KEGG ORTHOLOGY: K27071

ORTHOLOGY: K27071

Entry

K27071                      KO

Symbol

hadA

Name

meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-]

Pathway

map00074

Mycolic acid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00885

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)

M00886

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)

Reaction

R13260

long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

R13264

very-long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (very-long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

R13268

ultra-long-chain-mono-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein]-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00074 Mycolic acid biosynthesis
    K27071  hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K27071  hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA
Lipid biosynthesis proteins [BR:ko01004]
Fatty acid synthase
  Component type
   K27071  hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA

Genes

MTU:	Rv0635(hadA)

MTV:

RVBD_0635

MTC:

MT0664

MRA:

MRA_0646

MTF:	TBFG_10648

MTB:	TBMG_00646

MTK:	TBSG_00650

MTZ:	TBXG_000639

MTG:	MRGA327_03985

MTI:	MRGA423_03965

MTE:	CCDC5079_0592

MTUR:

CFBS_0667

MTL:	CCDC5180_0585

MTO:	MTCTRI2_0650

MTD:

UDA_0635

MTN:	ERDMAN_0703

MTJ:	J112_03405

MTUB:

MT7199_0653(hadA)

MTUC:

J113_04545

MTUE:

J114_03400

MTX:	M943_03315

MTUH:

MTUL:

MTUT:

MTUU:

MTQ:	HKBS1_0667

MBO:	BQ2027_MB0654(hadA)

MBB:

BCG_0684

MBT:

JTY_0654

MBM:	BCGMEX_0655

MBK:	K60_006770

MBX:

BCGT_0424

MAF:

MAF_06440

MMIC:

RN08_0710

MCE:	MCAN_06341

MCQ:	BN44_10697

MCV:	BN43_20059

MCX:	BN42_20379

MCZ:	BN45_10729

MORY:

MO_000675(hadA)

MLE:

MLB:

MPA:

MAO:

MAVI:

MAVU:

MAV:

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MLP:

MMAN:

MSER:

MSA:	Mycsm_00908

MUL:

MUL_0720

MMI:

MMAR_0968

MMAE:

MMARE11_09170

MLI:	MULP_01087

MPSE:

MSHO:

MMC:

MKM:

MJL:

MMM:

MKN:	MKAN_19335

MYV:	G155_06825

MYE:	AB431_05130

MHAD:

B586_19030

MDX:	BTO20_07095

MSHG:

MSG_00830

MFJ:	MFLOJ_26320

MSTO:

MSTO_30130

MSIM:

MSIM_16550

MSAK:

MSAS_44070

MKU:	I2456_04915(hadA)

MLW:	MJO58_04425(hadA)

MXE:	MYXE_40460

MNV:	MNVI_24720

MPAG:

C0J29_05300

MNM:	MNVM_11730

MGOR:

H0P51_04825(hadA)

MCOO:

MBAI:

MSEO:

MHEK:

MGAU:

MLJ:	MLAC_35430

MBRD:

MBRA_07000

MSHJ:

MSHI_28060

MMAM:

K3U93_04020(hadA)

MSPG:

F6B93_03995(hadA)

MOT:	LTS72_20820(hadA)

MLM:

MLPF_2422

MPAA:

MKK62_20395(hadA)

MMEH:

M5I08_03270(hadA)

MKY:	IWGMT90018_09640

MADI:

A7U43_25730

MWU:	PT015_22070(hadA)

MYW:	BVC93_04805

MSM:	MSMEG_1340

MSG:	MSMEI_1302

MSB:	LJ00_06680

MSN:	LI99_06680

MSH:	LI98_06680

MVA:

Mvan_1230

MGI:

Mflv_5121

MSP:	Mspyr1_45390

MCB:	Mycch_0876

MNE:	D174_06255

MYN:	MyAD_06130

MFT:	XA26_13630

MPHL:

MPHLCCUG_01193

MVQ:

MYVA_1039

MLL:	B1R94_04860

MRH:	MycrhN_0783

MTHN:

4412656_00849

MHAS:

MHAS_00156

MDU:	MDUV_34760

MCHT:

