

104251132(MTHFR)

CBOY:

140661655(MTHFR)

MAME:

142418620(MTHFR)

CLV:	102089900(MTHFR)

CNIC:

135997385(MTHFR)

MUI:	104548100(MTHFR)

PGUU:

104465847(MTHFR)

PLET:

104624937(MTHFR)

EHS:	104503465(MTHFR)

CMAC:

104479122(MTHFR)

CUCA:

104060557(MTHFR)

TEO:	104378985(MTHFR)

BREG:

104633204(MTHFR)

GAME:

129215732(MTHFR)

OHA:	104332674(MTHFR)

ACAR:

104523067(MTHFR)

CPEA:

104395435(MTHFR)

CVF:	104290447(MTHFR)

RTD:	128918501(MTHFR)

CRID:

134524047(MTHFR)

LMIC:

141732098(MTHFR)

NARQ:

141473909(MTHFR)

AAM:	106482439(MTHFR)

AROW:

112970030(MTHFR)

NPD:	112959653(MTHFR)

TGT:	104577392(MTHFR)

DNE:	112980540(MTHFR)

SCAM:

104141860(MTHFR)

ASN:	102373612(MTHFR)

AMJ:	102573230(MTHFR)

CPOO:

109314267(MTHFR)

GGN:	109293666(MTHFR)

PSS:	102448267(MTHFR)

CIZ:	142025623(MTHFR)

CMY:	102945698(MTHFR)

CCAY:

125624226(MTHFR)

LKP:	140900168(MTHFR)

NDS:	141974313(MTHFR)

DCC:	119845049(MTHFR)

CPIC:

101950023(MTHFR)

TST:	117867765(MTHFR)

CABI:

116821910(MTHFR)

MRV:	120387999(MTHFR)

ACS:	100554267(mthfr)

ASAO:

132764724(MTHFR)

PVT:	110073216(MTHFR)

SUND:

121936126(MTHFR)

PBI:	103051539(MTHFR)

PMUR:

107294169(MTHFR)

CTIG:

120313278(MTHFR)

PGUT:

117659694(MTHFR)

PCAE:

139325944(MTHFR)

APRI:

131187094(MTHFR)

PTEX:

113450046(MTHFR)

NSS:	113428245(MTHFR)

VKO:	123031059(MTHFR)

PRAF:

128419874(MTHFR)

ZVI:	118087419(MTHFR)

HCG:	128338595(MTHFR)

GJA:	107117727(MTHFR)

STOW:

125445948(MTHFR)

EMC:	129345036(MTHFR)

XLA:	108697556(mthfr.S) 379784(mthfr.L)

XTR:	100125082(mthfr)

NPR:	108799423(MTHFR)

RTEM:

120915514(MTHFR)

ACAT:

141111135(MTHFR)

PADS:

140340538(MTHFR)

BBUF:

120999546(MTHFR)

BGAR:

122928824(MTHFR)

DTC:	141097678(MTHFR)

PWL:	138301121(MTHFR)

MUO:	115456800(MTHFR)

GSH:	117348775(MTHFR)

DRE:	567547(mthfr)

SRX:	107710792(mthfr) 107748978

SANH:

107687111 107691055

SGH:	107595790 107602465

CCAR:

109092734 109093262

CAUA:

113097248 113107832

CGIB:

127962931 128018193

PTET:

122350940(mthfr)

LROH:

127169447(mthfr)

GRF:	141286516(mthfr)

OMC:	131546356(mthfr)

PPRM:

120490013(mthfr)

RKG:	130082031(mthfr)

MAMB:

125280298(mthfr)

CIDE:

127518047

CERY:

137027308(mthfr)

MASI:

127414475 127424732

TROS:

130549617(mthfr)

TDW:	130439745(mthfr)

MANU:

129414952(mthfr)

PDAB:

135729911(mthfr)

IPU:

108265037

IFU:	128607571(mthfr)

PHYP:

113533585(mthfr)

SMEO:

124399833(mthfr)

TFD:	113656298(mthfr)

TVC:	132853862(mthfr)

CGAR:

128529776(mthfr)

NGRA:

132892937(mthfr)

TRN:	134317787(mthfr)

AMEX:

103033176(mthfr)

CMAO:

118813595(mthfr)

EEE:	113578182(mthfr)

CHAR:

122131825(mthfr)

SPIL:

134087195(mthfr)

ASAD:

121712965(mthfr)

TRU:	101078210(mthfr)

TFS:	130530456(mthfr)

TNG:	GSTEN00004910G001

LCO:	104936586(mthfr)

NCC:

104955699

TBEN:

117481494(mthfr)

PGEO:

117449835(mthfr)

GACU:

117559267(mthfr)

EMAC:

134861515(mthfr)

ELY:	117258736(mthfr)

EFO:	125891990(mthfr)

PLEP:

121947149(mthfr)

SLUC:

116058866(mthfr)

ECRA:

117948295

ESP:	116691919(mthfr)

PFLV:

114558693(mthfr)

GAT:	120829205(mthfr)

PPUG:

119223711(mthfr)

AFB:	129099663(mthfr)

CLUM:

117733916(mthfr)

PSWI:

130199689(mthfr)

CANA:

137800094(mthfr)

CVE:	137889730(mthfr)

MSAM:

119904965(mthfr)

SCHU:

122883725(mthfr)

EARM:

139289158(mthfr)

CUD:	121518041(mthfr)

SPUL:

138589975(mthfr)

LMIX:

132989811(mthfr)

HTC:	141798775(mthfr)

ALAT:

119023563(mthfr)

ASTR:

137604061(mthfr)

PKLU:

139209683(mthfr)

MZE:	101481615(mthfr)

ONL:	100706052(mthfr)

OAU:	116326127(mthfr)

OLA:	101173920(mthfr)

OML:	112140866(mthfr)

CSAI:

133456301(mthfr)

XMA:	102216417(mthfr)

XCO:	114141964(mthfr)

XHE:	116724335(mthfr)

PRET:

103466998(mthfr)

PFOR:

103154252(mthfr)

PLAI:

106947843(mthfr)

PMEI:

106926580(mthfr)

GAF:	122832650 122833189

PPRL:

129371664(mthfr)

CVG:	107102655(mthfr)

CTUL:

119786289(mthfr)

GMU:	124872528(mthfr)

NFU:	107391521(mthfr)

KMR:	108249409(mthfr)

ALIM:

106529348(mthfr)

NWH:	119429280 119429296

AOCE:

111566112(mthfr)

EJA:	138193333(mthfr)

BFRE:

138618391(mthfr)

MCEP:

125024165(mthfr)

CSEM:

103384826(mthfr)

SSEN:

122777158(mthfr)

SSOE:

131468122(mthfr)

HHIP:

117765126(mthfr)

HSP:	118110475(mthfr)

PPLT:

128443060(mthfr)

SMAU:

118316574(mthfr)

LCF:

108900502

SDU:	111233770(mthfr)

SLAL:

111658836(mthfr)

XGL:	120803549(mthfr)

HCQ:	109528734(mthfr)

SSCV:

125987776(mthfr)

SBIA:

133511920(mthfr)

PEE:	133408300(mthfr)

PTAO:

133486619(mthfr)

BPEC:

110165619(mthfr)

ENY:	140363016(mthfr)

MALB:

109951049(mthfr)

SJO:	128357914(mthfr)

SSCO:

133988297(mthfr)

TTY:	137183985(mthfr)

GMH:	115547166(mthfr)

SASA:

106572128(mthfr)

STRU:

115166009 115168944

OTW:	112215984 112221595

OMY:	110491842 110532243

OGO:	124031907 124046174

ONE:	115102605 115132121

OKI:	109869406 109907962

OKE:	118360209 118361064

OMM:	135504442 135527384

OCLA:

