KEGG   ORTHOLOGY: K27542
Entry
K27542                      KO                                     
Symbol
argZ
Name
arginine dihydrolase [EC:3.5.3.27]
Pathway
map00220  Arginine biosynthesis
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00978  Ornithine-ammonia cycle
Reaction
R13308  L-arginine aminodihydrolase (L-ornithine-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K27542  argZ; arginine dihydrolase
   00330 Arginine and proline metabolism
    K27542  argZ; arginine dihydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.3  In linear amidines
    3.5.3.27  arginine dihydrolase
     K27542  argZ; arginine dihydrolase
Other DBs
COG: COG1834 COG1915
Genes
SYN: sll1336
SYZ: MYO_129650
SYY: SYNGTS_2937(sll1336)
SYT: SYNGTI_2936(sll1336)
SYS: SYNPCCN_2935(sll1336)
SYQ: SYNPCCP_2935(sll1336)
SYJ: D082_28860
SYO: C7I86_15345
SYNH: HTZ78_08690
SYNS: OLK001_11640
CYB: CYB_0250
TEL: tll0507
THN: NK55_08695(arcA)
MAR: MAE_40150
MPK: VL20_2884
CYT: cce_2552
TER: Tery_4659
GVI: glr1758
GLJ: GKIL_1230
ANA: alr4995
NSH: GXM_06923
AVA: Ava_2273
NAZ: Aazo_4047
CALH: IJ00_24475
SCYT: SAMD_52090
CTHE: Chro_5384
 » show all
Reference
  Authors
Zhang H, Liu Y, Nie X, Liu L, Hua Q, Zhao GP, Yang C.
  Title
The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase.
  Journal
Nat Chem Biol 14:575-581 (2018)
DOI:10.1038/s41589-018-0038-z
  Sequence
[syn:sll1336]
Reference
  Authors
Burnat M, Picossi S, Valladares A, Herrero A, Flores E.
  Title
Catabolic pathway of arginine in Anabaena involves a novel bifunctional enzyme that produces proline from arginine.
  Journal
Mol Microbiol 111:883-897 (2019)
DOI:10.1111/mmi.14203
  Sequence
[ana:alr4995]
LinkDB

KEGG   ORTHOLOGY: K27545
Entry
K27545                      KO                                     
Symbol
argZ
Name
arginine dihydrolase [EC:3.5.3.27]
Pathway
map00220  Arginine biosynthesis
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00134  Polyamine biosynthesis, arginine => ornithine => putrescine
M00978  Ornithine-ammonia cycle
Reaction
R13308  L-arginine aminodihydrolase (L-ornithine-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K27545  argZ; arginine dihydrolase
   00330 Arginine and proline metabolism
    K27545  argZ; arginine dihydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.3  In linear amidines
    3.5.3.27  arginine dihydrolase
     K27545  argZ; arginine dihydrolase
Other DBs
COG: COG1834
Genes
SARA: 101557043
BTAB: 109044769 109044770
CEL: CELE_F38H4.5(F38H4.5) CELE_T22B7.3(T22B7.3) CELE_ZK1307.1(ZK1307.1)
CBR: CBG_01062 CBG_06177 CBG_14718
CRQ: GCK72_003659 GCK72_014187 GCK72_024454
NAI: NECAME_00029 NECAME_10303
TSP: Tsp_00259 Tsp_09445
DGT: 114519962
XEN: 124441981
TET: TTHERM_01029920
PLU: plu4566
PAY: PAU_04066
XDO: XDD1_2168
PSD: DSC_01580
DKO: I596_603
CBU: CBU_0279
CBD: CBUD_1814
CBG: CbuG_1728
CBC: CbuK_0474
LFA: LFA_1334
FTN: FTN_0854
AEH: Mlg_0130
REH: H16_A0688(h16_A0688)
RME: Rmet_0585
CGD: CR3_2040
HAR: HEAR0123
MMS: mma_0148
CFU: CFU_4138
CARE: LT85_4705
NIM: W01_10030
RVA: Rvan_3087
MSC: BN69_2879
PZU: PHZ_c3110
RRU: Rru_A3467
RRF: F11_17760
RCE: RC1_0558
MXA: MXAN_6903
HOH: Hoch_5166