MCHIJ_01660

MDR:	MDOR_05160

MAUU:

NCTC10437_01012

MMAG:

MMAD_10290

MMOR:

MMOR_54940

MFX:	MFAL_21750

MAIC:

MAIC_46650

MIJ:	MINS_12790

MALV:

MALV_24920

MTY:	MTOK_31150

MPSC:

MARZ:

MGAD:

MANY:

MAUB:

MPOF:

MPHU:

MMUC:

C1S78_023360(hadA)

MMAT:

MMAGJ_41920

MBOK:

MBOE_62980

MFG:	K6L26_25820(hadA)

MSEI:

MSEDJ_23050

MFLV:

NCTC10271_04189

MCEE:

MCEL_23830

MMON:

EWR22_04960(hadA)

MGO:	AFA91_32190

MHOL:

K3U96_21975(hadA)

MSEN:

K3U95_05910(hadA)

MPAE:

K0O64_04710(hadA)

MRF:	MJO55_04985(hadA)

MDF:	K0O62_05315(hadA)

MCRO:

MI149_05365(hadA)

MGRO:

FZ046_10985(hadA)

MAUS:

JN090_04890(hadA)

MKR:	MKOR_23130

MPAK:

MIU77_15290(hadA)

MAB:

MAB_3898c

MMV:	MYCMA_2161

MABB:

MASS_3911

MABL:

MMASJCM_3915

MCHE:

BB28_19990

MIZ:	BAB75_22235

MSTE:

MSTE_04050

MSAO:

MYCSP_18045

MSAL:

DSM43276_03694

MJD:	JDM601_0658

MTER:

MMIN:

MHIB:

MHER:

MVM:	MJO54_03680(hadA)

ASD:

AS9A_0395

RHA:	RHA1_ro01984

RER:	RER_17130(hadA)

REY:

O5Y_08200

REB:	XU06_08440

RQI:	C1M55_08670

ROP:	ROP_16610(hadA)

ROA:	Pd630_LPD06155

RPY:	Y013_09115

RBY:	CEJ39_20005

RHB:

NY08_4830

RAV:	AAT18_18995

RHW:	BFN03_12350

RRZ:	CS378_08455

RHU:	A3Q40_00320

RHQ:	IM25_00955

RHOD:

AOT96_19040

RRT:	4535765_03637

RCR:	NCTC10994_03621

RTM:	G4H71_15970

RKO:	JWS14_10145

RGO:	KYT97_10025

ROZ:	CBI38_08150

RPSK:

JWS13_35690

RGOR:

NMQ04_15865(hadA)

RHOP:

D8W71_24865

RHOO:

RA302_08585(hadA)

RHOU:

KZJ41_20105

RHOW:

A4U64_05715

RFA:	A3L23_02895

RHS:	A3Q41_00466

REQ:

REQ_36890

PDEF:

P9209_09845(hadA)

TOY:	FO059_03315

» show all

Reference

PMID:17804795

Authors

Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A

Title

The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.

Journal

Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104

Sequence

[mtu:Rv0635]

LinkDB

ORTHOLOGY: K27072

Entry

K27072                      KO

Symbol

hadB

Name

meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-]

Pathway

map00074

Mycolic acid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00885

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)

M00886

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)

Reaction

R13260

long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

R13264

very-long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (very-long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

R13268

ultra-long-chain-mono-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein]-forming)

R13272

ultra-long-chain-di-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (ultra-long-chain di-unsaturated trans-2-enoyl-[acyl-carrier protein]-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00074 Mycolic acid biosynthesis
    K27072  hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K27072  hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB
Lipid biosynthesis proteins [BR:ko01004]
Fatty acid synthase
  Component type
   K27072  hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB

Other DBs

COG:

COG2030

Genes

MTU:	Rv0636(hadB)

MTV:

RVBD_0636

MTC:

MT0665

MRA:

MRA_0647

MTF:	TBFG_10649

MTB:	TBMG_00647

MTK:	TBSG_00651

MTZ:	TBXG_000640

MTI:	MRGA423_03970

MTE:	CCDC5079_0593

MTUR:

CFBS_0668(hadB)

MTL:	CCDC5180_0586

MTO:	MTCTRI2_0651

MTD:

UDA_0636

MTN:	ERDMAN_0704

MTJ:	J112_03410

MTUB:

MT7199_0654(hadB)

MTUC:

J113_04550

MTUE:

J114_03405

MTX:	M943_03320

MTUH:

I917_04550

MTUL:

TBHG_00632

MTUT:

HKBT1_0668(hadB)

MTUU:

HKBT2_0669(hadB)

MTQ:	HKBS1_0668(hadB)

MBO:	BQ2027_MB0655(hadB)

MBB:

BCG_0685

MBT:

JTY_0655

MBM:	BCGMEX_0656

MBK:	K60_006780

MBX:

BCGT_0425

MAF:

MAF_06450

MMIC:

RN08_0711

MCE:	MCAN_06351

MCQ:	BN44_10698

MCV:	BN43_20060

MCX:	BN42_20380

MCZ:	BN45_10730

MORY:

MO_000676(hadB)

MLE:

MLB:

MPA:

MAO:

MAVI:

MAVU:

MAV:

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MLP:

MMAN:

MMAN_32400(hadB)

MSER:

MTY59_07550(hadB)

MSA:	Mycsm_00909

MUL:

MUL_0721

MMI:

MMAR_0969

MMAE:

MMARE11_09180

MLI:	MULP_01088

MPSE:

MPSD_11010(hadB)

MSHO:

MSHO_27480(hadB)

MMC:

MKM:

MJL:

MMM:

MKN:	MKAN_19340

MYV:	G155_06830

MYE:	AB431_05135

MHAD:

B586_19025

MDX:	BTO20_07100

MSHG:

MSG_00831(hadB)

MFJ:	MFLOJ_26310(hadB)

MSTO:

MSTO_30120(hadB)

MSIM:

MSIM_16540(hadB)

MSAK:

MSAS_44080(hadB)

MKU:	I2456_04920(hadB)

MLW:	MJO58_04430(hadB)

MXE:	MYXE_40450(hadB)

MNV:	MNVI_24730(hadB)

MPAG:

C0J29_05305

MNM:	MNVM_11720(hadB)

MGOR:

H0P51_04830(hadB)

MCOO:

MCOO_41270(hadB)

MBAI:

MB901379_00828

MSEO:

MSEO_47800(hadB)

MHEK:

JMUB5695_03950(hadB)

MGAU:

MGALJ_53980(hadB)

MLJ:	MLAC_35420(hadB)

MBRD:

MBRA_06990(hadB)

MSHJ:

MSHI_28050(hadB)

MMAM:

K3U93_04025(hadB)

MSPG:

F6B93_04000(hadB)

MOT:	LTS72_20815(hadB)

MLM:

MLPF_2421

MPAA:

MKK62_20390(hadB)

MMEH:

M5I08_03275(hadB)

MKY:	IWGMT90018_09650(hadB)

MADI:

A7U43_25725

MWU:	PT015_22075(hadB)

MYW:	BVC93_04800

MSM:	MSMEG_1341

MSG:	MSMEI_1303

MSB:	LJ00_06685

MSN:	LI99_06685

MSH:	LI98_06685

MVA:

Mvan_1231

MGI:

Mflv_5120

MSP:	Mspyr1_45380

MCB:	Mycch_0877

MNE:	D174_06260

MYN:	MyAD_06135

MFT:	XA26_13640

MPHL:

MPHLCCUG_01194

MVQ:

MYVA_1040

MLL:	B1R94_04865

MRH:	MycrhN_0782

MTHN:

4412656_00850

MHAS:

MHAS_00157(phaJ_1)

MDU:	MDUV_34750(hadB)

MCHT:

MCHIJ_01650(hadB)

MDR:	MDOR_05170(hadB)

MAUU:

NCTC10437_01013

MMAG:

MMAD_10300(hadB)

MMOR:

MMOR_54930(hadB)

MFX:	MFAL_21740(hadB)

MAIC:

MAIC_46640

MIJ:	MINS_12800

MALV:

MALV_24910

MTY:	MTOK_31160(hadB)

MPSC:

MPSYJ_54460

MARZ:

MARA_28760

MGAD:

MGAD_28920(hadB)

MHEV:

MHEL_12740(hadB)

MSAR:

MSAR_24520

MANY:

MANY_48870

MAUB:

MAUB_22720(hadB)

MPOF:

MPOR_15070(hadB)

MPHU:

MPHO_47770(hadB)

MMUC:

C1S78_023355(hadB)

MMAT:

MMAGJ_41930

MBOK:

MBOE_62970

MFG:	K6L26_25815(hadB)

MSEI:

MSEDJ_23060

MFLV:

NCTC10271_04188

MCEE:

MCEL_23820(hadB)

MBRM:

L2Z93_003295(hadB)

MMON:

EWR22_04965(hadB)

MGO:	AFA91_32185

MHOL:

K3U96_21970(hadB)

MSEN:

K3U95_05915(hadB)

MPAE:

K0O64_04715(hadB)

MRF:	MJO55_04990(hadB)

MDF:	K0O62_05320(hadB)

MCRO:

MI149_05370(hadB)

MGRO:

FZ046_10990(hadB)

MAUS:

JN090_04895(hadB)

MKR:	MKOR_23120(hadB)

MPAK:

MIU77_15285(hadB)

MAB:

MAB_3897c

MMV:	MYCMA_05235

MABB:

MASS_3910

MABL:

MMASJCM_3914

MCHE:

BB28_19985

MIZ:	BAB75_22230

MSTE:

MSTE_04049

MSAO:

MYCSP_18040

MSAL:

DSM43276_03693

MJD:	JDM601_0659

MTER:

4434518_00645

MMIN:

MMIN_23280(hadB)

MHIB:

MHIB_01740(hadB)

MHER:

K3U94_03705(hadB)

MVM:	MJO54_03685(hadB)

ASD:	AS9A_0396(hadB)

RHA:	RHA1_ro01983

RER:	RER_17140(hadB)

REY:

O5Y_08205

REB:	XU06_08445

RQI:	C1M55_08675

ROP:	ROP_16600(hadB)

ROA:	Pd630_LPD06154

RPY:	Y013_09110

RBY:	CEJ39_20000

RHB:

NY08_4831

RAV:	AAT18_18990

RHW:	BFN03_12345

RRZ:	CS378_08450

RHU:	A3Q40_00321

RHQ:	IM25_00950

RHOD:

AOT96_19045

RRT:	4535765_03636

RCR:	NCTC10994_03622

RTM:	G4H71_15975(hadB)

RKO:	JWS14_10140(hadB)

RGO:	KYT97_10020(hadB)

ROZ:	CBI38_08155

RPSK:

JWS13_35695(hadB)

RGOR:

NMQ04_15860(hadB)

RHOP:

D8W71_24860(hadB)

RHOO:

RA302_08590(hadB)

RHOU:

KZJ41_20100(hadB)

RHOW:

A4U64_05720

RFA:	A3L23_02896

RHS:	A3Q41_00465

REQ:

REQ_36880

PDEF:

P9209_09850(hadB)

TPR:

Tpau_0739

TSM:	ASU32_03805

TPUL:

TPB0596_07450(hadB)

TSD:	MTP03_06310(hadB)

TOY:	FO059_03320

» show all

Reference

PMID:17804795

Authors

Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A

Title

The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.

Journal

Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104

Sequence

[mtu:Rv0636]

LinkDB

ORTHOLOGY: K27689

Entry

K27689                      KO

Symbol

hadAB

Name

meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadAB [EC:4.2.1.-]

Pathway

map00074

Mycolic acid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00885

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)

Reaction

R13260

long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

R13264

very-long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (very-long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

R13268

ultra-long-chain-mono-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein]-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00074 Mycolic acid biosynthesis
    K27689  hadAB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadAB
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K27689  hadAB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadAB
Lipid biosynthesis proteins [BR:ko01004]
Fatty acid synthase
  Component type
   K27689  hadAB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadAB

Other DBs

COG:

