KEGG ORTHOLOGY: K25221

ORTHOLOGY: K25221

Entry

K25221                      KO

Symbol

mtgA

Name

[methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.378]

Pathway

map00670

One carbon pool by folate

map00720

Other carbon fixation pathways

map01100

Metabolic pathways

Reaction

R02289

5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00720 Other carbon fixation pathways
    K25221  mtgA; [methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K25221  mtgA; [methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.378  [methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase
     K25221  mtgA; [methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase

Other DBs

COG:

COG1962

Genes

CACE:

CACET_c34490(mtrH)

DSY:

DSY3157

DHD:

Dhaf_4327

DDH:	Desde_3696

DOR:	Desor_0411

DMI:	Desmer_0447

FWA:	DCMF_08820

TJR:	TherJR_2947

AWO:	Awo_c07520(mttA2)

AWI:	CHL1_003005

AMAJ:

ACIUZZ_16590

GFE:	Gferi_19930

STED:

SPTER_06960(mtgA_2)

SSPH:

SPSPH_008890(mtgA_2)

SOVA:

SOV_47260

SSID:

SPSIL_045090(mtgA_3)

MVJ:	ACO0C9_02080

» show all

Reference

PMID:25313086

Authors

Ticak T, Kountz DJ, Girosky KE, Krzycki JA, Ferguson DJ Jr.

Title

A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase.

Journal

Proc Natl Acad Sci U S A 111:E4668-76 (2014)
DOI:10.1073/pnas.1409642111

Sequence

[dsy:DSY3157]

LinkDB

ENZYME: 2.1.1.378

Entry

EC 2.1.1.378                Enzyme

Name

[methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase;
mtgA (gene name);
DSY3157 (locus name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

[methyl-Co(III) glycine betaine-specific corrinoid protein]:tetrahydrofolate N-methyltransferase

Reaction(IUBMB)

a [methyl-Co(III) glycine betaine-specific corrinoid protein] + tetrahydrofolate = a [Co(I) glycine betaine-specific corrinoid protein] + 5-methyltetrahydrofolate [RN:R02289]

Reaction(KEGG)

R02289

Substrate

[methyl-Co(III) glycine betaine-specific corrinoid protein];
tetrahydrofolate [CPD:C00101]

Product

[Co(I) glycine betaine-specific corrinoid protein];
5-methyltetrahydrofolate [CPD:C00440]

Comment

This enzyme, characterized from the anaerobic bacterium Desulfitobacterium hafniense Y51, catalyses a similar reaction to that of EC 2.1.1.258, 5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase, but in the opposite direction, transferring a methyl group from a methylated corrinoid protein to tetrahydrofolate. The corrinoid protein is specifically methylated by EC 2.1.1.376, glycine betaine---corrinoid protein Co-methyltransferase.

History

EC 2.1.1.378 created 2021

Pathway

ec00670

One carbon pool by folate

ec00720

Other carbon fixation pathways

ec01100

Metabolic pathways

Orthology

K25221

[methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase

Genes

CACE:

CACET_c34490(mtrH)

DSY:

DSY3157

DHD:

Dhaf_4327

DDH:	Desde_3696

DOR:	Desor_0411

DMI:	Desmer_0447

FWA:	DCMF_08820

TJR:	TherJR_2947

AWO:	Awo_c07520(mttA2)

AWI:	CHL1_003005

AMAJ:

ACIUZZ_16590

GFE:	Gferi_19930

STED:

SPTER_06960(mtgA_2)

SSPH:

SPSPH_008890(mtgA_2)

SOVA:

SOV_47260

SSID:

SPSIL_045090(mtgA_3)

MVJ:	ACO0C9_02080

» show all

Reference

1 [PMID:25313086]

Authors

Ticak T, Kountz DJ, Girosky KE, Krzycki JA, Ferguson DJ Jr.

Title

A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase.

Journal

Proc Natl Acad Sci U S A 111:E4668-76 (2014)
DOI:10.1073/pnas.1409642111

Sequence

[dsy:DSY3157]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.378

IUBMB Enzyme Nomenclature:

2.1.1.378

ExPASy - ENZYME nomenclature database:

2.1.1.378

BRENDA, the Enzyme Database:

2.1.1.378

LinkDB

REACTION: R02289

Entry

R02289                      Reaction

Name

5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase;
[methyl-Co(III) glycine betaine-specific corrinoid protein]:tetrahydrofolate N-methyltransferase

Definition

5-Methyltetrahydrofolate + Co(I) corrinoid protein + H+ <=> Methyl-Co(III) corrinoid protein + Tetrahydrofolate

Equation

C00440 + C06021 + C00080 <=> C06020 + C00101

Reaction class

RC00113

C00101_C00440

RC01144

C06020_C06021

RC02871

C00440_C06020

Enzyme

2.1.1.258 2.1.1.378 2.1.1.385 2.1.1.389

Pathway

rn00670

One carbon pool by folate

rn00720

Other carbon fixation pathways

rn01100

Metabolic pathways

Module

M00377

Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway)

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.258
     R02289  5-Methyltetrahydrofolate + Co(I) corrinoid protein + H+ <=> Methyl-Co(III) corrinoid protein + Tetrahydrofolate
    2.1.1.378
     R02289  5-Methyltetrahydrofolate + Co(I) corrinoid protein + H+ <=> Methyl-Co(III) corrinoid protein + Tetrahydrofolate
    2.1.1.385
     R02289  5-Methyltetrahydrofolate + Co(I) corrinoid protein + H+ <=> Methyl-Co(III) corrinoid protein + Tetrahydrofolate
    2.1.1.389
     R02289  5-Methyltetrahydrofolate + Co(I) corrinoid protein + H+ <=> Methyl-Co(III) corrinoid protein + Tetrahydrofolate

Orthology

K15023

5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase [EC:2.1.1.258]

K25221

[methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.378]

K25915

[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.385]

K26930

[methyl-Co(III) quaternary-amine-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.389]

Other DBs

RHEA:

45203 66003 75874 75878

LinkDB

DBGET integrated database retrieval system