139368326 139416462

SALP:

111976745 112068446

SNH:	120059363 120060956

SFON:

129824390 129830041

CCLU:

121538303 121545939

ELS:	105013771(mthfr)

OEP:	134019124(mthfr)

SFM:	108924892(mthfr)

PKI:	111859074(mthfr)

AANG:

118207739(mthfr)

AROT:

135233870(mthfr)

CCOG:

133138640(mthfr)

LOC:	102688415(mthfr)

PSPA:

121329149 121329216

ARUT:

117425554 117426084

PSEX:

120531063(mthfr)

LCM:	102358326(MTHFR)

CMK:	103181396(mthfr)

RTP:	109914604(mthfr)

CPLA:

122540329(mthfr)

CPUN:

140487037(mthfr)

HOC:	132833517(mthfr)

SCAU:

119950864(mthfr)

LERI:

129711556(mthfr)

HAKA:

140718357(mthfr)

PMRN:

116955583(MTHFR)

BFO:

BBEL:

CIN:

SCLV:

CLEP:

SPU:	115924565 589576

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:	100368141(MTHFR)

PFLL:

DGR:

RZE:

FCD:

DPX:	DAPPUDRAFT_301720

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

OOT:

EAF:

TCF:

DPTE:

DFR:	124489958 124493973

CSCU:

CVS:

LPOL:

PMEO:

CEL:	CELE_C06A8.1(mthf-1)

CBR:

CBG_12960

CRQ:	GCK72_005714

NAI:	NECAME_11843

BMY:	BM_BM1999(Bma-mthf-1)

LOA:	LOAG_08597

TSP:

Tsp_08753

HRO:	HELRODRAFT_111699

LGI:	LOTGIDRAFT_214878

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106154846 106174355

LLON:

135496701

NVE:	5512577 5513626

EPA:	110252119 110252167

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:	114528959 114537439

XEN:

124457394

HMG:

100207609

HSY:	130624954 130641462

RES:	135688551 135688553

TAD:	TRIADDRAFT_26971

AQU:

100636961

SCE:	YGL125W(MET13) YPL023C(MET12)

SEUB:

DI49_1849 DI49_5433

SPAO:

SPAR_G01230 SPAR_P02400

AGO:	AGOS_AAR170W AGOS_AFR457W

ERC:	Ecym_1400 Ecym_3063

KLA:	KLLA0_D12188g KLLA0_F09647g

KMX:	KLMA_20276(MET13) KLMA_60378(MET12)

LTH:	KLTH0E11022g KLTH0H06446g

VPO:	Kpol_1007p12 Kpol_223p6

ZRO:	ZYRO0A02838g ZYRO0E01870g

CGR:	2887607(MET13) 2889935(MET12)

NCS:	NCAS_0C02530(NCAS0C02530) NCAS_0D03140(NCAS0D03140)

NDI:	NDAI_0E03230(NDAI0E03230) NDAI_0I01770(NDAI0I01770)

TPF:	TPHA_0C01840(TPHA0C01840) TPHA_0J01830(TPHA0J01830)

TBL:	TBLA_0D02780(TBLA0D02780) TBLA_0F02520(TBLA0F02520)

TGB:	HG536_0H01660 HG536_0H03600

TDL:	TDEL_0B01620(TDEL0B01620) TDEL_0G03480(TDEL0G03480)

KAF:	KAFR_0A04630(KAFR0A04630) KAFR_0H01590(KAFR0H01590)

KNG:	KNAG_0A02370(KNAG0A02370) KNAG_0F02500(KNAG0F02500)

ZMK:	HG535_0B03260 HG535_0C01620

SLUD:

SCDLUD_000993 SCDLUD_001942

DHA:	DEHA2F08976g DEHA2G01254g

PIC:	PICST_71674 PICST_83803

PGU:	PGUG_01501

SPAA:

SPAPADRAFT_137530 SPAPADRAFT_51518

LEL:	PVL30_002085(MET13) PVL30_003470(MET12)

LBG:	92207516(LODBEIA_P23200) 92208703(LODBEIA_P35070)

CAL:	CAALFM_C210460CA(CaO19.5321) CAALFM_C302950CA(MET13)

CTP:	CTRG_02026 CTRG_02573

COT:	CORT_0B03880 CORT_0C03560

CDU:	CD36_24470 CD36_82930

CTEN:

18248645(MET13)

CLU:	CLUG_02387 CLUG_05125

CLUS:

A9F13_03g01133 A9F13_24g00066

CAUR:

CJI96_0001128 CJI96_0002275

ASAU:

88173265(PUMCH_002200) 88175490(PUMCH_004430)

PPA:	PAS_chr2-2_0145 PAS_chr2-2_0182

PKZ:	C5L36_0B07640 C5L36_0D03770

BNN:	FOA43_000536 FOA43_004528

BBRX:

BRETT_001890 BRETT_003148

OPA:	HPODL_00022 HPODL_02993

YLI:	2906737(YALI2_C00796g)

SLB:	AWJ20_3315(MET13) AWJ20_715(MET12)

NCR:	NCU07690 NCU09545

NTE:	NEUTE1DRAFT128536(NEUTE1DRAFT_128536) NEUTE1DRAFT57029(NEUTE1DRAFT_57029)

SMP:	10803567(SMAC4_06582) 10807485(SMAC4_00862)

PAN:	PODANSg7263 PODANSg8765

PBEL:

QC761_209160(MET12) QC761_602690(MET13)

PPSD:

QC762_209160(MET12) QC762_602690(MET13)

PPSP:

QC763_209160(MET12) QC763_602690(MET13)

PPSA:

QC764_209160(MET12) QC764_602690(MET13)

TTT:	THITE_2107143 THITE_2115191

MTM:	MYCTH_2300974 MYCTH_2314160

CTHR:

CTHT_0033700 CTHT_0065570

RTHE:

98126177(VTJ83DRAFT_4984) 98127055(VTJ83DRAFT_5774)

MGR:	MGG_01728 MGG_08171

PPEI:

PpBr36_01245 PpBr36_01602

PGRI:

PgNI_03394 PgNI_03764

TMN:	UCRPA7_3085 UCRPA7_6818

SSCK:

SPSK_03199 SPSK_05053

FGR:	FGSG_07127 FGSG_09572

FPU:	FPSE_04091 FPSE_05848

FPOA:

FPOAC1_010897 FPOAC1_012085

FVN:	FVRRES_11909 FVRRES_13154

FVR:	FVEG_04126 FVEG_08038

FOX:	FOXG_01673 FOXG_06273

NHE:	NECHADRAFT_32750 NECHADRAFT_71723

FFC:	NCS54_00273400 NCS54_01131900

FKR:	NCS57_00269200 NCS57_01122500

FMU:	J7337_002907 J7337_004132

TRE:	TRIREDRAFT_55055 TRIREDRAFT_81824

TRR:	M419DRAFT_104048 M419DRAFT_135784

TATV:

25783884(TrAtP1_001274) 25786594(TrAtP1_011116)

TASP:

36607500(TrAFT101_001202) 36613616(TrAFT101_008965)

MAW:	19252082(MET13)

MAJ:	MAA_01221 MAA_07320

MBRN:

26239328(met9) 26241089(met11)

PCHM:

VFPPC_09868 VFPPC_13512

UVI:	66063890(UV8b_03112) 66065719(UV8b_04941)

CMT:	CCM_04157 CCM_05621

AMUS:

LMH87_004379 LMH87_006725

PLJ:	28882876(PLICBS_001097) 28889940(PLICBS_008653)

PTKZ:

JDV02_005288(MET12) JDV02_007903(MET13)

DCON:

63713339(DCS_00696) 63720277(DCS_07634)