COG2030

Genes

MMAL:

CKJ54_00365

MSER:

MTY59_19580

MSA:	Mycsm_06410

MMI:

MMAR_0106

MMAE:

MMARE11_00950

MLI:	MULP_00089

MPSE:

MSHO:

MMC:

MKM:

MJL:

MYV:	G155_29860

MYE:	AB431_28790

MDX:	BTO20_00965

MSHG:

MSG_03656

MFJ:	MFLOJ_44970

MSTO:

MSTO_49190

MSIM:

MSIM_23930

MSAK:

MSAS_43080

MKU:	I2456_00760

MLW:	MJO58_23005

MXE:	MYXE_48420

MNV:	MNVI_17600

MPAG:

C0J29_00515

MNM:	MNVM_19590

MGOR:

MCOO:

MBAI:

MSEO:

MHEK:

MGAU:

MBRD:

MMAM:

MPAA:

MMEH:

MKY:	IWGMT90018_01480

MADI:

A7U43_03595

MWU:	PT015_17975

MYW:	BVC93_13235

MSM:	MSMEG_6754

MSG:	MSMEI_6572

MSB:	LJ00_33370

MSN:	LI99_33375

MSH:	LI98_33380

MVA:

Mvan_5844

MGI:

Mflv_0994

MSP:	Mspyr1_51960

MCB:	Mycch_5231

MNE:	D174_01295

MYN:	MyAD_01265

MFT:	XA26_60360

MPHL:

MPHLCCUG_05132

MVQ:

MYVA_5786

MLL:	B1R94_28200

MRH:	MycrhN_1733

MTHN:

4412656_04651

MHAS:

MHAS_04312(phaJ_2)

MDU:	MDUV_43980

MCHT:

MCHIJ_13270

MDR:	MDOR_37240

MAUU:

NCTC10437_05651

MMAG:

MMAD_02770

MMOR:

MMOR_06270

MFX:	MFAL_09940

MAIC:

MAIC_00580

MIJ:	MINS_28960

MALV:

MALV_36480

MTY:	MTOK_14440

MPSC:

MARZ:

MGAD:

MHEV:

MSAR:

MANY:

MAUB:

MPOF:

MPHU:

MMUC:

MMAT:

MBOK:

MFG:	K6L26_01765

MSEI:

MFLV:

MCEE:

MBRM:

MMON:

MGO:	AFA91_05765

MHOL:

K3U96_00665

MSEN:

K3U95_28620

MPAE:

K0O64_28965

MRF:	MJO55_27090

MDF:	K0O62_00760

MCRO:

MI149_28750

MGRO:

FZ046_07210

MAUS:

JN090_29290

MKR:	MKOR_09120

MPAK:

MIU77_08975

MAB:

MAB_4780

MMV:	MYCMA_02975

MABB:

MASS_4852

MABL:

MMASJCM_4839

MCHE:

BB28_24340

MIZ:	BAB75_27065

MSTE:

MSTE_04931

MSAO:

MYCSP_22275

MSAL:

DSM43276_04606

MJD:	JDM601_4227

MTER:

MMIN:

MHIB:

MHER:

MVM:	MJO54_23060

NFA:

NFA_51180

NFR:	ERS450000_04773

NCY:	NOCYR_2781 NOCYR_4906

NBR:	O3I_014345 O3I_038520

NNO:	NONO_c69560 NONO_c72980

NSL:	BOX37_12080 BOX37_29300

NSR:	NS506_00060(phaJ)

NTP:	CRH09_36620

NOZ:	DMB37_17285 DMB37_38885

NOD:	FOH10_00310(hadB)

NAH:	F5544_41000(hadB)

NAD:	NCTC11293_00027 NCTC11293_03986

NWL:	NWFMUON74_65160

NIE:	KV110_37685(hadB)

NTC:	KHQ06_09460(hadB) KHQ06_25600

NHU:	H0264_08745(hadB) H0264_25240

NYA:	LTV02_10420 LTV02_24310

NGP:	LTT66_08445

NSPU:

IFM12276_56810

NYU:	D7D52_06680(hadB) D7D52_30400

RHB:

