KEGG ORTHOLOGY: K27308

ORTHOLOGY: K27308

Entry

K27308                      KO

Symbol

tdmh

Name

trehalose dimycolate hydrolase

Pathway

map00074

Mycolic acid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Reaction

R13279

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00074 Mycolic acid biosynthesis
    K27308  tdmh; trehalose dimycolate hydrolase

Other DBs

COG:

COG0400

Genes

MPA:

MAO:

MAVI:

MAVU:

MAV:

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MLP:

MMAN:

MSER:

MSA:	Mycsm_01084

MMC:

MKM:

MJL:

MMM:

MYV:	G155_06645 G155_07695

MYE:	AB431_23395

MDX:	BTO20_01460 BTO20_27935

MSHG:

MSG_01128

MFJ:	MFLOJ_22620

MSTO:

MSTO_26460

MSIM:

MSIM_13840

MSAK:

MSAS_47340

MLW:	MJO58_05920

MPAG:

MGOR:

MSEO:

MGAU:

MKY:	IWGMT90018_12650

MADI:

A7U43_24795

MYW:	BVC93_03725

MSM:	MSMEG_1529

MSG:	MSMEI_1493(cut4)

MSB:	LJ00_07640

MSN:	LI99_07640

MSH:	LI98_07640

MVA:

Mvan_1440

MGI:

Mflv_4966

MSP:	Mspyr1_43830

MCB:	Mycch_1045

MNE:	D174_07095

MYN:	MyAD_06960

MFT:	XA26_13270 XA26_15340

MPHL:

MPHLCCUG_01382 MPHLCCUG_01383

MVQ:

MYVA_1203

MLL:	B1R94_11095 B1R94_22525

MRH:	MycrhN_0621

MTHN:

4412656_01005(cut4)

MHAS:

MHAS_00317(cut3_1) MHAS_00318(cut3_2)

MDU:	MDUV_33150

MCHT:

MCHIJ_00570

MDR:	MDOR_07170

MAUU:

NCTC10437_01167

MMAG:

MMAD_12090

MMOR:

MMOR_53310

MFX:	MFAL_14020 MFAL_20630

MAIC:

MAIC_10750 MAIC_33290

MIJ:	MINS_32600

MALV:

MALV_23450

MTY:	MTOK_32830

MPSC:

MPSYJ_52820

MARZ:

MARA_27060

MGAD:

MGAD_27170

MHEV:

MHEL_33830 MHEL_58720

MSAR:

MSAR_06390 MSAR_35980

MANY:

MANY_18180 MANY_50400

MAUB:

MPOF:

MPHU:

MMUC:

MMAT:

MBOK:

MBOE_23900 MBOE_61060

MFG:	K6L26_07470 K6L26_24965

MSEI:

MSEDJ_24510

MFLV:

NCTC10271_04041 NCTC10271_04042

MCEE:

MCEL_22430

MBRM:

L2Z93_001295

MMON:

EWR22_05965

MGO:	AFA91_31260

MHOL:

K3U96_20650 K3U96_20655

MSEN:

K3U95_06755 K3U95_23350

MPAE:

K0O64_22950

MRF:	MJO55_05805

MDF:	K0O62_06545

MCRO:

MGRO:

MAUS:

AMOG:

Reference

PMID:20375425

Authors

Ojha AK, Trivelli X, Guerardel Y, Kremer L, Hatfull GF

Title

Enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms.

Journal

J Biol Chem 285:17380-9 (2010)
DOI:10.1074/jbc.M110.112813

Sequence

[msm:MSMEG_1529]

LinkDB

ORTHOLOGY: K27359

Entry

K27359                      KO

Symbol

cut3, tdmh

Name

trehalose dimycolate hydrolase

Pathway

map00074

Mycolic acid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Reaction

R13279

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00074 Mycolic acid biosynthesis
    K27359  cut3, tdmh; trehalose dimycolate hydrolase

Genes

MTU:	Rv3451(cut3)

MTV:

RVBD_3451

MTC:

MT3557

MRA:	MRA_3492(cut3)

MTF:	TBFG_13488

MTB:	TBMG_03499

MTK:	TBSG_03521

MTZ:	TBXG_003473

MTG:	MRGA327_21295

MTI:	MRGA423_21760

MTE:	CCDC5079_3197

MTUR:

CFBS_3669(cut3)

MTL:	CCDC5180_3151

MTO:	MTCTRI2_3519(cut3)

MTD:	UDA_3451(cut3)

MTN:	ERDMAN_3780(cut3)

MTJ:	J112_18575

MTUB:

MT7199_3500

MTUC:

J113_24175

MTUE:

J114_18490

MTX:	M943_17780

MTUH:

I917_24265

MTUL:

TBHG_03384

MTUT:

HKBT1_3655(cut3)

MTUU:

HKBT2_3663(cut3)

MTQ:	HKBS1_3666(cut3)

MBO:	BQ2027_MB3481(cut3)

MBB:	BCG_3517(cut3)

