KEGG   MODULE: M00620
Entry
M00620            Pathway   Module                                 
Name
Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate
Definition
(K00169+K00170+K00171+K00172) (K01959+K01960) K00024 (K01677+K01678) (K18209+K18210) (K01902+K01903) (K00174+K00175+K00176+K00177)
Diagram
M00620

Orthology
K00169,K00170,K00171,K00172  
pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196]
K01959,K01960  
pyruvate carboxylase [EC:6.4.1.1] [RN:R00344]
K00024  
malate dehydrogenase [EC:1.1.1.37] [RN:R00342]
K01677,K01678  
fumarate hydratase [EC:4.2.1.2] [RN:R01082]
K18209,K18210  
fumarate reductase (CoM/CoB) [EC:1.3.4.1] [RN:R10660]
K01902,K01903  
succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405]
K00174,K00175,K00176,K00177  
2-oxoglutarate ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197]
Class
Pathway modules; Energy metabolism; Carbon fixation
Pathway
map00720  Other carbon fixation pathways
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R01196  
R00344  
R00342  
R01082  
R10660  
R00405  
R01197  
Compound
C00024  Acetyl-CoA
C00022  Pyruvate
C00036  Oxaloacetate
C00149  (S)-Malate
C00122  Fumarate
C00042  Succinate
C00091  Succinyl-CoA
C00026  2-Oxoglutarate
Comment
Organism group: methanogenic archaea
Reference
PMID:29586
  Authors
Fuchs G, Stupperich E
  Title
Evidence for an incomplete reductive carboxylic acid cycle in Methanobacterium thermoautotrophicum.
  Journal
Arch Microbiol 118:121-5 (1978)
DOI:10.1007/BF00406084
Reference
PMID:3667534
  Authors
Shieh JS, Whitman WB
  Title
Pathway of acetate assimilation in autotrophic and heterotrophic methanococci.
  Journal
J Bacteriol 169:5327-9 (1987)
DOI:10.1128/JB.169.11.5327-5329.1987
Reference
PMID:9578488
  Authors
Heim S, Kunkel A, Thauer RK, Hedderich R
  Title
Thiol:fumarate reductase (Tfr) from Methanobacterium thermoautotrophicum--identification of the catalytic sites for fumarate reduction and thiol oxidation.
  Journal
Eur J Biochem 253:292-9 (1998)
DOI:10.1046/j.1432-1327.1998.2530292.x
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