MTU: Rv2323c
MTC: MT2385
MRA: MRA_2343
MTUR: CFBS_2458
MTD: UDA_2323c
MTUC: J113_16100
MTUE: J114_12445
MTUH: I917_16320
MTUL: TBHG_02261
MTUT: HKBT1_2449
MTUU: HKBT2_2451
MBB: BCG_2344c
MBT: JTY_2338
MBX: BCGT_2150
MAF: MAF_23350
MMIC: RN08_2576
MORY: MO_002438
MPA: MAP_2095c
MAO: MAP4_1728
MAVI: RC58_08640
MAVU: RE97_08640
MAV: MAV_2085
MLP: MLM_1817
MMAN: MMAN_19920
MUL: MUL_1242
MMI: MMAR_3623
MPSE: MPSD_36870
MSHO: MSHO_33450
MMC: Mmcs_0993
MKM: Mkms_1011
MJL: Mjls_1021
MHAD: B586_09480
MSHG: MSG_03306
MSTO: MSTO_58290
MSIM: MSIM_43300
MSAK: MSAS_14620
MCOO: MCOO_41670
MSEO: MSEO_21280
MVA: Mvan_1288
MGI: Mflv_5070
MVQ: MYVA_1093
MMAG: MMAD_11080
MMOR: MMOR_54250
MAIC: MAIC_45940
MALV: MALV_24410
MARZ: MARA_27950
MGAD: MGAD_28210
MHEV: MHEL_11960
MSAR: MSAR_25490
MANY: MANY_49560
MAUB: MAUB_22190
MPOF: MPOR_15710
MPHU: MPHO_48360
MBOK: MBOE_62410
MAB: MAB_3840
MABB: MASS_3852
MCHE: BB28_19665
MSTE: MSTE_03990
MSAL: DSM43276_03634(arcA_2)
NSR: NS506_05035(rocD)
ROP: ROP_62280
RHOJ: JVH1_05485(ddaH)
SCO: SCO1222(2SCG58.22)
SALB: XNR_4607
SMAL: SMALA_7232
SFA: Sfla_4552
SBH: SBI_07674
SVE: SVEN_1961
SALS: SLNWT_0288
STRP: F750_2138
SLD: T261_3879
STRM: M444_11625
SPRI: SPRI_1308
SLE: sle_58750(sle_58750)
STRD: NI25_33140
SLAU: SLA_1863
SALJ: SMD11_4809
SRJ: SRO_6239
SAUH: SU9_018235
STRL: HEP84_10650(ddaH) HEP84_17355(ddaH)
STSD: HEP87_10395(ddaH)
SRPZ: HEP85_06920(ddaH) HEP85_12615(ddaH)
SCT: SCAT_1360
LXL: KDY119_02898(rocD)
CMI: CMM_0629
CMS: CMS0487
CMC: CMN_00589
MTS: MTES_1968
BCV: Bcav_0887
XCE: Xcel_3304
IDO: I598_2650
CFL: Cfla_0780
CFI: Celf_0744
MPH: MLP_42200
KFL: Kfla_6873
NDA: Ndas_2244
NAL: B005_4578
TCU: Tcur_3814
SRO: Sros_2331
TBI: Tbis_1169
FAL: FRAAL4324
ACE: Acel_0453
KRA: Krad_1316
ACOR: LCL61_30000(ddaH) LCL61_41990(ddaH)
PSEA: WY02_13265
PAUT: Pdca_60790
SESP: BN6_80130
KAL: KALB_8278
ACTI: UA75_02665
ACAD: UA74_02660
ALO: CRK60104
CAI: Caci_7970
SNA: Snas_6044
VAB: WPS_06140
PSL: Psta_3749
LLH: I41_20940
BGOK: Pr1d_26450
CHYA: V22_19060
FTJ: FTUN_1182
IPA: Isop_3073
SACI: Sinac_5338
TPLA: ElP_46070
RMR: Rmar_1802
SRU: SRU_1195
SRM: SRM_01383(arcA)
CPRV: CYPRO_0776
NDE: NIDE0529
NJA: NSJP_1571
NIF: W02_28190
MOX: DAMO_0153
 » show all
Reference
  Authors
Zhuang N, Zhang H, Li L, Wu X, Yang C, Zhang Y.
  Title
Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism.
  Journal
J Biol Chem 295:2113-2124 (2020)
DOI:10.1074/jbc.RA119.011752
LinkDB

KEGG   ENZYME: 3.5.3.27
Entry
EC 3.5.3.27                 Enzyme                                 
Name
arginine dihydrolase;
argZ (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
Sysname
L-arginine aminodihydrolase (L-ornithine-forming)
Reaction(IUBMB)
L-arginine + 2 H2O = L-ornithine + CO2 + 2 ammonia [RN:R13308]
Reaction(KEGG)
R13308
Substrate
L-arginine [CPD:C00062];
H2O [CPD:C00001]
Product
L-ornithine [CPD:C00077];
CO2 [CPD:C00011];
ammonia [CPD:C00014]
Comment
The enzyme, characterized from different cyanobacterial species, is highly specific to arginine and does not require a metal cofactor. The enzyme from Nostoc is bifunctional, and also catalyses the activity of EC 4.3.1.12, ornithine cyclodeaminase.
