KEGG   ORTHOLOGY: K27776
Entry
K27776                      KO                                     
Symbol
SBE2
Name
polyneuridine aldehyde synthase [EC:1.14.19.81]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00979  Ajmaline biosynthesis, geissoschizine => ajmaline
Reaction
R05829  (19E)-geissoschizine:[oxidized NADPH---hemoprotein reductase] oxidoreductase (polyneuridine aldehyde forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K27776  SBE2; polyneuridine aldehyde synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.81  polyneuridine aldehyde synthase
     K27776  SBE2; polyneuridine aldehyde synthase
Genes
AG: WKU61929(SBE2)
Reference
PMID:38212296
  Authors
Guo J, Gao D, Lian J, Qu Y
  Title
De novo biosynthesis of antiarrhythmic alkaloid ajmaline.
  Journal
Nat Commun 15:457 (2024)
DOI:10.1038/s41467-024-44797-z
  Sequence
[ag:WKU61929]
LinkDB

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