VAL:	VDBG_00123

VDA:	VDAG_00463 VDAG_08410

CFJ:	CFIO01_02428 CFIO01_07029

CLUP:

CLUP02_08015 CLUP02_17462

CHIG:

CH63R_04201 CH63R_07780

CDET:

87941240(CDEST_04737) 87944998(CDEST_08495)

SAPO:

SAPIO_CDS7226

ELA:	UCREL1_6847 UCREL1_9493

PFY:	PFICI_05432 PFICI_08066

SSL:	SS1G_02009 SS1G_09764

BFU:	BCIN_07g02820 BCIN_07g06360

MBE:	MBM_01665 MBM_08501

PSCO:

LY89DRAFT_718062 LY89DRAFT_769751

GLZ:	GLAREA_11463 GLAREA_12614

ANI:	ANIA_05883 ANIA_08215

AFM:	AFUA_2G11300 AFUA_5G03480

ACT:	ACLA_001700 ACLA_070260

NFI:	NFIA_038640 NFIA_086570

AOR:	AO090026000520 AO090102000557

ANG:	An02g03270 An09g05860

AFV:	AFLA_005756 AFLA_011983

ALUC:

AKAW2_21343A AKAW2_40591A

ACHE:

ACHE_40648S ACHE_50694S

APUU:

APUU_10896A APUU_60645S

PCS:	N7525_008123 N7525_009990

PDP:	PDIP_10790 PDIP_48850

POU:	POX_a00488 POX_e07132

PPSF:

300789716(PFLUO_LOCUS3937) 300791519(PFLUO_LOCUS5560)

TMF:	EYB26_003580 EYB26_004262

TRG:	TRUGW13939_07742 TRUGW13939_08425

CIM:	CIMG_06560 CIMG_08202

CPW:	9690534(D8B26_004497) 9695334(D8B26_006209)

URE:	UREG_02453 UREG_03880

ABE:	ARB_01328 ARB_06846

TVE:	TRV_05244 TRV_07376

PBL:	PAAG_03665 PAAG_04294

PBN:	PADG_03172 PADG_07528

AJE:	HCAG_00541 HCAG_07107

BGH:	BDBG_00602 BDBG_01364

PNO:	SNOG_10985(SNOG_10984) SNOG_12690

PTE:	PTT_09481 PTT_18113

PTRR:

6347814(PtrM4_127600) 6349625(PtrM4_070860)

BZE:	COCCADRAFT_87884 COCCADRAFT_96319

BSC:	COCSADRAFT_136346 COCSADRAFT_140784

BOR:	COCMIDRAFT_28378 COCMIDRAFT_4719

AALT:

CC77DRAFT_1092254 CC77DRAFT_958941

ADAC:

96081519(ACET3X_001197) 96083639(ACET3X_003317)

ARAB:

EKO05_0009890 EKO05_0011104

ZTR:	MYCGRDRAFT_109648 MYCGRDRAFT_75203

PFJ:	MYCFIDRAFT_49642 MYCFIDRAFT_81197

FFU:	CLAFUR5_07224 CLAFUR5_07965

CBET:

CB0940_04150 CB0940_09049

BCOM:

BAUCODRAFT_210105 BAUCODRAFT_237275

NPA:	UCRNP2_6300 UCRNP2_9800

TML:	GSTUM_00003351001 GSTUM_00010817001

SPO:	2542993(met9) 2543105(met11)

SOM:	SOMG_01808(met9) SOMG_02033(met11)

CNE:	CNA07390 CNL04820

CNB:	CNBA7210 CNBI2020

CNG:	CNAG_00760 CNAG_05140

CGI:	CGB_A8490W CGB_D2260W

CDEU:

CNBG_1170 CNBG_9485

CDEC:

89987405(IAS62_000629) 89988446(IAS62_001672)

CTEG:

91987074(I308_100216) 91987825(I308_100967)

CBAS:

91980685(I312_100637) 91981001(I312_100953)

CDEP:

91088023(L203_103813) 91089035(L203_104826)

KMG:	30163963(I203_103755) 30166533(I203_100747)

KNE:	92179109(IAR55_001850) 92181595(IAR55_004337)

KDJ:	28968157(I303_104565) 28971481(I303_107777)

KBI:	30206066(I302_102971) 30209702(I302_106179)

KPIN:

30172861(I206_103935) 30175613(I206_106440)

KSH:	87955648(IL334_003517) 87959703(IL334_007573)

KER:	91100187(V865_001383) 91105369(V865_006568)

KSN:	43586640(CI109_101529) 43589620(CI109_105078)

KEP:	91094709(L201_004039) 91097793(L201_007124)

TMS:	TREMEDRAFT_38541 TREMEDRAFT_43239

TASA:

A1Q1_00789 A1Q1_04951

CCAC:

CcaHIS019_0509060(MET13) CcaHIS019_0510340(MET12)

TVS:	TRAVEDRAFT_164884 TRAVEDRAFT_28907

DSQ:	DICSQDRAFT_134054 DICSQDRAFT_177540

PCO:	PHACADRAFT_208793 PHACADRAFT_264540

SHS:	STEHIDRAFT_157081 STEHIDRAFT_75044

HIR:	HETIRDRAFT_445887 HETIRDRAFT_471420

PSQ:	PUNSTDRAFT_113018 PUNSTDRAFT_53586

ADL:	AURDEDRAFT_106360 AURDEDRAFT_142206

FME:	FOMMEDRAFT_100481 FOMMEDRAFT_88181

GTR:	GLOTRDRAFT_105411 GLOTRDRAFT_71781

RSX:	RhiXN_02363 RhiXN_05214

LBC:	LACBIDRAFT_182479 LACBIDRAFT_244474

CCI:	CC1G_00920 CC1G_01198

ABP:	AGABI1DRAFT111963(AGABI1DRAFT_111963) AGABI1DRAFT68194(AGABI1DRAFT_68194)

ABV:	AGABI2DRAFT193205(AGABI2DRAFT_193205) AGABI2DRAFT216007(AGABI2DRAFT_216007)

PCUB:

JR316_0003599 JR316_0008028

MRR:	Moror_1385 Moror_17235

E1B28_007686 E1B28_009106

SCM:	SCHCO_01284456(SCHCODRAFT_01284456) SCHCO_02607875(SCHCODRAFT_02607875)

CPUT:

CONPUDRAFT_117110 CONPUDRAFT_59824

SLA:	SERLADRAFT_363249

WSE:	WALSEDRAFT_37442 WALSEDRAFT_66783

WIC:	J056_001516 J056_004424

UMA:	UMAG_04612 UMAG_06065

PFP:	PFL1_01460 PFL1_02036

SGRA:

EX895_002182 EX895_003548

MGL:	MGL_3526 MGL_3786

MRT:	MRET_0589 MRET_0910

MSYM:

MSY001_1846 MSY001_2971

PGR:	PGTG_02893 PGTG_15769

PTRC:

PtA15_14A138 PtA15_17A7

PSTR:

Pst134EA_025877 Pst134EA_030187

MLR:	MELLADRAFT_42930 MELLADRAFT_45803

RIE:	OCT59_003347 OCT59_018836

» show all

Reference

PMID:7920641

Authors

Goyette P, Sumner JS, Milos R, Duncan AM, Rosenblatt DS, Matthews RG, Rozen R

Title

Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification.

Journal

Nat Genet 7:195-200 (1994)
DOI:10.1038/ng0694-195

Sequence

[hsa:4524]

Reference

PMID:29891918

Authors

Froese DS, Kopec J, Rembeza E, Bezerra GA, Oberholzer AE, Suormala T, Lutz S, Chalk R, Borkowska O, Baumgartner MR, Yue WW.

Title

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.