NY08_3148

RHU:	A3Q40_01427

RHOP:

D8W71_06140(hadB)

RFA:	A3L23_01345

RHS:	A3Q41_02009

WHR:	OG579_08195

GBR:	Gbro_0464 Gbro_1106

GPO:	GPOL_c06820 GPOL_c11830

GOR:	KTR9_0970 KTR9_2676

GOQ:	ACH46_16615

GTA:	BCM27_05915 BCM27_14185

GOC:	CXX93_18855

GIT:	C6V83_11905 C6V83_16775

GRU:	GCWB2_05220 GCWB2_10540

GOM:	D7316_03992 D7316_04775(phaJ)

GAV:	C5O27_17010 C5O27_22110

GOD:	GKZ92_04950 GKZ92_10240

GOS:	QAD21_05070 QAD21_13985

GOJ:	GR168_05145 GR168_13425

GAM:	GII34_04410

GPD:	GII33_18475

GJI:	H1R19_04955 H1R19_13430

GOI:	LK459_06980 LK459_14835

GHN:	MVF96_05310 MVF96_13925

GAMI:

IHQ52_08260 IHQ52_13480

GMG:	NWF22_04255

GSI:	P5P27_01850

SPIN:

KV203_03405(hadB) KV203_07150

» show all

Reference

PMID:17804795

Authors

Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A

Title

The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.

Journal

Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104

LinkDB

REACTION: R13260

Entry

R13260                      Reaction

Name

long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

Definition

Long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] <=> Long-chain trans-2-enoyl-[acyl-carrier protein] + H2O

Equation

C22859 <=> C22860 + C00001

Comment

general reaction

Reaction class

RC01095

C22859_C22860

Enzyme

4.2.1.-

Pathway

rn00074

Mycolic acid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00885

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)

M00886

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)

Brite

Enzymatic reactions [BR:br08201]
4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-
     R13260  Long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] <=> Long-chain trans-2-enoyl-[acyl-carrier protein] + H2O

Orthology

K27071

meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-]

K27072

meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-]

K27689

meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadAB [EC:4.2.1.-]

Reference

1 [PMID:17804795]

Authors

Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A

Title

The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.

Journal

Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104

Reference

2 [PMID:15653820]

Authors

Takayama K, Wang C, Besra GS.

Title

Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.

Journal

Clin Microbiol Rev 18:81-101 (2005)
DOI:10.1128/CMR.18.1.81-101.2005

Reference

3 [PMID:22216317]

Authors

Cantaloube S, Veyron-Churlet R, Haddache N, Daffe M, Zerbib D.

Title

The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes.

Journal

PLoS One 6:e29564 (2011)
DOI:10.1371/journal.pone.0029564

LinkDB

REACTION: R13264

Entry

R13264                      Reaction

Name

very-long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (very-long-chain trans-2-enoyl-[acyl-carrier protein]-forming)

Definition

Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] <=> Very-long-chain trans-2-enoyl-[acyl-carrier protein] + H2O

Equation

C22863 <=> C22864 + C00001

Comment

general reaction

Enzyme

4.2.1.-

Pathway

rn00074

Mycolic acid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00885

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)

M00886

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)

Brite

Enzymatic reactions [BR:br08201]
4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-
     R13264  Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] <=> Very-long-chain trans-2-enoyl-[acyl-carrier protein] + H2O

Orthology

K27071

meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-]

K27072

meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-]

K27689

meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadAB [EC:4.2.1.-]

Reference

1 [PMID:17804795]

Authors

Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A

Title

The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.

Journal

Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104

Reference

2 [PMID:15653820]

Authors

Takayama K, Wang C, Besra GS.

Title

Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.

Journal

Clin Microbiol Rev 18:81-101 (2005)
DOI:10.1128/CMR.18.1.81-101.2005

Reference

3 [PMID:22216317]

Authors

Cantaloube S, Veyron-Churlet R, Haddache N, Daffe M, Zerbib D.

Title

The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes.

Journal

PLoS One 6:e29564 (2011)
DOI:10.1371/journal.pone.0029564

LinkDB

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