History
EC 3.5.3.27 created 2024
Pathway
ec00220  Arginine biosynthesis
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K27542  arginine dihydrolase
K27545  arginine dihydrolase
Genes
SARA101557043
BTAB109044769 109044770
CELCELE_F38H4.5(F38H4.5) CELE_T22B7.3(T22B7.3) CELE_ZK1307.1(ZK1307.1)
CBRCBG_01062 CBG_06177 CBG_14718
CRQGCK72_003659 GCK72_014187 GCK72_024454
NAINECAME_00029 NECAME_10303
TSPTsp_00259 Tsp_09445
DGT114519962
XEN124441981
TETTTHERM_01029920
PACBM9782_07425
PLUplu4566
PLUMA4R40_22615
PAYPAU_04066
PTTVY86_06205
PAKHB0X70_23010
PLUICE143_23050
XDOXDD1_2168
XBUHGO23_16745
XGRQL128_10155
XSASB85_03810
XTNFD63_08335
XHYFZ025_16770
XTHG4Q83_05940
XAGHEP73_01846
XASHEP74_01768
XHAPG878_08875
XRYQN244_08550
PSDDSC_01580
PWIMWN52_00195
DKOI596_603
LRZBJI69_20370
LPYFIV34_12535
LANHKR767_18320
LAEOL2Y97_13730
LAESL2Y96_13365
CBUCBU_0279
CBSCOXBURSA331_A0382
CBDCBUD_1814
CBGCbuG_1728
CBCCbuK_0474
LFALFA_1334
FTNFTN_0854
FCFFNFX1_0864
FCNFN3523_0932
FHIFSC454_05415
FRFLO80_08425
FRMBBG19_0873
FADCDH04_05720
FOOCGC45_04430
AEHMlg_0130
RPJN234_03460
REHH16_A0688(h16_A0688)
CNCCNE_1c06790
CUHBJN34_03860
REUReut_A2672
RMERmet_0585
CTIRALTA_A0645
CBWRR42_m0814
CGDCR3_2040
CCUPBKK81_06275
CUPBKK80_05580
CUUBKK79_06710
CPAUEHF44_02460
COXE0W60_13925
CCAMM5D45_03145
CCAXKZ686_14980
CUKKB879_03655
CNANA2G96_04505
CUPRIC580_10685
CUPEKLP38_02980
PIGEGT29_14185
HARHEAR0123
MMSmma_0148
JAJEKL02_02540
CFUCFU_4138
CARELT85_4705
CPRACPter91_5141
GLCJQN73_07760
NIMW01_10030
URUDSM104443_01589
UPLDSM104440_01495
AZQG3580_03080
BEBABWI17_19060
MEDKQEV83_00305
RVARvan_3087
RLACQMO75_15715
RHZRHPLAN_25450 RHPLAN_41360
MSCBN69_2879
MBRYB1812_02895
MROSEHO51_02225
MHEYH2LOC_008910
MPARF7D14_04560
MIWASS37A_35340
MESZLNB28_05465
MTWCQW49_17890
MECQMSC49_09430
PSINCAK95_21460
PZUPHZ_c3110
GBEGbCGDNIH1_1191
GBHGbCGDNIH2_1191
GBCGbCGDNIH3_1191
GBSGbCGDNIH4_1191
NCHA0U93_04715
LCKHN018_09655
NAOY958_03055
RRURru_A3467
RRFF11_17760
RCERC1_0558
SMASHUE87_00135
MXAMXAN_6903
MSDMYSTI_07494
MYMA176_007654
MFBMFUL124B02_39790
MYXQEG98_38555
MLANJY572_29835
CCXCOCOR_07474
MFULILAB_11965
MMASMYMAC_006594
PPAKJY651_45270
PAUUE8A73_000505 E8A73_039650
MRMA7982_03651
HOHHoch_5166
BSEDDN745_11655 DN745_15820
PCAYFRD00_10315 FRD00_27185
BBAEFRD01_13500
SBFJCM31447_10270
PIJQEJ31_12320
SAQIAXG55_05010
EUZDVS28_a2780
MTURv2323c
MTVRVBD_2323c
MTCMT2385
MRAMRA_2343
MTFTBFG_12346
MTBTBMG_01656
MTKTBSG_01666
MTZTBXG_001641
MTGMRGA327_14310
MTIMRGA423_14445
MTECCDC5079_2148
MTURCFBS_2458
MTLCCDC5180_2120
MTOMTCTRI2_2364
MTDUDA_2323c
MTNERDMAN_2545
MTJJ112_12460
MTUBMT7199_2353
MTUCJ113_16100
MTUEJ114_12445
MTXM943_11995
MTUHI917_16320
MTULTBHG_02261
MTUTHKBT1_2449
MTUUHKBT2_2451
MTQHKBS1_2455
MBOBQ2027_MB2350C
MBBBCG_2344c
MBTJTY_2338
MBMBCGMEX_2333c
MBKK60_024140
MBXBCGT_2150
MAFMAF_23350
MMICRN08_2576
MCEMCAN_23541
MCQBN44_50283
MCVBN43_31582
MCXBN42_40248
MCZBN45_50680
MORYMO_002438
MPAMAP_2095c
MAOMAP4_1728
MAVIRC58_08640
MAVURE97_08640
MAVMAV_2085
MLPMLM_1817
MMANMMAN_19920
MSERMTY59_36350
MSAMycsm_00985
MULMUL_1242
MMIMMAR_3623
MMAEMMARE11_35300
MLIMULP_03866
MPSEMPSD_36870
MSHOMSHO_33450
MMCMmcs_0993
MKMMkms_1011
MJLMjls_1021
MYVG155_07095
MYEAB431_05510
MHADB586_09480
MDXBTO20_28630
MSHGMSG_03306
MFJMFLOJ_54200
MSTOMSTO_58290
MSIMMSIM_43300
