KEGG   ORTHOLOGY: K26037
Entry
K26037                      KO                                     
Symbol
CYP76AD1
Name
tyrosine hydroxylase / L-DOPA oxygenase [EC:1.14.-.-]
Pathway
map00965  Betalain biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00961  Betacyanin biosynthesis, L-tyrosine => amaranthin
Reaction
R13031  
R13032  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00965 Betalain biosynthesis
    K26037  CYP76AD1; tyrosine hydroxylase / L-DOPA oxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K26037  CYP76AD1; tyrosine hydroxylase / L-DOPA oxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP76 family
   K26037  CYP76AD1; tyrosine hydroxylase / L-DOPA oxygenase
Genes
BVG: 104904803 104904820 104904821 104904822 104908380
SOE: 110779367 110779509 110786794 110786796 110788013 110788024 110792889 110792903
CQI: 110685025 110685039 110699385 110733547 110740013
ATRI: 130803140 130806374 130819900 130820538 130820773 130820799
AG: AET43289(CYP76AD1)
Reference
PMID:22660548
  Authors
Hatlestad GJ, Sunnadeniya RM, Akhavan NA, Gonzalez A, Goldman IL, McGrath JM, Lloyd AM
  Title
The beet R locus encodes a new cytochrome P450 required for red betalain production.
  Journal
Nat Genet 44:816-20 (2012)
DOI:10.1038/ng.2297
  Sequence
[ag:AET43289]
Reference
PMID:34782819
  Authors
Tomizawa E, Ohtomo S, Asai K, Ohta Y, Takiue Y, Hasumi A, Nishihara M, Nakatsuka T
  Title
Additional betalain accumulation by genetic engineering leads to a novel flower color in lisianthus (Eustoma grandiflorum).
  Journal
Plant Biotechnol (Tokyo) 38:323-330 (2021)
DOI:10.5511/plantbiotechnology.21.0516a
LinkDB

KEGG   REACTION: R13032
Entry
R13032                      Reaction                               
Definition
3,4-Dihydroxy-L-phenylalanine + NADPH + Oxygen + H+ <=> 2-Carboxy-2,3-dihydro-5,6-dihydroxyindole + NADP+ + 2 H2O
Equation
C00355 + C00005 + C00007 + C00080 <=> C05604 + C00006 + 2 C00001
Comment
L-DOPA oxygenase
Enzyme
1.14.-.-
Pathway
rn00965  Betalain biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00961  Betacyanin biosynthesis, L-tyrosine => amaranthin
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.-  Acting on paired donors, with incorporation or reduction of molecular oxygen
    1.14.-.-
     R13032  3,4-Dihydroxy-L-phenylalanine + NADPH + Oxygen + H+ <=> 2-Carboxy-2,3-dihydro-5,6-dihydroxyindole + NADP+ + 2 H2O
Orthology
K26037  tyrosine hydroxylase / L-DOPA oxygenase [EC:1.14.-.-]
Reference
1  [PMID:32745157]
  Authors
Lichman BR.
  Title
The scaffold-forming steps of plant alkaloid biosynthesis.
  Journal
Nat Prod Rep 38:103-129 (2021)
DOI:10.1039/d0np00031k
LinkDB

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