Journal

Nat Commun 9:2261 (2018)
DOI:10.1038/s41467-018-04735-2

Sequence

[hsa:4524] [sce:YPL023C]

LinkDB

ENZYME: 1.5.1.53

Entry

EC 1.5.1.53                 Enzyme

Name

methylenetetrahydrofolate reductase (NADPH);
MTHFR (gene name);
methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase;
5,10-methylenetetrahydrofolate reductase (NADPH);
5,10-methylenetetrahydrofolic acid reductase (ambiguous);
5,10-CH2-H4folate reductase (ambiguous);
methylenetetrahydrofolate reductase (NADPH2);
5,10-methylenetetrahydrofolate reductase (ambiguous);
methylenetetrahydrofolate reductase (ambiguous);
N5,10-methylenetetrahydrofolate reductase (ambiguous);
5,10-methylenetetrahydropteroylglutamate reductase (ambiguous);
N5,N10-methylenetetrahydrofolate reductase (ambiguous);
methylenetetrahydrofolic acid reductase (ambiguous);
5-methyltetrahydrofolate:(acceptor) oxidoreductase (incorrect);
5,10-methylenetetrahydrofolate reductase (FADH2) (ambiguous)

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

5-methyltetrahydrofolate:NADP+ oxidoreductase

Reaction(IUBMB)

5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH + H+ [RN:R01224]

Reaction(KEGG)

R01224

Substrate

5-methyltetrahydrofolate [CPD:C00440];
NADP+ [CPD:C00006]

Product

5,10-methylenetetrahydrofolate [CPD:C00143];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

A flavoprotein (FAD). The enzyme from yeast and mammals catalyses a physiologically irreversible reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using NADPH as the electron donor. It plays an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. The enzyme contains an N-terminal catalytic domain and a C-terminal allosteric regulatory domain that binds S-adenosyl-L-methionine, which acts as an inhibitor. cf. EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]; and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin).

History

EC 1.5.1.53 created 2021

Pathway

ec00670

One carbon pool by folate

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K25004

methylenetetrahydrofolate reductase (NADPH)

Genes

HSA:	4524(MTHFR)

PTR:	469800(MTHFR)

PPS:	100975693(MTHFR)

GGO:	101134157(MTHFR)

PON:	100454623(MTHFR)

PPYG:

129007712(MTHFR)

NLE:	105738058(MTHFR)

HMH:	116812932(MTHFR)

SSYN:

129471863(MTHFR)

MCC:	714840(MTHFR)

MCF:	102117536(MTHFR)

MTHB:

126953028

MNI:	105473166(MTHFR)

CSAB:

103225598(MTHFR)

CATY:

105580856(MTHFR)

PANU:

101019898(MTHFR)

TGE:	112616737(MTHFR)

MLEU:

105551372(MTHFR)

RRO:	104657549(MTHFR)

RBB:	108539360(MTHFR)

TFN:	117093311(MTHFR)

PTEH:

111526316(MTHFR)

CANG:

105507372(MTHFR)

CJC:	100391000(MTHFR)

SBQ:	101043467(MTHFR)

CIMI:

108286453(MTHFR)

ANAN:

105731778(MTHFR)

CSYR:

103266205(MTHFR)

MMUR:

105882714(MTHFR)

LCAT:

123634470(MTHFR)

ERUF:

138390453(MTHFR)

PCOQ:

105824906(MTHFR)

OGA:	100960485(MTHFR)

MMU:	17769(Mthfr)

MCAL:

110293543(Mthfr)

MPAH:

110323320(Mthfr)

RNO:	362657(Mthfr)

MCOC:

116097006(Mthfr)

ANU:	117708999(Mthfr)

ASYL:

127681655(Mthfr)

MUN:	110555748(Mthfr)

CGE:	100774930(Mthfr)

MAUA:

101832815(Mthfr)

PROB:

127213260(Mthfr)

PLEU:

114709673(Mthfr)

PMAV:

102904692(Mthfr)

MORG:

121441775(Mthfr) 121447985

MFOT:

126508160

AAMP:

119817717(Mthfr)

CNL:	130883314(Mthfr)

NGI:	103747470(Mthfr)

HGL:	101719335(Mthfr)

CPOC:

100715703(Mthfr)

CCAN:

109697792(Mthfr)

DORD:

105997431(Mthfr)

DSP:	122121484(Mthfr)

DMER:

138838182(Mthfr)

PLOP:

125354578(Mthfr)

NCAR:

124983882

MMMA:

107155492(Mthfr)

ITI:	101956899(Mthfr)

OCU:

100352874

OPI:	101527929(MTHFR)

OCZ:	121161501(MTHFR)

TUP:	102476978(MTHFR)

GVR:	103605195(MTHFR)

CFA:	478230(MTHFR)

CLUD:

112678116(MTHFR)

VVP:	112929750(MTHFR)

VLG:	121496764(MTHFR)

NPO:	129513898(MTHFR)

AML:	100469351(MTHFR)

UMR:	103666650(MTHFR)

UAH:	113270501(MTHFR)

UAR:	123779081(MTHFR)

ELK:

111154700

LLV:

125096774

MPUF:

101694159(MTHFR)

MNP:	132001220(MTHFR)

MLK:	131810442(MTHFR)

NVS:	122899460(MTHFR)

ORO:	101367692(MTHFR)

EJU:	114213206(MTHFR)

ZCA:	113933704(MTHFR)

MLX:	118020001(MTHFR)

NSU:	110574669(MTHFR)

LWW:	102742884(MTHFR)

FCA:	101100576(MTHFR)

PYU:	121021216(MTHFR)

PCOO:

112871980(MTHFR)

PBG:	122479932(MTHFR)

PVIV:

125171998(MTHFR)

LRUF:

124514789

LGF:	123597189(MTHFR)

AJU:

106971872

PTG:	102969340(MTHFR)

PPAD:

109274118(MTHFR)

PUC:

125913110

PLEZ:

122228801(MTHFR)

HHV:	120233615(MTHFR)

BTA:	497032(MTHFR)

BOM:	102286710(MTHFR)

BIU:	109570335(MTHFR)

BBUB:

102395627(MTHFR)

BKE:	129653043(MTHFR)

BBIS:

104995835(MTHFR)

CHX:	102182523(MTHFR)

OAS:	101111645(MTHFR)

BTAX:

128061407(MTHFR)

CSUM:

138090547(MTHFR)

ODA:	120880227(MTHFR)

CCAD:

122451796(MTHFR)

MREE:

136168371(MTHFR)

OVR:	110137929(MTHFR)

MBEZ:

129551542(MTHFR)

SSC:	397180(MTHFR)

CFR:	102505417(MTHFR)

CBAI:

105070965(MTHFR)

CDK:	105107034(MTHFR)

VPC:	102532634(MTHFR)

BACU:

102998853(MTHFR)

BMUS:

118905488(MTHFR)

LVE:	103079236(MTHFR)

OOR:	101287316(MTHFR)

LALB:

132515228(MTHFR)

GMF:	115864539(MTHFR)

DDP:	132427212(MTHFR)

DLE:	111187289(MTHFR)

PCAD:

102986652(MTHFR)

PSIU:

116748237(MTHFR)

PPHC:

136121646(MTHFR)

NASI:

112402713(MTHFR)

ECB:	100050979(MTHFR)

EPZ:	103552183(MTHFR)

EAI:	106836668(MTHFR)

MYB:	102245334(MTHFR)

MYD:	102764267(MTHFR)

MMYO:

118675486(MTHFR)

MLF:	102437960(MTHFR)

MDT:	132231678(MTHFR)

MYUM:

139002875(MTHFR)

PKL:	118732048(MTHFR)

EFUS:

103295330(MTHFR)

MNA:	107531557(MTHFR)