MSAKMSAS_14620
MLWMJO58_18150
MPAGC0J29_20225
MGORH0P51_18220
MCOOMCOO_41670
MBAIMB901379_03213
MSEOMSEO_21280
MGAUMGALJ_54660
MLJMLAC_23830
MMAMK3U93_15380
MSPGF6B93_14750
MPAAMKK62_20175
MMEHM5I08_03640
MKYIWGMT90018_21880
MADIA7U43_25350
MWUPT015_22290
MSMMSMEG_1414
MSGMSMEI_1379
MSBLJ00_07050
MSNLI99_07050
MSHLI98_07050
MVAMvan_1288
MGIMflv_5070
MSPMspyr1_44880
MCBMycch_0925
MNED174_06565
MYNMyAD_06435
MFTXA26_14180
MPHLMPHLCCUG_01284
MVQMYVA_1093
MLLB1R94_05195
MRHMycrhN_0716
MCHTMCHIJ_01270
MAUUNCTC10437_01070
MMAGMMAD_11080
MMORMMOR_54250
MFXMFAL_21420
MAICMAIC_45940
MALVMALV_24410
MTYMTOK_31870
MPSCMPSYJ_53930
MARZMARA_27950
MGADMGAD_28210
MHEVMHEL_11960
MSARMSAR_25490
MANYMANY_49560
MAUBMAUB_22190
MPOFMPOR_15710
MPHUMPHO_48360
MMUCC1S78_023045
MMATMMAGJ_42530
MBOKMBOE_62410
MFGK6L26_25550
MSEIMSEDJ_23700
MFLVNCTC10271_04129
MBRML2Z93_003257
MMONEWR22_05350
MGOAFA91_31845
MSENK3U95_06170
MPAEK0O64_05045
MRFMJO55_05290
MDFK0O62_05930
MCROMI149_05770
MGROFZ046_11310
MAUSJN090_05185
MFREEXE63_09515
MABMAB_3840
MMVMYCMA_05355
MABBMASS_3852
MABLMMASJCM_3856
MCHEBB28_19665
MIZBAB75_21940
MSTEMSTE_03990
MSAOMYCSP_17735
MSALDSM43276_03634(arcA_2)
NBRO3I_026660
NSLBOX37_11660
NSRNS506_05035(rocD)
NTPCRH09_17440 CRH09_29790
NOZDMB37_05565
NODFOH10_31840
NAHF5544_26290
NADNCTC11293_04429
NIEKV110_25865
NTCKHQ06_26040
NHUH0264_20990
NYALTV02_13080
NGPLTT66_27305
NSPUIFM12276_23890
NYUD7D52_17665 D7D52_19685
RHARHA1_ro06168
ROPROP_62280
ROAPd630_LPD02818
RHWBFN03_03650
RKOJWS14_33600
ROZCBI38_19900
RANTRHODO2019_02055
RHOJJVH1_05485(ddaH)
SPINKV203_14830
SCOSCO1222(2SCG58.22)
SALBXNR_4607
SMASAVERM_7113
SGRSGR_5233 SGR_672
SGBWQO_09165 WQO_31845
SFISFUL_1857 SFUL_6767
SANLKZO11_08940 KZO11_35395
SGRFSGFS_095610
SCYER2B67_02060 R2B67_27110
SCBSCAB_11871 SCAB_78481
SSXSACTE_1709
SVLStrvi_3918
SHYSHJG_2657 SHJG_6174
SHOSHJGH_2421 SHJGH_5935
SRCM271_05875
SMALSMALA_7232
SSOII1A49_39925
SFASfla_4552
SBHSBI_07674
SVESVEN_1961
SDVBN159_4230 BN159_7361
SALSSLNWT_0288
STRPF750_2138
SCIB446_06370
SLVSLIV_31685
SGUSGLAU_04885
SVTSVTN_11115
STREGZL_02916 GZL_04455
SCWTU94_04830
SLDT261_3879
SLCSL103_34400
SXISXIM_53270
STRMM444_11625
STRCAA958_07380
SAMBSAM23877_1302
SPRISPRI_1308
SCZABE83_02190 ABE83_07150 ABE83_21735 ABE83_26645
SCXAS200_37590
SRWTUE45_01609
STRFASR50_05915
SLEsle_58750(sle_58750)
SRNA4G23_03529 A4G23_04556
SPAVSpa2297_04425
STRTA8713_04080 A8713_08770
SCLFBB341_20665
SGSAVL59_10980 AVL59_31560
STSIA4E84_06000
SKYD0C37_24840
SALWCP975_10100
SGMGCM10017557_71900
SCADDN051_32920
SPHWNFX46_23560 NFX46_26405
SLSSLINC_1384
SNRSNOUR_12595 SNOUR_19905
SALUDC74_4436 DC74_6676
SALLSAZ_23570 SAZ_34695
SPLULK06_002280
STRDNI25_33140
SNWBBN63_25090
SAUOBV401_39775
SSIAA7J05_25590
SVUB1H20_08265 B1H20_32650
SPUNBFF78_35540
SGVB1H19_22415
SLAUSLA_1863
SALFSMD44_02498
SALJSMD11_4809
SLXSLAV_17285 SLAV_25845
STROSTRMOE7_12210 STRMOE7_21105
SFKKY5_2281 KY5_4570
SNZDC008_04315
SGEDWG14_07270
SRJSRO_6239
SLKSLUN_11275
SDXC4B68_35405
SGDELQ87_33660
SQZFQU76_08140
SCYAEJ357_06630
SASTCD934_29590
SNQCP978_05795
STIRDDW44_04585
SKACP970_18575 CP970_31070
SGZC0216_24440
SVNCP980_23470 CP980_30600
SNKCP967_24570
SHAWCEB94_06480
SRKFGW37_09690
SFICEIZ62_23730
SGALCP966_04470
SSPODDQ41_04040
SVRCP971_02015 CP971_03115 CP971_09845 CP971_29685
