Entry
Name
N1-aminopropylagmatine ureohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
BRITE hierarchy
Sysname
N1-(aminopropyl)agmatine amidinohydrolase
Reaction(IUBMB)
N1-(aminopropyl)agmatine + H2O = spermidine + urea [RN:
R10347 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, which has been characterized from the hyperthermophilic archaeon Pyrococcus kodakarensis and the thermophilic Gram-negative bacterium Thermus thermophilus, is involved in the biosynthesis of spermidine.
History
EC 3.5.3.24 created 2013
Pathway
ec00330 Arginine and proline metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K27683 N1-aminopropylagmatine ureohydrolase
Genes
CBS : COXBURSA331_A0838(speB)
CEY : CleRT_04840 CleRT_06280
CHJ : NCTC10426_00531(speB)
FIL : BN1229_v1_2598(sepB)
FIY : BN1229_v1_3319(sepB)
SYY : SYNGTS_0134(sll0228)
SYT : SYNGTI_0134(sll0228)
SYS : SYNPCCN_0134(sll0228)
SYQ : SYNPCCP_0134(sll0228)
SYP : SYNPCC7002_A1109(speB)
SYNN : NIES970_14390(speB)
PRUN : PCC7821_02885(speB1)
PBAS : SMSP2_02853(speB_4)
VBL : L21SP4_01465(speB_2)
» show all
Taxonomy
Reference
Authors
Ohnuma M, Terui Y, Tamakoshi M, Mitome H, Niitsu M, Samejima K, Kawashima E, Oshima T
Title
N1-aminopropylagmatine, a new polyamine produced as a key intermediate in polyamine biosynthesis of an extreme thermophile, Thermus thermophilus.
Journal
Sequence
Reference
Authors
Morimoto N, Fukuda W, Nakajima N, Masuda T, Terui Y, Kanai T, Oshima T, Imanaka T, Fujiwara S
Title
Dual biosynthesis pathway for longer-chain polyamines in the hyperthermophilic archaeon Thermococcus kodakarensis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.3.24
ExPASy - ENZYME nomenclature database: 3.5.3.24
LinkDB
All DBs