DRO:	112299114(MTHFR)

SHON:

118986343(MTHFR)

AJM:	119064129(MTHFR)

PDIC:

114496601(MTHFR)

PHAS:

123831738(MTHFR)

MMF:	118626195(MTHFR)

PPAM:

129075652(MTHFR)

HAI:	109381260(MTHFR)

RFQ:	117027712(MTHFR)

PALE:

102882062(MTHFR)

PGIG:

120585812(MTHFR)

PVP:	105294362(MTHFR)

RAY:	107513124(MTHFR)

MJV:	108385719(MTHFR)

TOD:	119236603(MTHFR)

SFUM:

130020331(MTHFR)

SETR:

126011521(MTHFR)

LAV:	100661160(MTHFR)

TMU:

101359718

ETF:	101638069(MTHFR)

DNM:	101428504(MTHFR)

MDO:	100018128(MTHFR)

GAS:	123240311(MTHFR)

AFZ:

127555865

PCW:	110199057(MTHFR)

TVP:	118838870(MTHFR)

PBRV:

138154551(MTHFR)

MLAO:

141509141(MTHFR)

OAA:	100086119(MTHFR)

TACU:

119928296(MTHFR)

GGA:	419489(MTHFR)

PCOC:

116242702(MTHFR)

MGP:	100543073(MTHFR)

CJO:	107323372(MTHFR)

TPAI:

128084952(MTHFR)

LMUT:

125703509(MTHFR)

NMEL:

110408579(MTHFR)

APLA:

101805333(MTHFR)

AACU:

137843222(MTHFR)

ACYG:

106040241(MTHFR)

CATA:

118253386(MTHFR)

AFUL:

116497721(MTHFR)

TGU:	100220660(MTHFR)

LSR:	110479731(MTHFR)

SCAN:

103820847(MTHFR)

PMOA:

120496725(MTHFR)

OTC:	121343904(MTHFR)

PRUF:

121358379(MTHFR)

ATRC:

139600792(MTHFR)

GFR:	102033068(MTHFR)

FAB:	101817361(MTHFR)

OMA:	130261721(MTHFR)

PHI:	102109675(MTHFR)

PMAJ:

107213633(MTHFR)

CCAE:

111938714(MTHFR)

CCW:	104693242(MTHFR)

CBRC:

103616120(MTHFR)

ACOE:

138121462(MTHFR)

ETL:	114056920(MTHFR)

ZAB:	102071430(MTHFR)

ZLE:	135456507(MTHFR)

ACHL:

103807228(MTHFR)

SVG:	106856415(MTHFR)

MMEA:

130583060(MTHFR)

HRT:	120762427(MTHFR)

SATI:

136370757(MTHFR)

CFAI:

136300708(MTHFR)

CCIC:

134053014(MTHFR)

FPG:	101920680(MTHFR)

FCH:	102053108(MTHFR)

CCRI:

104162212(MTHFR)

NNT:	104403185(MTHFR)

SHAB:

115617312(MTHFR)

ACUN:

113487781(MTHFR)

SURA:

141953970(MTHFR)

TALA:

104368439(MTHFR)

ACHC:

115343387(MTHFR)

HALD:

104317869(MTHFR)

HLE:	104837887(MTHFR)

AGEN:

126036762

HHAR:

128144633(MTHFR)

BBUT:

142030914(MTHFR)

GCL:

127024779

CSTI:

104554865(MTHFR)

LDI:	104347526(MTHFR)

MNB:	103776798(MTHFR)

DPUB:

104305839(MTHFR)

PPUS:

135190648(MTHFR)

AVIT:

104269937(MTHFR)

EGZ:	104133086(MTHFR)

NNI:	104009002(MTHFR)

PCRI:

104028163(MTHFR)

PCAO:

104042256(MTHFR)

PADL:

103918045(MTHFR)

AFOR:

103907443(MTHFR)

FGA:	104079210(MTHFR)

CBOR:

142092447(MTHFR)

GSTE:

104251132(MTHFR)

CBOY:

140661655(MTHFR)

MAME:

142418620(MTHFR)

CLV:	102089900(MTHFR)

CNIC:

135997385(MTHFR)

MUI:	104548100(MTHFR)

PGUU:

104465847(MTHFR)

PLET:

104624937(MTHFR)

EHS:	104503465(MTHFR)

CMAC:

104479122(MTHFR)

CUCA:

104060557(MTHFR)

TEO:	104378985(MTHFR)

BREG:

104633204(MTHFR)

GAME:

129215732(MTHFR)

OHA:	104332674(MTHFR)

ACAR:

104523067(MTHFR)

CPEA:

104395435(MTHFR)

CVF:	104290447(MTHFR)

RTD:	128918501(MTHFR)

CRID:

134524047(MTHFR)

LMIC:

141732098(MTHFR)

NARQ:

141473909(MTHFR)

AAM:	106482439(MTHFR)

AROW:

112970030(MTHFR)

NPD:	112959653(MTHFR)

TGT:	104577392(MTHFR)

DNE:	112980540(MTHFR)

SCAM:

104141860(MTHFR)

ASN:	102373612(MTHFR)

AMJ:	102573230(MTHFR)

CPOO:

109314267(MTHFR)

GGN:	109293666(MTHFR)

PSS:	102448267(MTHFR)

CIZ:	142025623(MTHFR)

CMY:	102945698(MTHFR)

CCAY:

125624226(MTHFR)

LKP:	140900168(MTHFR)

NDS:	141974313(MTHFR)

DCC:	119845049(MTHFR)

CPIC:

101950023(MTHFR)

TST:	117867765(MTHFR)

CABI:

116821910(MTHFR)

MRV:	120387999(MTHFR)

ACS:	100554267(mthfr)

ASAO:

132764724(MTHFR)

PVT:	110073216(MTHFR)

SUND:

121936126(MTHFR)

PBI:	103051539(MTHFR)

PMUR:

107294169(MTHFR)

CTIG:

120313278(MTHFR)

PGUT:

117659694(MTHFR)

PCAE:

139325944(MTHFR)

APRI:

131187094(MTHFR)

PTEX:

113450046(MTHFR)

NSS:	113428245(MTHFR)

VKO:	123031059(MTHFR)

PRAF:

128419874(MTHFR)

ZVI:	118087419(MTHFR)

HCG:	128338595(MTHFR)

GJA:	107117727(MTHFR)

STOW:

125445948(MTHFR)

EMC:	129345036(MTHFR)

XLA:	108697556(mthfr.S) 379784(mthfr.L)

XTR:	100125082(mthfr)

NPR:	108799423(MTHFR)

RTEM:

120915514(MTHFR)

ACAT:

141111135(MTHFR)

PADS:

140340538(MTHFR)

BBUF:

120999546(MTHFR)

BGAR:

122928824(MTHFR)

DTC:	141097678(MTHFR)

PWL:	138301121(MTHFR)

MUO:	115456800(MTHFR)

GSH:	117348775(MTHFR)

DRE:	567547(mthfr)

SRX:	107710792(mthfr) 107748978

SANH:

107687111 107691055

SGH:	107595790 107602465

CCAR:

109092734 109093262

CAUA:

113097248 113107832

CGIB:

127962931 128018193

PTET:

122350940(mthfr)

LROH:

127169447(mthfr)

GRF:	141286516(mthfr)

OMC:	131546356(mthfr)

PPRM:

120490013(mthfr)

RKG:	130082031(mthfr)

MAMB:

125280298(mthfr)

CIDE:

127518047

CERY:

137027308(mthfr)

MASI:

127414475 127424732

TROS:

130549617(mthfr)

TDW:	130439745(mthfr)

MANU:

129414952(mthfr)

PDAB:

135729911(mthfr)

IPU:

108265037

IFU:	128607571(mthfr)