SPADDVK44_07370 DVK44_35395
SFYGFH48_28610 GFH48_34335 GFH48_36475
SAQUEJC51_08560
SGFHEP81_06590
SCAVCVT27_08075 CVT27_31340
SSEOD0Z67_03200
SBYH7H31_26075
SRIMCP984_09620 CP984_29400
SSUBCP968_23350
SPHVF9278_05675
SCINCP977_10285
SFUGCNQ36_04755
SPACB1H29_31435
STSUB7R87_00190 B7R87_08095
SCHACP983_20570 CP983_37255
SGXH4W23_02085 H4W23_04860 H4W23_11490
SCOECP976_06495
SBATG4Z16_14280 G4Z16_24995
SSPBCP982_13295
SNFJYK04_02980 JYK04_04424 JYK04_04430
SPLACP981_11435 CP981_20840
SBROGQF42_08540 GQF42_30085 GQF42_36655
STUIGCM10017668_08180
SATAC5746_12455
SCHFIPT68_05250
SHUNDWB77_05424
SHARHUT13_01765
SCYGS1361_06770
SFEUIM697_16915
SDWK7C20_10795 K7C20_20185
SVDCP969_07260
SCALI6J39_08440 I6J39_32445
SAUHSU9_018235
SFBCP974_19140 CP974_24480
SMOBJ7W19_00310 J7W19_09295
SPRACP972_05415
SPEUCGZ69_30635 CGZ69_34420
SROIIAG44_34315
SXNIAG42_03070
SGJIAG43_27320
SHKJ2N69_09925 J2N69_28750
SANUK7396_16715
STRYEQG64_08170 EQG64_32555
SDDD9753_30885
SACTDMT42_05135
SMAOCAG99_24615
SGOBtest1122_04650
SINEKI385_24530
SLFJEQ17_33050 JEQ17_39820
SDECL3078_07205
SAOVG3H79_26625
SDURM4V62_00725 M4V62_29580
SYANNRK68_10460 NRK68_26220
SRUGF0345_07025
SAKBK1J60_38290
STAALDH80_01665 LDH80_27860
SNIGHEK616_67620
SVIOHWN34_23285
SCAEIHE65_38390
STUBMMF93_09750
SSPNLXH13_05570
SCIRSTRCI_001148
SXTKPP03845_102514
SLONLGI35_15310 LGI35_39605
SDRZNEH16_22735
STUDSTRTU_003260
STEEF3L20_23040
SENGOJ254_07870
SGKPET44_10245
SANTQR300_04915
SYUNMOV08_12405 MOV08_19945
SARGHKX69_08150 HKX69_30235
SJNRI060_05595 RI060_36585
SCYNN8I84_06695
SOVQZH56_26115
SFIYF0344_06610
SHAUK9S39_12195 K9S39_21790
SKGKJK29_33355
SCOAQU709_37785
SLAIP8A22_27880
SROCRGF97_24585 RGF97_32630
SFPQUY26_28645
SCHGNRO40_07875
STTNBSL84_10140
SINNABB07_32705 ABB07_39010 ABB07_39665
STRZOYE22_25370
SCAYPYS65_31075
KBUQ4V64_06770
SARMDVA86_08655 DVA86_26495 DVA86_28285
SPRFK4G22_06170
SLUOPS467_04095
STPBQR97_10695 QR97_20220
SRPAHEP86_12640 HEP86_21950
SMIBSMIR_27565 SMIR_34120
SCAJO1G22_35710
STRWQHG49_30020
STRLHEP84_10650(ddaH) HEP84_17355(ddaH)
STSDHEP87_10395(ddaH)
SRPZHEP85_06920(ddaH) HEP85_12615(ddaH)
SCHEQRN89_09600
SGLYP8A20_26380
SCTSCAT_1360
SCYSCATT_13600
KSKKSE_07370 KSE_17770
KABB7C62_08160 B7C62_31600 B7C62_33865
KAUB6264_04925 B6264_28705
KITCFP65_7158
KISHUT16_02780 HUT16_07610
KCHO1G21_04805
YIALO772_13590
STRHGXP74_14810 GXP74_27210 GXP74_28730
ABRYNYE86_08575
AGLAOIE69_27890 OIE69_37490
LXLKDY119_02898(rocD)
PSICJ4E96_16890
LEIFHF024_01290
CMICMM_0629
CMHVO01_02915
CMSCMS0487
CMCCMN_00589
CCAPAES38_02625
CZHH9X71_02785
CPHAFGI33_10260
CCAFFGD68_05230
MTSMTES_1968
MIMAKG07_10520
MIOAOA12_02900
MIXAB663_000385
MIPAXH82_04210
MCWA8L33_02015
MIHBJP65_10745
MICRBMW26_15250
MAURBOH66_02130
MHOSCXR34_02675
MFOLDXT68_14700
MOOBWL13_02539
MLVCVS47_02993
MWAE4K62_16815
MPRTET475_03330
MSEDE3O41_12315
MOYCVS54_03286
MSFIT882_14330
MCAWF6J84_13465
MLZF6J85_15845
MRNK8F61_16105
MBINLXM64_14120
MLIQNMQ05_15885
MTECOAU46_00865
MPAOIZR02_14660
MAZANFX31_14785
MELYL2X98_29175
MSUWGCM10025863_30230
MRGSM116_03535
MINVT9R20_02935
MESTPTQ19_13600
MOJD7D94_12260
MLIYRYJ27_01425
MICEEHF32_14560
MAUGKV397_02075
MSUFKV394_02575
MHOTPU630_13550
MGABKV396_04110
MBETN8K70_02230
MCHNHCR76_01895
RTNA6122_2574
RRYC1O28_12145
RIAC7V51_13830
RFSC1I64_14690
RTEGSU10_01480
