KEGG   MODULE: M00620
Entry
M00620            Pathway   Module                                 
Name
Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate
Definition
(K00169+K00170+K00171+K00172) (K01959+K01960) K00024 (K01677+K01678) (K18209+K18210) (K01902+K01903) (K00174+K00175+K00176+K00177)
Diagram
M00620  Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate
M00620

Class
Pathway modules; Energy metabolism; Carbon fixation
Pathway
map00720  Other carbon fixation pathways
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Orthology
K00169,K00170,K00171,K00172  
pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196]
K01959,K01960  
pyruvate carboxylase [EC:6.4.1.1] [RN:R00344]
K00024  
malate dehydrogenase [EC:1.1.1.37] [RN:R00342]
K01677,K01678  
fumarate hydratase [EC:4.2.1.2] [RN:R01082]
K18209,K18210  
fumarate reductase (CoM/CoB) [EC:1.3.4.1] [RN:R10660]
K01902,K01903  
succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405]
K00174,K00175,K00176,K00177  
2-oxoglutarate ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197]
Complete
mja  Methanocaldococcus jannaschii
mfe  Methanocaldococcus fervens
mvu  Methanocaldococcus vulcanius
mfs  Methanocaldococcus sp. FS406-22
mif  Methanocaldococcus infernus
mjh  Methanocaldococcus bathoardescens
mesg  Methanocaldococcus lauensis SG7
mesa  Methanocaldococcus lauensis SG1
mig  Methanotorris igneus
mmp  Methanococcus maripaludis S2
mmq  Methanococcus maripaludis C5
mmx  Methanococcus maripaludis C6
mmz  Methanococcus maripaludis C7
mmd  Methanococcus maripaludis X1
mmak  Methanococcus maripaludis KA1
mmao  Methanococcus maripaludis OS7
mmad  Methanococcus maripaludis DSM 2067
mae  Methanococcus aeolicus
mvn  Methanococcus vannielii
mvo  Methanococcus voltae
mok  Methanothermococcus okinawensis
metf  Methanofervidicoccus sp. A16
mmg  Methanothermobacter marburgensis
mwo  Methanothermobacter wolfeii
mtee  Methanothermobacter tenebrarum
metc  Methanothermobacter sp. CaT2
mete  Methanothermobacter sp. EMTCatA1
metz  Methanothermobacter sp. MT-2
metk  Methanothermobacter sp. KEPCO-1
mthm  Methanothermobacter sp. THM-1
mst  Methanosphaera stadtmanae
metb  Methanosphaera sp. BMS
meis  Methanosphaera sp. ISO3-F5
mru  Methanobrevibacter ruminantium
mmil  Methanobrevibacter millerae
mol  Methanobrevibacter olleyae
mel  Methanobacterium lacus
mew  Methanobacterium paludis
meth  Methanobacterium sp. MB1
mfc  Methanobacterium formicicum BRM9
mfi  Methanobacterium formicicum DSM1535
mcub  Methanobacterium congolense
msub  Methanobacterium subterraneum
mett  Methanobacterium sp. BRmetb2
meto  Methanobacterium sp. BAmetb5
meme  Methanobacterium alkalithermotolerans
mfeg  Methanobacterium ferruginis
mrid  Methanobacterium aridiramus
mhu  Methanospirillum hungatei
mrtj  Methanospirillum purgamenti
mla  Methanocorpusculum labreanum
mem  Methanoculleus marisnigri
mbg  Methanoculleus bourgensis MS2
mema  Methanoculleus bourgensis MAB1
mchk  Methanoculleus chikugoensis
msum  Methanoculleus submarinus
mrc  Methanoculleus receptaculi
mpi  Methanolacinia petrolearia
mend  Methanoplanus endosymbiosus
mefw  Methanochimaera problematica
maqe  Methanofollis aquaemaris
mfk  Methanofollis formosanus
mou  Methanogenium organophilum
mesb  Methanogenium sp. S4BF
manq  Methanomicrobium antiquum
mbn  Methanoregula boonei
mfo  Methanoregula formicica
mpl  Methanosphaerula palustris
 » show all
Reaction
R01196  
R00344  
R00342  
R01082  
R10660  
R00405  
R01197  
Compound
C00024  Acetyl-CoA
C00022  Pyruvate
C00036  Oxaloacetate
C00149  (S)-Malate
C00122  Fumarate
C00042  Succinate
C00091  Succinyl-CoA
C00026  2-Oxoglutarate
Comment
Organism group: methanogenic archaea
Reference
PMID:29586
  Authors
Fuchs G, Stupperich E
  Title
Evidence for an incomplete reductive carboxylic acid cycle in Methanobacterium thermoautotrophicum.
  Journal
Arch Microbiol 118:121-5 (1978)
DOI:10.1007/BF00406084
Reference
PMID:3667534
  Authors
Shieh JS, Whitman WB
  Title
Pathway of acetate assimilation in autotrophic and heterotrophic methanococci.
  Journal
J Bacteriol 169:5327-9 (1987)
DOI:10.1128/JB.169.11.5327-5329.1987
Reference
PMID:9578488
  Authors
Heim S, Kunkel A, Thauer RK, Hedderich R
  Title
Thiol:fumarate reductase (Tfr) from Methanobacterium thermoautotrophicum--identification of the catalytic sites for fumarate reduction and thiol oxidation.
  Journal
Eur J Biochem 253:292-9 (1998)
DOI:10.1046/j.1432-1327.1998.2530292.x
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