KEGG   ORTHOLOGY: K25522
Entry
K25522                      KO                                     
Symbol
CYP76F112
Name
marmesin synthase [EC:1.14.14.66]
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various plant secondary metabolites
    K25522  CYP76F112; marmesin synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K25522  CYP76F112; marmesin synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.66  marmesin synthase
     K25522  CYP76F112; marmesin synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP76 family
   K25522  CYP76F112; marmesin synthase
Other DBs
RN: R08997
Genes
AG: QVT76730(CYP76F112)
Reference
  Authors
Villard C, Munakata R, Kitajima S, van Velzen R, Schranz ME, Larbat R, Hehn A
  Title
A new P450 involved in the furanocoumarin pathway underlies a recent case of convergent evolution.
  Journal
New Phytol 231:1923-1939 (2021)
DOI:10.1111/nph.17458
  Sequence
LinkDB

KEGG   ENZYME: 1.14.14.66
Entry
EC 1.14.14.66               Enzyme                                 
Name
marmesin synthase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
demethylsuberosin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
demethylsuberosin + [reduced NADPH---hemoprotein reductase] + O2 = (+)-marmesin + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R08997]
Reaction(KEGG)
R08997
Substrate
demethylsuberosin [CPD:C18083];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(+)-marmesin [CPD:C09276];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A P-450 monoxygenase involved in psoralen biosynthesis, see EC 1.14.13.102, psoralen synthase.
History
EC 1.14.14.66 created 2018
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01110  Biosynthesis of secondary metabolites
Orthology
K25522  marmesin synthase
Reference
1  [PMID:2828055]
  Authors
Hamerski D, Matern U
  Title
Elicitor-induced biosynthesis of psoralens in Ammi majus L. suspension cultures.  Microsomal conversion of demethylsuberosin into (+)marmesin and psoralen.
  Journal
Eur J Biochem 171:369-75 (1988)
DOI:10.1111/j.1432-1033.1988.tb13800.x
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.66
IUBMB Enzyme Nomenclature: 1.14.14.66
ExPASy - ENZYME nomenclature database: 1.14.14.66
BRENDA, the Enzyme Database: 1.14.14.66
LinkDB

KEGG   REACTION: R08997
Entry
R08997                      Reaction                               
Name
demethylsuberosin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Definition
Demethylsuberosin + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Marmesin + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Enzyme
Pathway
rn00999  Biosynthesis of various plant secondary metabolites
rn01110  Biosynthesis of secondary metabolites
Orthology
K25522  marmesin synthase [EC:1.14.14.66]
Other DBs
RHEA: 32474
LinkDB

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