ROEQ0F99_09785
RATHGSU68_01630
CUMNI26_00650
CUBBJK06_07305
CUGC1N91_00625
CCITQPK07_00570
CUFKM842_12720
CUYI8920_00725
CPOIOE229_03475
MVDAWU67_15275
FRPAX769_04745
FSBGCM10025867_10510
AGMDCE93_00905
AARCG127AT_08895
AMAUDSM26151_02070
AMAVGCM10025877_18080
CARTPA27867_0159
CRYB7495_00705
CPHYB5808_01530
PSAIC3B54_11218
MALKMalAC0309_0300
CHREIE160_00430
MDBOVN18_05350
MYLC3E77_00760
SALCC2138_00315
SALAESZ53_10480
SALDFVA74_13195
HUMDVJ78_01150
HUWFPZ11_13865
LYDD7I47_06540
LYKFLP23_02465
PROAH4J02_13420
PLAPEAO79_02240
PFLUBWO91_18325
AGGC1N71_13645
AGROJSQ78_08565
MANTBHD05_01420
HEHL3i23_00790
FRNF1C15_08720
GLNF1C58_00585
AGXAGREI_0222
SUBTKPL76_04125
SUBALQ955_15735
HOMOF852_09505
NAEIGCM126_13530
AOGLH407_08010
ARIUM93_02370
BCVBcav_0887
HMMR3I40_08435
XCEXcel_3304
XYLET495_12585
XYAET471_04840
IVAIsova_2938
IDOI598_2650
CETB8281_07745
CCEUCBR64_03605
CPRTFIC82_006475
SKESked_30700
SANWG7063_12000
CFLCfla_0780
CFICelf_0744
CGACelgi_0508
CEZCBP52_16610
CELZE5225_14130
CEJGC089_14850
CELHGXP71_12795
CIRALFM56_14405
CPALF1D97_06135
CELCK5O09_03000
CDONKKR89_03885
CWANKG103_04115
CFENKG102_02565
CWNNP075_04055
CCHENP064_03495
CXIENP048_04005
CELEP9841_07685
PSEIGCE65_02895
GEZFE251_01840
DEMLGT36_008935
DCPRN607_02670
MPHMLP_42200
TEZBKM78_05750
TLATLA_TLA_01163
NOYEXE57_13000
NOOFE634_20160
NANOG5V58_23685
NAROCFH99_12080 CFH99_21765
NAQUENKNEFLB_04316
NPCKUV85_08145
NPSKRR39_21240
NMARHPC71_19935
NBISHK19_19885
AERAERYTH_13535
AEZC3E78_14780
AEBC6I20_01610
AEFGEV26_14890
ASEZH9L21_02465
ADBNP095_02435
AWNNQV15_15000
MUZH4N58_03100
SGRGL0C25_08745
KFLKfla_6873
KQIF1D05_19310
KSLOG809_10265
KRIOX958_02680
NDANdas_2244
NALB005_4578
NEXNE857_17725
NAKEKGD83_14335
NCGKGD84_16555
SNAHOUQ99_15990
TCUTcur_3814
ACTWF7P10_27905
AGRAAGRA3207_002510
ACIROG979_26125
SPIQOHA34_06810 OHA34_15765
ACTQOG417_43085
SROSros_2331
NOABKM31_32925
NOWGBF35_11760
NCXNocox_10985
NGNLCN96_12390
NFSOIE67_34615
TBITbis_1169
MHAIOHB01_22350
FALFRAAL4324
FREFranean1_2012
FSYFsymDg_2616
ACEAcel_0453
BLAPMVA48_06875
KRAKrad_1316
SENSACE_4332 SACE_6885
SACGFDZ84_09210
SVISvir_03350
SACCEYD13_01905
AMDAMED_0544 AMED_3639
AMNRAM_02790 RAM_18505
AMMAMES_0542 AMES_3598
AMZB737_0543 B737_3598
AOIAORI_0550 AORI_3165
AJAAJAP_19615 AJAP_23535 AJAP_36890
AMQAMETH_0505
AMYCCU254_01455
AMYBBKN51_19465 BKN51_19845 BKN51_36950
AABA4R43_33255
AMYYYIM_37965 YIM_44970
AORISD37_16145 SD37_38465
AACDLWP59_02420 LWP59_10720
APRTMUY14_33855
AROONQK81_06750 NQK81_20070
ATHML1857_05135
ARHDVSH64_40350
AMOGQRX60_08515
ACYNORV05_23000 ORV05_30545
ACORLCL61_30000(ddaH) LCL61_41990(ddaH)
AMYZHUW46_03227
ACABQRX50_04690
ANWQP939_00785 QP939_09680
PSEAWY02_13265
PSEEFRP1_00965 FRP1_28995
PSEHXF36_00380 XF36_26675
PSEQAD006_08600
PECQAD017_16430
PHHAFB00_14255
PAUTPdca_60790
PSDSK1T35_22525
APRECNX65_13500 CNX65_32830
AMIAmir_2664 Amir_6661
SESPBN6_80130
SSYIEKG83_44265
SACXIOD16_34100
KALKALB_8278
KUTJJ691_83380
KPHYAOZ06_50160
LEDBBK82_17230
AHMTL08_02705
ACTIUA75_02665
ACADUA74_02660
AHGAHOG_02610
ACTAC1701_13075
ALOCRK60104
PMADBAY61_02255
SACEGIY23_20710
ACTUActkin_01202 Actkin_05999
CROSN8J89_38765
UMERM788_22655
STPStrop_3676 Strop_4529
SAQSare_2147 Sare_4052 Sare_5039
MAUMicau_5200 Micau_6232
MILML5_3092 ML5_6194
MICBMicB006_4216 MicB006_6243
MTUACSH63_26470 CSH63_31400