MBT:	JTY_3517(cut3)

MBM:	BCGMEX_3515(cut3)

MBK:	K60_035880

MBX:

BCGT_3319

MAF:	MAF_34660(cut3)

MMIC:

RN08_3813

MCE:	MCAN_34681(cut3)

MCQ:	BN44_80127(cut)

MCV:	BN43_70119(cut)

MCX:	BN42_50129(cut)

MCZ:	BN45_70108(cut)

MORY:

MPA:

MAO:

MAVI:

MAVU:

MAV:

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MMAN:

MSER:

MSA:	Mycsm_03967

MUL:	MUL_0856(cut3)

MMI:	MMAR_1098(cut3)

MMAE:

MMARE11_10560(cut3)

MLI:	MULP_01230(cut3)

MSHO:

MSHO_29020(cut3)

MMM:

W7S_21390

MKN:	MKAN_20050

MYV:	G155_10250

MYE:	AB431_09020

MHAD:

B586_18340

MDX:	BTO20_24730

MSHG:

MSG_00989(cut3)

MFJ:	MFLOJ_24810

MSTO:

MSTO_28010

MSIM:

MSIM_15160

MSAK:

MSAS_45880

MKU:	I2456_05585

MLW:	MJO58_05210

MXE:	MYXE_39010

MNV:	MNVI_26280

MPAG:

C0J29_06060

MNM:	MNVM_27970(cut3)

MGOR:

MCOO:

MBAI:

MSEO:

MHEK:

JMUB5695_03820(cut3)

MLJ:	MLAC_33980(cut3)

MBRD:

MBRA_05550(cut3)

MSHJ:

MSHI_26780(cut3)

MMAM:

K3U93_04705

MSPG:

F6B93_04660

MOT:	LTS72_20150

MPAA:

MKK62_19590

MMEH:

M5I08_20980

MKY:	IWGMT90018_10920(cut3)

MWU:	PT015_22805

MSM:	MSMEG_2095

MSG:	MSMEI_2048(cut3)

MSB:	LJ00_10435

MSN:	LI99_10435

MSH:	LI98_10435

MFT:	XA26_20960

MLL:	B1R94_20335

MCHT:

MCHIJ_48750

MMAG:

MMAD_28010

MAIC:

MAIC_15670

MIJ:	MINS_16990

MALV:

MHEV:

MANY:

MAUB:

MPHU:

MMUC:

MMAT:

MBOK:

MFG:	K6L26_22240

MSEI:

MSEDJ_58070

MBRM:

L2Z93_002891

MGO:	AFA91_28610

MSEN:

MPAE:

MCRO:

MGRO:

MKR:	MKOR_22130(cut3)

MPAK:

MIU77_14755

MAB:

MAB_3766

MMV:	MYCMA_2073

MABB:

MASS_3776

MABL:

MMASJCM_3779

MCHE:

BB28_19300

MIZ:	BAB75_21450

MSTE:

MSTE_03915

MSAO:

MYCSP_17385

MSAL:

DSM43276_03561

MJD:	JDM601_3276(cut3)

MTER:

4434518_03263(cut3)

MMIN:

MMIN_09750

MHIB:

MHIB_26840

MHER:

K3U94_18485

MVM:	MJO54_18655

» show all

Reference

PMID:24528862

Authors

Yang Y, Kulka K, Montelaro RC, Reinhart TA, Sissons J, Aderem A, Ojha AK

Title

A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis.

Journal

Cell Host Microbe 15:153-63 (2014)
DOI:10.1016/j.chom.2014.01.008

Sequence

[mtu:Rv3451]

LinkDB

REACTION: R13279

Entry

R13279                      Reaction

Definition

Trehalose dimycolate + H2O <=> Mycolic acid + Trehalose monomycolate

Equation

C22877 + C00001 <=> C22878 + C22876

Comment

general reaction

Pathway

rn00074

Mycolic acid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Orthology

K27308

trehalose dimycolate hydrolase

K27359

trehalose dimycolate hydrolase

Reference

1 [PMID:20375425]

Authors

Ojha AK, Trivelli X, Guerardel Y, Kremer L, Hatfull GF

Title

Enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms.

Journal

J Biol Chem 285:17380-9 (2010)
DOI:10.1074/jbc.M110.112813

Reference

2 [PMID:23155047]

Authors

Yang Y, Bhatti A, Ke D, Gonzalez-Juarrero M, Lenaerts A, Kremer L, Guerardel Y, Zhang P, Ojha AK.

Title

Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species.

Journal

J Biol Chem 288:382-92 (2013)
DOI:10.1074/jbc.M112.419754

Reference

3 [PMID:24528862]

Authors

Yang Y, Kulka K, Montelaro RC, Reinhart TA, Sissons J, Aderem A, Ojha AK

Title

A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis.

Journal

Cell Host Microbe 15:153-63 (2014)
DOI:10.1016/j.chom.2014.01.008

LinkDB

DBGET integrated database retrieval system