KEGG ORTHOLOGY: K25915

ORTHOLOGY: K25915

Entry

K25915                      KO

Symbol

mtvA

Name

[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.385]

Pathway

map00670

One carbon pool by folate

map00720

Other carbon fixation pathways

map01100

Metabolic pathways

Reaction

R02289

5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00720 Other carbon fixation pathways
    K25915  mtvA; [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K25915  mtvA; [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.385  [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase
     K25915  mtvA; [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase

Other DBs

COG:

COG1410

Genes

DOR:	Desor_3940

DAI:	Desaci_1203

DMI:	Desmer_3054

AACX:

DEACI_1429

TPZ:	Tph_c01810

MTA:	Moth_0385 Moth_1318

MTHO:

MOTHE_c03140(acsE1) MOTHE_c13030(acsE4)

MTHZ:

MOTHA_c04100(acsE1) MOTHA_c13890(acsE4)

MHUI:

MHLNE_19910(acsE_2)

NCJ:	MCACP_21280(acsE_2)

Reference

PMID:18631365

Authors

Pierce E, Xie G, Barabote RD, Saunders E, Han CS, Detter JC, Richardson P, Brettin TS, Das A, Ljungdahl LG, Ragsdale SW

Title

The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum).

Journal

Environ Microbiol 10:2550-73 (2008)
DOI:10.1111/j.1462-2920.2008.01679.x

Sequence

[mta:Moth_0385 Moth_1318]

LinkDB

ENZYME: 2.1.1.385

Entry

EC 2.1.1.385                Enzyme

Name

[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase;
mtvA (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

[methylated methoxylated-aromatic-compound-specific corrinoid protein]:tetrahydrofolaten methyltransferase

Reaction(IUBMB)

a [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein] + tetrahydrofolate = N5-methyltetrahydrofolate + a [Co(I) methoxylated-aromatic-compound-specific corrinoid protein] [RN:R02289]

Reaction(KEGG)

R02289

Substrate

[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein];
tetrahydrofolate [CPD:C00101]

Product

N5-methyltetrahydrofolate;
[Co(I) methoxylated-aromatic-compound-specific corrinoid protein]

Comment

The enzyme, found in acetogenic bacteria, participates in a pathway for the degradation of methoxylated aromatic compounds (methoxydotrophic growth). The enzyme catalyses the transfer of a methyl group bound to the cobalt cofactor of a dedicated corrinoid protein (MtvC) to tetrahydrofolate. cf. EC 2.1.1.384, [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydromethanopterin methyltransferase.

History

EC 2.1.1.385 created 2022

Pathway

ec00670

One carbon pool by folate

ec00720

Other carbon fixation pathways

ec01100

Metabolic pathways

Orthology

K25915

[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase

Genes

DOR:	Desor_3940

DAI:	Desaci_1203

DMI:	Desmer_3054

AACX:

DEACI_1429

TPZ:	Tph_c01810

MTA:	Moth_0385 Moth_1318

MTHO:

MOTHE_c03140(acsE1) MOTHE_c13030(acsE4)

MTHZ:

MOTHA_c04100(acsE1) MOTHA_c13890(acsE4)

MHUI:

MHLNE_19910(acsE_2)

NCJ:	MCACP_21280(acsE_2)

Reference

1 [PMID:9654069]

Authors

Kaufmann F, Wohlfarth G, Diekert G.

Title

O-demethylase from Acetobacterium dehalogenans--substrate specificity and function of the participating proteins.

Journal

Eur J Biochem 253:706-11 (1998)
DOI:10.1046/j.1432-1327.1998.2530706.x

Reference

2 [PMID:11344134]

Authors

Naidu D, Ragsdale SW.

Title

Characterization of a three-component vanillate O-demethylase from Moorella thermoacetica.

Journal

J Bacteriol 183:3276-81 (2001)
DOI:10.1128/JB.183.11.3276-3281.2001

Reference

3 [PMID:18631365]

Authors

Pierce E, Xie G, Barabote RD, Saunders E, Han CS, Detter JC, Richardson P, Brettin TS, Das A, Ljungdahl LG, Ragsdale SW

Title

The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum).

Journal

Environ Microbiol 10:2550-73 (2008)
DOI:10.1111/j.1462-2920.2008.01679.x

Sequence

[mta:Moth_0385 Moth_1318]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.385

IUBMB Enzyme Nomenclature:

2.1.1.385

ExPASy - ENZYME nomenclature database:

2.1.1.385

BRENDA, the Enzyme Database:

2.1.1.385

LinkDB

REACTION: R02289

Entry

R02289                      Reaction

Name

5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase;
[methyl-Co(III) glycine betaine-specific corrinoid protein]:tetrahydrofolate N-methyltransferase

Definition

5-Methyltetrahydrofolate + Co(I) corrinoid protein + H+ <=> Methyl-Co(III) corrinoid protein + Tetrahydrofolate

Equation

C00440 + C06021 + C00080 <=> C06020 + C00101

Reaction class

RC00113

C00101_C00440

RC01144

C06020_C06021

RC02871

C00440_C06020

Enzyme

2.1.1.258 2.1.1.378 2.1.1.385 2.1.1.389

Pathway

rn00670

One carbon pool by folate

rn00720

Other carbon fixation pathways

rn01100

Metabolic pathways

Module

M00377

Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway)

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.258
     R02289  5-Methyltetrahydrofolate + Co(I) corrinoid protein + H+ <=> Methyl-Co(III) corrinoid protein + Tetrahydrofolate
    2.1.1.378
     R02289  5-Methyltetrahydrofolate + Co(I) corrinoid protein + H+ <=> Methyl-Co(III) corrinoid protein + Tetrahydrofolate
    2.1.1.385
     R02289  5-Methyltetrahydrofolate + Co(I) corrinoid protein + H+ <=> Methyl-Co(III) corrinoid protein + Tetrahydrofolate
    2.1.1.389
     R02289  5-Methyltetrahydrofolate + Co(I) corrinoid protein + H+ <=> Methyl-Co(III) corrinoid protein + Tetrahydrofolate

Orthology

K15023

5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase [EC:2.1.1.258]

K25221

[methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.378]

K25915

[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.385]

K26930

[methyl-Co(III) quaternary-amine-specific corrinoid protein]---tetrahydrofolate methyltransferase [EC:2.1.1.389]

Other DBs

RHEA:

45203 66003 75874 75878

LinkDB

DBGET integrated database retrieval system