MICHFJK98_27175 FJK98_32625
MTEMGCE86_20610 GCE86_25245
MCABHXZ27_26135 HXZ27_31350
MSAGGCM10017556_14590 GCM10017556_25420
VMAVAB18032_04135 VAB18032_29861
MCRAID554_13450 ID554_20460
VERHUT12_27055 HUT12_31790
MENOJiend_29200 Jiend_39020
MCHLPVK74_16230 PVK74_20715
MFEUH1D33_01475 H1D33_06570
MPRNQ3V37_07325 Q3V37_11920
MHAWRMN56_12030 RMN56_16870
MCAYPVK37_00985 PVK37_05860
MICFQQG74_26595 QQG74_31235
ASEACPL_7531 ACPL_8312
AMSAMIS_72610 AMIS_80560
ACTNL083_7178 L083_8142
ACTSACWT_7401 ACWT_8181
AIHAiant_33650 Aiant_42100
ACTRAsp14428_47920 Asp14428_58720
ACTLL3i22_098530 L3i22_106660
ASICQ0Z83_088880 Q0Z83_097370
AOUACTOB_007798 ACTOB_008703
ACTEACTI_12740 ACTI_20660
AFSAFR_37870 AFR_42610
PLKCIK06_23875 CIK06_28650
PLABC6361_14205 C6361_18105
PLATC6W10_10945 C6W10_30480
PFLAPflav_070660 Pflav_081660
PSUUPsuf_033090 Psuf_044470
ATLAthai_65220
ASERAsera_10240
PRYPrubr_25740 Prubr_36120 Prubr_57420
CATICS0771_17560 CS0771_20980
DVCDvina_00565 Dvina_45590
DFUDfulv_00645 Dfulv_40290
DROSDrose_00545 Drose_15980 Drose_30505
DAURDaura_00615 Daura_43895
DMATDmats_00610 Dmats_39955
DACTKZZ52_00655 KZZ52_21810 KZZ52_51990
NHYJQS43_00360
CCAZCOUCH_01345 COUCH_06710
CAICaci_7970
SNASnas_6044
NAVJQS30_00430
GLYK3N28_16795
AEYCDG81_20395
AQZKSP35_08725
IAMHC251_05975
SYNsll1336
SYZMYO_129650
SYYSYNGTS_2937(sll1336)
SYTSYNGTI_2936(sll1336)
SYSSYNPCCN_2935(sll1336)
SYQSYNPCCP_2935(sll1336)
SYJD082_28860
SYOC7I86_15345
SYNHHTZ78_08690
SYNSOLK001_11640
CYBCYB_0250
SYNESyn6312_0130
SYNPSyn7502_00223
WNAKA717_12945
CMPCha6605_4523
CYNCyan7425_3854
CEPCri9333_0830
TVNNIES2134_103220
SLWBRW62_04545
TELtll0507
THNNK55_08695(arcA)
THECFFX45_06625
THEYJW907_10695
TSQD3A95_08665
TSZOOK60_15505
LENLEP3755_02960
LETO77CONTIG1_03894
LBOLBWT_16730
KOVK9N68_25110
LSCKIK02_13250
LSKJ5X98_14995
PSEUPse7367_1615
PSERABRG53_1101
PGXOA858_04845
THEUHPC62_13610
TOGHNI00_13090
TSINOXH18_05340
GLPGlo7428_0907
CHONNIES4102_21780
GDUP0S91_18625
GENGM3709_1472
GEEGM3708_2477
CANCyan10605_0853
CSNCyast_2086
CYLAA637_06955
SYPSYNPCC7002_A0271
SYVAWQ23_01510
SYLAWQ21_01360
LEPLepto7376_0934
SYNNNIES970_11570
PIPFEK30_05420
MARMAE_40150
MPKVL20_2884
MIQB5D77_04875
MVZmyaer102_14930
CYTcce_2552
CWACwatDRAFT_0830
CYPPCC8801_2742
CYHCyan8802_3360
CYCPCC7424_3232
CYJCyan7822_0744
TERTery_4659
ARPNIES39_K04020
PAGHNIES204_16860
PPSUNO713_04583
PRUNPCC7821_02038
MVAGD0A34_09455
LFSHFV01_01950
LIXH2674_23545
OXYHCG48_06535
OACOscil6304_0740
ONIOsc7112_2263
MPROBJP34_32000
PHORJWS08_12855
PYHNEA10_18985
MICMic7113_4989
GEIGEI7407_1727
GVIglr1758
GLJGKIL_1230
GMLISF26_08285
ANAalr4995
NPUNpun_F2429
NOSNos7107_0975
NOPNos7524_2965
NONNOS3756_43270
NFLCOO91_00179
NOECLI64_10430
NSHGXM_06923
NEDHUN01_33985
NPZACX27_08300
NLKNIES25_32620
NCWNIES2107_51620
NCFANSO36C_21850
AVAAva_2273
NAZAazo_4047
ANBANA_C12142
ACYAnacy_0717
AWAAA650_06965
ANNEH233_15780
CSGCylst_2757
RSINB6N60_00909
HBQQI031_19375
CALOCal7507_5398
CALTCal6303_4803
CALHIJ00_24475
CALNNIES2098_63900
CALSNIES3974_41170
RIVRiv7116_3825
MDPNIES3275_60480
FISFIS3754_25160
NSPBMF81_01957
NSPHBDGGKGIB_02232
DOUBMF77_03291
DHTNG743_19880
DCMNIES806_17560
DOTEZY12_23325
DOZHEP80_12715
DOCHEQ26_21170
CCURIAR63_10115
CRKL3I90_00980
AFLOHEQ12_00640
STOQK2F26_24210
SKVNIES73_02940
AEEIM676_00975
RCSNIES932_23560