PHYP:

113533585(mthfr)

SMEO:

124399833(mthfr)

TFD:	113656298(mthfr)

TVC:	132853862(mthfr)

CGAR:

128529776(mthfr)

NGRA:

132892937(mthfr)

TRN:	134317787(mthfr)

AMEX:

103033176(mthfr)

CMAO:

118813595(mthfr)

EEE:	113578182(mthfr)

CHAR:

122131825(mthfr)

SPIL:

134087195(mthfr)

ASAD:

121712965(mthfr)

TRU:	101078210(mthfr)

TFS:	130530456(mthfr)

TNG:	GSTEN00004910G001

LCO:	104936586(mthfr)

NCC:

104955699

TBEN:

117481494(mthfr)

PGEO:

117449835(mthfr)

GACU:

117559267(mthfr)

EMAC:

134861515(mthfr)

ELY:	117258736(mthfr)

EFO:	125891990(mthfr)

PLEP:

121947149(mthfr)

SLUC:

116058866(mthfr)

ECRA:

117948295

ESP:	116691919(mthfr)

PFLV:

114558693(mthfr)

GAT:	120829205(mthfr)

PPUG:

119223711(mthfr)

AFB:	129099663(mthfr)

CLUM:

117733916(mthfr)

PSWI:

130199689(mthfr)

CANA:

137800094(mthfr)

CVE:	137889730(mthfr)

MSAM:

119904965(mthfr)

SCHU:

122883725(mthfr)

EARM:

139289158(mthfr)

CUD:	121518041(mthfr)

SPUL:

138589975(mthfr)

LMIX:

132989811(mthfr)

HTC:	141798775(mthfr)

ALAT:

119023563(mthfr)

ASTR:

137604061(mthfr)

PKLU:

139209683(mthfr)

MZE:	101481615(mthfr)

ONL:	100706052(mthfr)

OAU:	116326127(mthfr)

OLA:	101173920(mthfr)

OML:	112140866(mthfr)

CSAI:

133456301(mthfr)

XMA:	102216417(mthfr)

XCO:	114141964(mthfr)

XHE:	116724335(mthfr)

PRET:

103466998(mthfr)

PFOR:

103154252(mthfr)

PLAI:

106947843(mthfr)

PMEI:

106926580(mthfr)

GAF:	122832650 122833189

PPRL:

129371664(mthfr)

CVG:	107102655(mthfr)

CTUL:

119786289(mthfr)

GMU:	124872528(mthfr)

NFU:	107391521(mthfr)

KMR:	108249409(mthfr)

ALIM:

106529348(mthfr)

NWH:	119429280 119429296

AOCE:

111566112(mthfr)

EJA:	138193333(mthfr)

BFRE:

138618391(mthfr)

MCEP:

125024165(mthfr)

CSEM:

103384826(mthfr)

SSEN:

122777158(mthfr)

SSOE:

131468122(mthfr)

HHIP:

117765126(mthfr)

HSP:	118110475(mthfr)

PPLT:

128443060(mthfr)

SMAU:

118316574(mthfr)

LCF:

108900502

SDU:	111233770(mthfr)

SLAL:

111658836(mthfr)

XGL:	120803549(mthfr)

HCQ:	109528734(mthfr)

SSCV:

125987776(mthfr)

SBIA:

133511920(mthfr)

PEE:	133408300(mthfr)

PTAO:

133486619(mthfr)

BPEC:

110165619(mthfr)

ENY:	140363016(mthfr)

MALB:

109951049(mthfr)

SJO:	128357914(mthfr)

SSCO:

133988297(mthfr)

TTY:	137183985(mthfr)

GMH:	115547166(mthfr)

SASA:

106572128(mthfr)

STRU:

115166009 115168944

OTW:	112215984 112221595

OMY:	110491842 110532243

OGO:	124031907 124046174

ONE:	115102605 115132121

OKI:	109869406 109907962

OKE:	118360209 118361064

OMM:	135504442 135527384

OCLA:

139368326 139416462

SALP:

111976745 112068446

SNH:	120059363 120060956

SFON:

129824390 129830041

CCLU:

121538303 121545939

ELS:	105013771(mthfr)

OEP:	134019124(mthfr)

SFM:	108924892(mthfr)

PKI:	111859074(mthfr)

AANG:

118207739(mthfr)

AROT:

135233870(mthfr)

CCOG:

133138640(mthfr)

LOC:	102688415(mthfr)

PSPA:

121329149 121329216

ARUT:

117425554 117426084

PSEX:

120531063(mthfr)

LCM:	102358326(MTHFR)

CMK:	103181396(mthfr)

RTP:	109914604(mthfr)

CPLA:

122540329(mthfr)

CPUN:

140487037(mthfr)

HOC:	132833517(mthfr)

SCAU:

119950864(mthfr)

LERI:

129711556(mthfr)

HAKA:

140718357(mthfr)

PMRN:

116955583(MTHFR)

BFO:

118430292

BBEL:

109472626

CIN:

100180174

SCLV:

120326455

CLEP:

143446714

SPU:	115924565 589576

LPIC:

129276741

LVG:

121427223

AJJ:

139975676

APLC:

110979147

ARUN:

117302263

AAMU:

139950428

AFIL:

140167885

AJC:

117106607

SKO:	100368141(MTHFR)

PFLL:

139137353

DGR:

6558496

RZE:

108372277

FCD:

110842614

DPX:	DAPPUDRAFT_301720

DMK:

116931209

DPZ:

124340499

AFRA:

136026694

PVM:

113812240

PJA:

122261979

PCHN:

125024515

PMOO:

119568400

HAME:

121871205

PCLA:

123760246

CQD:

128703779

PTRU:

123503654

ESN:

127002737

MNZ:

135210982

MRJ:

136828643

PORN:

139767199

HAZT:

108681433

OOT:

143018589

EAF:

111701357

TCF:

131884906

DPTE:

113790060 113794623

DFR:	124489958 124493973

CSCU:

111641837

CVS:

136977030

LPOL:

106476448

PMEO:

129593250

CEL:	CELE_C06A8.1(mthf-1)

CBR:

CBG_12960

CRQ:	GCK72_005714

NAI:	NECAME_11843

BMY:	BM_BM1999(Bma-mthf-1)

LOA:	LOAG_08597

TSP:

Tsp_08753

HRO:	HELRODRAFT_111699

LGI:	LOTGIDRAFT_214878

PVUL:

126827707

PCAN:

112556236

LSAX:

138978658

BARL:

143287501

BGT:

106068520

GAE:

121390023

HRF:

124132255

HRJ:

124273373

HASI:

137268460

HCRA:

139470702

CRG:

105340188

CANU:

128189541

CVN:

111138100

OED:

125683372

PMAX:

117344501

AIRR:

138318958

YBA:

132543017

MCAF:

127720074

MMER:

123527799

RPHI:

132735169

DPOL:

127881221

MAEA:

128203507

OBI:

106882151

OSN:

115209099

LJP:

135475130

LAK:	106154846 106174355

LLON:

135496701

NVE:	5512577 5513626

EPA:	110252119 110252167

ATEN:

116304937 116305961

ADF:

107327049

AMIL:

114962073 114969824

MCAZ:

138051197 138051867

MFOO:

137997517 137998011

PDAM:

113668139 113679154

SPIS:

111327128 111332195

DGT:	114528959 114537439

XEN:

124457394

HMG:

100207609

HSY:	130624954 130641462

RES:	135688551 135688553

TAD:	TRIADDRAFT_26971

AQU:

100636961

SCE:	YGL125W(MET13) YPL023C(MET12)

SEUB:

DI49_1849 DI49_5433

SPAO:

SPAR_G01230 SPAR_P02400

AGO:	AGOS_AAR170W AGOS_AFR457W

ERC:	Ecym_1400 Ecym_3063

KLA:	KLLA0_D12188g KLLA0_F09647g

KMX:	KLMA_20276(MET13) KLMA_60378(MET12)

LTH:	KLTH0E11022g KLTH0H06446g

VPO:	Kpol_1007p12 Kpol_223p6

ZRO:	ZYRO0A02838g ZYRO0E01870g

CGR:	2887607(MET13) 2889935(MET12)

NCS:	NCAS_0C02530(NCAS0C02530) NCAS_0D03140(NCAS0D03140)

NDI:	NDAI_0E03230(NDAI0E03230) NDAI_0I01770(NDAI0I01770)

TPF:	TPHA_0C01840(TPHA0C01840) TPHA_0J01830(TPHA0J01830)

TBL:	TBLA_0D02780(TBLA0D02780) TBLA_0F02520(TBLA0F02520)

TGB:	HG536_0H01660 HG536_0H03600

TDL:	TDEL_0B01620(TDEL0B01620) TDEL_0G03480(TDEL0G03480)

KAF:	KAFR_0A04630(KAFR0A04630) KAFR_0H01590(KAFR0H01590)

KNG:	KNAG_0A02370(KNAG0A02370) KNAG_0F02500(KNAG0F02500)

ZMK:	HG535_0B03260 HG535_0C01620

SLUD:

SCDLUD_000993 SCDLUD_001942

DHA:	DEHA2F08976g DEHA2G01254g

PIC:	PICST_71674 PICST_83803

PGU:	PGUG_01501

SPAA:

SPAPADRAFT_137530 SPAPADRAFT_51518

LEL:	PVL30_002085(MET13) PVL30_003470(MET12)

LBG:	92207516(LODBEIA_P23200) 92208703(LODBEIA_P35070)

CAL:	CAALFM_C210460CA(CaO19.5321) CAALFM_C302950CA(MET13)

CTP:	CTRG_02026 CTRG_02573

COT:	CORT_0B03880 CORT_0C03560

CDU:	CD36_24470 CD36_82930

CTEN:

18248645(MET13)

CLU:	CLUG_02387 CLUG_05125

CLUS:

A9F13_03g01133 A9F13_24g00066

CAUR:

CJI96_0001128 CJI96_0002275

ASAU:

88173265(PUMCH_002200) 88175490(PUMCH_004430)

PPA:	PAS_chr2-2_0145 PAS_chr2-2_0182

PKZ:	C5L36_0B07640 C5L36_0D03770

BNN:	FOA43_000536 FOA43_004528

BBRX:

BRETT_001890 BRETT_003148

OPA:	HPODL_00022 HPODL_02993

YLI:	2906737(YALI2_C00796g)

SLB:	AWJ20_3315(MET13) AWJ20_715(MET12)

NCR:	NCU07690 NCU09545

NTE:	NEUTE1DRAFT128536(NEUTE1DRAFT_128536) NEUTE1DRAFT57029(NEUTE1DRAFT_57029)

SMP:	10803567(SMAC4_06582) 10807485(SMAC4_00862)

PAN:	PODANSg7263 PODANSg8765

PBEL:

QC761_209160(MET12) QC761_602690(MET13)

PPSD:

QC762_209160(MET12) QC762_602690(MET13)

PPSP:

QC763_209160(MET12) QC763_602690(MET13)

PPSA:

QC764_209160(MET12) QC764_602690(MET13)

TTT:	THITE_2107143 THITE_2115191

MTM:	MYCTH_2300974 MYCTH_2314160

CTHR:

CTHT_0033700 CTHT_0065570

RTHE:

98126177(VTJ83DRAFT_4984) 98127055(VTJ83DRAFT_5774)

MGR:	MGG_01728 MGG_08171

PPEI:

PpBr36_01245 PpBr36_01602

PGRI:

PgNI_03394 PgNI_03764

TMN:	UCRPA7_3085 UCRPA7_6818

SSCK:

SPSK_03199 SPSK_05053

FGR:	FGSG_07127 FGSG_09572

FPU:	FPSE_04091 FPSE_05848

FPOA:

FPOAC1_010897 FPOAC1_012085

FVN:	FVRRES_11909 FVRRES_13154

FVR:	FVEG_04126 FVEG_08038

FOX:	FOXG_01673 FOXG_06273

NHE:	NECHADRAFT_32750 NECHADRAFT_71723

FFC:	NCS54_00273400 NCS54_01131900

FKR:	NCS57_00269200 NCS57_01122500

FMU:	J7337_002907 J7337_004132

TRE:	TRIREDRAFT_55055 TRIREDRAFT_81824

TRR:	M419DRAFT_104048 M419DRAFT_135784

TATV:

25783884(TrAtP1_001274) 25786594(TrAtP1_011116)

TASP:

36607500(TrAFT101_001202) 36613616(TrAFT101_008965)

MAW:	19252082(MET13)

MAJ:	MAA_01221 MAA_07320

MBRN:

26239328(met9) 26241089(met11)

PCHM:

VFPPC_09868 VFPPC_13512

UVI:	66063890(UV8b_03112) 66065719(UV8b_04941)

CMT:	CCM_04157 CCM_05621

AMUS:

LMH87_004379 LMH87_006725

PLJ:	28882876(PLICBS_001097) 28889940(PLICBS_008653)

PTKZ:

JDV02_005288(MET12) JDV02_007903(MET13)

DCON:

63713339(DCS_00696) 63720277(DCS_07634)

VAL:	VDBG_00123

VDA:	VDAG_00463 VDAG_08410

CFJ:	CFIO01_02428 CFIO01_07029

CLUP:

CLUP02_08015 CLUP02_17462

CHIG:

CH63R_04201 CH63R_07780

CDET:

87941240(CDEST_04737) 87944998(CDEST_08495)

SAPO:

SAPIO_CDS7226

ELA:	UCREL1_6847 UCREL1_9493

PFY:	PFICI_05432 PFICI_08066

SSL:	SS1G_02009 SS1G_09764

BFU:	BCIN_07g02820 BCIN_07g06360

MBE:	MBM_01665 MBM_08501

PSCO:

LY89DRAFT_718062 LY89DRAFT_769751

GLZ:	GLAREA_11463 GLAREA_12614

ANI:	ANIA_05883 ANIA_08215

AFM:	AFUA_2G11300 AFUA_5G03480

ACT:	ACLA_001700 ACLA_070260

NFI:	NFIA_038640 NFIA_086570

AOR:	AO090026000520 AO090102000557

ANG:	An02g03270 An09g05860

AFV:	AFLA_005756 AFLA_011983

ALUC:

AKAW2_21343A AKAW2_40591A

ACHE:

ACHE_40648S ACHE_50694S

APUU:

APUU_10896A APUU_60645S

PCS:	N7525_008123 N7525_009990

PDP:	PDIP_10790 PDIP_48850

POU:	POX_a00488 POX_e07132

PPSF:

300789716(PFLUO_LOCUS3937) 300791519(PFLUO_LOCUS5560)

TMF:	EYB26_003580 EYB26_004262

TRG:	TRUGW13939_07742 TRUGW13939_08425

CIM:	CIMG_06560 CIMG_08202

CPW:	9690534(D8B26_004497) 9695334(D8B26_006209)

URE:	UREG_02453 UREG_03880

ABE:	ARB_01328 ARB_06846

TVE:	TRV_05244 TRV_07376

PBL:	PAAG_03665 PAAG_04294

PBN:	PADG_03172 PADG_07528

AJE:	HCAG_00541 HCAG_07107

BGH:	BDBG_00602 BDBG_01364

PNO:	SNOG_10985(SNOG_10984) SNOG_12690

PTE:	PTT_09481 PTT_18113

PTRR:

6347814(PtrM4_127600) 6349625(PtrM4_070860)

BZE:	COCCADRAFT_87884 COCCADRAFT_96319

BSC:	COCSADRAFT_136346 COCSADRAFT_140784

BOR:	COCMIDRAFT_28378 COCMIDRAFT_4719

AALT:

CC77DRAFT_1092254 CC77DRAFT_958941

ADAC:

96081519(ACET3X_001197) 96083639(ACET3X_003317)

ARAB:

EKO05_0009890 EKO05_0011104

ZTR:	MYCGRDRAFT_109648 MYCGRDRAFT_75203

PFJ:	MYCFIDRAFT_49642 MYCFIDRAFT_81197

FFU:	CLAFUR5_07224 CLAFUR5_07965

CBET:

CB0940_04150 CB0940_09049

BCOM:

BAUCODRAFT_210105 BAUCODRAFT_237275

NPA:	UCRNP2_6300 UCRNP2_9800

TML:	GSTUM_00003351001 GSTUM_00010817001

SPO:	2542993(met9) 2543105(met11)

SOM:	SOMG_01808(met9) SOMG_02033(met11)

CNE:	CNA07390 CNL04820

CNB:	CNBA7210 CNBI2020

CNG:	CNAG_00760 CNAG_05140

CGI:	CGB_A8490W CGB_D2260W

CDEU:

CNBG_1170 CNBG_9485

CDEC:

89987405(IAS62_000629) 89988446(IAS62_001672)

CTEG:

91987074(I308_100216) 91987825(I308_100967)

CBAS:

91980685(I312_100637) 91981001(I312_100953)

CDEP:

91088023(L203_103813) 91089035(L203_104826)

KMG:	30163963(I203_103755) 30166533(I203_100747)

KNE:	92179109(IAR55_001850) 92181595(IAR55_004337)

KDJ:	28968157(I303_104565) 28971481(I303_107777)

KBI:	30206066(I302_102971) 30209702(I302_106179)

KPIN:

30172861(I206_103935) 30175613(I206_106440)

KSH:	87955648(IL334_003517) 87959703(IL334_007573)

KER:	91100187(V865_001383) 91105369(V865_006568)

KSN:	43586640(CI109_101529) 43589620(CI109_105078)

KEP:	91094709(L201_004039) 91097793(L201_007124)

TMS:	TREMEDRAFT_38541 TREMEDRAFT_43239

TASA:

A1Q1_00789 A1Q1_04951

CCAC:

CcaHIS019_0509060(MET13) CcaHIS019_0510340(MET12)

TVS:	TRAVEDRAFT_164884 TRAVEDRAFT_28907

DSQ:	DICSQDRAFT_134054 DICSQDRAFT_177540

PCO:	PHACADRAFT_208793 PHACADRAFT_264540

SHS:	STEHIDRAFT_157081 STEHIDRAFT_75044

HIR:	HETIRDRAFT_445887 HETIRDRAFT_471420

PSQ:	PUNSTDRAFT_113018 PUNSTDRAFT_53586

ADL:	AURDEDRAFT_106360 AURDEDRAFT_142206

FME:	FOMMEDRAFT_100481 FOMMEDRAFT_88181

GTR:	GLOTRDRAFT_105411 GLOTRDRAFT_71781

RSX:	RhiXN_02363 RhiXN_05214

LBC:	LACBIDRAFT_182479 LACBIDRAFT_244474

CCI:	CC1G_00920 CC1G_01198

ABP:	AGABI1DRAFT111963(AGABI1DRAFT_111963) AGABI1DRAFT68194(AGABI1DRAFT_68194)

ABV:	AGABI2DRAFT193205(AGABI2DRAFT_193205) AGABI2DRAFT216007(AGABI2DRAFT_216007)

PCUB:

JR316_0003599 JR316_0008028

MRR:	Moror_1385 Moror_17235

E1B28_007686 E1B28_009106

SCM:	SCHCO_01284456(SCHCODRAFT_01284456) SCHCO_02607875(SCHCODRAFT_02607875)

CPUT:

CONPUDRAFT_117110 CONPUDRAFT_59824

SLA:	SERLADRAFT_363249

WSE:	WALSEDRAFT_37442 WALSEDRAFT_66783

WIC:	J056_001516 J056_004424

UMA:	UMAG_04612 UMAG_06065

PFP:	PFL1_01460 PFL1_02036

SGRA:

EX895_002182 EX895_003548

MGL:	MGL_3526 MGL_3786

MRT:	MRET_0589 MRET_0910

MSYM:

MSY001_1846 MSY001_2971

PGR:	PGTG_02893 PGTG_15769

PTRC:

PtA15_14A138 PtA15_17A7

PSTR:

Pst134EA_025877 Pst134EA_030187

MLR:	MELLADRAFT_42930 MELLADRAFT_45803

RIE:	OCT59_003347 OCT59_018836

» show all

Reference

1 [PMID:13817476]

Authors

DONALDSON KO, KERESZTESY JC.

Title

Naturally occurring forms of folic acid. I. "Prefolic A": preparation of concentrate and enzymatic conversion to citrovorum factor.

Journal

J Biol Chem 234:3235-40 (1959)

Reference

2 [PMID:4399897]

Authors

Kutzbach C, Stokstad EL.

Title

Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine.

Journal

Biochim Biophys Acta 250:459-77 (1971)
DOI:10.1016/0005-2744(71)90247-6

Reference

3 [PMID:6975779]

Authors

Daubner SC, Matthews RG.

Title

Purification and properties of methylenetetrahydrofolate reductase from pig liver.

Journal

J Biol Chem 257:140-5 (1982)

Reference

4 [PMID:2383427]

Authors

Zhou J, Kang SS, Wong PW, Fournier B, Rozen R.

Title

Purification and characterization of methylenetetrahydrofolate reductase from human cadaver liver.

Journal

Biochem Med Metab Biol 43:234-42 (1990)
DOI:10.1016/0885-4505(90)90029-z

Reference

5 [PMID:11729203]

Authors

Roje S, Chan SY, Kaplan F, Raymond RK, Horne DW, Appling DR, Hanson AD.

Title

Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo.

Journal

J Biol Chem 277:4056-61 (2002)
DOI:10.1074/jbc.M110651200

Reference

6 [PMID:29891918]

Authors

Froese DS, Kopec J, Rembeza E, Bezerra GA, Oberholzer AE, Suormala T, Lutz S, Chalk R, Borkowska O, Baumgartner MR, Yue WW.

Title

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition.

Journal

Nat Commun 9:2261 (2018)
DOI:10.1038/s41467-018-04735-2

Sequence

[hsa:4524] [sce:YPL023C]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.53

IUBMB Enzyme Nomenclature:

1.5.1.53

ExPASy - ENZYME nomenclature database:

1.5.1.53

BRENDA, the Enzyme Database:

1.5.1.53

CAS:	71822-25-8

LinkDB

REACTION: R01224

Entry

R01224                      Reaction

Name

5-methyltetrahydrofolate:NADP+ oxidoreductase

Definition

5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+

Equation

C00440 + C00006 <=> C00143 + C00005 + C00080

Reaction class

RC00001

C00005_C00006

RC00081

C00143_C00440

Enzyme

1.5.1.20 1.5.1.53

Pathway

rn00670

One carbon pool by folate

rn01100

Metabolic pathways

rn01120

Microbial metabolism in diverse environments

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.20
     R01224  5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+
    1.5.1.53
     R01224  5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+

Orthology

K25004

methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.53]

K25009

methylenetetrahydrofolate reductase [NAD(P)H] [EC:1.5.1.20]

Other DBs

RHEA:

19820

LinkDB

DBGET integrated database retrieval system