OCFWJM97_07365
TOQHCG51_21760
TTQNIES37_11310
ALAXNIES50_08520
SCYTSAMD_52090
SCYSNIES4073_40490 NIES4073_43750
BSENDP114_15235
BOXDP113_15175
NCNBZZ01_06165
CTHEChro_5384
PLPPle7327_1245
SCSSta7437_2134
STANSTA3757_13270
GLTGlitD10_0747
GCYLQF76_03340
CCZCCALI_00210
CCOTCCAX7_63340
VABWPS_06140
ROOG5S37_22875
PSLPsta_3749
LCREPla8534_16220
AAGGETAA8_31790
LPAVPLANPX_2342
LLHI41_20940
AMUCPan181_53610
PNDPla175_10070
BGOKPr1d_26450
PLSVT03_12485
PLHVT85_06760
GMRGmarT_46700
GPNPan110_44570
GFMEnr17x_47060
GAZPan241w_46140
GAWV144x_13260
GAXPan161_47120
MRIMal4_13340
SDYNMal52_29800
PLONPla110_38900
SVPPan189_08940
CHYAV22_19060
CCOSPan44_44450
PVARSH412_004331
GESVT84_32780
GOGC1280_03550
GMSSOIL9_62010
TIMGMBLW1_32500
LRSPX52LOC_04469
FTJFTUN_1182
ULIETAA1_41260
TSPHKIH39_00950
IPAIsop_3073
SACISinac_5338
PBORBSF38_05621
AGVOJF2_59920
TPLAElP_46070
LPROPQO03_11765
ACMAciX9_2194
GMAAciX8_2441
GRBGOB94_01185
TALBFTW19_07985
EDAGWR55_04335 GWR55_08140
EDGH7846_10305 H7846_11500
EPLP4G45_06450 P4G45_07695
ADINH7849_09335
TGIRBB81_12380 RBB81_15965
TEMPRBB75_16025 RBB75_17710
TPSCRBB77_13750 RBB77_15865
BHUMJXR92_008365
MICAP0L94_11930
SDJNCTC13534_01227
RMRRmar_1802
RMGRhom172_1758
RBARAWN76_003225
SRUSRU_1195
SRMSRM_01383(arcA)
CPRVCYPRO_0776
NDENIDE0529
NMVNITMOv2_0477
NIONITINOP_1205
NJANSJP_1571
NKFNkreftii_003762
NIFW02_28190
NTIDNFV4_00826
NALLPP769_05240
NNEOPQG83_16425
NLIG3M70_07845
NWTNSPWAT_0469
NVAG3M78_05395
MOXDAMO_0153
KBNHYS26_03575
HEZZEO776_17005
HRUHalru_0124
 » show all
Reference
1  [PMID:29632414]
  Authors
Zhang H, Liu Y, Nie X, Liu L, Hua Q, Zhao GP, Yang C.
  Title
The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase.
  Journal
Nat Chem Biol 14:575-581 (2018)
DOI:10.1038/s41589-018-0038-z
  Sequence
[syn:sll1336]
Reference
2  [PMID:30636068]
  Authors
Burnat M, Picossi S, Valladares A, Herrero A, Flores E.
  Title
Catabolic pathway of arginine in Anabaena involves a novel bifunctional enzyme that produces proline from arginine.
  Journal
Mol Microbiol 111:883-897 (2019)
DOI:10.1111/mmi.14203
  Sequence
[ana:alr4995]
Reference
3  [PMID:31914412]
  Authors
Zhuang N, Zhang H, Li L, Wu X, Yang C, Zhang Y.
  Title
Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism.
  Journal
J Biol Chem 295:2113-2124 (2020)
DOI:10.1074/jbc.RA119.011752
  Sequence
[syn:sll1336]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.3.27
IUBMB Enzyme Nomenclature: 3.5.3.27
ExPASy - ENZYME nomenclature database: 3.5.3.27
BRENDA, the Enzyme Database: 3.5.3.27
LinkDB

KEGG   REACTION: R13308
Entry
R13308                      Reaction                               
Name
L-arginine aminodihydrolase (L-ornithine-forming)
Definition
L-Arginine + 2 H2O <=> L-Ornithine + CO2 + 2 Ammonia
Equation
Reaction class
RC00024  C00062_C00077
Enzyme
Pathway
rn00220  Arginine biosynthesis
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00134  Polyamine biosynthesis, arginine => ornithine => putrescine
M00978  Ornithine-ammonia cycle
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.3  In linear amidines
    3.5.3.27
     R13308  L-Arginine + 2 H2O <=> L-Ornithine + CO2 + 2 Ammonia
Orthology
K27542  arginine dihydrolase [EC:3.5.3.27]
K27545  arginine dihydrolase [EC:3.5.3.27]
LinkDB

DBGET integrated database retrieval system